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The map label for this gene is tolC [C]

Identifier: 46446269

GI number: 46446269

Start: 778257

End: 779525

Strand: Reverse

Name: tolC [C]

Synonym: pc0635

Alternate gene names: 46446269

Gene position: 779525-778257 (Counterclockwise)

Preceding gene: 46446270

Following gene: 46446268

Centisome position: 32.29

GC content: 34.28

Gene sequence:

>1269_bases
ATGCATGTCTATTTTTTATTTTTTTCAGTGCTAGTAACTTTGTTATCTCCCCTGTCTCTTGTAGCTAAACTTACTTTGGA
AGAATGTCAAACAATCGCTCTTGAGAACGGAGAAAAAAAAACAATTGCAGATCTTCAAGCTTTAATTGCTTATGATCGAA
TTGATGAAGCACGAAGCACCGGTCGTCCTAAGTTAAATATTCATGGCGATTATATGACCTCTGGAGAAACTAAACACTGG
CGACATAATACACGAAATAGACATGTCAAAGTTTCTCTTGTGATTCCAATTTGTAATTTTGGGTTAACTAAAGAGGCTGT
TAAATCTCAGAAAAATCTTTATCAGTCTTCTCTTCATTCTTTAGACCAAATCAAGCAAGACATTCTGCATGCAGTTAGTG
AGGCTTATTTTGAATTATTAATTTTTCAAAAGCTTGAATGGATTGTTGAAGAGTCTATTCGATCATTGCATAGGCAAATC
GAAGTAACCCAAGATTTTCTAAATCAAGGATTAATACATAGAAATGAAGCTTTATTATTCGAAGTTCAATTGGCACAATT
TCAACAAAATTCCATGGAAGCTAAACTTAACACGAAATTAGCGACTGAAAGGCTTAATCGACTGATGAATAAAAATTTAG
ATAATTTAATTGAAATTGAAGATATTTTGACTTTTACAAATCAGGAAATTTGCCTAGACAATTTAATCGAAGCGGCTAAA
CTTAACCATCCTCAACTTTTAGCCTTATCCGCACAAATCCAAGCAGTTAAACATGGGTATCGTTCTGAAAAAGCAACCTT
ATATCCAAATTTGTATGCTTTTTCCAATTACAGTAATACCTCTGATTATACGCTTCCTTATCGTCAAGGATTAGATGCAG
GAATTGCTATTGATCTATCTTTGTACGATGGAGGTTATACCTACGCCAAACTCCGCAGAATAAAAAAAGAATTAAGTCAA
TTAGAGTGGCGTTATCAAGAACTTGAAAGAGATATCGAGTTAAATATCCGCTCCTCTTTTTTAGCCATTCAAACCGCCCT
CGGAAAAATCCCCGTTGCTCAAACAGGAGTTACTTTAGCAGAAGAAAATCTCGCAATCACTCAAAATTTATTCGAAGAGG
GATTGGTGACTAATCTTGACGTGGTACATGATCATGAAAATTTATTAGAAGCACGAGTAAGCTATTTTAAAACGCTTTAT
ACATATCACAAATCAAGGGCTAATTTGATCCATTCAGCAGGAATGATGCATAAAAAAGGATATCTCTAA

Upstream 100 bases:

>100_bases
AAACAACTTTCCAATTCACTTGTGAATAATTGTGACAACATTTAGCATCACTGGGAAACCAATTTAATTTTTGAGTCAAA
TCTATTTTTAAAGATTGTTT

Downstream 100 bases:

>100_bases
TATGTTAAATCTTCATCAAATGTTTAAAGCGATCATATTGGGCGCTTGTTATTTCTTTTTTCAACAATCTGTTCTTGCTA
CGGATTTCTCTACTGTTGGA

Product: putative outer membrane protein TolC

Products: NA

Alternate protein names: Type I Secretion Outer Membrane Protein; Outer Membrane Protein lC; Type I Secretion Outer Membrane Protein lC; Outer Membrane Protein; Outer Membrane Channel; Type I Secretion Outer Membrane Protein lC Family; LC-Like Protein; Outer Membrane Protein CyaE; RND Family Efflux Pump Outer Membrane Protein

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MHVYFLFFSVLVTLLSPLSLVAKLTLEECQTIALENGEKKTIADLQALIAYDRIDEARSTGRPKLNIHGDYMTSGETKHW
RHNTRNRHVKVSLVIPICNFGLTKEAVKSQKNLYQSSLHSLDQIKQDILHAVSEAYFELLIFQKLEWIVEESIRSLHRQI
EVTQDFLNQGLIHRNEALLFEVQLAQFQQNSMEAKLNTKLATERLNRLMNKNLDNLIEIEDILTFTNQEICLDNLIEAAK
LNHPQLLALSAQIQAVKHGYRSEKATLYPNLYAFSNYSNTSDYTLPYRQGLDAGIAIDLSLYDGGYTYAKLRRIKKELSQ
LEWRYQELERDIELNIRSSFLAIQTALGKIPVAQTGVTLAEENLAITQNLFEEGLVTNLDVVHDHENLLEARVSYFKTLY
TYHKSRANLIHSAGMMHKKGYL

Sequences:

>Translated_422_residues
MHVYFLFFSVLVTLLSPLSLVAKLTLEECQTIALENGEKKTIADLQALIAYDRIDEARSTGRPKLNIHGDYMTSGETKHW
RHNTRNRHVKVSLVIPICNFGLTKEAVKSQKNLYQSSLHSLDQIKQDILHAVSEAYFELLIFQKLEWIVEESIRSLHRQI
EVTQDFLNQGLIHRNEALLFEVQLAQFQQNSMEAKLNTKLATERLNRLMNKNLDNLIEIEDILTFTNQEICLDNLIEAAK
LNHPQLLALSAQIQAVKHGYRSEKATLYPNLYAFSNYSNTSDYTLPYRQGLDAGIAIDLSLYDGGYTYAKLRRIKKELSQ
LEWRYQELERDIELNIRSSFLAIQTALGKIPVAQTGVTLAEENLAITQNLFEEGLVTNLDVVHDHENLLEARVSYFKTLY
TYHKSRANLIHSAGMMHKKGYL
>Mature_422_residues
MHVYFLFFSVLVTLLSPLSLVAKLTLEECQTIALENGEKKTIADLQALIAYDRIDEARSTGRPKLNIHGDYMTSGETKHW
RHNTRNRHVKVSLVIPICNFGLTKEAVKSQKNLYQSSLHSLDQIKQDILHAVSEAYFELLIFQKLEWIVEESIRSLHRQI
EVTQDFLNQGLIHRNEALLFEVQLAQFQQNSMEAKLNTKLATERLNRLMNKNLDNLIEIEDILTFTNQEICLDNLIEAAK
LNHPQLLALSAQIQAVKHGYRSEKATLYPNLYAFSNYSNTSDYTLPYRQGLDAGIAIDLSLYDGGYTYAKLRRIKKELSQ
LEWRYQELERDIELNIRSSFLAIQTALGKIPVAQTGVTLAEENLAITQNLFEEGLVTNLDVVHDHENLLEARVSYFKTLY
TYHKSRANLIHSAGMMHKKGYL

Specific function: Required For Proper Expression Of Outer Membrane Protein Genes Such As Ompf, Nmpc, Protein 2, Hemolysin, Colicin V, Or Colicin E1. May Be Specialized For Signal Sequence Independent, Extracellular Secretion In Gram-Negative Bacteria. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Outer Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 48498; Mature: 48498

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVYFLFFSVLVTLLSPLSLVAKLTLEECQTIALENGEKKTIADLQALIAYDRIDEARST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
GRPKLNIHGDYMTSGETKHWRHNTRNRHVKVSLVIPICNFGLTKEAVKSQKNLYQSSLHS
CCCEEEECCCEECCCCCHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LDQIKQDILHAVSEAYFELLIFQKLEWIVEESIRSLHRQIEVTQDFLNQGLIHRNEALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EVQLAQFQQNSMEAKLNTKLATERLNRLMNKNLDNLIEIEDILTFTNQEICLDNLIEAAK
EHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LNHPQLLALSAQIQAVKHGYRSEKATLYPNLYAFSNYSNTSDYTLPYRQGLDAGIAIDLS
CCCCCEEHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCCCCCCHHHHCCCCCEEEEEE
LYDGGYTYAKLRRIKKELSQLEWRYQELERDIELNIRSSFLAIQTALGKIPVAQTGVTLA
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEE
EENLAITQNLFEEGLVTNLDVVHDHENLLEARVSYFKTLYTYHKSRANLIHSAGMMHKKG
CCCHHHHHHHHHCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YL
CC
>Mature Secondary Structure
MHVYFLFFSVLVTLLSPLSLVAKLTLEECQTIALENGEKKTIADLQALIAYDRIDEARST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
GRPKLNIHGDYMTSGETKHWRHNTRNRHVKVSLVIPICNFGLTKEAVKSQKNLYQSSLHS
CCCEEEECCCEECCCCCHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LDQIKQDILHAVSEAYFELLIFQKLEWIVEESIRSLHRQIEVTQDFLNQGLIHRNEALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EVQLAQFQQNSMEAKLNTKLATERLNRLMNKNLDNLIEIEDILTFTNQEICLDNLIEAAK
EHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LNHPQLLALSAQIQAVKHGYRSEKATLYPNLYAFSNYSNTSDYTLPYRQGLDAGIAIDLS
CCCCCEEHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCCCCCCCHHHHCCCCCEEEEEE
LYDGGYTYAKLRRIKKELSQLEWRYQELERDIELNIRSSFLAIQTALGKIPVAQTGVTLA
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEE
EENLAITQNLFEEGLVTNLDVVHDHENLLEARVSYFKTLYTYHKSRANLIHSAGMMHKKG
CCCHHHHHHHHHCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA