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The map label for this gene is zwf [H]

Identifier: 46446455

GI number: 46446455

Start: 1003120

End: 1004670

Strand: Reverse

Name: zwf [H]

Synonym: pc0821

Alternate gene names: 46446455

Gene position: 1004670-1003120 (Counterclockwise)

Preceding gene: 46446457

Following gene: 46446454

Centisome position: 41.61

GC content: 39.14

Gene sequence:

>1551_bases
ATGCATAACTCGCATTATTTTGTTAATCCTTTGAACGAACCGAATCGGCCCATAAAAATTCCAGAATCTTGTATTTTAGT
CATTTTTGGAGCGACCGGTGATTTAACAGCTCGTAAACTAATTCCAGCTTTGTATAACTTAGCGAGAGACGGCCAACTTC
CTGGTCATTTTGCCTGTGTAGGCTTTGCTAGAAGGGCAAAAACACATGATGAGTTTCGGGAAGAAATGTTAGAAGCAGTT
AACAAATTTTCAAGATCGAAACCAGTTGAACAAGGACTCTGGAAACGCTTTCGTGAACAATTGTTTTATCATCAATCAGA
ATTTGATGATGATGAAGGGTATAAAAGCTTAAACCAATTTTTAGAAAAACTCGACACACAAATGGGAACTAAAGGTAACC
GAGTTTTTTATTTATCTATCCAGCCTAGCTATTTTCCTCTCGTTGTTGAAAAGCTTAGCCAACACCAATTGACATATCCA
GTTAAACAAGTCAAAGACAAATGGAGTCGTGTCATTATAGAAAAGCCTTTTGGAAGAGATATTGAATCAGCAAAACAACT
TCAACAAGATCTTGTGCAACACCTAGATGAAAGTCAAATTTATCGAATTGATCATTATTTGGGAAAAGAAACTGTACAAA
ATTTATTAGTTTTTAGATTTGGTAATCCCATCTTTGAATCAGTTTGGAATAACCATCATATTGATAATATTCAAATTACT
GTTGGTGAAGAAATTGGAATTGGTTCTCGCGGTCGATTTTGGGAAGAAGCAGGAATGTTGCGAGATATTGTCCAAAATCA
TGTGATGCAACTCCTTTCTCTTGTTGCGATGGAACCCCCGACGAGTCTCCAAGCCAACTCAGTCCGCGGCGAAAAAGTTA
AAGTCATTGAAGCTATTAGACCTATCCCCTTCGATTCAATGGAACAATGCGTTATCCGGGGCCAATATGGATCTGGATTC
ATTAACGGGGAACCCGTTAAAGGATATCGAGACGAGGAAAATGTAGACTCTAAATCTTTTGTTGAAACCTACGTTGCCTT
GCAACTTTCTATCGATAACTGGCGTTGGGCTGGAGTTCCCTTCTATTTACGTGCTGGTAAACGCCTACCCAAACGAGCTA
CTGAAATTGCGATTACTTTCAAAAAAGCCCCCGGATATCTATTTGAAGGAACTTCAGCTTTGATTGACTCAAACGTTTTA
GTGATTCGTATTCAACCGGATGAAGGAATTTCATTGAGAATTAATTGCAAAGTCCCTGCATTAAACACAGTCATTCAACC
GGTGAAAATGGATTTTCGTTACGGATCTTACTTTGGTGCCATTCCTCCCGAAGCTTATGAAAGATTAATTTGTGATTGCA
TGGCCGGGGATAATACTTTATTTGCTAGAGATGACGAAGTCATTATGTCTTGGAAGTTGCTCACACCTATTTTAGAACAT
TGGCAAGAAACATCCCCGACAGATTTTCCAAATTATGCCGCGGGAACTTGGGGGCCAGACCGAGCCGAAGAAATGCTAAA
ACGCCAAGGACGTCATTGGAGACTTATTTAA

Upstream 100 bases:

>100_bases
GACGAAAATTTCTTAAATAAGCCTAATCAATTTACAAATCACGTAGCGATGGAAATGCTAATTCGCTATGCTGCGATTAA
ATTATTAGGTGGTTTTAACT

Downstream 100 bases:

>100_bases
CCATATCAAATATCAAAAGGTAATTTATAAACCATCGATAAAGCATAATTTTGTGAATTGACTTAAATTTATGTGTTTAT
TTTTGATATTTGGTATAGCC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MHNSHYFVNPLNEPNRPIKIPESCILVIFGATGDLTARKLIPALYNLARDGQLPGHFACVGFARRAKTHDEFREEMLEAV
NKFSRSKPVEQGLWKRFREQLFYHQSEFDDDEGYKSLNQFLEKLDTQMGTKGNRVFYLSIQPSYFPLVVEKLSQHQLTYP
VKQVKDKWSRVIIEKPFGRDIESAKQLQQDLVQHLDESQIYRIDHYLGKETVQNLLVFRFGNPIFESVWNNHHIDNIQIT
VGEEIGIGSRGRFWEEAGMLRDIVQNHVMQLLSLVAMEPPTSLQANSVRGEKVKVIEAIRPIPFDSMEQCVIRGQYGSGF
INGEPVKGYRDEENVDSKSFVETYVALQLSIDNWRWAGVPFYLRAGKRLPKRATEIAITFKKAPGYLFEGTSALIDSNVL
VIRIQPDEGISLRINCKVPALNTVIQPVKMDFRYGSYFGAIPPEAYERLICDCMAGDNTLFARDDEVIMSWKLLTPILEH
WQETSPTDFPNYAAGTWGPDRAEEMLKRQGRHWRLI

Sequences:

>Translated_516_residues
MHNSHYFVNPLNEPNRPIKIPESCILVIFGATGDLTARKLIPALYNLARDGQLPGHFACVGFARRAKTHDEFREEMLEAV
NKFSRSKPVEQGLWKRFREQLFYHQSEFDDDEGYKSLNQFLEKLDTQMGTKGNRVFYLSIQPSYFPLVVEKLSQHQLTYP
VKQVKDKWSRVIIEKPFGRDIESAKQLQQDLVQHLDESQIYRIDHYLGKETVQNLLVFRFGNPIFESVWNNHHIDNIQIT
VGEEIGIGSRGRFWEEAGMLRDIVQNHVMQLLSLVAMEPPTSLQANSVRGEKVKVIEAIRPIPFDSMEQCVIRGQYGSGF
INGEPVKGYRDEENVDSKSFVETYVALQLSIDNWRWAGVPFYLRAGKRLPKRATEIAITFKKAPGYLFEGTSALIDSNVL
VIRIQPDEGISLRINCKVPALNTVIQPVKMDFRYGSYFGAIPPEAYERLICDCMAGDNTLFARDDEVIMSWKLLTPILEH
WQETSPTDFPNYAAGTWGPDRAEEMLKRQGRHWRLI
>Mature_516_residues
MHNSHYFVNPLNEPNRPIKIPESCILVIFGATGDLTARKLIPALYNLARDGQLPGHFACVGFARRAKTHDEFREEMLEAV
NKFSRSKPVEQGLWKRFREQLFYHQSEFDDDEGYKSLNQFLEKLDTQMGTKGNRVFYLSIQPSYFPLVVEKLSQHQLTYP
VKQVKDKWSRVIIEKPFGRDIESAKQLQQDLVQHLDESQIYRIDHYLGKETVQNLLVFRFGNPIFESVWNNHHIDNIQIT
VGEEIGIGSRGRFWEEAGMLRDIVQNHVMQLLSLVAMEPPTSLQANSVRGEKVKVIEAIRPIPFDSMEQCVIRGQYGSGF
INGEPVKGYRDEENVDSKSFVETYVALQLSIDNWRWAGVPFYLRAGKRLPKRATEIAITFKKAPGYLFEGTSALIDSNVL
VIRIQPDEGISLRINCKVPALNTVIQPVKMDFRYGSYFGAIPPEAYERLICDCMAGDNTLFARDDEVIMSWKLLTPILEH
WQETSPTDFPNYAAGTWGPDRAEEMLKRQGRHWRLI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=491, Percent_Identity=36.8635437881874, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=36.8635437881874, Blast_Score=328, Evalue=9e-90,
Organism=Homo sapiens, GI52145310, Length=499, Percent_Identity=29.8597194388778, Blast_Score=185, Evalue=9e-47,
Organism=Escherichia coli, GI1788158, Length=500, Percent_Identity=38.8, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17538218, Length=499, Percent_Identity=36.4729458917836, Blast_Score=339, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6324088, Length=499, Percent_Identity=35.8717434869739, Blast_Score=322, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=39.344262295082, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=39.344262295082, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI221513548, Length=493, Percent_Identity=29.4117647058824, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 59405; Mature: 59405

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNSHYFVNPLNEPNRPIKIPESCILVIFGATGDLTARKLIPALYNLARDGQLPGHFACV
CCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
GFARRAKTHDEFREEMLEAVNKFSRSKPVEQGLWKRFREQLFYHQSEFDDDEGYKSLNQF
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LEKLDTQMGTKGNRVFYLSIQPSYFPLVVEKLSQHQLTYPVKQVKDKWSRVIIEKPFGRD
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCCC
IESAKQLQQDLVQHLDESQIYRIDHYLGKETVQNLLVFRFGNPIFESVWNNHHIDNIQIT
HHHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEE
VGEEIGIGSRGRFWEEAGMLRDIVQNHVMQLLSLVAMEPPTSLQANSVRGEKVKVIEAIR
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
PIPFDSMEQCVIRGQYGSGFINGEPVKGYRDEENVDSKSFVETYVALQLSIDNWRWAGVP
CCCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEECCEEECCCC
FYLRAGKRLPKRATEIAITFKKAPGYLFEGTSALIDSNVLVIRIQPDEGISLRINCKVPA
HHHHCCCCCCCCCEEEEEEEECCCCCEECCCHHHHCCCEEEEEEECCCCCEEEEEECCCH
LNTVIQPVKMDFRYGSYFGAIPPEAYERLICDCMAGDNTLFARDDEVIMSWKLLTPILEH
HHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
WQETSPTDFPNYAAGTWGPDRAEEMLKRQGRHWRLI
HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHNSHYFVNPLNEPNRPIKIPESCILVIFGATGDLTARKLIPALYNLARDGQLPGHFACV
CCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
GFARRAKTHDEFREEMLEAVNKFSRSKPVEQGLWKRFREQLFYHQSEFDDDEGYKSLNQF
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LEKLDTQMGTKGNRVFYLSIQPSYFPLVVEKLSQHQLTYPVKQVKDKWSRVIIEKPFGRD
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCCC
IESAKQLQQDLVQHLDESQIYRIDHYLGKETVQNLLVFRFGNPIFESVWNNHHIDNIQIT
HHHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEE
VGEEIGIGSRGRFWEEAGMLRDIVQNHVMQLLSLVAMEPPTSLQANSVRGEKVKVIEAIR
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
PIPFDSMEQCVIRGQYGSGFINGEPVKGYRDEENVDSKSFVETYVALQLSIDNWRWAGVP
CCCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEECCEEECCCC
FYLRAGKRLPKRATEIAITFKKAPGYLFEGTSALIDSNVLVIRIQPDEGISLRINCKVPA
HHHHCCCCCCCCCEEEEEEEECCCCCEECCCHHHHCCCEEEEEEECCCCCEEEEEECCCH
LNTVIQPVKMDFRYGSYFGAIPPEAYERLICDCMAGDNTLFARDDEVIMSWKLLTPILEH
HHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
WQETSPTDFPNYAAGTWGPDRAEEMLKRQGRHWRLI
HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]