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The map label for this gene is ribA [H]

Identifier: 46446524

GI number: 46446524

Start: 1075048

End: 1076286

Strand: Reverse

Name: ribA [H]

Synonym: pc0890

Alternate gene names: 46446524

Gene position: 1076286-1075048 (Counterclockwise)

Preceding gene: 46446525

Following gene: 46446523

Centisome position: 44.58

GC content: 36.08

Gene sequence:

>1239_bases
ATGAAAACCTATCGATTAGAAGATGCGCTTTTAGCCTTAAAAGAAGGAAAATTTGTTATTGTTGTTGACGATGAAAATAG
AGAAAATGAAGGAGATTTGATTTTAGCTGCAGAAAAAGCACATCCAAGTTCATTGGGATTTATGATCAGGCATACTACAG
GCATTATCTGCTTAGCCATGAAAGGACAACGTCTAGATGAATTAAAACTCCCTCCAATGGTTACAGATAATACAGATCGT
AAACAAACAGCTTTTACAGTCTCTGTTGATTATTTGCATCAAGGTGTAACAACTGGAGTTTCGGCTGAAGATAGAACTAA
AACAATTTTATCTCTCATTCACCCTCATACAAAACCAGAAGATTTAGGCCGCCCGGGACATATCTTCCCTCTTCGTTACA
AAGAAGGGGGCGTTCTAAAAAGGGCAGGTCACACAGAAGCTGCTGTTGATCTGACAAACTTAGCCAAACTTTATCCGGCA
GGTATCCTTGCAGAACTTATCAATGAAGATGGTTCCATGATGCGTTTACCAGAATTGGAGAAATTTTCCGACCTTCATCA
AATTCCCATTATTACGATTGCAGAGCTTATTCGTTTTAGAAGAAGGCATGAAAAATTAGTGAGCTGTTTTTCACAATCCC
CTATTCCTACTCCATTTGGAGATTTTAACGCTTATGTTTATGAATCACAATTAGATGGAATTCAACATATTGCATTAGTG
AAAGGCGAAATAAAAAATCAAAAAAACATTCTTGTAAGAATGCATTCGGAATGCTTAACTGGCGATGTTTTTGGTTCTAA
ACGATGCGATTGTGGCTCCCAGCTAAAACTTGCCATGGAAAAAATAGAGCAAGAAGGACGAGGAGTGATTATTTATTTAC
GAGGGCATGAAGGAAGAGGAATTGGAATTGGTCATAAATTAAAAGCTTACAATCTTCAAGATCAAGGGAAAGACACATTA
GAAGCTAACCTTGAACTAGGTTTTCCAATTGATTCTCGCGAATATGGAATAGGAGCCCAAATTTTAGTTGATTTAGGATT
ATCGACAATCCGATTAATGACAAATAATTTAGCTAAATATAATGGGCTAGCAGGGTATGATTTAGAAATTACTGAAAGGG
TGCCTTTACCTGTTTGTGTAACAAAAGAGAATAAACATTATTTACAAACTAAAAAAGACAAACTCGGTCATTTGATTGAC
TTAAGTGAAGATAAATTAGAAATTCATCATTCGACGTAA

Upstream 100 bases:

>100_bases
AGAAAAGGAAAAGGTGATTTAGTTAATGTAGAAGTAGATTTAATGGCTAAATATATTGAAAAATTGATGACTCCCTATCA
CAACCAAGGATAATGAATTC

Downstream 100 bases:

>100_bases
CTTTTTCTTTAAATAAACAGGAATCATTAGATGAAAGAATATAAGGGTAAATTAAATATTTCAAAAGCTCGTATTGGAAT
TGTTATTTCTCGTTTTAACG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKTYRLEDALLALKEGKFVIVVDDENRENEGDLILAAEKAHPSSLGFMIRHTTGIICLAMKGQRLDELKLPPMVTDNTDR
KQTAFTVSVDYLHQGVTTGVSAEDRTKTILSLIHPHTKPEDLGRPGHIFPLRYKEGGVLKRAGHTEAAVDLTNLAKLYPA
GILAELINEDGSMMRLPELEKFSDLHQIPIITIAELIRFRRRHEKLVSCFSQSPIPTPFGDFNAYVYESQLDGIQHIALV
KGEIKNQKNILVRMHSECLTGDVFGSKRCDCGSQLKLAMEKIEQEGRGVIIYLRGHEGRGIGIGHKLKAYNLQDQGKDTL
EANLELGFPIDSREYGIGAQILVDLGLSTIRLMTNNLAKYNGLAGYDLEITERVPLPVCVTKENKHYLQTKKDKLGHLID
LSEDKLEIHHST

Sequences:

>Translated_412_residues
MKTYRLEDALLALKEGKFVIVVDDENRENEGDLILAAEKAHPSSLGFMIRHTTGIICLAMKGQRLDELKLPPMVTDNTDR
KQTAFTVSVDYLHQGVTTGVSAEDRTKTILSLIHPHTKPEDLGRPGHIFPLRYKEGGVLKRAGHTEAAVDLTNLAKLYPA
GILAELINEDGSMMRLPELEKFSDLHQIPIITIAELIRFRRRHEKLVSCFSQSPIPTPFGDFNAYVYESQLDGIQHIALV
KGEIKNQKNILVRMHSECLTGDVFGSKRCDCGSQLKLAMEKIEQEGRGVIIYLRGHEGRGIGIGHKLKAYNLQDQGKDTL
EANLELGFPIDSREYGIGAQILVDLGLSTIRLMTNNLAKYNGLAGYDLEITERVPLPVCVTKENKHYLQTKKDKLGHLID
LSEDKLEIHHST
>Mature_412_residues
MKTYRLEDALLALKEGKFVIVVDDENRENEGDLILAAEKAHPSSLGFMIRHTTGIICLAMKGQRLDELKLPPMVTDNTDR
KQTAFTVSVDYLHQGVTTGVSAEDRTKTILSLIHPHTKPEDLGRPGHIFPLRYKEGGVLKRAGHTEAAVDLTNLAKLYPA
GILAELINEDGSMMRLPELEKFSDLHQIPIITIAELIRFRRRHEKLVSCFSQSPIPTPFGDFNAYVYESQLDGIQHIALV
KGEIKNQKNILVRMHSECLTGDVFGSKRCDCGSQLKLAMEKIEQEGRGVIIYLRGHEGRGIGIGHKLKAYNLQDQGKDTL
EANLELGFPIDSREYGIGAQILVDLGLSTIRLMTNNLAKYNGLAGYDLEITERVPLPVCVTKENKHYLQTKKDKLGHLID
LSEDKLEIHHST

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=49.5098039215686, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1787533, Length=190, Percent_Identity=47.3684210526316, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=43.9024390243902, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=46.551724137931, Blast_Score=136, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46076; Mature: 46076

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYRLEDALLALKEGKFVIVVDDENRENEGDLILAAEKAHPSSLGFMIRHTTGIICLAM
CCCEEHHHHHHHEECCCEEEEECCCCCCCCCCEEEEECCCCCCHHCEEEEECCCEEEEEE
KGQRLDELKLPPMVTDNTDRKQTAFTVSVDYLHQGVTTGVSAEDRTKTILSLIHPHTKPE
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
DLGRPGHIFPLRYKEGGVLKRAGHTEAAVDLTNLAKLYPAGILAELINEDGSMMRLPELE
HCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
KFSDLHQIPIITIAELIRFRRRHEKLVSCFSQSPIPTPFGDFNAYVYESQLDGIQHIALV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHEEEEE
KGEIKNQKNILVRMHSECLTGDVFGSKRCDCGSQLKLAMEKIEQEGRGVIIYLRGHEGRG
HHHHCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCC
IGIGHKLKAYNLQDQGKDTLEANLELGFPIDSREYGIGAQILVDLGLSTIRLMTNNLAKY
CCCCCEEEEECCCCCCCCCEEECEEECCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHH
NGLAGYDLEITERVPLPVCVTKENKHYLQTKKDKLGHLIDLSEDKLEIHHST
CCCCCCCEEEECCCCCCEEEECCCCHHHHCCHHHCCCEEECCCCEEEEEECC
>Mature Secondary Structure
MKTYRLEDALLALKEGKFVIVVDDENRENEGDLILAAEKAHPSSLGFMIRHTTGIICLAM
CCCEEHHHHHHHEECCCEEEEECCCCCCCCCCEEEEECCCCCCHHCEEEEECCCEEEEEE
KGQRLDELKLPPMVTDNTDRKQTAFTVSVDYLHQGVTTGVSAEDRTKTILSLIHPHTKPE
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
DLGRPGHIFPLRYKEGGVLKRAGHTEAAVDLTNLAKLYPAGILAELINEDGSMMRLPELE
HCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
KFSDLHQIPIITIAELIRFRRRHEKLVSCFSQSPIPTPFGDFNAYVYESQLDGIQHIALV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHEEEEE
KGEIKNQKNILVRMHSECLTGDVFGSKRCDCGSQLKLAMEKIEQEGRGVIIYLRGHEGRG
HHHHCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCC
IGIGHKLKAYNLQDQGKDTLEANLELGFPIDSREYGIGAQILVDLGLSTIRLMTNNLAKY
CCCCCEEEEECCCCCCCCCEEECEEECCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHH
NGLAGYDLEITERVPLPVCVTKENKHYLQTKKDKLGHLIDLSEDKLEIHHST
CCCCCCCEEEECCCCCCEEEECCCCHHHHCCHHHCCCEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]