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The map label for this gene is gcvT [H]

Identifier: 46445915

GI number: 46445915

Start: 392664

End: 393698

Strand: Direct

Name: gcvT [H]

Synonym: pc0281

Alternate gene names: 46445915

Gene position: 392664-393698 (Clockwise)

Preceding gene: 46445914

Following gene: 46445916

Centisome position: 16.26

GC content: 37.78

Gene sequence:

>1035_bases
ATGATTGATTTTGCTGGATGGAGCATGCCTATTCATTACAAAGGTATTTTAGCAGAGCATCAAGCTGTGAGAGAAAAAGT
TGGGTTGTTTGACGTCTCTCATATGGGAAAAATCGATGTTCGAGGACCTGATGCAGAGCGTTTTTTAGATTACCTTTCCA
CGAATCGCATTATGGGAAAAGGATCAAACACAGCTACTTATACTGTTTGGTGTAACTCTCAAGGAGGATCTATTGATGAT
GTTATCATTTATCGTCATTCTTCGACCTATTTTTTTGTCATTGTAAATGCAAGTAACCGCCAAAAAGATTTAGCTCATAT
GCAAAAGCAGGCAGCTGAGTTTCAAGTGACTATTCAACCTCAATTTGAAAATTCTGGGATACTTGCTTTACAAGGACCCT
TCTCGTTTCCATTAGTCGACATGCTTTTTCCAGGAAACTTATCATTAAAACCTATGTCGTTTACGTCGATCCAAGAACTA
GATCAACCTTTGATTCTTTCGCGTACAGGTTATACCGGAGCTGGAGGATTTGAATTTTATGGTACAAATGAACAAATAAT
CTCCTTATGGGATCGCCTGCTTAATACAGGAAAAACTTTTGGAATTGAACCTATTGGGCTTGGAGCAAGGGATACACTTC
GTTTAGAAATGGGTTTTGCTTTATACGGGCACGAAATATCAGATACCATTGCCCCAACTGAAAGTGTATCTGCTTGGGCA
GTAAAATTTGATAAAACTGATTTTTTAGGAAAGCAAGCCTTAAAAAGCCTTGAGGCAACACCCATAAAGCGAATGGCATA
TGGGGTCAAATTAAAAGAACCTGGTATCGCTAGACAAGGCTATCCTATTTTTAAAGATGGTATTAGAATTGGAGAGGTTA
CCTCAGGTTCTATATCTCCTTCTTTAAATGAAGCCGTTGCTTTAATTTTAGTAGATACACCACTCAAAATCAAACAAGAT
ATTAAAATACAAATTCGGCAAACACAATGCCACGCTGAAGTGGTTCAATTGCCTTTTATTAGGAAAAACAGATGA

Upstream 100 bases:

>100_bases
TCTTTATGGGCATCGGTAAAGCTTATTAAGTAACACCAAAATCCAAATTAAAATAATGCAAACTGCTTTATATTCTCGCC
ACCTTAATCTTCAGGGTAAA

Downstream 100 bases:

>100_bases
AATATACAGATTCTCATGAATGGGTTGTTTTAGAATCGACTGATGTAGCTCGTATTGGTGTGACGCAGTTTGCGCAAAAA
GAACTCGGTGATATTGTTTA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIDFAGWSMPIHYKGILAEHQAVREKVGLFDVSHMGKIDVRGPDAERFLDYLSTNRIMGKGSNTATYTVWCNSQGGSIDD
VIIYRHSSTYFFVIVNASNRQKDLAHMQKQAAEFQVTIQPQFENSGILALQGPFSFPLVDMLFPGNLSLKPMSFTSIQEL
DQPLILSRTGYTGAGGFEFYGTNEQIISLWDRLLNTGKTFGIEPIGLGARDTLRLEMGFALYGHEISDTIAPTESVSAWA
VKFDKTDFLGKQALKSLEATPIKRMAYGVKLKEPGIARQGYPIFKDGIRIGEVTSGSISPSLNEAVALILVDTPLKIKQD
IKIQIRQTQCHAEVVQLPFIRKNR

Sequences:

>Translated_344_residues
MIDFAGWSMPIHYKGILAEHQAVREKVGLFDVSHMGKIDVRGPDAERFLDYLSTNRIMGKGSNTATYTVWCNSQGGSIDD
VIIYRHSSTYFFVIVNASNRQKDLAHMQKQAAEFQVTIQPQFENSGILALQGPFSFPLVDMLFPGNLSLKPMSFTSIQEL
DQPLILSRTGYTGAGGFEFYGTNEQIISLWDRLLNTGKTFGIEPIGLGARDTLRLEMGFALYGHEISDTIAPTESVSAWA
VKFDKTDFLGKQALKSLEATPIKRMAYGVKLKEPGIARQGYPIFKDGIRIGEVTSGSISPSLNEAVALILVDTPLKIKQD
IKIQIRQTQCHAEVVQLPFIRKNR
>Mature_344_residues
MIDFAGWSMPIHYKGILAEHQAVREKVGLFDVSHMGKIDVRGPDAERFLDYLSTNRIMGKGSNTATYTVWCNSQGGSIDD
VIIYRHSSTYFFVIVNASNRQKDLAHMQKQAAEFQVTIQPQFENSGILALQGPFSFPLVDMLFPGNLSLKPMSFTSIQEL
DQPLILSRTGYTGAGGFEFYGTNEQIISLWDRLLNTGKTFGIEPIGLGARDTLRLEMGFALYGHEISDTIAPTESVSAWA
VKFDKTDFLGKQALKSLEATPIKRMAYGVKLKEPGIARQGYPIFKDGIRIGEVTSGSISPSLNEAVALILVDTPLKIKQD
IKIQIRQTQCHAEVVQLPFIRKNR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=356, Percent_Identity=30.3370786516854, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI257796258, Length=318, Percent_Identity=31.1320754716981, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=27.3809523809524, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=28.9808917197452, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI257796254, Length=353, Percent_Identity=26.0623229461756, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI197927446, Length=335, Percent_Identity=20.8955223880597, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI21361378, Length=335, Percent_Identity=20.8955223880597, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI194306651, Length=321, Percent_Identity=25.8566978193146, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789272, Length=356, Percent_Identity=35.1123595505618, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17560118, Length=362, Percent_Identity=31.2154696132597, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71994045, Length=345, Percent_Identity=25.2173913043478, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=345, Percent_Identity=25.2173913043478, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32563613, Length=317, Percent_Identity=26.1829652996845, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320222, Length=328, Percent_Identity=33.5365853658537, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129441, Length=361, Percent_Identity=31.0249307479224, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI28571104, Length=318, Percent_Identity=26.1006289308176, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38256; Mature: 38256

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFAGWSMPIHYKGILAEHQAVREKVGLFDVSHMGKIDVRGPDAERFLDYLSTNRIMGK
CCCCCCCCCCEEEHHHHHHHHHHHHHHCEEECCCCCEEEECCCCHHHHHHHHHCCCEEEC
GSNTATYTVWCNSQGGSIDDVIIYRHSSTYFFVIVNASNRQKDLAHMQKQAAEFQVTIQP
CCCCEEEEEEECCCCCCCCEEEEEEECCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEE
QFENSGILALQGPFSFPLVDMLFPGNLSLKPMSFTSIQELDQPLILSRTGYTGAGGFEFY
CCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEE
GTNEQIISLWDRLLNTGKTFGIEPIGLGARDTLRLEMGFALYGHEISDTIAPTESVSAWA
CCCHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEE
VKFDKTDFLGKQALKSLEATPIKRMAYGVKLKEPGIARQGYPIFKDGIRIGEVTSGSISP
EEECCCHHHHHHHHHHHCCCCHHHHHCCEEECCCCCCCCCCCCHHCCEEEEEEECCCCCC
SLNEAVALILVDTPLKIKQDIKIQIRQTQCHAEVVQLPFIRKNR
CCCCEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHCCCEECCC
>Mature Secondary Structure
MIDFAGWSMPIHYKGILAEHQAVREKVGLFDVSHMGKIDVRGPDAERFLDYLSTNRIMGK
CCCCCCCCCCEEEHHHHHHHHHHHHHHCEEECCCCCEEEECCCCHHHHHHHHHCCCEEEC
GSNTATYTVWCNSQGGSIDDVIIYRHSSTYFFVIVNASNRQKDLAHMQKQAAEFQVTIQP
CCCCEEEEEEECCCCCCCCEEEEEEECCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEE
QFENSGILALQGPFSFPLVDMLFPGNLSLKPMSFTSIQELDQPLILSRTGYTGAGGFEFY
CCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCEEEE
GTNEQIISLWDRLLNTGKTFGIEPIGLGARDTLRLEMGFALYGHEISDTIAPTESVSAWA
CCCHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEE
VKFDKTDFLGKQALKSLEATPIKRMAYGVKLKEPGIARQGYPIFKDGIRIGEVTSGSISP
EEECCCHHHHHHHHHHHCCCCHHHHHCCEEECCCCCCCCCCCCHHCCEEEEEEECCCCCC
SLNEAVALILVDTPLKIKQDIKIQIRQTQCHAEVVQLPFIRKNR
CCCCEEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA