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The map label for this gene is norM

Identifier: 45658991

GI number: 45658991

Start: 3879930

End: 3881351

Strand: Reverse

Name: norM

Synonym: LIC13169

Alternate gene names: 45658991

Gene position: 3881351-3879930 (Counterclockwise)

Preceding gene: 45658992

Following gene: 45658990

Centisome position: 90.75

GC content: 38.96

Gene sequence:

>1422_bases
TTGAAAATGAATAGTTTTTCTGCTTCTTACAAAAATCTTGGAAGAACCGTGAGAACCTTACATCATTTAGCTCATACTTT
TTATAGAAACATACGTCCGAGTCTTTTAAATTCCATGATCTTAAAACTCGCGGTGCCGGTTGTGTTTGGGATGCTTAGTC
AAACTGTGGTTTGGGTGACCGATACAATGATGGTAGGAAGACTTGGAAAACATTCCATTGCTTCGATCGGAATCGGAGGA
ATTGCACATTTTACTGTGCTTGCGTTTCTGATGGGATTTTCGATGGGGATACAAGTAATCGTAGCTAGAAGGTTCGGAGA
AAAAAACGATTCTGAAATTGGAAAGATCGGAGTCACTGCTTTGTATCTTGTGATAGTATTTGGAAGCATTTTATCGATCG
GAGGGGCTACTATCAGTGAATGGTTGATGAACCTTCTCAATAAAGATGAAATCGTAAGAAGACTTTCCAGTGAATATTTA
TACTTTCGTTTTTTAGGGACTATTTTTTTCTTTTTACTATTTACTACAAGAGCCTTTACCGATGGATTAGGGATCACTAC
GGCAGGTCTTGCGTCCATGATTATAACATGTTTTACGAATATATTTTTAAATTGGATGTTGATCTATGGGAACTTAGGTT
TTGAACCTATGGGAGTTAAGGGAGCGGCGATCGCTTCTTCTTTGGCGGGTGGAGCGGGATTATTTGCGTTTCCTTTTTAT
TTTTATTCAAAAGATTTAGGAAAGTATTTTTCTCATATATCTTGGGTGTTTAGTTGGGATCATTTCCGAGAAATTTTAAA
GGCGAGTACGGCGCCTGCACTTGCAGAACTTCTAAATAACATTTCCTTTATGATCTTTACGGAGTTTGCGACAATTGTGG
GAACAACTGCATTAGCCGTAACTAATATGCTTTTTAGTACTTTGAGTCTTTCCTTTTTACCAGGATACGCTTTTGGGATT
GCTGCGACGACTATACTTGGGCAAGCCTTGGGGGCGGGGAAGCCAAAACTTGCTTATCACGGAGCGTTTCGGTCCGCTTT
TTTTGCCGCTTGTGTGATGGGAAGTATGGGACTTGTTTTTATTTTTTGGGGAAAGGATATGTTATCTTTTTATACAAAGG
ATCAGGAACTGATTGAAGAAGCTTATTCTCCTTTATTAATATTAGGAATGATTCAAGTTGTGGATGCTTATCATATGGTA
ATTGCTTGTGCTCTTCGTGGAGCAGGACTTCAAGATTTTGTATTTCGTGCATATACGGCCGCGTCTTATTTAGTGTTTTT
ACCTTCTGCTTACTTTATGGGAATTTATTTAGGAATGGGATCAGCTGGGTTGTGGTCTGGGATTGTGGCTTGGGTTTTAG
TGCTGGCTAGTGTGTTCGTAGTTCGATTTAGAAGAAAGGATTGGGTTCAAAATCCAGTTTAA

Upstream 100 bases:

>100_bases
AATTTTAAACAACCCTATTTTAAAATTCATTTCTAATCTTAAAATAAAATTGAGAATTCTCTACAAAAAGTTAAAATCTT
AAACAAAGAAAAAAGTTTTT

Downstream 100 bases:

>100_bases
ACTTTCTTGCCAGATCGGGTTTTAGGGTTTTTTTGGTCTGAAGATGAAAAAAGCTCTCATAACCGGGATTACAGGACAAG
ACGGATCTTATTTAACTGAA

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKMNSFSASYKNLGRTVRTLHHLAHTFYRNIRPSLLNSMILKLAVPVVFGMLSQTVVWVTDTMMVGRLGKHSIASIGIGG
IAHFTVLAFLMGFSMGIQVIVARRFGEKNDSEIGKIGVTALYLVIVFGSILSIGGATISEWLMNLLNKDEIVRRLSSEYL
YFRFLGTIFFFLLFTTRAFTDGLGITTAGLASMIITCFTNIFLNWMLIYGNLGFEPMGVKGAAIASSLAGGAGLFAFPFY
FYSKDLGKYFSHISWVFSWDHFREILKASTAPALAELLNNISFMIFTEFATIVGTTALAVTNMLFSTLSLSFLPGYAFGI
AATTILGQALGAGKPKLAYHGAFRSAFFAACVMGSMGLVFIFWGKDMLSFYTKDQELIEEAYSPLLILGMIQVVDAYHMV
IACALRGAGLQDFVFRAYTAASYLVFLPSAYFMGIYLGMGSAGLWSGIVAWVLVLASVFVVRFRRKDWVQNPV

Sequences:

>Translated_473_residues
MKMNSFSASYKNLGRTVRTLHHLAHTFYRNIRPSLLNSMILKLAVPVVFGMLSQTVVWVTDTMMVGRLGKHSIASIGIGG
IAHFTVLAFLMGFSMGIQVIVARRFGEKNDSEIGKIGVTALYLVIVFGSILSIGGATISEWLMNLLNKDEIVRRLSSEYL
YFRFLGTIFFFLLFTTRAFTDGLGITTAGLASMIITCFTNIFLNWMLIYGNLGFEPMGVKGAAIASSLAGGAGLFAFPFY
FYSKDLGKYFSHISWVFSWDHFREILKASTAPALAELLNNISFMIFTEFATIVGTTALAVTNMLFSTLSLSFLPGYAFGI
AATTILGQALGAGKPKLAYHGAFRSAFFAACVMGSMGLVFIFWGKDMLSFYTKDQELIEEAYSPLLILGMIQVVDAYHMV
IACALRGAGLQDFVFRAYTAASYLVFLPSAYFMGIYLGMGSAGLWSGIVAWVLVLASVFVVRFRRKDWVQNPV
>Mature_473_residues
MKMNSFSASYKNLGRTVRTLHHLAHTFYRNIRPSLLNSMILKLAVPVVFGMLSQTVVWVTDTMMVGRLGKHSIASIGIGG
IAHFTVLAFLMGFSMGIQVIVARRFGEKNDSEIGKIGVTALYLVIVFGSILSIGGATISEWLMNLLNKDEIVRRLSSEYL
YFRFLGTIFFFLLFTTRAFTDGLGITTAGLASMIITCFTNIFLNWMLIYGNLGFEPMGVKGAAIASSLAGGAGLFAFPFY
FYSKDLGKYFSHISWVFSWDHFREILKASTAPALAELLNNISFMIFTEFATIVGTTALAVTNMLFSTLSLSFLPGYAFGI
AATTILGQALGAGKPKLAYHGAFRSAFFAACVMGSMGLVFIFWGKDMLSFYTKDQELIEEAYSPLLILGMIQVVDAYHMV
IACALRGAGLQDFVFRAYTAASYLVFLPSAYFMGIYLGMGSAGLWSGIVAWVLVLASVFVVRFRRKDWVQNPV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=457, Percent_Identity=22.7571115973742, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=20.9821428571429, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=465, Percent_Identity=21.505376344086, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 52057; Mature: 52057

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]