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The map label for this gene is msrA [H]

Identifier: 46446598

GI number: 46446598

Start: 1159552

End: 1160406

Strand: Reverse

Name: msrA [H]

Synonym: pc0964

Alternate gene names: 46446598

Gene position: 1160406-1159552 (Counterclockwise)

Preceding gene: 46446600

Following gene: 46446597

Centisome position: 48.06

GC content: 36.14

Gene sequence:

>855_bases
ATGAAAAAATACCATTCTCTGACGCCGGAAGAAAATTCTGTCATCAATTTTAAAGGGACAGAATATCCAAACACAGGAAA
ATATAATCACTTTTCAGAACCCGGTGTTTATGTCTGCAAAAAATGTGATGCTCCTCTTTATTTATCTTCAGATAAATTCT
TGTCTCATTGCGGCTGGCCTAGCTTTGATGATGAAATTAAAGGAAGCGTGGATAAGAAAGTAGATTCCGATGGGAGAAGA
ATAGAAATTTTGTGCCATCGATGTGGCGGACATTTAGGACATGTATTTAAAGGCGAAGGATTAACAACAAAAAATTTAAG
GCACTGCGTGAACTCCGTATCTTTATCCTTCCTCCCTGCTTTAACGAAAGAGAGTTATGAACGAGCTTTATTTGCCGGAG
GATGTTTTTGGGGAGTCGAGTATTTATTCCAAAAGCTTACAGGAGTTATTAAGACGAAAGTAGGATATAGCGGGGGAGTA
ACCATTGATCCTACTTATGAAGACATTTGTTCGGGAAGAACAAAACATGCTGAAACCTTAGAAGTTGTTTATGATAAGAA
TAAAATTACTTATGAAGCATTAGCGAAATTTTTTTTTGAGATCCACGATCCTTCTCAATTTCAAAGGCAGGGTCCAGATA
TTGGGAATCAATATCGCTCTGCTATTTTTTATTTAACAAAGCAACAAGAAGAAATAGCTCAGTGCCTAATCCAACTTCTT
TCCACTAAAGGAATTCCTATCGTGACAGAAGTTATTCCAGCAAGTGTTTTTTATCCAGCAGAAAACTATCATCAAAATTA
TTATGGCAAAACAGGAAAGACACCTTATTGCCATATTTATACAAAGCGATTTTAA

Upstream 100 bases:

>100_bases
CCTTCTAATGTATTTATTTAAATACGCATTTTATTTTTTTTACTAAACTTGATACATAAGTGTAATTATCTTAAATTACC
CTTAAATGATAAGGGGAAAA

Downstream 100 bases:

>100_bases
TTCTTTGGTTATAAAAACAATAAAGATTAATAAAATTTTTTATTGATTGTTTTTTGTGGGGCGAATATGTTCGGGCAAAA
GGCTCCAAACATTTATAAGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKKYHSLTPEENSVINFKGTEYPNTGKYNHFSEPGVYVCKKCDAPLYLSSDKFLSHCGWPSFDDEIKGSVDKKVDSDGRR
IEILCHRCGGHLGHVFKGEGLTTKNLRHCVNSVSLSFLPALTKESYERALFAGGCFWGVEYLFQKLTGVIKTKVGYSGGV
TIDPTYEDICSGRTKHAETLEVVYDKNKITYEALAKFFFEIHDPSQFQRQGPDIGNQYRSAIFYLTKQQEEIAQCLIQLL
STKGIPIVTEVIPASVFYPAENYHQNYYGKTGKTPYCHIYTKRF

Sequences:

>Translated_284_residues
MKKYHSLTPEENSVINFKGTEYPNTGKYNHFSEPGVYVCKKCDAPLYLSSDKFLSHCGWPSFDDEIKGSVDKKVDSDGRR
IEILCHRCGGHLGHVFKGEGLTTKNLRHCVNSVSLSFLPALTKESYERALFAGGCFWGVEYLFQKLTGVIKTKVGYSGGV
TIDPTYEDICSGRTKHAETLEVVYDKNKITYEALAKFFFEIHDPSQFQRQGPDIGNQYRSAIFYLTKQQEEIAQCLIQLL
STKGIPIVTEVIPASVFYPAENYHQNYYGKTGKTPYCHIYTKRF
>Mature_284_residues
MKKYHSLTPEENSVINFKGTEYPNTGKYNHFSEPGVYVCKKCDAPLYLSSDKFLSHCGWPSFDDEIKGSVDKKVDSDGRR
IEILCHRCGGHLGHVFKGEGLTTKNLRHCVNSVSLSFLPALTKESYERALFAGGCFWGVEYLFQKLTGVIKTKVGYSGGV
TIDPTYEDICSGRTKHAETLEVVYDKNKITYEALAKFFFEIHDPSQFQRQGPDIGNQYRSAIFYLTKQQEEIAQCLIQLL
STKGIPIVTEVIPASVFYPAENYHQNYYGKTGKTPYCHIYTKRF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=45.3947368421053, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=45.0980392156863, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=41.1290322580645, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=41.1290322580645, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=41.1290322580645, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=41.1290322580645, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI117606353, Length=123, Percent_Identity=40.650406504065, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI208609993, Length=130, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1790665, Length=169, Percent_Identity=46.1538461538462, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788077, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=37.4149659863946, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=39.1666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=39.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319816, Length=125, Percent_Identity=48.8, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=37.1794871794872, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221378664, Length=120, Percent_Identity=42.5, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24645799, Length=118, Percent_Identity=42.3728813559322, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45553335, Length=118, Percent_Identity=42.3728813559322, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356369, Length=118, Percent_Identity=42.3728813559322, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.8794326241135, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221378662, Length=127, Percent_Identity=40.1574803149606, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=36.7647058823529, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645801, Length=129, Percent_Identity=38.7596899224806, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645804, Length=129, Percent_Identity=38.7596899224806, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.1702127659575, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 32245; Mature: 32245

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYHSLTPEENSVINFKGTEYPNTGKYNHFSEPGVYVCKKCDAPLYLSSDKFLSHCGWP
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHCCCC
SFDDEIKGSVDKKVDSDGRRIEILCHRCGGHLGHVFKGEGLTTKNLRHCVNSVSLSFLPA
CCCHHHCCCHHHCCCCCCCEEEEEEEHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LTKESYERALFAGGCFWGVEYLFQKLTGVIKTKVGYSGGVTIDPTYEDICSGRTKHAETL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHCCCCCCCCEE
EVVYDKNKITYEALAKFFFEIHDPSQFQRQGPDIGNQYRSAIFYLTKQQEEIAQCLIQLL
EEEECCCCCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHEEECCHHHHHHHHHHHH
STKGIPIVTEVIPASVFYPAENYHQNYYGKTGKTPYCHIYTKRF
HCCCCCCHHHHHCCCEECCCHHHHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKKYHSLTPEENSVINFKGTEYPNTGKYNHFSEPGVYVCKKCDAPLYLSSDKFLSHCGWP
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHCCCC
SFDDEIKGSVDKKVDSDGRRIEILCHRCGGHLGHVFKGEGLTTKNLRHCVNSVSLSFLPA
CCCHHHCCCHHHCCCCCCCEEEEEEEHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LTKESYERALFAGGCFWGVEYLFQKLTGVIKTKVGYSGGVTIDPTYEDICSGRTKHAETL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHCCCCCCCCEE
EVVYDKNKITYEALAKFFFEIHDPSQFQRQGPDIGNQYRSAIFYLTKQQEEIAQCLIQLL
EEEECCCCCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHEEECCHHHHHHHHHHHH
STKGIPIVTEVIPASVFYPAENYHQNYYGKTGKTPYCHIYTKRF
HCCCCCCHHHHHCCCEECCCHHHHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]