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The map label for this gene is serS

Identifier: 45659295

GI number: 45659295

Start: 4255880

End: 4257133

Strand: Reverse

Name: serS

Synonym: LIC13480

Alternate gene names: 45659295

Gene position: 4257133-4255880 (Counterclockwise)

Preceding gene: 45659296

Following gene: 45659294

Centisome position: 99.53

GC content: 36.36

Gene sequence:

>1254_bases
ATGCTTGATTTGCGTTATATCACTGAAAATACAGAAGATCTCAAAAAAGTTTTAGAACTCAGAGGTTTTAAAGAAATTGG
AATCATTGACGAACTCAAATCGATTATTCAAAGAAAACGTGAATTTCAAAAAGAAGCAGATATTCTTAGAGAGGAACGTA
ACAAAGCTAGTAAAGAAGTCGGGAAAATTAAACAGTCTGGCGGAGATATTACGAAAATTTCTGCTTCTGTGAAACTCGTT
GGCGAAAAAATAAAAGAAATAGAATCCAAACTTGAACAAGAAGAAAACGCTCTTTTAAATATTAATTTAGGGCTTCCTAA
TATTCTGGATCCAAAGGTCCCGCCGGGAAAATCAGAACATGATAATATTGTTCAGTACGAAGTAGGAAAAATTCCTACTT
TTCAGTTTGTTCCAAAAACTCATTTTGAAATCGGAGAGGCATTACACTGGATCGATTTTGAAAAAGGGGTAAAACTTTCC
GGAGCAAGGGCTTATACTTATTGGAAAGACGGCGCGAGACTAGAAAGAGCTTTGATGAATTTTATGTTAGACGTTCATAC
TAAGGAACATGATTATACGGAAGTTTGGGTGCCTTCGATGGTTAACGACGAATCTATGATGGCGACCGGACAGTATCCTA
AATTTAAGGATGAATTTTATAGAATCGATAAGGATGAACTCAATTTAATTCCTACCGCAGAAGTTCCCCTTACAAATTTG
TATAGAGACGAGATCATCCCGGAAGATCAACTTCCGATTTCCGTAACGGCACATACGTCTTGTTTTAGAAGAGAAGCGGG
ATCTTACGGTAAAGATACGCGAGGACTGGTTCGGGTTCATCAGTTTCAGAAAGTTGAACTCGTAAAGTTTTGTAAACCTG
AGGATTCAGAAGAAGAACATAAAAAAATGCTTTCTCATGCGGAGAATATTCTGAAAAAATTAGAACTTCCATATCGGGTT
ATTATTCTTTGTTCGGGAGATATTTCCGCAAATTCTTCGATCACTTATGATATTGAAGTCTGGATGCCCGGTTTGAATCG
ATATATGGAAATTTCGTCTGTATCCAATTTTCGTGATTTTCAGGCGAGAAGGGGAAAAATTCGTTATAAATCCAAAGATG
GTAAGAATCAACTCGTACATACGATCAATGGTTCTGGTCTTGCACTGGGAAGAACTTACGCTGCGATTTTGGAAAATTTT
CAAAATGAAGATGGAACACTTCGTATTCCAGAAGTTTTAAAATCTTATTTTTAA

Upstream 100 bases:

>100_bases
GATAAAATGTTTTCTCTTAAAAAAGAATCTAACTCAGATGTGGAAAATAAACTTTTTGAAAACAGCATTAAATTTATGAA
TCGTAAGGCGTACCACTACA

Downstream 100 bases:

>100_bases
TTTGATTCGGATTTCTGAAAAAATCTGTACTTATTAAACGATTTTATACATTTGTTTTAATGAGAAAGGCGGAGAAATTA
ATTTTTAAACAATTTTATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLDLRYITENTEDLKKVLELRGFKEIGIIDELKSIIQRKREFQKEADILREERNKASKEVGKIKQSGGDITKISASVKLV
GEKIKEIESKLEQEENALLNINLGLPNILDPKVPPGKSEHDNIVQYEVGKIPTFQFVPKTHFEIGEALHWIDFEKGVKLS
GARAYTYWKDGARLERALMNFMLDVHTKEHDYTEVWVPSMVNDESMMATGQYPKFKDEFYRIDKDELNLIPTAEVPLTNL
YRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEHKKMLSHAENILKKLELPYRV
IILCSGDISANSSITYDIEVWMPGLNRYMEISSVSNFRDFQARRGKIRYKSKDGKNQLVHTINGSGLALGRTYAAILENF
QNEDGTLRIPEVLKSYF

Sequences:

>Translated_417_residues
MLDLRYITENTEDLKKVLELRGFKEIGIIDELKSIIQRKREFQKEADILREERNKASKEVGKIKQSGGDITKISASVKLV
GEKIKEIESKLEQEENALLNINLGLPNILDPKVPPGKSEHDNIVQYEVGKIPTFQFVPKTHFEIGEALHWIDFEKGVKLS
GARAYTYWKDGARLERALMNFMLDVHTKEHDYTEVWVPSMVNDESMMATGQYPKFKDEFYRIDKDELNLIPTAEVPLTNL
YRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEHKKMLSHAENILKKLELPYRV
IILCSGDISANSSITYDIEVWMPGLNRYMEISSVSNFRDFQARRGKIRYKSKDGKNQLVHTINGSGLALGRTYAAILENF
QNEDGTLRIPEVLKSYF
>Mature_417_residues
MLDLRYITENTEDLKKVLELRGFKEIGIIDELKSIIQRKREFQKEADILREERNKASKEVGKIKQSGGDITKISASVKLV
GEKIKEIESKLEQEENALLNINLGLPNILDPKVPPGKSEHDNIVQYEVGKIPTFQFVPKTHFEIGEALHWIDFEKGVKLS
GARAYTYWKDGARLERALMNFMLDVHTKEHDYTEVWVPSMVNDESMMATGQYPKFKDEFYRIDKDELNLIPTAEVPLTNL
YRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEHKKMLSHAENILKKLELPYRV
IILCSGDISANSSITYDIEVWMPGLNRYMEISSVSNFRDFQARRGKIRYKSKDGKNQLVHTINGSGLALGRTYAAILENF
QNEDGTLRIPEVLKSYF

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=431, Percent_Identity=30.3944315545244, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI225579074, Length=433, Percent_Identity=30.4849884526559, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI16306548, Length=441, Percent_Identity=31.2925170068027, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1787120, Length=425, Percent_Identity=45.4117647058823, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539260, Length=451, Percent_Identity=29.9334811529933, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=360, Percent_Identity=29.1666666666667, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=437, Percent_Identity=34.324942791762, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=365, Percent_Identity=31.7808219178082, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24581334, Length=449, Percent_Identity=30.2895322939866, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17737985, Length=337, Percent_Identity=32.9376854599407, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48021; Mature: 48021

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLRYITENTEDLKKVLELRGFKEIGIIDELKSIIQRKREFQKEADILREERNKASKEV
CCEEEEECCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKIKQSGGDITKISASVKLVGEKIKEIESKLEQEENALLNINLGLPNILDPKVPPGKSEH
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
DNIVQYEVGKIPTFQFVPKTHFEIGEALHWIDFEKGVKLSGARAYTYWKDGARLERALMN
CCEEEEECCCCCCEEECCCHHHHHHHHHHHEECCCCCEECCCEEEEEECCHHHHHHHHHH
FMLDVHTKEHDYTEVWVPSMVNDESMMATGQYPKFKDEFYRIDKDELNLIPTAEVPLTNL
HHHHHCCCCCCCCEEECCCCCCCCHHEECCCCCCHHHHHHCCCHHHCCCCCCCCCCHHHH
YRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEH
HHHHCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
KKMLSHAENILKKLELPYRVIILCSGDISANSSITYDIEVWMPGLNRYMEISSVSNFRDF
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCHHHEEHHHHHHHHHH
QARRGKIRYKSKDGKNQLVHTINGSGLALGRTYAAILENFQNEDGTLRIPEVLKSYF
HHHCCCEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCC
>Mature Secondary Structure
MLDLRYITENTEDLKKVLELRGFKEIGIIDELKSIIQRKREFQKEADILREERNKASKEV
CCEEEEECCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKIKQSGGDITKISASVKLVGEKIKEIESKLEQEENALLNINLGLPNILDPKVPPGKSEH
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
DNIVQYEVGKIPTFQFVPKTHFEIGEALHWIDFEKGVKLSGARAYTYWKDGARLERALMN
CCEEEEECCCCCCEEECCCHHHHHHHHHHHEECCCCCEECCCEEEEEECCHHHHHHHHHH
FMLDVHTKEHDYTEVWVPSMVNDESMMATGQYPKFKDEFYRIDKDELNLIPTAEVPLTNL
HHHHHCCCCCCCCEEECCCCCCCCHHEECCCCCCHHHHHHCCCHHHCCCCCCCCCCHHHH
YRDEIIPEDQLPISVTAHTSCFRREAGSYGKDTRGLVRVHQFQKVELVKFCKPEDSEEEH
HHHHCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
KKMLSHAENILKKLELPYRVIILCSGDISANSSITYDIEVWMPGLNRYMEISSVSNFRDF
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCHHHEEHHHHHHHHHH
QARRGKIRYKSKDGKNQLVHTINGSGLALGRTYAAILENFQNEDGTLRIPEVLKSYF
HHHCCCEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA