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The map label for this gene is ribH

Identifier: 46446523

GI number: 46446523

Start: 1074499

End: 1075017

Strand: Reverse

Name: ribH

Synonym: pc0889

Alternate gene names: 46446523

Gene position: 1075017-1074499 (Counterclockwise)

Preceding gene: 46446524

Following gene: 46446510

Centisome position: 44.52

GC content: 37.76

Gene sequence:

>519_bases
ATGAAAGAATATAAGGGTAAATTAAATATTTCAAAAGCTCGTATTGGAATTGTTATTTCTCGTTTTAACGAAACCATAAC
CAAAAATCTTCTTGAGGGGTCCTTAGATGAATTAGAAAGATATGGAATATCAACACAAAACCTTCCTGTTGCTTGGGTAC
CTGGTGCTTTTGAAATTCCTTTAATTGCAAAACAAATGGCCCTTTCAGGAGAATTTGATGCCATTATTTGTTTGGGAGCT
ATTATTCGTGGGACCACCCCCCATTTTGACTATGTTGCTAGCCAATCTGCTGCAGGAATTCTGAATGTTTCTTTAGAAAT
TAATCTTCCGGTTGTATTTGGAATCTTAACAACGGATACGGTGGAACAAGCCATGGAACGCTCAGGAGTGAAAATGGGAA
ATAAAGGGCGGGAAGCCGTTCAAACAGCCATAGAGATGATAGACTTGACTGATCAACTCTCTTTGCTTAGAAATCATCCC
CATTCTTCGACTGCCAATAATACTTCTGTTTGTAAATAA

Upstream 100 bases:

>100_bases
TAAAAAAGACAAACTCGGTCATTTGATTGACTTAAGTGAAGATAAATTAGAAATTCATCATTCGACGTAACTTTTTCTTT
AAATAAACAGGAATCATTAG

Downstream 100 bases:

>100_bases
TAACTAATAAATGGTATTTAATTAATAACAGGAAAATTTATATAAAATTACCATTTTTTATAATAAAATAATATAAAAAC
AAAAATGTTCATATGAATCC

Product: riboflavin synthase beta chain

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIPLIAKQMALSGEFDAIICLGA
IIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDTVEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHP
HSSTANNTSVCK

Sequences:

>Translated_172_residues
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIPLIAKQMALSGEFDAIICLGA
IIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDTVEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHP
HSSTANNTSVCK
>Mature_172_residues
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIPLIAKQMALSGEFDAIICLGA
IIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDTVEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHP
HSSTANNTSVCK

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=138, Percent_Identity=50.7246376811594, Blast_Score=155, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324429, Length=145, Percent_Identity=32.4137931034483, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PARUW (Q6MCT6)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007888.1
- HSSP:   P11998
- ProteinModelPortal:   Q6MCT6
- SMR:   Q6MCT6
- STRING:   Q6MCT6
- GeneID:   2780952
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0889
- NMPDR:   fig|264201.1.peg.889
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   Q6MCT6
- BioCyc:   CPRO264201:PC0889-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 18703; Mature: 18703

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIP
CCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCH
LIAKQMALSGEFDAIICLGAIIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDT
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEHHHHH
VEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHPHSSTANNTSVCK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIP
CCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCH
LIAKQMALSGEFDAIICLGAIIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDT
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEHHHHH
VEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHPHSSTANNTSVCK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA