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The map label for this gene is uppS [H]

Identifier: 46445955

GI number: 46445955

Start: 439355

End: 440131

Strand: Reverse

Name: uppS [H]

Synonym: pc0321

Alternate gene names: 46445955

Gene position: 440131-439355 (Counterclockwise)

Preceding gene: 46445956

Following gene: 46445954

Centisome position: 18.23

GC content: 36.29

Gene sequence:

>777_bases
TTGATTGATCACGCTGTTATACCATTGCAAGAAAGTTCTAGCTATTTCTTGCCATCGCAACTAGAGAGTTTAAATTTTTC
TCGTATCCCACAACACATCGCCATTATTCCTGACGGCAATCGACGTTGGGCAAGAAAACGATTATCCAGCTCAAATGAAG
GACACCGAGAAGGAGCTGATATTTTAATGGAAACCGTTAAAGCAGCAAAGGAACTTGGAATTAAAGCAATTACATTCTAT
ACATTTTCTACTGAAAACTGGTCTCGTTCATTTGATGAAATTTCTGCTCTCATGCTTTTATTTGCCTCTTATCTAAGCGA
ACAATGTGATTCAATGATTCAAAATGGAATTAAATTAGAAACCATCGGTGAGCTTGATCCTCTTCCTGAATTTTTAAAAG
ACACTTTGAAGGAAACAAAAAAAGCTACTTGTGCATGTGATCAAATTGATTTAATTCTTGCTATGAACTACGGTTCTCGC
AATGAACTACAACGGGCTTTTACGAGGATATTAGATGAAGTCGAACAGGGAAATTTGAAAAAAGAAGAAGTGAACGAAAC
AACTATCGCTCAATATTTAGACACCCATCAATGGCCAGATCCTGAGCTATTAATTCGAACAAGTGGTGAAATGAGAATTA
GTAATTTTCTTCTTTGGCAAATTTCTTATACAGAAATTTATATTGCACCTGTCCTTTGGCCAGATTTTACTCCTAATCAT
CTTCTGGAAGCCATTGTCGATTATCAAAAAAGAGAAAGAAGATGGGGAGGCGTATAA

Upstream 100 bases:

>100_bases
ATTAAAAGCTGGAGATTAATTTTGGAGAGTTGGCAAAAGATAAATCTATTCGATCAAATCCATTTACGTTATTCTTTTGC
AAATTTCTAGAGGGTCTATG

Downstream 100 bases:

>100_bases
ATTGGCAAATCAGTTTAAACAACGAGTTGTCACAAGCAGCGTGACTATTTTCTTAGTCATTATCTCGATTTATTTTTCTC
ATGTTCCTTACTTTAAACCT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIDHAVIPLQESSSYFLPSQLESLNFSRIPQHIAIIPDGNRRWARKRLSSSNEGHREGADILMETVKAAKELGIKAITFY
TFSTENWSRSFDEISALMLLFASYLSEQCDSMIQNGIKLETIGELDPLPEFLKDTLKETKKATCACDQIDLILAMNYGSR
NELQRAFTRILDEVEQGNLKKEEVNETTIAQYLDTHQWPDPELLIRTSGEMRISNFLLWQISYTEIYIAPVLWPDFTPNH
LLEAIVDYQKRERRWGGV

Sequences:

>Translated_258_residues
MIDHAVIPLQESSSYFLPSQLESLNFSRIPQHIAIIPDGNRRWARKRLSSSNEGHREGADILMETVKAAKELGIKAITFY
TFSTENWSRSFDEISALMLLFASYLSEQCDSMIQNGIKLETIGELDPLPEFLKDTLKETKKATCACDQIDLILAMNYGSR
NELQRAFTRILDEVEQGNLKKEEVNETTIAQYLDTHQWPDPELLIRTSGEMRISNFLLWQISYTEIYIAPVLWPDFTPNH
LLEAIVDYQKRERRWGGV
>Mature_258_residues
MIDHAVIPLQESSSYFLPSQLESLNFSRIPQHIAIIPDGNRRWARKRLSSSNEGHREGADILMETVKAAKELGIKAITFY
TFSTENWSRSFDEISALMLLFASYLSEQCDSMIQNGIKLETIGELDPLPEFLKDTLKETKKATCACDQIDLILAMNYGSR
NELQRAFTRILDEVEQGNLKKEEVNETTIAQYLDTHQWPDPELLIRTSGEMRISNFLLWQISYTEIYIAPVLWPDFTPNH
LLEAIVDYQKRERRWGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=38.8392857142857, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=38.8392857142857, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=38.5964912280702, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=37.0044052863436, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=31.1627906976744, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=29.1479820627803, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=35.3982300884956, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29748; Mature: 29748

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDHAVIPLQESSSYFLPSQLESLNFSRIPQHIAIIPDGNRRWARKRLSSSNEGHREGAD
CCCCCEEEEECCCCCCCHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHH
ILMETVKAAKELGIKAITFYTFSTENWSRSFDEISALMLLFASYLSEQCDSMIQNGIKLE
HHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TIGELDPLPEFLKDTLKETKKATCACDQIDLILAMNYGSRNELQRAFTRILDEVEQGNLK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
KEEVNETTIAQYLDTHQWPDPELLIRTSGEMRISNFLLWQISYTEIYIAPVLWPDFTPNH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEEEEEECEEEEEEEECCCCCHHH
LLEAIVDYQKRERRWGGV
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDHAVIPLQESSSYFLPSQLESLNFSRIPQHIAIIPDGNRRWARKRLSSSNEGHREGAD
CCCCCEEEEECCCCCCCHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHH
ILMETVKAAKELGIKAITFYTFSTENWSRSFDEISALMLLFASYLSEQCDSMIQNGIKLE
HHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TIGELDPLPEFLKDTLKETKKATCACDQIDLILAMNYGSRNELQRAFTRILDEVEQGNLK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
KEEVNETTIAQYLDTHQWPDPELLIRTSGEMRISNFLLWQISYTEIYIAPVLWPDFTPNH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEEEEEECEEEEEEEECCCCCHHH
LLEAIVDYQKRERRWGGV
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]