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The map label for this gene is gmd

Identifier: 45658990

GI number: 45658990

Start: 3878864

End: 3879886

Strand: Reverse

Name: gmd

Synonym: LIC13168

Alternate gene names: 45658990

Gene position: 3879886-3878864 (Counterclockwise)

Preceding gene: 45658991

Following gene: 45658987

Centisome position: 90.71

GC content: 41.15

Gene sequence:

>1023_bases
ATGAAAAAAGCTCTCATAACCGGGATTACAGGACAAGACGGATCTTATTTAACTGAATTTTTACTTCAGAAGGGGTATCA
AGTTCATGGAATTGTCAGAAGATCCAGTATGTTCAACCGAGCGAGAATTGAACATCTACGTGGGAACTCCAACCTTGTTC
TACATTATGGAGATTTAACCGATTCGAGCAATTTAAACCGAATTTTGGAAAAGGTTTCTCCGGACGAAATTTACAATCTC
GCGGCTCAATCACATGTAGGAGTTTCTTTTGAGGTTCCAGAATATACCGCTGAAGCGGACGCGGTAGGAACACTTCGAAT
TTTAGATGCAATCAAACAGATCGGAGTAAAGAGTCGATTTTATCAAGCTTCTACGTCCGAACTTTACGGAAAAGTGCAAG
CAATCCCACAAACCGAAACAACTCCGTTTTATCCTAGATCACCTTATGCTGTGGCAAAGTTATACGCTTATTGGGCTGTA
GTAAATTATAGAGAGGCGTTTGGAATTCATGCTTCTAATGGAATTCTTTTCAATCACGAATCACCTAGACGTGGAGAAGG
GTTTGTAACAAGAAAGATTACTCTCGGAGTTGCTAATCTACTCGCTAAAAAAGGCGGGCCCATTCAGCTCGGAAACATGG
ACGCAAAAAGAGACTGGGGATACGCGCCCGACTATGTAGAAATGATGTGGATGATGTTACAACAACCGGAAGCGGATGAT
TATGTAGTAGCGACTAACGAAACACATACGGTAAGAGAGTTTGTGGAAAAGTCTTTTGGATTTGTAGGAATTCAAGTGCG
CTGGGAAGGAAATGGAGATTCCGAAAAGGGGTTTGATGCAAAATCTGGACAATTGCTTGTAGAAGTGAATCCAAAGTTCT
ATCGCCCAACGGAAGTAGACATTTTAATCGGAGATCCCGCAAAAGCAAAAAAGAAATTGGGTTGGGAGCCTAAAGTAAAA
TTTGAAGAACTGGTCAAGATTATGACTAAGGCGGATTGCGAGTCAATCGGAATCAAAATTTAA

Upstream 100 bases:

>100_bases
GCTAGTGTGTTCGTAGTTCGATTTAGAAGAAAGGATTGGGTTCAAAATCCAGTTTAAACTTTCTTGCCAGATCGGGTTTT
AGGGTTTTTTTGGTCTGAAG

Downstream 100 bases:

>100_bases
AAACATTCTTATATTAAAATATAAGAATGTTTTGAATATTTATATGTGCTATGTGTTTTTCTGAATTGATTTTCAATTTA
AAAAAATCAGTTTTATAGAA

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKKALITGITGQDGSYLTEFLLQKGYQVHGIVRRSSMFNRARIEHLRGNSNLVLHYGDLTDSSNLNRILEKVSPDEIYNL
AAQSHVGVSFEVPEYTAEADAVGTLRILDAIKQIGVKSRFYQASTSELYGKVQAIPQTETTPFYPRSPYAVAKLYAYWAV
VNYREAFGIHASNGILFNHESPRRGEGFVTRKITLGVANLLAKKGGPIQLGNMDAKRDWGYAPDYVEMMWMMLQQPEADD
YVVATNETHTVREFVEKSFGFVGIQVRWEGNGDSEKGFDAKSGQLLVEVNPKFYRPTEVDILIGDPAKAKKKLGWEPKVK
FEELVKIMTKADCESIGIKI

Sequences:

>Translated_340_residues
MKKALITGITGQDGSYLTEFLLQKGYQVHGIVRRSSMFNRARIEHLRGNSNLVLHYGDLTDSSNLNRILEKVSPDEIYNL
AAQSHVGVSFEVPEYTAEADAVGTLRILDAIKQIGVKSRFYQASTSELYGKVQAIPQTETTPFYPRSPYAVAKLYAYWAV
VNYREAFGIHASNGILFNHESPRRGEGFVTRKITLGVANLLAKKGGPIQLGNMDAKRDWGYAPDYVEMMWMMLQQPEADD
YVVATNETHTVREFVEKSFGFVGIQVRWEGNGDSEKGFDAKSGQLLVEVNPKFYRPTEVDILIGDPAKAKKKLGWEPKVK
FEELVKIMTKADCESIGIKI
>Mature_340_residues
MKKALITGITGQDGSYLTEFLLQKGYQVHGIVRRSSMFNRARIEHLRGNSNLVLHYGDLTDSSNLNRILEKVSPDEIYNL
AAQSHVGVSFEVPEYTAEADAVGTLRILDAIKQIGVKSRFYQASTSELYGKVQAIPQTETTPFYPRSPYAVAKLYAYWAV
VNYREAFGIHASNGILFNHESPRRGEGFVTRKITLGVANLLAKKGGPIQLGNMDAKRDWGYAPDYVEMMWMMLQQPEADD
YVVATNETHTVREFVEKSFGFVGIQVRWEGNGDSEKGFDAKSGQLLVEVNPKFYRPTEVDILIGDPAKAKKKLGWEPKVK
FEELVKIMTKADCESIGIKI

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=339, Percent_Identity=63.1268436578171, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI42516563, Length=330, Percent_Identity=27.5757575757576, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7657641, Length=334, Percent_Identity=25.748502994012, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788366, Length=351, Percent_Identity=59.2592592592593, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI48994969, Length=243, Percent_Identity=28.8065843621399, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788353, Length=356, Percent_Identity=25, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786974, Length=358, Percent_Identity=24.8603351955307, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507723, Length=340, Percent_Identity=62.6470588235294, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=61.4705882352941, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=61.4705882352941, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539422, Length=340, Percent_Identity=61.4705882352941, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI133901788, Length=340, Percent_Identity=61.4705882352941, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI133901786, Length=340, Percent_Identity=61.4705882352941, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539532, Length=334, Percent_Identity=25.1497005988024, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24158427, Length=341, Percent_Identity=62.1700879765396, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI21356223, Length=330, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38156; Mature: 38156

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALITGITGQDGSYLTEFLLQKGYQVHGIVRRSSMFNRARIEHLRGNSNLVLHYGDLT
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCC
DSSNLNRILEKVSPDEIYNLAAQSHVGVSFEVPEYTAEADAVGTLRILDAIKQIGVKSRF
CCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHH
YQASTSELYGKVQAIPQTETTPFYPRSPYAVAKLYAYWAVVNYREAFGIHASNGILFNHE
HCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCEEECCC
SPRRGEGFVTRKITLGVANLLAKKGGPIQLGNMDAKRDWGYAPDYVEMMWMMLQQPEADD
CCCCCCCEEEEEEHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
YVVATNETHTVREFVEKSFGFVGIQVRWEGNGDSEKGFDAKSGQLLVEVNPKFYRPTEVD
EEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEECCCEEE
ILIGDPAKAKKKLGWEPKVKFEELVKIMTKADCESIGIKI
EEECCCHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MKKALITGITGQDGSYLTEFLLQKGYQVHGIVRRSSMFNRARIEHLRGNSNLVLHYGDLT
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCC
DSSNLNRILEKVSPDEIYNLAAQSHVGVSFEVPEYTAEADAVGTLRILDAIKQIGVKSRF
CCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHH
YQASTSELYGKVQAIPQTETTPFYPRSPYAVAKLYAYWAVVNYREAFGIHASNGILFNHE
HCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCEEECCC
SPRRGEGFVTRKITLGVANLLAKKGGPIQLGNMDAKRDWGYAPDYVEMMWMMLQQPEADD
CCCCCCCEEEEEEHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
YVVATNETHTVREFVEKSFGFVGIQVRWEGNGDSEKGFDAKSGQLLVEVNPKFYRPTEVD
EEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEECCCEEE
ILIGDPAKAKKKLGWEPKVKFEELVKIMTKADCESIGIKI
EEECCCHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]