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The map label for this gene is dnaX

Identifier: 45659289

GI number: 45659289

Start: 4248234

End: 4249673

Strand: Direct

Name: dnaX

Synonym: LIC13474

Alternate gene names: 45659289

Gene position: 4248234-4249673 (Clockwise)

Preceding gene: 45659288

Following gene: 45659290

Centisome position: 99.32

GC content: 35.76

Gene sequence:

>1440_bases
ATGGCAGGAACTCACGAAGTCCTTTCCCGAAAATATCGTCCTCAAAAATTTCGGGACGTAATTCATCAAGACCTTGCTAT
AGGTGCTCTTCAAAACGCTCTTAAATCTGGAAAGATTGGTCATGCGTATATATTCTTCGGCCCTCGTGGAGTTGGTAAAA
CCACAATCGCAAGAATTCTCGCAAAACGTTTAAACTGTCAAAATCCTATCGACAATGAGCCATGTAACGAATGCAATTCT
TGCAGCGAAATTACTCGAGGAATTTCCAGCGACGTTTTAGAAATAGACGCAGCAAGTAACCGAGGAATTGAAAACATCCG
CGAACTTAGAGACAATGTGAAGTTCGCTCCGATGGGCGGGAAATATAAGGTTTATATCATAGATGAAGTCCACATGCTTA
CAGACCAATCATTTAACGCACTTTTAAAAACATTAGAAGAACCTCCTGCTCATATTGTTTTCGTTTTAGCTACTACAGAG
TTTCATAAAATTCCAGAGACAATTCTTTCTAGATGTCAGGACTTTATTTTTAAAAAAGTCCCTTTGTCCGTTTTACAAGA
TTATTCCGAAAAACTTTGTAAAATCGAAAATGTTCAATACGATCAGGAAGGTCTTTTCTGGGTCGCCAAAAAAGGAGACG
GTTCCGTAAGAGACATGCTTTCATTTATGGAACAGGCCATCGTATTTACCGACTCAAAACTGTTAGGCGCTGCAATTCGT
AAAATGATAGGTTATCATGGAATCGAATTTTTGACTTCGTTTATCAAAAGTTTAGTCGATCCAGACAATCATTCTAAATC
CCTGGAAATCATCGAATCTCTTTATCAAGAAGGCCAGGACATCTATAAATTTTTATGGGATTCCATAGAATTTACTCACA
CTCTCAATTTAATTCGAGATTCTCTTGCAGATCCCGAATCCGTTAATTTTCCAAAAGAAGATCTCGTAAAAATGAAATCG
GATTTCGAGAATGTAGATTCTTCCAAATTGAATTTTCTTTCCGGAAAACTTTTTGAGATCTATGAAAGAATTAAAACGAT
TCGTTTGAGAAACTCTTTTGAAATTAAAGTTTTTACTGAAATTCAAATCAAAAAACTCGTAGAAGAACTTACTTATCCAA
GTTTGGCGGGTTTAATCGATAAAATCAACCACCTGATTCTTATGGTTCAAGGTTCTAAAAATGTTTTATCAGATGTGAAT
CAAAATACCGCTTTTGCACTTAAAGATACGTTGCAACCGGAAACTTCTAAAAAAAAAGATAAACTTTCTTCAGACGTTAT
TTTAGAATCTCAGTTTGAGTCTAATCAACAGGATTCTAATTTAGAAAACACAAAACCTGCCGAACTAAGTTCTCGGAAGT
TTGACACAAGCACTGAGATTAAAAAAAAGTTTTTAGGTACAGAAGTAGACCCAAACCAAACTCCTAAATTGGATTCTTAA

Upstream 100 bases:

>100_bases
GCTACAGGAGAAGTGTCAGAGTGGTCTATTGTGCATGCTTGGAAAGCATGTGTGCCAAAAGCACCCCGGGTTCGAATCCC
GGCTTCTCCGATTTCATATT

Downstream 100 bases:

>100_bases
TGTTATGTTTGATAAGATAAAAAATTTTTCAGAAATTCTATCCAACATGGGCTCTTTCCGTGAAAAAATGGAAGAAGTAA
AAAAACGAATCGCTTCGATT

Product: DNA polymerase III subunit gamma

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MAGTHEVLSRKYRPQKFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCQNPIDNEPCNECNS
CSEITRGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFVLATTE
FHKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWVAKKGDGSVRDMLSFMEQAIVFTDSKLLGAAIR
KMIGYHGIEFLTSFIKSLVDPDNHSKSLEIIESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADPESVNFPKEDLVKMKS
DFENVDSSKLNFLSGKLFEIYERIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLIDKINHLILMVQGSKNVLSDVN
QNTAFALKDTLQPETSKKKDKLSSDVILESQFESNQQDSNLENTKPAELSSRKFDTSTEIKKKFLGTEVDPNQTPKLDS

Sequences:

>Translated_479_residues
MAGTHEVLSRKYRPQKFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCQNPIDNEPCNECNS
CSEITRGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFVLATTE
FHKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWVAKKGDGSVRDMLSFMEQAIVFTDSKLLGAAIR
KMIGYHGIEFLTSFIKSLVDPDNHSKSLEIIESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADPESVNFPKEDLVKMKS
DFENVDSSKLNFLSGKLFEIYERIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLIDKINHLILMVQGSKNVLSDVN
QNTAFALKDTLQPETSKKKDKLSSDVILESQFESNQQDSNLENTKPAELSSRKFDTSTEIKKKFLGTEVDPNQTPKLDS
>Mature_478_residues
AGTHEVLSRKYRPQKFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCQNPIDNEPCNECNSC
SEITRGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFVLATTEF
HKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWVAKKGDGSVRDMLSFMEQAIVFTDSKLLGAAIRK
MIGYHGIEFLTSFIKSLVDPDNHSKSLEIIESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADPESVNFPKEDLVKMKSD
FENVDSSKLNFLSGKLFEIYERIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLIDKINHLILMVQGSKNVLSDVNQ
NTAFALKDTLQPETSKKKDKLSSDVILESQFESNQQDSNLENTKPAELSSRKFDTSTEIKKKFLGTEVDPNQTPKLDS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=232, Percent_Identity=28.0172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI31881687, Length=232, Percent_Identity=28.0172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI31563534, Length=231, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI6677723, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI194306571, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI194306567, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=300, Percent_Identity=42, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1787341, Length=151, Percent_Identity=31.7880794701987, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=223, Percent_Identity=23.7668161434978, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=221, Percent_Identity=27.6018099547511, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=312, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324478, Length=222, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=230, Percent_Identity=27.8260869565217, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=178, Percent_Identity=28.0898876404494, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17647857, Length=224, Percent_Identity=26.7857142857143, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921076, Length=273, Percent_Identity=23.8095238095238, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859927, Length=233, Percent_Identity=24.4635193133047, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 54407; Mature: 54276

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTHEVLSRKYRPQKFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARIL
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
AKRLNCQNPIDNEPCNECNSCSEITRGISSDVLEIDAASNRGIENIRELRDNVKFAPMGG
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCC
KYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFVLATTEFHKIPETILSRCQDFIFKKV
CEEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
PLSVLQDYSEKLCKIENVQYDQEGLFWVAKKGDGSVRDMLSFMEQAIVFTDSKLLGAAIR
CHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
KMIGYHGIEFLTSFIKSLVDPDNHSKSLEIIESLYQEGQDIYKFLWDSIEFTHTLNLIRD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLADPESVNFPKEDLVKMKSDFENVDSSKLNFLSGKLFEIYERIKTIRLRNSFEIKVFTE
HCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
IQIKKLVEELTYPSLAGLIDKINHLILMVQGSKNVLSDVNQNTAFALKDTLQPETSKKKD
HHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCHHHHHHCCCCCEEEEHHCCCCCCHHHHH
KLSSDVILESQFESNQQDSNLENTKPAELSSRKFDTSTEIKKKFLGTEVDPNQTPKLDS
HHHHHHEEHHHHCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGTHEVLSRKYRPQKFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARIL
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
AKRLNCQNPIDNEPCNECNSCSEITRGISSDVLEIDAASNRGIENIRELRDNVKFAPMGG
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCC
KYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFVLATTEFHKIPETILSRCQDFIFKKV
CEEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
PLSVLQDYSEKLCKIENVQYDQEGLFWVAKKGDGSVRDMLSFMEQAIVFTDSKLLGAAIR
CHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
KMIGYHGIEFLTSFIKSLVDPDNHSKSLEIIESLYQEGQDIYKFLWDSIEFTHTLNLIRD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLADPESVNFPKEDLVKMKSDFENVDSSKLNFLSGKLFEIYERIKTIRLRNSFEIKVFTE
HCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
IQIKKLVEELTYPSLAGLIDKINHLILMVQGSKNVLSDVNQNTAFALKDTLQPETSKKKD
HHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCHHHHHHCCCCCEEEEHHCCCCCCHHHHH
KLSSDVILESQFESNQQDSNLENTKPAELSSRKFDTSTEIKKKFLGTEVDPNQTPKLDS
HHHHHHEEHHHHCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]