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The map label for this gene is yngJ [H]

Identifier: 45658836

GI number: 45658836

Start: 3661220

End: 3662893

Strand: Reverse

Name: yngJ [H]

Synonym: LIC13009

Alternate gene names: 45658836

Gene position: 3662893-3661220 (Counterclockwise)

Preceding gene: 45658838

Following gene: 45658835

Centisome position: 85.64

GC content: 42.77

Gene sequence:

>1674_bases
ATGAGCGCAATCAAAACAATCGATCAGACAACCGCTAAAAAAGCACTTACTGTTTCCGCAGGAGTGATCGAAGAAGTTAC
GAAGGCACTTGCCGCACGTTGTAGTGTAAACGGAAAAGTTTCCGTGGATAAGATGGACGAAAATCAACTCGTTCAATACC
AGATCGCTTGGCTTACTTCCGAACAAAGAATAGCAGAAAAATTTATTGAATATGCTTGGGACTCTTCCCGTGGAACTGGA
GATTTAGAACAAGAAATGGCAGTTGTATTTGCGGCGGAAACCGTAAATCATATACGATCTGAAATTAGTTCTCGTCCTTC
CGAATACGGAATCAAATCTTCCGATTTAGTTTCTAAAATTTTCAACGATGAAATCAATCAATTCTTAGAAAACGCGATGG
CGATCCAAAACTATAATGAGATCGCGGAGAAGATCGTTGCGAAAGGACATTTCGGAGCTTACGGTTTGGATGAAGATCAC
GAAATGTTTCGTGAGACTTTTAAGAAGTTTGCAGAAGACGTAGTGATACCTCATGCGGAACACGTTCACAGACACGACGA
TATCATTCCGGAAGACATCATCGGCGGATTAAAAGAAATGGGATGTTTTGGACTTTGTATTCCTGAATCGTATGGTGGAA
TTCAACCTAACGATAAACCGGATAATCTTTCCATGCTCGTAGTGACCGAAGAATTATCCAGAGGTGGTTTAGGAATTGCA
GGTTCATTGATTACAAGACCAGAGATCATGTCCAAGGCTCTTCTGAAAGGTGGGACTCAGGAACAGAAAGACAAGTGGCT
TCCTCTTCTCGCTTCCGGAGAAAGAATGGCAGGGATCATGGTAACGGAACCGAATTACGGGTCAGACGTTGCAGGAGTTT
CCGTTACCGCAAAACCAGCTAACGGTGGTTGGGTGATCAACGGAGTCAAGACCTGGTGTACTTTTGCAGGTTATGCAAAC
CTATTATTAATTCTTTGTAGAACGGAGTCGGATCCTTCTTTAAAACACAAGGGATTATCAATTCTTTTAGCAGAAAAACC
AACTTTTACTGGACACGAATTTACATACACACAACCAGAAGGTGGAAAGATAGAAGGGAAAGCGATCGGAACGATCGGTT
ATCGAGGAATGCATTCTTTTGAAGTTTCTTTTGACAATTACTTTGTTCCCGCAGAAAACTTGTTAGGCGGAGAAGCAGGA
AGAGGGAAGGGATTTTACTTTCAGATGGAAGGGTTTGCGGGAGGAAGAATTCAAACCGCTGCGCGCGCGCATGGAGTGAT
GCAAGCTGCTTTGGAAGCGGCGCTACGTTATGCGCGAGAGAGAGCCGTATTCCAAAAGCCAATCTACGAATATAATTTAA
CAAAATATAAAATTGCAAGAATGGCCGTAATCTTACAAGCGTCTCGTCAATATGCAAATCACGTGGCCAATTTGTTAGAT
AACCACAAAGGACAAATGGAAGCGACTCTGATCAAATTTTACGCGTCTAAAGTGGCGGAGTGGGTGACAAGAGAAGCGAT
GCAGATACACGGTGGAATGGGATATGCGGAAGAATACGCGGTTTCTCGTTATTTTGTGGACGCTAGAGTTTTTTCTATCT
TTGAAGGTGCAGAAGAAGTGATGGCTTTGAGAGTAATTGCAAAATCTCTAATGGACCAATACTCGGCGAGTTAA

Upstream 100 bases:

>100_bases
GAAGATGGATCAAAAAGCAAATGACAGAGGGATAAGTTTTGATTTTCTAGTAAACGGATTCCAACTTTAAATATCATACT
ACCAGGATTCGAAAACAAAC

Downstream 100 bases:

>100_bases
TTTTTAAGGTAAAAACTGAAAACACTCTATTCAAAAATTAGAATGGAGTGTTGGAACAAAGAGTGTGCTCTGCGGGTAAT
CTGTCGTTGTACATCCGCTG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSAIKTIDQTTAKKALTVSAGVIEEVTKALAARCSVNGKVSVDKMDENQLVQYQIAWLTSEQRIAEKFIEYAWDSSRGTG
DLEQEMAVVFAAETVNHIRSEISSRPSEYGIKSSDLVSKIFNDEINQFLENAMAIQNYNEIAEKIVAKGHFGAYGLDEDH
EMFRETFKKFAEDVVIPHAEHVHRHDDIIPEDIIGGLKEMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIA
GSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKPANGGWVINGVKTWCTFAGYAN
LLLILCRTESDPSLKHKGLSILLAEKPTFTGHEFTYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAG
RGKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYARERAVFQKPIYEYNLTKYKIARMAVILQASRQYANHVANLLD
NHKGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYSAS

Sequences:

>Translated_557_residues
MSAIKTIDQTTAKKALTVSAGVIEEVTKALAARCSVNGKVSVDKMDENQLVQYQIAWLTSEQRIAEKFIEYAWDSSRGTG
DLEQEMAVVFAAETVNHIRSEISSRPSEYGIKSSDLVSKIFNDEINQFLENAMAIQNYNEIAEKIVAKGHFGAYGLDEDH
EMFRETFKKFAEDVVIPHAEHVHRHDDIIPEDIIGGLKEMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIA
GSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKPANGGWVINGVKTWCTFAGYAN
LLLILCRTESDPSLKHKGLSILLAEKPTFTGHEFTYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAG
RGKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYARERAVFQKPIYEYNLTKYKIARMAVILQASRQYANHVANLLD
NHKGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYSAS
>Mature_556_residues
SAIKTIDQTTAKKALTVSAGVIEEVTKALAARCSVNGKVSVDKMDENQLVQYQIAWLTSEQRIAEKFIEYAWDSSRGTGD
LEQEMAVVFAAETVNHIRSEISSRPSEYGIKSSDLVSKIFNDEINQFLENAMAIQNYNEIAEKIVAKGHFGAYGLDEDHE
MFRETFKKFAEDVVIPHAEHVHRHDDIIPEDIIGGLKEMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIAG
SLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKPANGGWVINGVKTWCTFAGYANL
LLILCRTESDPSLKHKGLSILLAEKPTFTGHEFTYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAGR
GKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYARERAVFQKPIYEYNLTKYKIARMAVILQASRQYANHVANLLDN
HKGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYSAS

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=400, Percent_Identity=32, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI4557235, Length=407, Percent_Identity=31.9410319410319, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI76496475, Length=408, Percent_Identity=32.5980392156863, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=32.8767123287671, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI4501859, Length=407, Percent_Identity=29.2383292383292, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI226958412, Length=400, Percent_Identity=28.75, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI187960098, Length=403, Percent_Identity=29.5285359801489, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI4557231, Length=403, Percent_Identity=29.5285359801489, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI226958414, Length=384, Percent_Identity=28.90625, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4501857, Length=400, Percent_Identity=26.75, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7656849, Length=403, Percent_Identity=28.287841191067, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI38505218, Length=306, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=25.5050505050505, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI7669494, Length=388, Percent_Identity=25.2577319587629, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI48976061, Length=294, Percent_Identity=27.891156462585, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI211971008, Length=294, Percent_Identity=27.891156462585, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1786223, Length=371, Percent_Identity=28.0323450134771, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87081958, Length=405, Percent_Identity=29.1358024691358, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=26.9896193771626, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081702, Length=389, Percent_Identity=24.9357326478149, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=407, Percent_Identity=31.4496314496315, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534899, Length=393, Percent_Identity=32.0610687022901, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=407, Percent_Identity=29.97542997543, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17570075, Length=402, Percent_Identity=29.8507462686567, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=31.4917127071823, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=400, Percent_Identity=26.25, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508101, Length=402, Percent_Identity=27.1144278606965, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=428, Percent_Identity=26.6355140186916, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=402, Percent_Identity=28.3582089552239, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=397, Percent_Identity=25.4408060453401, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=321, Percent_Identity=28.9719626168224, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17534353, Length=393, Percent_Identity=25.4452926208651, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71990804, Length=316, Percent_Identity=26.2658227848101, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=250, Percent_Identity=26, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=303, Percent_Identity=25.4125412541254, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=296, Percent_Identity=22.972972972973, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356377, Length=402, Percent_Identity=32.3383084577114, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24660351, Length=406, Percent_Identity=31.5270935960591, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355753, Length=405, Percent_Identity=30.8641975308642, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24646207, Length=412, Percent_Identity=30.0970873786408, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281363737, Length=401, Percent_Identity=30.9226932668329, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666513, Length=402, Percent_Identity=28.6069651741293, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19920834, Length=397, Percent_Identity=25.9445843828715, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 61465; Mature: 61333

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIKTIDQTTAKKALTVSAGVIEEVTKALAARCSVNGKVSVDKMDENQLVQYQIAWLTS
CCCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECC
EQRIAEKFIEYAWDSSRGTGDLEQEMAVVFAAETVNHIRSEISSRPSEYGIKSSDLVSKI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHH
FNDEINQFLENAMAIQNYNEIAEKIVAKGHFGAYGLDEDHEMFRETFKKFAEDVVIPHAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
HVHRHDDIIPEDIIGGLKEMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIA
HHHHCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCEE
GSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKPA
HHHHCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCEEEEEECC
NGGWVINGVKTWCTFAGYANLLLILCRTESDPSLKHKGLSILLAEKPTFTGHEFTYTQPE
CCCEEEECHHHHHHHHHHHHEEEEEEECCCCCCCHHCCCEEEEECCCCCCCCEEEEECCC
GGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAGRGKGFYFQMEGFAGGRIQTA
CCEECCEEEEEECCCCCEEEEEECCCEECCHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ARAHGVMQAALEAALRYARERAVFQKPIYEYNLTKYKIARMAVILQASRQYANHVANLLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHKGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MALRVIAKSLMDQYSAS
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAIKTIDQTTAKKALTVSAGVIEEVTKALAARCSVNGKVSVDKMDENQLVQYQIAWLTS
CCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECC
EQRIAEKFIEYAWDSSRGTGDLEQEMAVVFAAETVNHIRSEISSRPSEYGIKSSDLVSKI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHH
FNDEINQFLENAMAIQNYNEIAEKIVAKGHFGAYGLDEDHEMFRETFKKFAEDVVIPHAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
HVHRHDDIIPEDIIGGLKEMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIA
HHHHCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCEE
GSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKPA
HHHHCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCEEEEEECC
NGGWVINGVKTWCTFAGYANLLLILCRTESDPSLKHKGLSILLAEKPTFTGHEFTYTQPE
CCCEEEECHHHHHHHHHHHHEEEEEEECCCCCCCHHCCCEEEEECCCCCCCCEEEEECCC
GGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAGRGKGFYFQMEGFAGGRIQTA
CCEECCEEEEEECCCCCEEEEEECCCEECCHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ARAHGVMQAALEAALRYARERAVFQKPIYEYNLTKYKIARMAVILQASRQYANHVANLLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHKGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MALRVIAKSLMDQYSAS
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]