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The map label for this gene is rfbC [H]

Identifier: 46445758

GI number: 46445758

Start: 194405

End: 194959

Strand: Direct

Name: rfbC [H]

Synonym: pc0124

Alternate gene names: 46445758

Gene position: 194405-194959 (Clockwise)

Preceding gene: 46445757

Following gene: 46445759

Centisome position: 8.05

GC content: 35.5

Gene sequence:

>555_bases
ATGGAAATCATTGATTTGCAACTTAAAGGGTTAAAATTGGTGAAGCCTAACGTATTTAAAGATAATAGAGGTTTTTTTCT
AGAAAGTTTTCAGCAACCCCTCTATCAAAAAATGGGGATTCAAGAGACTTTTTTACAAGATAATCATTCTTTTTCTCAAA
AAGGGTGCATTCGTGGAATGCATTTCCAATCTTTTCCAGGTCAGGCAAAACTTGTGAGAGTGGCTGTGGGAAAAATTTAT
GATGTGGCTGTTGATATTCGTCCTGAATCTCCTACATTTGGACAGTGGGAAGGGATTATTTTAGATGATAAAAAACACCA
TCAACTTTTTATTCCAGTGGGATTTGCGCATGGATTTTGCGTTTTGAGTCAAGAAGCCCATGTAATGTATAAAGTGAGCA
CTCCCTATGATCCTCTCTATGAAAAAGGTTTTCGTTGGAATGATTCACAATTAAATATTCAATGGCCTATAGAGCAACCA
ATAGTTTCTGAAAGAGATAAACAATCTCCTTCCTTTCGTGAAAGCATGCTTCAATTAACTGAGATTAGAAAATGA

Upstream 100 bases:

>100_bases
AAATTTATTTCTCAAGCCCAGTTAAAATTGTTGGGTGAAAAACTCGGGAAAAGCTTGTACGGACGTTATTTAATGGAAAT
TGCAGAAAAAGGACCTTACT

Downstream 100 bases:

>100_bases
AAAAGATTTGGGTATGTGGCGCATCGGGTATGCTTGGTTCTCATTTCAAACGTTTATTAAACAAACGGCAACTGTCTTTT
GTTGCCAATGATGATAAAAA

Product: dTDP-4-dehydrorhamnose 3,5-epimerase, rfbC

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MEIIDLQLKGLKLVKPNVFKDNRGFFLESFQQPLYQKMGIQETFLQDNHSFSQKGCIRGMHFQSFPGQAKLVRVAVGKIY
DVAVDIRPESPTFGQWEGIILDDKKHHQLFIPVGFAHGFCVLSQEAHVMYKVSTPYDPLYEKGFRWNDSQLNIQWPIEQP
IVSERDKQSPSFRESMLQLTEIRK

Sequences:

>Translated_184_residues
MEIIDLQLKGLKLVKPNVFKDNRGFFLESFQQPLYQKMGIQETFLQDNHSFSQKGCIRGMHFQSFPGQAKLVRVAVGKIY
DVAVDIRPESPTFGQWEGIILDDKKHHQLFIPVGFAHGFCVLSQEAHVMYKVSTPYDPLYEKGFRWNDSQLNIQWPIEQP
IVSERDKQSPSFRESMLQLTEIRK
>Mature_184_residues
MEIIDLQLKGLKLVKPNVFKDNRGFFLESFQQPLYQKMGIQETFLQDNHSFSQKGCIRGMHFQSFPGQAKLVRVAVGKIY
DVAVDIRPESPTFGQWEGIILDDKKHHQLFIPVGFAHGFCVLSQEAHVMYKVSTPYDPLYEKGFRWNDSQLNIQWPIEQP
IVSERDKQSPSFRESMLQLTEIRK

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=171, Percent_Identity=44.4444444444444, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17550412, Length=177, Percent_Identity=49.1525423728814, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21418; Mature: 21418

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIDLQLKGLKLVKPNVFKDNRGFFLESFQQPLYQKMGIQETFLQDNHSFSQKGCIRGM
CEEEEEEECCEEEECCCCEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCC
HFQSFPGQAKLVRVAVGKIYDVAVDIRPESPTFGQWEGIILDDKKHHQLFIPVGFAHGFC
CCCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCEE
VLSQEAHVMYKVSTPYDPLYEKGFRWNDSQLNIQWPIEQPIVSERDKQSPSFRESMLQLT
EEECCCEEEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
EIRK
HHCC
>Mature Secondary Structure
MEIIDLQLKGLKLVKPNVFKDNRGFFLESFQQPLYQKMGIQETFLQDNHSFSQKGCIRGM
CEEEEEEECCEEEECCCCEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCC
HFQSFPGQAKLVRVAVGKIYDVAVDIRPESPTFGQWEGIILDDKKHHQLFIPVGFAHGFC
CCCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCEE
VLSQEAHVMYKVSTPYDPLYEKGFRWNDSQLNIQWPIEQPIVSERDKQSPSFRESMLQLT
EEECCCEEEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
EIRK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]