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The map label for this gene is nudH

Identifier: 45659002

GI number: 45659002

Start: 3891862

End: 3892350

Strand: Reverse

Name: nudH

Synonym: LIC13180

Alternate gene names: 45659002

Gene position: 3892350-3891862 (Counterclockwise)

Preceding gene: 45659004

Following gene: 45659001

Centisome position: 91.0

GC content: 37.22

Gene sequence:

>489_bases
ATGGACAAACCCTACCGAAAAAATGTCGGGATGGTCGTATTTAACTCTCGTGGAGAGGTTTTGGTTGGAGAAAGATTGAA
TTTTCTAGGTTCTTGGCAATTTCCACAAGGTGGAATTGACGACGATGAAGATCCGATCAAGGCAGCCATGAGAGAATTAT
ATGAAGAAGTCGGAATCGATTCTGGAAAAATCGTAGCTGAATATCCAGATTGGATTTCCTATGACTTTCCCGAAAACCTT
CCTCTAAACCGTCATCTTCAAAAATATAGGGGACAACTTCAAAAGTGGTTTCTTATCTATTGGGACGGGGAAGTGGATCA
ATGTGATTTGGATATTCATGAAAGAGAATTTGGAACGGTTCGTTTTATTCCTATAAAAAACACGTTGAATACAGTCGTTC
CTTTTAAAAAAGATGTATATTATAAAATTGTAAATGACTTTGAGCCTAAGATCCAAAACTTTTTGCAAGACATCGGAAAT
AGATCGTAA

Upstream 100 bases:

>100_bases
ATTGATTTTTTATTTAGTTCTGCGTTTGTATAATATTGGGGTTAAATAAGTGACTTTAAAACTTCTTGTCATAGAATAGA
GTTAACGGGAGCTTATTCGT

Downstream 100 bases:

>100_bases
TGTCCTTTTTTATTCCACCTGGTGGCCCTCCGGGACCAATTCCTGGTTTACAATTGGTTTTCGGTTCTGTTGGCGAAAAT
AGTCTTCGTAAACTCGTTTC

Product: (di)nucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MDKPYRKNVGMVVFNSRGEVLVGERLNFLGSWQFPQGGIDDDEDPIKAAMRELYEEVGIDSGKIVAEYPDWISYDFPENL
PLNRHLQKYRGQLQKWFLIYWDGEVDQCDLDIHEREFGTVRFIPIKNTLNTVVPFKKDVYYKIVNDFEPKIQNFLQDIGN
RS

Sequences:

>Translated_162_residues
MDKPYRKNVGMVVFNSRGEVLVGERLNFLGSWQFPQGGIDDDEDPIKAAMRELYEEVGIDSGKIVAEYPDWISYDFPENL
PLNRHLQKYRGQLQKWFLIYWDGEVDQCDLDIHEREFGTVRFIPIKNTLNTVVPFKKDVYYKIVNDFEPKIQNFLQDIGN
RS
>Mature_162_residues
MDKPYRKNVGMVVFNSRGEVLVGERLNFLGSWQFPQGGIDDDEDPIKAAMRELYEEVGIDSGKIVAEYPDWISYDFPENL
PLNRHLQKYRGQLQKWFLIYWDGEVDQCDLDIHEREFGTVRFIPIKNTLNTVVPFKKDVYYKIVNDFEPKIQNFLQDIGN
RS

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=164, Percent_Identity=33.5365853658537, Blast_Score=87, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19084; Mature: 19084

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKPYRKNVGMVVFNSRGEVLVGERLNFLGSWQFPQGGIDDDEDPIKAAMRELYEEVGID
CCCCCCCCCCEEEECCCCCEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
SGKIVAEYPDWISYDFPENLPLNRHLQKYRGQLQKWFLIYWDGEVDQCDLDIHEREFGTV
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEECCCCCCCCCCEE
RFIPIKNTLNTVVPFKKDVYYKIVNDFEPKIQNFLQDIGNRS
EEEEECCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKPYRKNVGMVVFNSRGEVLVGERLNFLGSWQFPQGGIDDDEDPIKAAMRELYEEVGID
CCCCCCCCCCEEEECCCCCEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
SGKIVAEYPDWISYDFPENLPLNRHLQKYRGQLQKWFLIYWDGEVDQCDLDIHEREFGTV
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEECCCCCCCCCCEE
RFIPIKNTLNTVVPFKKDVYYKIVNDFEPKIQNFLQDIGNRS
EEEEECCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA