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The map label for this gene is kefC [H]

Identifier: 46446549

GI number: 46446549

Start: 1107563

End: 1109578

Strand: Reverse

Name: kefC [H]

Synonym: pc0915

Alternate gene names: 46446549

Gene position: 1109578-1107563 (Counterclockwise)

Preceding gene: 46446550

Following gene: 46446548

Centisome position: 45.96

GC content: 34.67

Gene sequence:

>2016_bases
ATGGAATTATTTCTATTTACAGATTTATTAATTCTGTTTGCTATATCGATTATTATCCTTCTAGTGGGTTATCGATTTAA
CATTCCTCCTGTTGTTTGTTTTCTTTTAACAGGTATGTTAGCAGGCCCGCACGGATTAGCCTTCGTGCAAGAAAGTAAAG
ATGTAGAAATGTTAGCTCAATTGGGAATCGTTCTCCTTTTGTTTGGAATTGGAATGGAGTTTTCCATTAAAAAACTTTTT
CAGATTAAACGGCTCTTTTTTTTAGGAGGTTCTCTACAAGTTGGCTTAACCATTCTATTTACTTATATTTTAACCCAGCT
CATGCAATTGCCATGGAAAGAATCTATCTTTATCGGCTGTTTAATATCTATGAGCAGCACAGCAATTGTTGTTAGACTTT
TAGATCAAAAAGGGGAGAGCTTAAGTCCTCAGGGTAAACTTTCCATCTCGATTCTGATTTTTCAAGATTTGATTGCAATT
CCAATGATTTTGTTTATTCCTATGCTTTCTGGAAATATGGAAGAAAAACAATTTCAAATAGAGTGGACAGTTTTTAAACC
TTTTATGGTAGGAATGTTAATTTTAGTTGCTGTCTTTTTTAGTGCGCAACGGATCGTCCCTCGTTTATTACTACAAGTGG
CGAGAACGCGAAATAAAGATCTCTTTTTATTAAGTGTATTAACTCTTTGCTTTGGTGTTGCATGGCTGACGTCAACCTTA
GGACTTTCCTTAACGATCGGTGCATTTTTAGCTGGTTTAATTATTTCTGAATCAGAGTATAGCCATGAAGCTGTGGGTCA
TATCTTTCCTTTGCAAACGCTTTTCATTAGCTTCTTTTTTGTTTCCATAGGCATGTTGTTAAATATCGATTTTTTCATCC
ATCATTTATTTACTATTCTAGCTTTAGCTACCCTCGTCATTATTTTAAAGATTTTCGTGACAGGATTAACAACATTGATG
ATTGGTTTACCCATGCGAACAGCTATTTTAACAGGTTTAATGCTAAGTCAAGTTGGAGAATTTTCTTTTGTCTTAGCAAA
CGCTGGAATGCCTTTTAGACTCCTAACGGATTATGAATACCAACTCTTTTTATCAATTTCACTTGTTTCTCTTGCTATTA
GTCCAATTTTGATTTCTTTTTCTCCAAAAATTGTTAGTTTCATCTGTTCTTTACCTTTACCACAAAAATTACTTTCAGGG
CTAAGAGAACAACGAAAAAGTGATGATAGGTCACTCAGTAATCACGTGATTATTGTTGGGTTTGGGATCAGTGGGAAAAA
TCTAGCGCGTTCAAGCAAATTAGCAAATATTCCTTATACAATACTAGAAATGAACCCAGATATTGTCAGGGAACAACGGA
CACTTAATGAACCAATTTATTTTGGTGATGCGACACATCTAACTGTCTTAGAACACTCCCACATTCATAAAGCCAAAGCA
ATTGCTGTTTTAGTTAATGATCCTATTGCAGCAAGACGAATTGTTAAAATTGCACGAGAATCTAATCCAACCATTTACAT
TGTTGTAAGAACGCGTTACATGCGAGAAATGCTGTTAATGCATAAATTAGGTGCTGATGAAGTAATTCCTGATGAATTGG
GAACTTCTGTAGAAATTTTTTCTCGTGTATTAAAACAATACTATATCCCAGATGAAGAAATCCATCAACTTGTCACAGAG
GTTCGAGCAGATGGATACAAAATGTTACGCGATCAACAAGCTCCTTTAACAAATTTATCAGAAGTTAAGCTAAATTTATC
AAACGTTGAAATGGGAACTTTCCGTTTACACGAAAATTCTCCCCTGGTTGGGATGCTTTTATCTGAATCAAATTTACGTA
AAAAACACGGAATGACGGTTTTATTAATTAGGCGCGAAAAAGCTGTTATTTCTAACCCCTCTCCGGATACTCAATTACTC
GCTAATGATGTTTTAGTTGTTGTGGGTGAAAAGACGCCTTTAAAGCAAGCACTAGAATTATTTGGAAAATTAGAAAAACA
ATCGACTATTAATTAA

Upstream 100 bases:

>100_bases
TAGCAAAAAATCATTTCTTTCACTTCAATCTTTAATTTGCTAATTAAAACTCTCTGGCTTAAAAAACAAAGCTCCATTTG
CAAGTAAAGTAGGATTCGAT

Downstream 100 bases:

>100_bases
AGGTTTTCATGGCAAAATTTCCCAAACCCGTTTTTCTTCCAGCGGATGTTTATCTCAAAAGAGCTCAACGCAGTCAACTT
ATTCTTCGATCTGCTAAATT

Product: putative glutathione-regulated potassium-efflux system protein

Products: NA

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MELFLFTDLLILFAISIIILLVGYRFNIPPVVCFLLTGMLAGPHGLAFVQESKDVEMLAQLGIVLLLFGIGMEFSIKKLF
QIKRLFFLGGSLQVGLTILFTYILTQLMQLPWKESIFIGCLISMSSTAIVVRLLDQKGESLSPQGKLSISILIFQDLIAI
PMILFIPMLSGNMEEKQFQIEWTVFKPFMVGMLILVAVFFSAQRIVPRLLLQVARTRNKDLFLLSVLTLCFGVAWLTSTL
GLSLTIGAFLAGLIISESEYSHEAVGHIFPLQTLFISFFFVSIGMLLNIDFFIHHLFTILALATLVIILKIFVTGLTTLM
IGLPMRTAILTGLMLSQVGEFSFVLANAGMPFRLLTDYEYQLFLSISLVSLAISPILISFSPKIVSFICSLPLPQKLLSG
LREQRKSDDRSLSNHVIIVGFGISGKNLARSSKLANIPYTILEMNPDIVREQRTLNEPIYFGDATHLTVLEHSHIHKAKA
IAVLVNDPIAARRIVKIARESNPTIYIVVRTRYMREMLLMHKLGADEVIPDELGTSVEIFSRVLKQYYIPDEEIHQLVTE
VRADGYKMLRDQQAPLTNLSEVKLNLSNVEMGTFRLHENSPLVGMLLSESNLRKKHGMTVLLIRREKAVISNPSPDTQLL
ANDVLVVVGEKTPLKQALELFGKLEKQSTIN

Sequences:

>Translated_671_residues
MELFLFTDLLILFAISIIILLVGYRFNIPPVVCFLLTGMLAGPHGLAFVQESKDVEMLAQLGIVLLLFGIGMEFSIKKLF
QIKRLFFLGGSLQVGLTILFTYILTQLMQLPWKESIFIGCLISMSSTAIVVRLLDQKGESLSPQGKLSISILIFQDLIAI
PMILFIPMLSGNMEEKQFQIEWTVFKPFMVGMLILVAVFFSAQRIVPRLLLQVARTRNKDLFLLSVLTLCFGVAWLTSTL
GLSLTIGAFLAGLIISESEYSHEAVGHIFPLQTLFISFFFVSIGMLLNIDFFIHHLFTILALATLVIILKIFVTGLTTLM
IGLPMRTAILTGLMLSQVGEFSFVLANAGMPFRLLTDYEYQLFLSISLVSLAISPILISFSPKIVSFICSLPLPQKLLSG
LREQRKSDDRSLSNHVIIVGFGISGKNLARSSKLANIPYTILEMNPDIVREQRTLNEPIYFGDATHLTVLEHSHIHKAKA
IAVLVNDPIAARRIVKIARESNPTIYIVVRTRYMREMLLMHKLGADEVIPDELGTSVEIFSRVLKQYYIPDEEIHQLVTE
VRADGYKMLRDQQAPLTNLSEVKLNLSNVEMGTFRLHENSPLVGMLLSESNLRKKHGMTVLLIRREKAVISNPSPDTQLL
ANDVLVVVGEKTPLKQALELFGKLEKQSTIN
>Mature_671_residues
MELFLFTDLLILFAISIIILLVGYRFNIPPVVCFLLTGMLAGPHGLAFVQESKDVEMLAQLGIVLLLFGIGMEFSIKKLF
QIKRLFFLGGSLQVGLTILFTYILTQLMQLPWKESIFIGCLISMSSTAIVVRLLDQKGESLSPQGKLSISILIFQDLIAI
PMILFIPMLSGNMEEKQFQIEWTVFKPFMVGMLILVAVFFSAQRIVPRLLLQVARTRNKDLFLLSVLTLCFGVAWLTSTL
GLSLTIGAFLAGLIISESEYSHEAVGHIFPLQTLFISFFFVSIGMLLNIDFFIHHLFTILALATLVIILKIFVTGLTTLM
IGLPMRTAILTGLMLSQVGEFSFVLANAGMPFRLLTDYEYQLFLSISLVSLAISPILISFSPKIVSFICSLPLPQKLLSG
LREQRKSDDRSLSNHVIIVGFGISGKNLARSSKLANIPYTILEMNPDIVREQRTLNEPIYFGDATHLTVLEHSHIHKAKA
IAVLVNDPIAARRIVKIARESNPTIYIVVRTRYMREMLLMHKLGADEVIPDELGTSVEIFSRVLKQYYIPDEEIHQLVTE
VRADGYKMLRDQQAPLTNLSEVKLNLSNVEMGTFRLHENSPLVGMLLSESNLRKKHGMTVLLIRREKAVISNPSPDTQLL
ANDVLVVVGEKTPLKQALELFGKLEKQSTIN

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=372, Percent_Identity=26.8817204301075, Blast_Score=93, Evalue=7e-19,
Organism=Escherichia coli, GI1786685, Length=527, Percent_Identity=29.4117647058824, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789749, Length=577, Percent_Identity=28.9428076256499, Blast_Score=226, Evalue=5e-60,
Organism=Escherichia coli, GI1786232, Length=524, Percent_Identity=27.2900763358779, Blast_Score=200, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 75125; Mature: 75125

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFLFTDLLILFAISIIILLVGYRFNIPPVVCFLLTGMLAGPHGLAFVQESKDVEMLAQ
CEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHH
LGIVLLLFGIGMEFSIKKLFQIKRLFFLGGSLQVGLTILFTYILTQLMQLPWKESIFIGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LISMSSTAIVVRLLDQKGESLSPQGKLSISILIFQDLIAIPMILFIPMLSGNMEEKQFQI
HHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
EWTVFKPFMVGMLILVAVFFSAQRIVPRLLLQVARTRNKDLFLLSVLTLCFGVAWLTSTL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GLSLTIGAFLAGLIISESEYSHEAVGHIFPLQTLFISFFFVSIGMLLNIDFFIHHLFTIL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATLVIILKIFVTGLTTLMIGLPMRTAILTGLMLSQVGEFSFVLANAGMPFRLLTDYEY
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCE
QLFLSISLVSLAISPILISFSPKIVSFICSLPLPQKLLSGLREQRKSDDRSLSNHVIIVG
EEHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEE
FGISGKNLARSSKLANIPYTILEMNPDIVREQRTLNEPIYFGDATHLTVLEHSHIHKAKA
ECCCCCHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHE
IAVLVNDPIAARRIVKIARESNPTIYIVVRTRYMREMLLMHKLGADEVIPDELGTSVEIF
EEEEECCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCHHHHCCHHHHH
SRVLKQYYIPDEEIHQLVTEVRADGYKMLRDQQAPLTNLSEVKLNLSNVEMGTFRLHENS
HHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHEEEECCEEEEEEEEECCC
PLVGMLLSESNLRKKHGMTVLLIRREKAVISNPSPDTQLLANDVLVVVGEKTPLKQALEL
CEEEEEECCCCCHHHCCCEEEEEECCCHHCCCCCCCHHHHHCCEEEEECCCCCHHHHHHH
FGKLEKQSTIN
HHHHHHHCCCC
>Mature Secondary Structure
MELFLFTDLLILFAISIIILLVGYRFNIPPVVCFLLTGMLAGPHGLAFVQESKDVEMLAQ
CEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHH
LGIVLLLFGIGMEFSIKKLFQIKRLFFLGGSLQVGLTILFTYILTQLMQLPWKESIFIGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LISMSSTAIVVRLLDQKGESLSPQGKLSISILIFQDLIAIPMILFIPMLSGNMEEKQFQI
HHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
EWTVFKPFMVGMLILVAVFFSAQRIVPRLLLQVARTRNKDLFLLSVLTLCFGVAWLTSTL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GLSLTIGAFLAGLIISESEYSHEAVGHIFPLQTLFISFFFVSIGMLLNIDFFIHHLFTIL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATLVIILKIFVTGLTTLMIGLPMRTAILTGLMLSQVGEFSFVLANAGMPFRLLTDYEY
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCE
QLFLSISLVSLAISPILISFSPKIVSFICSLPLPQKLLSGLREQRKSDDRSLSNHVIIVG
EEHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEE
FGISGKNLARSSKLANIPYTILEMNPDIVREQRTLNEPIYFGDATHLTVLEHSHIHKAKA
ECCCCCHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHE
IAVLVNDPIAARRIVKIARESNPTIYIVVRTRYMREMLLMHKLGADEVIPDELGTSVEIF
EEEEECCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCHHHHCCHHHHH
SRVLKQYYIPDEEIHQLVTEVRADGYKMLRDQQAPLTNLSEVKLNLSNVEMGTFRLHENS
HHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHEEEECCEEEEEEEEECCC
PLVGMLLSESNLRKKHGMTVLLIRREKAVISNPSPDTQLLANDVLVVVGEKTPLKQALEL
CEEEEEECCCCCHHHCCCEEEEEECCCHHCCCCCCCHHHHHCCEEEEECCCCCHHHHHHH
FGKLEKQSTIN
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA