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The map label for this gene is ndk

Identifier: 45659145

GI number: 45659145

Start: 4081553

End: 4081966

Strand: Direct

Name: ndk

Synonym: LIC13326

Alternate gene names: 45659145

Gene position: 4081553-4081966 (Clockwise)

Preceding gene: 45659144

Following gene: 45659146

Centisome position: 95.43

GC content: 40.58

Gene sequence:

>414_bases
ATGTCCAGAACGTTCATCATGATAAAACCAGACGGAGTTAAAAACAAACACGTCGGAAACATTCTCTCTAGAATTGAAAA
AGAAGGATTCAAAATTCTAGGTTTAAAATACCTCAAGTTATCTCTCGAAGATGCTAAACAGTTTTATAAAGTGCATTCTG
CTCGTCCGTTTTACAACGACTTATGCAACTACATGTCTTCCGGTCCAATCGTCGCCGCTGCTCTTGAAAGAGACAACGCA
GTTCTTCATTGGAGGGAAGTAATCGGGGCCACCGATCCAAAAGAAGCCGCCGCTGGAACCATTCGAGCTCTTTATGCAGA
AAGTAAAGAAGCCAATGCAGTCCACGGTTCGGATTCAGATGACAATGCAGCATTAGAAATTTCTTTCTTTTTTAAAGGAA
ACGAATTATTCTAA

Upstream 100 bases:

>100_bases
CGTAAAAGAAGTAGCAAGACATGGAAGAGACGTAAGCAATCAGGTCCCAGAAATCGTAAGTAAAGCATTACTTAAAAAAC
TCTCTCAATAAGGAAAAAAA

Downstream 100 bases:

>100_bases
AACGAACTACATAAATCAAAGAGGAGTTTCAAGACTTCTCTTTGATTTATATGGAGTTTGTTAGTTCTATTACTAACAAA
ACGATTTTATCGATTCGTTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MSRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNA
VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDDNAALEISFFFKGNELF

Sequences:

>Translated_137_residues
MSRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNA
VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDDNAALEISFFFKGNELF
>Mature_136_residues
SRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV
LHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDDNAALEISFFFKGNELF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=42.2222222222222, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=42.5373134328358, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4826862, Length=134, Percent_Identity=41.044776119403, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=42.5373134328358, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI37574614, Length=132, Percent_Identity=37.8787878787879, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI7019465, Length=132, Percent_Identity=37.8787878787879, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=36.2962962962963, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI5031951, Length=132, Percent_Identity=34.0909090909091, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.1594202898551, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=48.5294117647059, Blast_Score=139, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=41.044776119403, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=134, Percent_Identity=42.5373134328358, Blast_Score=114, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45549037, Length=134, Percent_Identity=44.0298507462687, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=34.3283582089552, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=29.1970802919708, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15255; Mature: 15123

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYND
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEHHEEEEEHHHHHHHHHHHCCCCHHHH
LCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSD
HHHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCC
DNAALEISFFFKGNELF
CCEEEEEEEEECCCCCC
>Mature Secondary Structure 
SRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYND
CCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEHHEEEEEHHHHHHHHHHHCCCCHHHH
LCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSD
HHHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCC
DNAALEISFFFKGNELF
CCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA