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The map label for this gene is uhpC [H]

Identifier: 46446021

GI number: 46446021

Start: 516386

End: 517768

Strand: Direct

Name: uhpC [H]

Synonym: pc0387

Alternate gene names: 46446021

Gene position: 516386-517768 (Clockwise)

Preceding gene: 46446015

Following gene: 46446022

Centisome position: 21.39

GC content: 37.02

Gene sequence:

>1383_bases
GTGAATAAATTGCTCAATTTGCTGCAACCAGCTCCCCATATTCCTGAATTAAAAGACCAAGAGCTTGTCAAAGATCAATA
TAAATATTGGCGTATTCGCATTCTTTATTCGATGTTCATAGGATATGCTTTCTATTATTTTACTCGAAAAAGTTTTACTT
TTGCGATGCCTGGTCTTATTCAAGATTTGGGCTTTGATAAAAGCCAGTTAGGAATTTTAGGAAGTATTCTTTCAATTACG
TATGGAGTGAGTAAATTTGCAAGTGGGATCATTGGAGATCGTACTAACTCTCGTTATATGATGGCCATTGGGTTAATGTT
AACGGGCATTTGTAATATTTGTTTTGGGCTTTCTTCTTCTATTTTCTTTTTTGCCCTATTTTGGGGTCTTAATGGATGGT
TTCAGGGATTTGGTTGGCCTCCTTGTGCGCGCTTTTTAACTCAATGGTATTCACATTCAGAGAGAGGTTCGTGGTGGTCC
ACATGGAATGTTTCACATAATGTAGGCGGTTTTTTAATCCCCTGGATAGCAGGAATTACTCTTCAATATTTTGGCTGGCG
TTATGCCATGTATATTCCTGGAATTTTATGCATCCTCATCAGTTTTTTCTTAATCAATCGTTTAAGAGATACTCCGCAGT
CTCTTGGATTACCTCCTATTGAAAAATACCGTAATGATTATGTGGATAAAGCTGAGGCAGACAAAGAGGCTGAACAATTA
ACAACAAAACAACTATTAGTCAATTTTGTTCTTAAAAATTCCTATATTTGGATATTAGCGCTCGCCTATTTTTTTGTTTA
TGCCGTGCGAACAGGAATCAATGATTGGACAGCTTTATTTTTAGTTGAATCCAAAGGATATAGTAGCATTGGAGCAAATG
GATGTGTTTCTTTATTTGAAGTTGGCGGATTTTTTGGAAGTCTAGCTGCTGGTTGGTCATCAGATAAACTTTTCGGCGCA
AAAAGAGGACCTATTAATGTTCTATTTACACTAGGAATGTTTGCTTTTATTGCCATTTTTTGGATGATACCCTCTGGCTA
TTTGTTATTTGATTCTGTCCTCATGTTTTGTATAGGTTTTTCTATTTTTGGCCCACAAATGATGATTGGTTTAGCGGCTG
CAGAACTGTCTCATAAAAAAGCGGTGGCAACTTCAACTGGATTTGTTGGTTTTTTTGCTTATATCGGAGCTGCTTTTGCA
GGCTATCCCTTGGGATATATCACTCAGCAATGGGGATGGCAAGGTTTTTATTGGGCTTTAATGGGATGTTGTATTATTGC
ACTATTTCTACTTATTCCACTTTGGTCAGTTTCTGCCACCACTTTAAAGCCTAAAAATAAATCGAGTTCTCCTGTTAGTT
CGCCTGCGTTAGCTTCTAAATAA

Upstream 100 bases:

>100_bases
AACCAACCTGAACCTAAGCTGAATGCGGCAATTGCAGCCTGTTCAAACGTTAATTAAATTCGGTTTGCTATAGCCTTAGG
ATGAACTTTAAGGAGACCTT

Downstream 100 bases:

>100_bases
GAAGATAAAAAACTACAGTAAAATAAATTTGCAATTTGGAACTTCTTTAATAGTTGATTCCATTTTGCAGTTTATTTTTT
TTTGACAATAAAATCTACTT

Product: regulatory protein uhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNKLLNLLQPAPHIPELKDQELVKDQYKYWRIRILYSMFIGYAFYYFTRKSFTFAMPGLIQDLGFDKSQLGILGSILSIT
YGVSKFASGIIGDRTNSRYMMAIGLMLTGICNICFGLSSSIFFFALFWGLNGWFQGFGWPPCARFLTQWYSHSERGSWWS
TWNVSHNVGGFLIPWIAGITLQYFGWRYAMYIPGILCILISFFLINRLRDTPQSLGLPPIEKYRNDYVDKAEADKEAEQL
TTKQLLVNFVLKNSYIWILALAYFFVYAVRTGINDWTALFLVESKGYSSIGANGCVSLFEVGGFFGSLAAGWSSDKLFGA
KRGPINVLFTLGMFAFIAIFWMIPSGYLLFDSVLMFCIGFSIFGPQMMIGLAAAELSHKKAVATSTGFVGFFAYIGAAFA
GYPLGYITQQWGWQGFYWALMGCCIIALFLLIPLWSVSATTLKPKNKSSSPVSSPALASK

Sequences:

>Translated_460_residues
MNKLLNLLQPAPHIPELKDQELVKDQYKYWRIRILYSMFIGYAFYYFTRKSFTFAMPGLIQDLGFDKSQLGILGSILSIT
YGVSKFASGIIGDRTNSRYMMAIGLMLTGICNICFGLSSSIFFFALFWGLNGWFQGFGWPPCARFLTQWYSHSERGSWWS
TWNVSHNVGGFLIPWIAGITLQYFGWRYAMYIPGILCILISFFLINRLRDTPQSLGLPPIEKYRNDYVDKAEADKEAEQL
TTKQLLVNFVLKNSYIWILALAYFFVYAVRTGINDWTALFLVESKGYSSIGANGCVSLFEVGGFFGSLAAGWSSDKLFGA
KRGPINVLFTLGMFAFIAIFWMIPSGYLLFDSVLMFCIGFSIFGPQMMIGLAAAELSHKKAVATSTGFVGFFAYIGAAFA
GYPLGYITQQWGWQGFYWALMGCCIIALFLLIPLWSVSATTLKPKNKSSSPVSSPALASK
>Mature_460_residues
MNKLLNLLQPAPHIPELKDQELVKDQYKYWRIRILYSMFIGYAFYYFTRKSFTFAMPGLIQDLGFDKSQLGILGSILSIT
YGVSKFASGIIGDRTNSRYMMAIGLMLTGICNICFGLSSSIFFFALFWGLNGWFQGFGWPPCARFLTQWYSHSERGSWWS
TWNVSHNVGGFLIPWIAGITLQYFGWRYAMYIPGILCILISFFLINRLRDTPQSLGLPPIEKYRNDYVDKAEADKEAEQL
TTKQLLVNFVLKNSYIWILALAYFFVYAVRTGINDWTALFLVESKGYSSIGANGCVSLFEVGGFFGSLAAGWSSDKLFGA
KRGPINVLFTLGMFAFIAIFWMIPSGYLLFDSVLMFCIGFSIFGPQMMIGLAAAELSHKKAVATSTGFVGFFAYIGAAFA
GYPLGYITQQWGWQGFYWALMGCCIIALFLLIPLWSVSATTLKPKNKSSSPVSSPALASK

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI4503847, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI256219483, Length=428, Percent_Identity=34.1121495327103, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI256219543, Length=448, Percent_Identity=33.7053571428571, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI256219564, Length=354, Percent_Identity=32.4858757062147, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI46361976, Length=390, Percent_Identity=26.4102564102564, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI38093649, Length=466, Percent_Identity=24.4635193133047, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI223717983, Length=466, Percent_Identity=24.4635193133047, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI49619231, Length=450, Percent_Identity=26.4444444444444, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI14150047, Length=167, Percent_Identity=28.1437125748503, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082310, Length=430, Percent_Identity=46.5116279069767, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1788573, Length=437, Percent_Identity=40.5034324942792, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI2367259, Length=411, Percent_Identity=32.8467153284672, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789152, Length=459, Percent_Identity=24.6187363834423, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI2367379, Length=457, Percent_Identity=23.1947483588621, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI133901854, Length=472, Percent_Identity=23.5169491525424, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17561094, Length=413, Percent_Identity=24.9394673123487, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI133901856, Length=454, Percent_Identity=23.3480176211454, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17542316, Length=444, Percent_Identity=22.5225225225225, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133930953, Length=431, Percent_Identity=22.2737819025522, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17539138, Length=288, Percent_Identity=26.0416666666667, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656861, Length=477, Percent_Identity=24.3186582809224, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656866, Length=477, Percent_Identity=24.3186582809224, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45550478, Length=477, Percent_Identity=24.3186582809224, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51635; Mature: 51635

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]