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The map label for this gene is phoR [H]

Identifier: 45659091

GI number: 45659091

Start: 4008668

End: 4010059

Strand: Direct

Name: phoR [H]

Synonym: LIC13270

Alternate gene names: 45659091

Gene position: 4008668-4010059 (Clockwise)

Preceding gene: 45659090

Following gene: 45659092

Centisome position: 93.72

GC content: 37.14

Gene sequence:

>1392_bases
ATGAGGCGTAGTTTATTTTCAAAACTTCTTCTTAGTAATTGGCTACTTCTACTTGTACTTCTTGTGGTCGCCGGTATTGC
TCTTTTCGTAGAGAAGTTCGTTCATTCTGATTTTAAAATCCTTTTGTTCTCTTTTTACGTTCTTTTTGCGATGTTTGGTA
CATTCTACATGTCTTACTCAATCGCTAAAAGTGTTGTAGAACCATTAGATCGAATCGAAAAAAAAACCGGAGAAATTAAC
GCAGGTGATTTCGGTTCAGAACTAACACTTTCTGATATTCGAGAGCTTGCAGACCTTGCGTCTTCGATCAACTTAATGTC
TACAAGACTTAAAAATCAATTTGTGGATCTCACGATAGAAAAAGAAAAATTCGATTCCGTTTTACAAAACTTAAAGGAAG
GAGTTTTTGCAATCGATCCGGAAAACGCTTCTATTCTTTTTCAAAATAAAAGTGTTCCAGGATCTTTGATCGAACCAAAT
TCAAGATCTAGGAAATTAACCGATGCAACTAGAGATTTAAGGCTTCTAGAATTTGTATTAAACCACCTTAAAGGCTCCGG
CGATTCTAAAATGGAACTCGACCTTGGTCAAAATTTTTACGCGATCAAAATGTATCCTCTTAAAACAAACGGTAAAACTC
TAATGTACATCGGAGTAATCCGAAACATCACCGAAGAAAAACAATCCCACATCATTCGAGAGCAATTCGTTCAAAACGCT
TCTCATGAACTCAAAACTCCTATTACATCCATTAAGGGATATACGGAAACGTTACTCGATCGTTTGCGCCTTTCGCCTGA
AAGCCATGAAAAAAGATTTTTAGACGCAATTTCTAGGAACACGGATCGTATGGTTCGGATCGTAGAGGACATGCTCACAA
TCACACGAATCGAAAACCAAACCAAAATTTCAAGTGAAGAAGAATTCTCCTTAAAATCTCTCGTAGAAAACCTAAGTTAT
ACAGTAGAAGGAGTTGTTTCATCCAAAGGTCAGAAGTTTGTAGTTGAGATGCCCAATCCTTTGATGATTTCTGCGGACTG
GATCCTTTTAGAACACATGCTCTTAAATTTAATTTCAAACGCGTCGTCTTATTCTTCCGAAGGAAAAACGATTACTCTCA
AAATTTTACCTATCAAATCGGATCAGGTTCAATTTCAAGTAATTGATCAGGGAATTGGTATTCAAGATGAGGACAAGATT
AGAATTTTCGAAAGATTCTTCCGAGTCGATAAAAATCGTTCCCGAAAAGAAGGTGGAACCGGTTTAGGTCTTTCTATTGT
GAAACATATCGTTCGTCTTCACCACGGTTCCGTTAAAGTTTTTGATAATCCAGAAGGTGGAACCATTTTTTCAGTTACGA
TTCCCACTCGTTATCAGACCGAAACATCCTGA

Upstream 100 bases:

>100_bases
ACCGATAGAGCAGTAGACGTAAATATCAAAAGACTACGCGATAAACTCGGAGACGAAAAGGAAAGACTAGAAACGATACG
CGGAATCGGCTATAGATTCA

Downstream 100 bases:

>100_bases
ATTTATTCTTTTCGACAGAGATAATTTTCTAAATATAGATCCAATCGACTCGCTCAAGGGATCTACTCATGCACATGCCT
AAAGGATTTTTATCTTTTGG

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGIALFVEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVVEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKNQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSVPGSLIEPN
SRSRKLTDATRDLRLLEFVLNHLKGSGDSKMELDLGQNFYAIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVEDMLTITRIENQTKISSEEEFSLKSLVENLSY
TVEGVVSSKGQKFVVEMPNPLMISADWILLEHMLLNLISNASSYSSEGKTITLKILPIKSDQVQFQVIDQGIGIQDEDKI
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNPEGGTIFSVTIPTRYQTETS

Sequences:

>Translated_463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGIALFVEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVVEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKNQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSVPGSLIEPN
SRSRKLTDATRDLRLLEFVLNHLKGSGDSKMELDLGQNFYAIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVEDMLTITRIENQTKISSEEEFSLKSLVENLSY
TVEGVVSSKGQKFVVEMPNPLMISADWILLEHMLLNLISNASSYSSEGKTITLKILPIKSDQVQFQVIDQGIGIQDEDKI
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNPEGGTIFSVTIPTRYQTETS
>Mature_463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGIALFVEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVVEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKNQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSVPGSLIEPN
SRSRKLTDATRDLRLLEFVLNHLKGSGDSKMELDLGQNFYAIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVEDMLTITRIENQTKISSEEEFSLKSLVENLSY
TVEGVVSSKGQKFVVEMPNPLMISADWILLEHMLLNLISNASSYSSEGKTITLKILPIKSDQVQFQVIDQGIGIQDEDKI
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNPEGGTIFSVTIPTRYQTETS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=256, Percent_Identity=34.765625, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786783, Length=229, Percent_Identity=32.3144104803493, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=30.8641975308642, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.1304347826087, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=31.6742081447964, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.5486725663717, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=27.7056277056277, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=27.5590551181102, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=32.3529411764706, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788713, Length=290, Percent_Identity=24.8275862068966, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=223, Percent_Identity=32.7354260089686, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=28.6343612334802, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=29.3877551020408, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=28.6343612334802, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=237, Percent_Identity=24.8945147679325, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52607; Mature: 52607

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSLFSKLLLSNWLLLLVLLVVAGIALFVEKFVHSDFKILLFSFYVLFAMFGTFYMSYS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAKSVVEPLDRIEKKTGEINAGDFGSELTLSDIRELADLASSINLMSTRLKNQFVDLTIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
KEKFDSVLQNLKEGVFAIDPENASILFQNKSVPGSLIEPNSRSRKLTDATRDLRLLEFVL
HHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NHLKGSGDSKMELDLGQNFYAIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVEDMLTITRIENQ
HHHHHCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKISSEEEFSLKSLVENLSYTVEGVVSSKGQKFVVEMPNPLMISADWILLEHMLLNLISN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHC
ASSYSSEGKTITLKILPIKSDQVQFQVIDQGIGIQDEDKIRIFERFFRVDKNRSRKEGGT
CCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKHIVRLHHGSVKVFDNPEGGTIFSVTIPTRYQTETS
CCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MRRSLFSKLLLSNWLLLLVLLVVAGIALFVEKFVHSDFKILLFSFYVLFAMFGTFYMSYS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAKSVVEPLDRIEKKTGEINAGDFGSELTLSDIRELADLASSINLMSTRLKNQFVDLTIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
KEKFDSVLQNLKEGVFAIDPENASILFQNKSVPGSLIEPNSRSRKLTDATRDLRLLEFVL
HHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NHLKGSGDSKMELDLGQNFYAIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVEDMLTITRIENQ
HHHHHCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKISSEEEFSLKSLVENLSYTVEGVVSSKGQKFVVEMPNPLMISADWILLEHMLLNLISN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHC
ASSYSSEGKTITLKILPIKSDQVQFQVIDQGIGIQDEDKIRIFERFFRVDKNRSRKEGGT
CCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKHIVRLHHGSVKVFDNPEGGTIFSVTIPTRYQTETS
CCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]