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The map label for this gene is sufS [H]

Identifier: 46445826

GI number: 46445826

Start: 286018

End: 287250

Strand: Direct

Name: sufS [H]

Synonym: pc0192

Alternate gene names: 46445826

Gene position: 286018-287250 (Clockwise)

Preceding gene: 46445825

Following gene: 46445827

Centisome position: 11.85

GC content: 36.74

Gene sequence:

>1233_bases
ATGAATCCTTTAGAAAAATCTGCTGTTAACAGGCTCAGGCAAGACTTTCCCATGTTGAATAAAATGATGCATGGACATCC
TCTTATTTATTTCGATTCTGCGGCAACAACTCAAAAACCGAGCGCTGTTATTGATTGTATGAGTGATTTTTATCGGAATC
ATTATGGAACTGTTCACCGTGCTGTTTACGAATTAGCCATTCATTCCACTGAAAATTATCAAGACACACGTTTAAAAGTT
CAACGTTTTATCAATGCTGCCAATACAGAAGAAATTGTTTTTACTCGAGGCGCTACAGATTCGATTAATATGGTTGCCTA
TTCCTTTGGCAAGGTTTTTGTGAAGCCAGGTGATGAAATTTTGATTAGTGCCATGGAGCATCATGCAAATATTGTGCCTT
GGCAAATTTTATGTGAAGATCGAGGAGCTGTTCTAAAAGTTATTCCTATGAATAAAAAGGGAGAACTACTTTTTGATGAG
TATGTAAAGCTTCTAAGCCCAAAAACTCGCCTTGTCGCTATCACTCATGTGGCAAATTCTCTTGGAACGATTAATCCCAT
TAAAGAAATTATTAAAAAAGCGCATGAAGCAGGGGCAAAAGTTCTCGTAGACGGTGCACAAAGTGCCCCTCATCTTAAAA
TTGATGTGCAAGATTTAGACGCAGATTTTTTTGTTTTTTCAGGTCATAAACTAATGGGACCTACCGGCATCGGTATTTTA
TATGGTAAGGCGGAAATTCTCGATCAAATGCCTCCGTATCAAGGAGGAGGAGATATGATTGAAAAAGTGACGTTTGTTAA
AACAACTTATAATCAACTTCCTCTAAAATTTGAAGCAGGCACTCCTATGATTGCAGAGGTCATGGGATTGGGGGCAGCTT
TAGATTATCTTAATCAAATTGGGATAGAGCGTATTCAAACTTATGAACATACCCTGTTAGAGTATGCGACCAAGAAATTG
ATGCAGATTCCAGATCTTCATATTATTGGTCAAGCAGTTAACAAAACTTCTTTAATCAGTTTTGTGATCGAAGAAATTCA
TCCTTTAGATATAGGAACATTTTTAGATTTAAAAGGAATTGCAATTCGTACCGGACATCATTGTGCACAACCTGTTATGC
AATTTTTTAATATTCCTGCCACAGCACGGGTATCTTTTGCTTTTTATAATACGGCTGATGAAATTGACCGGCTACATTTA
GCTTTAAGTGATATTATTAAGCGGTTAAAATAA

Upstream 100 bases:

>100_bases
TTTATGGTTTTGCTGAACAAGTCATCGAAATGATTCCTATCAATTCTATTAAAGAAGCAATTTCTCAAAGGGCGCATCGT
TATCTAACAAAAGGTTGATT

Downstream 100 bases:

>100_bases
AATTTATGCGTATTAATGTGGAAGAAGCGATTGAGAAATTGTTAGCGAATCAATTAGTCGCAATGCCGACAGAAACAGTT
TATGGGTTAGCAGCTAGGCT

Product: SufS L-cysteine desulfurase/L-selenocysteine lyase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNPLEKSAVNRLRQDFPMLNKMMHGHPLIYFDSAATTQKPSAVIDCMSDFYRNHYGTVHRAVYELAIHSTENYQDTRLKV
QRFINAANTEEIVFTRGATDSINMVAYSFGKVFVKPGDEILISAMEHHANIVPWQILCEDRGAVLKVIPMNKKGELLFDE
YVKLLSPKTRLVAITHVANSLGTINPIKEIIKKAHEAGAKVLVDGAQSAPHLKIDVQDLDADFFVFSGHKLMGPTGIGIL
YGKAEILDQMPPYQGGGDMIEKVTFVKTTYNQLPLKFEAGTPMIAEVMGLGAALDYLNQIGIERIQTYEHTLLEYATKKL
MQIPDLHIIGQAVNKTSLISFVIEEIHPLDIGTFLDLKGIAIRTGHHCAQPVMQFFNIPATARVSFAFYNTADEIDRLHL
ALSDIIKRLK

Sequences:

>Translated_410_residues
MNPLEKSAVNRLRQDFPMLNKMMHGHPLIYFDSAATTQKPSAVIDCMSDFYRNHYGTVHRAVYELAIHSTENYQDTRLKV
QRFINAANTEEIVFTRGATDSINMVAYSFGKVFVKPGDEILISAMEHHANIVPWQILCEDRGAVLKVIPMNKKGELLFDE
YVKLLSPKTRLVAITHVANSLGTINPIKEIIKKAHEAGAKVLVDGAQSAPHLKIDVQDLDADFFVFSGHKLMGPTGIGIL
YGKAEILDQMPPYQGGGDMIEKVTFVKTTYNQLPLKFEAGTPMIAEVMGLGAALDYLNQIGIERIQTYEHTLLEYATKKL
MQIPDLHIIGQAVNKTSLISFVIEEIHPLDIGTFLDLKGIAIRTGHHCAQPVMQFFNIPATARVSFAFYNTADEIDRLHL
ALSDIIKRLK
>Mature_410_residues
MNPLEKSAVNRLRQDFPMLNKMMHGHPLIYFDSAATTQKPSAVIDCMSDFYRNHYGTVHRAVYELAIHSTENYQDTRLKV
QRFINAANTEEIVFTRGATDSINMVAYSFGKVFVKPGDEILISAMEHHANIVPWQILCEDRGAVLKVIPMNKKGELLFDE
YVKLLSPKTRLVAITHVANSLGTINPIKEIIKKAHEAGAKVLVDGAQSAPHLKIDVQDLDADFFVFSGHKLMGPTGIGIL
YGKAEILDQMPPYQGGGDMIEKVTFVKTTYNQLPLKFEAGTPMIAEVMGLGAALDYLNQIGIERIQTYEHTLLEYATKKL
MQIPDLHIIGQAVNKTSLISFVIEEIHPLDIGTFLDLKGIAIRTGHHCAQPVMQFFNIPATARVSFAFYNTADEIDRLHL
ALSDIIKRLK

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=405, Percent_Identity=24.1975308641975, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156713448, Length=334, Percent_Identity=27.8443113772455, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=51.3647642679901, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1789175, Length=388, Percent_Identity=40.979381443299, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI48994898, Length=215, Percent_Identity=31.1627906976744, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=225, Percent_Identity=28.8888888888889, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=375, Percent_Identity=24.8, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=27.6649746192893, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=383, Percent_Identity=25.065274151436, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45833; Mature: 45833

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLEKSAVNRLRQDFPMLNKMMHGHPLIYFDSAATTQKPSAVIDCMSDFYRNHYGTVHR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCHHHHH
AVYELAIHSTENYQDTRLKVQRFINAANTEEIVFTRGATDSINMVAYSFGKVFVKPGDEI
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHEEECCEEEECCCHHH
LISAMEHHANIVPWQILCEDRGAVLKVIPMNKKGELLFDEYVKLLSPKTRLVAITHVANS
HHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHHH
LGTINPIKEIIKKAHEAGAKVLVDGAQSAPHLKIDVQDLDADFFVFSGHKLMGPTGIGIL
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEECCEEECCCCCEEE
YGKAEILDQMPPYQGGGDMIEKVTFVKTTYNQLPLKFEAGTPMIAEVMGLGAALDYLNQI
ECHHHHHHCCCCCCCCCHHHHHHHHEEEHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
GIERIQTYEHTLLEYATKKLMQIPDLHIIGQAVNKTSLISFVIEEIHPLDIGTFLDLKGI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEECCCCE
AIRTGHHCAQPVMQFFNIPATARVSFAFYNTADEIDRLHLALSDIIKRLK
EEECCCHHHHHHHHHHCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPLEKSAVNRLRQDFPMLNKMMHGHPLIYFDSAATTQKPSAVIDCMSDFYRNHYGTVHR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCHHHHH
AVYELAIHSTENYQDTRLKVQRFINAANTEEIVFTRGATDSINMVAYSFGKVFVKPGDEI
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHEEECCEEEECCCHHH
LISAMEHHANIVPWQILCEDRGAVLKVIPMNKKGELLFDEYVKLLSPKTRLVAITHVANS
HHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHHH
LGTINPIKEIIKKAHEAGAKVLVDGAQSAPHLKIDVQDLDADFFVFSGHKLMGPTGIGIL
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEECCEEECCCCCEEE
YGKAEILDQMPPYQGGGDMIEKVTFVKTTYNQLPLKFEAGTPMIAEVMGLGAALDYLNQI
ECHHHHHHCCCCCCCCCHHHHHHHHEEEHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
GIERIQTYEHTLLEYATKKLMQIPDLHIIGQAVNKTSLISFVIEEIHPLDIGTFLDLKGI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEECCCCE
AIRTGHHCAQPVMQFFNIPATARVSFAFYNTADEIDRLHLALSDIIKRLK
EEECCCHHHHHHHHHHCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA