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The map label for this gene is groEl

Identifier: 46445664

GI number: 46445664

Start: 44688

End: 46361

Strand: Reverse

Name: groEl

Synonym: pc0030

Alternate gene names: 46445664

Gene position: 46361-44688 (Counterclockwise)

Preceding gene: 46445665

Following gene: 46445663

Centisome position: 1.92

GC content: 40.98

Gene sequence:

>1674_bases
ATGGCAAAATTATTACAATTTAACGAAGAAGCCTTAAAATCAATCTTAAAAGGTGTAAAAACGCTTGCTAAAGCCGTTAA
AGTCACTTTAGGCCCAAAAGGGCGCAACGTTGTCATCAACAAAGGATTTGGCTCTCCTCTTTCTACTAAAGATGGTGTCA
CAGTCGCCAAAGAAGTTGTTCTCAAAGACAAATTTGAAAACATGGGTGCTCAATTAGTTAATCAAGTTGCTGCTAAAACA
TCTGATGTAGCAGGAGATGGAACAACAACAGCCATTGTTTTAGCTGAAGCCATTTATTCTGCTGGTGTCAAAAACGTGGC
AGCCGGTGCAAACCCAATGAGTTTAAAAAGGGGAATAGATCAAGCTGTTGAAACAATAACTCGCTCTCTAGATCACCTTT
CTACGCCAGTAAATACAGCCCAAGAAGTTAGACAGATTGCCACAATTTCTGCTAATAATGATGGCGAGATCGGCCGTATT
ATTGGAGAAGCAATGGAAAGAGTGGGTAAAGATGGAATCATCACTGTTGCTGAAGCAAAAGGAATTGAAACACATGTAGA
TTATGTAGAAGGCATGCAATTTGATAAAGGATACGTTTCCCCTTACTTTATCACCAATGCAGAACAAATGAGTGTTGAGC
TCTCAAACGCAGATATTCTAATCACAGACAAAAAATTATCCGCAGCTAAAGATATTATTCCTGTCTTAGAAAAAATTATG
GAAAAAGGAGCACGCCCTTTGCTCATTATTGCCGAAGATATTGATGGAGAAGCTCTTGCAACTCTTGTCGTCAATAAACT
AAAAGCAGGGATGACTGTTTGTGCAGTAAAAGCACCAGGTTTTGGGGATCGACGTAAAGCTATGTTGCAAGATATTGCCA
TTTTGACAGGAGGAAAAGTCGTTTCAGAAGAAGTAGGTCTAAAATTGGATGAAGTAGGACCAGAAGTTCTTGGAAGAGCA
AAGACTATTAAGGTTTCAAAAGAAGAAACAACGATTATCGATGGAGCTGGACAATCAAATGAGGTGAAAAGCCGCCTTGC
TCAAATTAAAGCTGAACTTGCGAATGCAAGTACTTCTAAATATGACAAAGAAAAATTAGAGGAACGACTAGCAAAAATGG
TCGGCGGTGTTGCAGTTGTTAATGTCGGAGCAGCGACTGAAACAGAATTAAAAGAAAAGAAAGCGCGTGTGGAAGACGCA
TTACATGCCACACGGGCAGCTGTTGCGCAAGGAATCGTTCCGGGTGGCGGAGTCGCTCTTCTTCGCGCTGTTAAATCCCT
TGAAAAATTGCAACTTACAGGCGATGAAGCGATAGGCGTAACCATTATTAAGCAAGCCGCTTTTGCGCCAGCAATAGCTA
TTGCTAATAACTGTGGGAAACAAGGAAATTTGATTGCTGAAAAGATTTATGAAGCAACAGGTTCTTATGGATATGATGGT
TTAACCGACGAATTTAAAGATTTGTTAAAAGCAGGAGTAATAGATCCTGTTTTAGTCACCAAAAGCGCGCTAATCAATGC
AGCTTCTATTGCAGGACTTTTACTTACAACAGCTGCAATGATTACTGATAAACCCCAACCTAAATCTCAACCTGCTGGCA
TGCCAGGCATGGATGGCATGGGTGGTATGGGAATGGGTGGCATGGGTGGTATGGGCGGCATGGGAATGATGTAA

Upstream 100 bases:

>100_bases
TGGTACAGAGGTTAAAGATAATGATGAAGATTATTTAATCTTATCCGAAAACGATATTCTAGGAATTTTATCTTAATCTT
TTTAATGCAAGGACCCGTTT

Downstream 100 bases:

>100_bases
GCTTCTCACCCATTTAAATAATCCATCCCTTTGAGATACAAAGGGATGGATTTTAAATATTCTTGTTAAAAAAATCCTTC
AGAGATTACCGAAAGAATAA

Product: 60 kDa chaperonin (GroEL)

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MAKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVVLKDKFENMGAQLVNQVAAKT
SDVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGIDQAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRI
IGEAMERVGKDGIITVAEAKGIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIM
EKGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKVVSEEVGLKLDEVGPEVLGRA
KTIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSKYDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDA
LHATRAAVAQGIVPGGGVALLRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDG
LTDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGMGGMGMGGMGGMGGMGMM

Sequences:

>Translated_557_residues
MAKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVVLKDKFENMGAQLVNQVAAKT
SDVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGIDQAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRI
IGEAMERVGKDGIITVAEAKGIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIM
EKGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKVVSEEVGLKLDEVGPEVLGRA
KTIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSKYDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDA
LHATRAAVAQGIVPGGGVALLRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDG
LTDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGMGGMGMGGMGGMGGMGMM
>Mature_556_residues
AKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVVLKDKFENMGAQLVNQVAAKTS
DVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGIDQAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRII
GEAMERVGKDGIITVAEAKGIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIME
KGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKVVSEEVGLKLDEVGPEVLGRAK
TIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSKYDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDAL
HATRAAVAQGIVPGGGVALLRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDGL
TDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGMGGMGMGGMGGMGGMGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=47.5563909774436, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=47.5563909774436, Blast_Score=486, Evalue=1e-137,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=54.7528517110266, Blast_Score=569, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=46.5160075329567, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=43.8679245283019, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25144674, Length=554, Percent_Identity=22.3826714801444, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=50.2857142857143, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=48.7666034155598, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=48.7666034155598, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=47.5285171102662, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=47.5285171102662, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=47.5285171102662, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=41.7721518987342, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24584129, Length=538, Percent_Identity=35.6877323420074, Blast_Score=305, Evalue=7e-83,
Organism=Drosophila melanogaster, GI19921262, Length=538, Percent_Identity=35.6877323420074, Blast_Score=305, Evalue=7e-83,
Organism=Drosophila melanogaster, GI17647245, Length=555, Percent_Identity=21.981981981982, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PARUW (Q6MF95)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007029.1
- ProteinModelPortal:   Q6MF95
- SMR:   Q6MF95
- STRING:   Q6MF95
- GeneID:   2780418
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0030
- NMPDR:   fig|264201.1.peg.30
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- ProtClustDB:   CLSK2762045
- BioCyc:   CPRO264201:PC0030-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58096; Mature: 57965

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVV
CCCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LKDKFENMGAQLVNQVAAKTSDVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHH
QAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRIIGEAMERVGKDGIITVAEAK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHEEEECCCEEEEECCHHHHHHHHHHHHHHHH
EKGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKV
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCH
VSEEVGLKLDEVGPEVLGRAKTIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSK
HHHHHCCCHHHCCHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCH
YDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDALHATRAAVAQGIVPGGGVAL
HHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
LTDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGM
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMGMGGMGGMGGMGMM
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVV
CCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LKDKFENMGAQLVNQVAAKTSDVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHH
QAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRIIGEAMERVGKDGIITVAEAK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHEEEECCCEEEEECCHHHHHHHHHHHHHHHH
EKGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKV
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCH
VSEEVGLKLDEVGPEVLGRAKTIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSK
HHHHHCCCHHHCCHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCH
YDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDALHATRAAVAQGIVPGGGVAL
HHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
LTDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGM
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMGMGGMGGMGGMGMM
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA