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The map label for this gene is trpC

Identifier: 45658617

GI number: 45658617

Start: 3391956

End: 3392714

Strand: Reverse

Name: trpC

Synonym: LIC12786

Alternate gene names: 45658617

Gene position: 3392714-3391956 (Counterclockwise)

Preceding gene: 45658618

Following gene: 45658616

Centisome position: 79.32

GC content: 39.26

Gene sequence:

>759_bases
ATGTCTTCTTCTCAACCTCACCGGGTTCTCCGGGAAATCATTTCTACAAAACAAAATGAAATCAAAAAAATTTCAGCCTG
GGACCCTCTTCCACATCGTGGTCTCAGTCTTCGTGATTCTTTAAAAAGTAGAACCTTTTCCATTATTGCAGAGTGTAAAC
GAAAGAGTCCATCGGCCGGTGAACTTCGTGCGGATTATCGTCCGGTTCAAATCGCTAAAACATACGAAGAGTTAGGCGCT
TCTGCTATTTCTGTACTTACGGATCAGAATTACTTTGGAGGTTCTTTGGAAGATCTGAAGGACGTCTCTTCAGAATTGAA
AATTCCAGTTTTAAGAAAAGATTTTATTCTGGATGAAATTCAGATTCGGGAAGCAAGGGCTTTCGGTGCATCCGCAATTT
TATTGATCGTCAGAATTTTGACTCCGGAACAGATTAAGTCTTTTTTAAAGTTAGCTTCTTCTTTGGGAATGGATTGTTTG
GTTGAAGTTCATACTTCGGATGAGGCGAAACTTGCTCTGGATTGTGGTGCGGAAATTATTGGAATCAATACGAGAGATTT
AGATACGTTTCAAATTCATCAGAATCTGGTAGAAGAAGTATCCGCCTTCTTACCACCTAACATAGTAAAAGTAGGTGAAT
CCGGTATAAAAAAACGTTCCGACTTGGACACTTTTCGTAAATTAGTGGACGCGGCTTTGATCGGGACCTATTTTATGGAA
AAACAAGATATTCGAAAAGCCTGGTTGAATTTATTTTAG

Upstream 100 bases:

>100_bases
TAAACCTGCAGTCAAAAGAATCTTTGATGTAATCGAGTTAACTTCTCTTTTCGATATTTGCGAAACCGAAGACGAGGCTT
TAAAGTCCTTTTAAAACTGA

Downstream 100 bases:

>100_bases
AATATTCTTATATTATAATTCTCTTTTTGGGAATTTTTTTGTATATAAATCAAAGCAAAGTTTCTTATATAAAAGTAATG
GATTTTTATGTAATATTTCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGA
SAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCL
VEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME
KQDIRKAWLNLF

Sequences:

>Translated_252_residues
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGA
SAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCL
VEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME
KQDIRKAWLNLF
>Mature_251_residues
SSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGAS
AISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLV
EVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFMEK
QDIRKAWLNLF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=209, Percent_Identity=38.755980861244, Blast_Score=139, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=208, Percent_Identity=38.4615384615385, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LEPIC (Q72NP6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002703.1
- ProteinModelPortal:   Q72NP6
- SMR:   Q72NP6
- GeneID:   2770882
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12786
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK13957
- BioCyc:   LINT267671:LIC_12786-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28229; Mature: 28098

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAG
CCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEI
CCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
QIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEII
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEEE
GINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME
ECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQDIRKAWLNLF
HHHHHHHHHHCC
>Mature Secondary Structure 
SSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAG
CCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEI
CCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
QIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEII
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEEE
GINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME
ECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQDIRKAWLNLF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA