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The map label for this gene is mutL [H]

Identifier: 46445773

GI number: 46445773

Start: 212429

End: 214387

Strand: Reverse

Name: mutL [H]

Synonym: pc0139

Alternate gene names: 46445773

Gene position: 214387-212429 (Counterclockwise)

Preceding gene: 46445779

Following gene: 46445765

Centisome position: 8.88

GC content: 35.07

Gene sequence:

>1959_bases
ATGGCTTCGTTACCTAAAATCCATGTTTTAACTGAACAAACTATTAATCAAATTGCTGCTGGAGAGGTTATTGAAAATCC
CGCTTCGGTAGTCAAAGAATTAGTTGAAAACTCCATGGATGCTGGAGCAACAGAGATTTGCGTTGAAATACAGGGAGGAG
GGCGACAACTTATCCGTATTTCTGATAACGGATGTGGAATGAGCGAAGATGACGCTCTTTTGTGTTTAGAAAGACACGCT
ACATCCAAAATAAAAAATGTGGACGATATTGAAAATATTCTTACTATGGGATTTAGAGGAGAAGCTATCCCTTCAATCGC
TTCGATTTCGAAATTTTCACTTCTTACCACACCTCAATCAGGCGTTAGTTCAATTGATAAATTAATGCAAGGGTCTTTGA
CAATTGTCGAAGGTGGGCGTATTCAATCACATGGGAAAGCGACTCGTTCTCCTGGTACAACAATTGAAGTTAAATCACTT
TTTTTTAATGTGCCAGTCAGACGTAAATTTCAACGCTCACCTAATTATGATACACAAGAAATCGTTAAAATTCTGACAAA
TTTGAGTTTAGCTTATCCAAATATTGCTTTTGAGCTAATTAGCGATCAAAAATCCATCTTGAAAATGCCTCTTATTTCAA
TCGATATTAATCATCAACAGCAATTATTAAAAAAAATCGAAACATTACTAGGTAAAGAATTTTCTCATTCTCTCTGCCCT
CTTACTTTTTCTTCTCCTCCTTATGAAATAGAAGGCTATATTGGGCTACCTTCTATTCATAAACCCAACCGAACCAGTCA
ATACCTATTCATTAATCGCCGCGCTGTTTATTCTCCTCTTATTGGGGTAGCTATTCGAGAAGGATATGGAACTATGCTCG
GTACAAATAGGTATCCCGTTTTTATTTTACATCTCCGCCTTCCAGGCTCACTTTTTGACGTTAATGTACACCCACAAAAA
AAAGAAGTGCGCTTAAGACAGGAGCAAAAACTTAAAGAGACTTTAATCAATGCTGTTCAAAAAGCCTTAAGACAAGAAAA
TCCCCATCAAGCCTTTTCCGAAATGGCTAACCAAGTTCAAAATGAAACTTGCGTTTATCCTTGGTCAGCCCCCTCTTTTC
AAACTCCTTTTCAGGTCAAAGAAGAGTCATGGGAATTCAAACCTAATCACAAATTTTCTACATCGATCGATGAAAACCCC
ACTTTTATTAAAAACATAGAAAATTTAGAGTTAAAAAATGAAACTTTTAATCCCTCTTCTTTTATCCAAACTAGGTCTCT
TCCTACTAAAGAAGAACCAACTTTTTTTATTTCCCATCAACAAAAAGCGCCTAAAGTATTACAAACTTTAACAGGCTATT
GTTTGTTAGATGCTTGTCAAGTAAAAGGAACATTTAATAGCAATCAAGAATTGAATGGACTTCTATTGCTCGATCAAAAA
CAAGCCTATTCGCGTATTAAATATGAAAAACTGCTTTTTAATCTCAAAGGAAAGCAAGCTATTCAGCAATTAATTGTCCC
TCTGACGTTCCAATTTTCTATTCCAGAAACTACGTTATTAAAGACACACTTAGAAAGTTTAAATCAGTTAGGTTTTTCGA
TGCGTGAATTTGGAAATCAAACATTCGTGTTAGATGCTTTTCCTTCTATAATGTCTGAACAAGAAATTGAAACTTGTTTG
TTAGAAATGATTCAAGATTTGTCAACTTTACAACAGAGTCAGCAACTCCAGATAAAAATAACAGAAAAGCTTGCGTTAAC
TGCTAGCCGTTCTTCTTTTTCTAAAAATATCCAATTATCAATCGATGAAGGTCAAGGATTAGTCGATCAACTTTTTATGT
GCGATATGCCTTATCTTAGCCCCTCAGGATCTCCTATTTTTGCCTATTTTAAACTTCAAGAGCTAGCTGATTTATTTCGA
AAATATTCTTATTTCCCTTCTCAAGATTCAACTTTTTAA

Upstream 100 bases:

>100_bases
GATAACTAAAATTTTCTAAAAAAATGCGATTTTTGAATAAGATTTAAAAGTTTCTGATTTAGTTTTAAAAGGCCCATTTT
CAATCGAATCAGGCAGGCTT

Downstream 100 bases:

>100_bases
ATCTATAAAAAATAAAAAAAATTCTCCATCAAAATTTCTAAAGAAACTCCAGAATTTATATTTCGTATAAAAGGTACTTT
TTAAATAGTTTTTAAAATTA

Product: putative methyl-directed mismatch repair (MMR) protein, mutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MASLPKIHVLTEQTINQIAAGEVIENPASVVKELVENSMDAGATEICVEIQGGGRQLIRISDNGCGMSEDDALLCLERHA
TSKIKNVDDIENILTMGFRGEAIPSIASISKFSLLTTPQSGVSSIDKLMQGSLTIVEGGRIQSHGKATRSPGTTIEVKSL
FFNVPVRRKFQRSPNYDTQEIVKILTNLSLAYPNIAFELISDQKSILKMPLISIDINHQQQLLKKIETLLGKEFSHSLCP
LTFSSPPYEIEGYIGLPSIHKPNRTSQYLFINRRAVYSPLIGVAIREGYGTMLGTNRYPVFILHLRLPGSLFDVNVHPQK
KEVRLRQEQKLKETLINAVQKALRQENPHQAFSEMANQVQNETCVYPWSAPSFQTPFQVKEESWEFKPNHKFSTSIDENP
TFIKNIENLELKNETFNPSSFIQTRSLPTKEEPTFFISHQQKAPKVLQTLTGYCLLDACQVKGTFNSNQELNGLLLLDQK
QAYSRIKYEKLLFNLKGKQAIQQLIVPLTFQFSIPETTLLKTHLESLNQLGFSMREFGNQTFVLDAFPSIMSEQEIETCL
LEMIQDLSTLQQSQQLQIKITEKLALTASRSSFSKNIQLSIDEGQGLVDQLFMCDMPYLSPSGSPIFAYFKLQELADLFR
KYSYFPSQDSTF

Sequences:

>Translated_652_residues
MASLPKIHVLTEQTINQIAAGEVIENPASVVKELVENSMDAGATEICVEIQGGGRQLIRISDNGCGMSEDDALLCLERHA
TSKIKNVDDIENILTMGFRGEAIPSIASISKFSLLTTPQSGVSSIDKLMQGSLTIVEGGRIQSHGKATRSPGTTIEVKSL
FFNVPVRRKFQRSPNYDTQEIVKILTNLSLAYPNIAFELISDQKSILKMPLISIDINHQQQLLKKIETLLGKEFSHSLCP
LTFSSPPYEIEGYIGLPSIHKPNRTSQYLFINRRAVYSPLIGVAIREGYGTMLGTNRYPVFILHLRLPGSLFDVNVHPQK
KEVRLRQEQKLKETLINAVQKALRQENPHQAFSEMANQVQNETCVYPWSAPSFQTPFQVKEESWEFKPNHKFSTSIDENP
TFIKNIENLELKNETFNPSSFIQTRSLPTKEEPTFFISHQQKAPKVLQTLTGYCLLDACQVKGTFNSNQELNGLLLLDQK
QAYSRIKYEKLLFNLKGKQAIQQLIVPLTFQFSIPETTLLKTHLESLNQLGFSMREFGNQTFVLDAFPSIMSEQEIETCL
LEMIQDLSTLQQSQQLQIKITEKLALTASRSSFSKNIQLSIDEGQGLVDQLFMCDMPYLSPSGSPIFAYFKLQELADLFR
KYSYFPSQDSTF
>Mature_651_residues
ASLPKIHVLTEQTINQIAAGEVIENPASVVKELVENSMDAGATEICVEIQGGGRQLIRISDNGCGMSEDDALLCLERHAT
SKIKNVDDIENILTMGFRGEAIPSIASISKFSLLTTPQSGVSSIDKLMQGSLTIVEGGRIQSHGKATRSPGTTIEVKSLF
FNVPVRRKFQRSPNYDTQEIVKILTNLSLAYPNIAFELISDQKSILKMPLISIDINHQQQLLKKIETLLGKEFSHSLCPL
TFSSPPYEIEGYIGLPSIHKPNRTSQYLFINRRAVYSPLIGVAIREGYGTMLGTNRYPVFILHLRLPGSLFDVNVHPQKK
EVRLRQEQKLKETLINAVQKALRQENPHQAFSEMANQVQNETCVYPWSAPSFQTPFQVKEESWEFKPNHKFSTSIDENPT
FIKNIENLELKNETFNPSSFIQTRSLPTKEEPTFFISHQQKAPKVLQTLTGYCLLDACQVKGTFNSNQELNGLLLLDQKQ
AYSRIKYEKLLFNLKGKQAIQQLIVPLTFQFSIPETTLLKTHLESLNQLGFSMREFGNQTFVLDAFPSIMSEQEIETCLL
EMIQDLSTLQQSQQLQIKITEKLALTASRSSFSKNIQLSIDEGQGLVDQLFMCDMPYLSPSGSPIFAYFKLQELADLFRK
YSYFPSQDSTF

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=349, Percent_Identity=29.512893982808, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4505911, Length=337, Percent_Identity=29.9703264094956, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI189458898, Length=337, Percent_Identity=29.9703264094956, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=28.5302593659942, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=28.5302593659942, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458896, Length=328, Percent_Identity=29.5731707317073, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI91992162, Length=275, Percent_Identity=29.0909090909091, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI91992160, Length=275, Percent_Identity=29.0909090909091, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI263191589, Length=260, Percent_Identity=23.4615384615385, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790612, Length=578, Percent_Identity=29.4117647058824, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=30.7926829268293, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=357, Percent_Identity=26.0504201680672, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=353, Percent_Identity=28.6118980169972, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324247, Length=354, Percent_Identity=28.5310734463277, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=353, Percent_Identity=24.0793201133144, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323063, Length=352, Percent_Identity=24.7159090909091, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=350, Percent_Identity=31.4285714285714, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136970, Length=366, Percent_Identity=25.1366120218579, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73559; Mature: 73428

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLPKIHVLTEQTINQIAAGEVIENPASVVKELVENSMDAGATEICVEIQGGGRQLIRI
CCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEE
SDNGCGMSEDDALLCLERHATSKIKNVDDIENILTMGFRGEAIPSIASISKFSLLTTPQS
CCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCH
GVSSIDKLMQGSLTIVEGGRIQSHGKATRSPGTTIEVKSLFFNVPVRRKFQRSPNYDTQE
HHHHHHHHHCCCEEEEECCEECCCCCCCCCCCCEEEEEHHEECCCHHHHHCCCCCCCHHH
IVKILTNLSLAYPNIAFELISDQKSILKMPLISIDINHQQQLLKKIETLLGKEFSHSLCP
HHHHHHHCHHCCCCHHHHHHHCCHHHHHCCEEEEECCHHHHHHHHHHHHHCCHHCCCCCC
LTFSSPPYEIEGYIGLPSIHKPNRTSQYLFINRRAVYSPLIGVAIREGYGTMLGTNRYPV
EEECCCCCEEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCEECCCCCCE
FILHLRLPGSLFDVNVHPQKKEVRLRQEQKLKETLINAVQKALRQENPHQAFSEMANQVQ
EEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NETCVYPWSAPSFQTPFQVKEESWEFKPNHKFSTSIDENPTFIKNIENLELKNETFNPSS
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEECCCCCCCHH
FIQTRSLPTKEEPTFFISHQQKAPKVLQTLTGYCLLDACQVKGTFNSNQELNGLLLLDQK
HHEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECH
QAYSRIKYEKLLFNLKGKQAIQQLIVPLTFQFSIPETTLLKTHLESLNQLGFSMREFGNQ
HHHHHHHHHHHHHHCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCC
TFVLDAFPSIMSEQEIETCLLEMIQDLSTLQQSQQLQIKITEKLALTASRSSFSKNIQLS
EEEEECCHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHEEEEECCCCCCCCEEEE
IDEGQGLVDQLFMCDMPYLSPSGSPIFAYFKLQELADLFRKYSYFPSQDSTF
ECCCCCHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ASLPKIHVLTEQTINQIAAGEVIENPASVVKELVENSMDAGATEICVEIQGGGRQLIRI
CCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEE
SDNGCGMSEDDALLCLERHATSKIKNVDDIENILTMGFRGEAIPSIASISKFSLLTTPQS
CCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCH
GVSSIDKLMQGSLTIVEGGRIQSHGKATRSPGTTIEVKSLFFNVPVRRKFQRSPNYDTQE
HHHHHHHHHCCCEEEEECCEECCCCCCCCCCCCEEEEEHHEECCCHHHHHCCCCCCCHHH
IVKILTNLSLAYPNIAFELISDQKSILKMPLISIDINHQQQLLKKIETLLGKEFSHSLCP
HHHHHHHCHHCCCCHHHHHHHCCHHHHHCCEEEEECCHHHHHHHHHHHHHCCHHCCCCCC
LTFSSPPYEIEGYIGLPSIHKPNRTSQYLFINRRAVYSPLIGVAIREGYGTMLGTNRYPV
EEECCCCCEEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCEECCCCCCE
FILHLRLPGSLFDVNVHPQKKEVRLRQEQKLKETLINAVQKALRQENPHQAFSEMANQVQ
EEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NETCVYPWSAPSFQTPFQVKEESWEFKPNHKFSTSIDENPTFIKNIENLELKNETFNPSS
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEECCCCCCCHH
FIQTRSLPTKEEPTFFISHQQKAPKVLQTLTGYCLLDACQVKGTFNSNQELNGLLLLDQK
HHEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECH
QAYSRIKYEKLLFNLKGKQAIQQLIVPLTFQFSIPETTLLKTHLESLNQLGFSMREFGNQ
HHHHHHHHHHHHHHCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCC
TFVLDAFPSIMSEQEIETCLLEMIQDLSTLQQSQQLQIKITEKLALTASRSSFSKNIQLS
EEEEECCHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHEEEEECCCCCCCCEEEE
IDEGQGLVDQLFMCDMPYLSPSGSPIFAYFKLQELADLFRKYSYFPSQDSTF
ECCCCCHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA