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The map label for this gene is dxs

Identifier: 46446253

GI number: 46446253

Start: 759582

End: 761489

Strand: Reverse

Name: dxs

Synonym: pc0619

Alternate gene names: 46446253

Gene position: 761489-759582 (Counterclockwise)

Preceding gene: 46446254

Following gene: 46446252

Centisome position: 31.54

GC content: 36.27

Gene sequence:

>1908_bases
ATGACACAATCAATTCTATCGAATTTGAATCATCCCAATGATATCAAAAATCTTTCCTATAGTGATCTCAAGTACTTAGC
TCATGAAATTAGACAACGCATTATTGAAGTTTTATCTGTTAATGGAGGACATTTAGCCTCAAATTTGGGTGTGGTTGAAC
TCACTTTAGCTCTGCATAAAGTTTTTGAGTCCCCTGATGACAAATTTATCTGGGATGTTAGTCACCAAACTTATGTTCAT
AAATTACTAACAGGTCGAAATGATCGCTTTCATGAAATTAGACAATTCAAAGGATTGTGTGGATTTTCTCATCCTAAGGA
ATCTATTCATGATCACTTCCATGCAGGACATGCAGGAACCGCTCTTTCCTTAGCATTAGGTGTTGCCAAAAATAGAGACT
TAACCAAGAGAAAAGATTATATTATCCCAATTATTGGTGATGCAACTTTAACATGTGGATTAACTTTAGAGGCCCTAAAC
AATATTTCTCGAGAGCTTAAACGCTTTATCGTAATTCTCAATGATAATGCTATGTCTATTTCTAAAAATGTGGGAGCAAT
TACGCATATTTTAAGTCGCTTACTAAGTAATCCTACAACAAATAAAATTCACCAAGAGCTTGATACAATCGTTTCTAAAA
TACCTAATTATGGTCCCATTCTTTCACAACAAGGACATAAAATCACTGAATCTTTAAAAAACTTGGTGAGCCCTGCCGTT
TATTTTGAACAATATGGTCTTTCTTATATAGGACCGATTGATGGACACGACACAAAAAAACTAGTGGATGTTTTAGAAGG
TGTAAAAGACTCTAACTGGCCAGTTATCATTCATGTTTTGACCAGAAAAGGGGAAGGAATGGATGAAGCCATCAAAAATC
CCATCTCTTACCACGGAGCCAAGCCGTTTAGTAAAGATACTGGTAAATTTTTACCAAACCCGGTAACCAAACCTACTTTT
CCCAAAATATTTGGTTCTCATCTTTTAAAAATGGCTGAAAAAGATCCTAGCATTGTGGCAATAACCCCAGCCATGTCTGC
AGGGTCTTGCTTAGATGATTTTATGAAAACTTTTCCTGAACGCTGTATTGATGTGGGTATTGCTGAATCTCATGCGATTA
CTTTTGCAGGGGGTATGGCATATGGAGGTAAAATGAAAATCGTCGCCTCTATTTATGCAACTTTCTTACAAAGAGCTTTT
GACAACGTTTTTCATGATATTTGCTTGCAAGAGTTACCGGTCGTATTTGCCATTGATCGAGCAGGAATTTCAGGACCTGA
TGGTTCTACCCATCACGGGATCTATGATATTTCATTTTTGAATGCGATGCCAAATATGATTATTGCACAGCCTCGTAATG
GACAGGTTTTAAAAGAGTTGATGGAATCGGCTTTTAGTTGGAAAAGGCCAACGGCTATCCGTTATCCAAACTTAATGACC
GAAGAATTTAACCATCCTATTTGTGAAAGAGAATTAGGAAAGGGAGAAGTTCTAATTGAAGGCACCGAAATTTTAATTGT
CGCCTTAGGTCATATGAATCAGGCGGCATTAAAAGTCCGAGACCTATTAGCTCAGACTGGCATTGAAGCTACAGTTTTAG
ATCCTATTTTTGTTAAACCATTAGACTCGGAACTTTTTTGTAAGCTGCTTCTTAATCACAATAAAATTGTCACCATTGAA
GAACATAGTGTTGTTTCTGGGATGGGCTCGATTATTAACAACTTTTTAGTTGGACAAGGGTTTAATCAAATACAAGTTTT
AAATTTGGGAATACCCGAAGCTTTTCTCGATCATGGTAGAAATCAGGATCTTTTAAACGAGATTGGCTTGGTGCCTGAAA
AAATTTTCAGACAAATTCAATCTCATTTTAATTTAATAGCACAAAATACCCTTAATCCTGTTGCTTAA

Upstream 100 bases:

>100_bases
CCTCTTAATTTATCTTTTTATTGCAGTCTTCCGTCTTAGAATGTCAATAAAAACTTTTTGAGAGATGACTTTTTAATTAA
GTGACTATAAAGGATTTTGA

Downstream 100 bases:

>100_bases
ATTATTTTCAAAGTTTGTAAGACATACTTGAACAAGTAGATATGCTATGATGATTGCACTATTTCCTAATGAAAGTAAAG
ATCCCTCCTTAAAAATTGCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MTQSILSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHKVFESPDDKFIWDVSHQTYVH
KLLTGRNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGTALSLALGVAKNRDLTKRKDYIIPIIGDATLTCGLTLEALN
NISRELKRFIVILNDNAMSISKNVGAITHILSRLLSNPTTNKIHQELDTIVSKIPNYGPILSQQGHKITESLKNLVSPAV
YFEQYGLSYIGPIDGHDTKKLVDVLEGVKDSNWPVIIHVLTRKGEGMDEAIKNPISYHGAKPFSKDTGKFLPNPVTKPTF
PKIFGSHLLKMAEKDPSIVAITPAMSAGSCLDDFMKTFPERCIDVGIAESHAITFAGGMAYGGKMKIVASIYATFLQRAF
DNVFHDICLQELPVVFAIDRAGISGPDGSTHHGIYDISFLNAMPNMIIAQPRNGQVLKELMESAFSWKRPTAIRYPNLMT
EEFNHPICERELGKGEVLIEGTEILIVALGHMNQAALKVRDLLAQTGIEATVLDPIFVKPLDSELFCKLLLNHNKIVTIE
EHSVVSGMGSIINNFLVGQGFNQIQVLNLGIPEAFLDHGRNQDLLNEIGLVPEKIFRQIQSHFNLIAQNTLNPVA

Sequences:

>Translated_635_residues
MTQSILSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHKVFESPDDKFIWDVSHQTYVH
KLLTGRNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGTALSLALGVAKNRDLTKRKDYIIPIIGDATLTCGLTLEALN
NISRELKRFIVILNDNAMSISKNVGAITHILSRLLSNPTTNKIHQELDTIVSKIPNYGPILSQQGHKITESLKNLVSPAV
YFEQYGLSYIGPIDGHDTKKLVDVLEGVKDSNWPVIIHVLTRKGEGMDEAIKNPISYHGAKPFSKDTGKFLPNPVTKPTF
PKIFGSHLLKMAEKDPSIVAITPAMSAGSCLDDFMKTFPERCIDVGIAESHAITFAGGMAYGGKMKIVASIYATFLQRAF
DNVFHDICLQELPVVFAIDRAGISGPDGSTHHGIYDISFLNAMPNMIIAQPRNGQVLKELMESAFSWKRPTAIRYPNLMT
EEFNHPICERELGKGEVLIEGTEILIVALGHMNQAALKVRDLLAQTGIEATVLDPIFVKPLDSELFCKLLLNHNKIVTIE
EHSVVSGMGSIINNFLVGQGFNQIQVLNLGIPEAFLDHGRNQDLLNEIGLVPEKIFRQIQSHFNLIAQNTLNPVA
>Mature_634_residues
TQSILSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHKVFESPDDKFIWDVSHQTYVHK
LLTGRNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGTALSLALGVAKNRDLTKRKDYIIPIIGDATLTCGLTLEALNN
ISRELKRFIVILNDNAMSISKNVGAITHILSRLLSNPTTNKIHQELDTIVSKIPNYGPILSQQGHKITESLKNLVSPAVY
FEQYGLSYIGPIDGHDTKKLVDVLEGVKDSNWPVIIHVLTRKGEGMDEAIKNPISYHGAKPFSKDTGKFLPNPVTKPTFP
KIFGSHLLKMAEKDPSIVAITPAMSAGSCLDDFMKTFPERCIDVGIAESHAITFAGGMAYGGKMKIVASIYATFLQRAFD
NVFHDICLQELPVVFAIDRAGISGPDGSTHHGIYDISFLNAMPNMIIAQPRNGQVLKELMESAFSWKRPTAIRYPNLMTE
EFNHPICERELGKGEVLIEGTEILIVALGHMNQAALKVRDLLAQTGIEATVLDPIFVKPLDSELFCKLLLNHNKIVTIEE
HSVVSGMGSIINNFLVGQGFNQIQVLNLGIPEAFLDHGRNQDLLNEIGLVPEKIFRQIQSHFNLIAQNTLNPVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=668, Percent_Identity=22.0059880239521, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=668, Percent_Identity=22.0059880239521, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=423, Percent_Identity=23.1678486997636, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225637459, Length=423, Percent_Identity=23.1678486997636, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637461, Length=423, Percent_Identity=23.1678486997636, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=466, Percent_Identity=22.7467811158798, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1786622, Length=608, Percent_Identity=38.8157894736842, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17539652, Length=410, Percent_Identity=23.4146341463415, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24666278, Length=253, Percent_Identity=28.0632411067194, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551847, Length=390, Percent_Identity=25.1282051282051, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550715, Length=390, Percent_Identity=25.1282051282051, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24645119, Length=267, Percent_Identity=27.3408239700375, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PARUW (Q6MDK6)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007618.1
- ProteinModelPortal:   Q6MDK6
- SMR:   Q6MDK6
- STRING:   Q6MDK6
- GeneID:   2779454
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0619
- NMPDR:   fig|264201.1.peg.619
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q6MDK6
- ProtClustDB:   PRK05444
- BioCyc:   CPRO264201:PC0619-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70341; Mature: 70210

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSILSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHK
CCHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHH
VFESPDDKFIWDVSHQTYVHKLLTGRNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGT
HHCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCH
ALSLALGVAKNRDLTKRKDYIIPIIGDATLTCGLTLEALNNISRELKRFIVILNDNAMSI
HHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHEEEEECCCCHHH
SKNVGAITHILSRLLSNPTTNKIHQELDTIVSKIPNYGPILSQQGHKITESLKNLVSPAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
YFEQYGLSYIGPIDGHDTKKLVDVLEGVKDSNWPVIIHVLTRKGEGMDEAIKNPISYHGA
HHHHCCCCEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHCCCHHHCCC
KPFSKDTGKFLPNPVTKPTFPKIFGSHLLKMAEKDPSIVAITPAMSAGSCLDDFMKTFPE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
RCIDVGIAESHAITFAGGMAYGGKMKIVASIYATFLQRAFDNVFHDICLQELPVVFAIDR
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGISGPDGSTHHGIYDISFLNAMPNMIIAQPRNGQVLKELMESAFSWKRPTAIRYPNLMT
CCCCCCCCCCCCCEEEHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCHHH
EEFNHPICERELGKGEVLIEGTEILIVALGHMNQAALKVRDLLAQTGIEATVLDPIFVKP
HHHCCCHHHHHCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCHHCCC
LDSELFCKLLLNHNKIVTIEEHSVVSGMGSIINNFLVGQGFNQIQVLNLGIPEAFLDHGR
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCC
NQDLLNEIGLVPEKIFRQIQSHFNLIAQNTLNPVA
CHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TQSILSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHK
CHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHH
VFESPDDKFIWDVSHQTYVHKLLTGRNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGT
HHCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCH
ALSLALGVAKNRDLTKRKDYIIPIIGDATLTCGLTLEALNNISRELKRFIVILNDNAMSI
HHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHEEEEECCCCHHH
SKNVGAITHILSRLLSNPTTNKIHQELDTIVSKIPNYGPILSQQGHKITESLKNLVSPAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
YFEQYGLSYIGPIDGHDTKKLVDVLEGVKDSNWPVIIHVLTRKGEGMDEAIKNPISYHGA
HHHHCCCCEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHCCCHHHCCC
KPFSKDTGKFLPNPVTKPTFPKIFGSHLLKMAEKDPSIVAITPAMSAGSCLDDFMKTFPE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
RCIDVGIAESHAITFAGGMAYGGKMKIVASIYATFLQRAFDNVFHDICLQELPVVFAIDR
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGISGPDGSTHHGIYDISFLNAMPNMIIAQPRNGQVLKELMESAFSWKRPTAIRYPNLMT
CCCCCCCCCCCCCEEEHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCHHH
EEFNHPICERELGKGEVLIEGTEILIVALGHMNQAALKVRDLLAQTGIEATVLDPIFVKP
HHHCCCHHHHHCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCHHCCC
LDSELFCKLLLNHNKIVTIEEHSVVSGMGSIINNFLVGQGFNQIQVLNLGIPEAFLDHGR
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCC
NQDLLNEIGLVPEKIFRQIQSHFNLIAQNTLNPVA
CHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA