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The map label for this gene is obgE

Identifier: 45658606

GI number: 45658606

Start: 3379484

End: 3380554

Strand: Reverse

Name: obgE

Synonym: LIC12773

Alternate gene names: 45658606

Gene position: 3380554-3379484 (Counterclockwise)

Preceding gene: 45658607

Following gene: 45658605

Centisome position: 79.04

GC content: 39.68

Gene sequence:

>1071_bases
ATGGAATCCTTTGTAGATGAAGTCGCCATAGAAGTATTCGCCGGTCATGGCGGAGCTGGGTCCGTTCATTTTCGCAGAGA
AAAATACGTCGAGTTTGGAGGTCCGGACGGAGGAGACGGAGGAATCGGGGGGAATGTAGTCATTCGTCCCAATCTTTCTA
TGTATACCCTTGATAAATATCTATCTAAAAGGAAATTTAAAGCTCAGGCAGGATTTCCAGGAGTAGGAGATAACTGTTCC
GGTAAAAAAGGAGAAGACTTAGTTTTGTTTGTTCCTCTCGGAACACAAATCTATGACGAGGAAACGGGGGATCTGCTATT
CGATTTTGTATCTGATTCCCAAGAATTTGTAGTAGCCCGTGGAGGTAGAGGAGGAAAGGGAAACGCACATTTTAAAACTT
CTACCAATCAAACCCCACGTTTTGCACAACCGGGCGAAGAAGGAGAATATAAATTCCTACGTCTTTCTCTTAAGTTGTTA
GCGGACGTAGGAATTGTAGGTTTGCCAAACGCAGGTAAATCTACTTTAATTTCTAAAATTACAGACGCACATCCAAAAAT
AGCAGGCTACGCATTTACAACACTTTCTCCTAACCTAGGCGTTGTTAAACGAAGAGGAGATATTTTCCGTTTTACGATTG
CTGATATTCCCGGGATTATCGAGGGCGCGAGTATGGGGATCGGACTTGGACTCTCCTTTTTGCGTCATATCGAAAGGGTC
AAAGGAATATTATATTTGTTTGATGCATCTTCTCTTGATATTGAAGAGGACCTTAAAATGCTTCGAAACGAACTTTCCAC
TTATAATCCAGAATTATTAAATCGACCCTATCTGATCGTATTGAATAAGATTGATATTTGGAACGATCCTGAATTTACAA
AGGATGTGATCGCGAAGGTATCACACTTAGGAAAGGTAGTTGCGATTTCGGCAGATCAAGAAGTAAATTTAGAAGAGCTT
TTAGAAAATATGGATGAAGTTTTTTTCAAAAATGAAATCGAAAAAATTCTAAATCCAATCAAAGATACAAAGCCTATCTC
TTTGGATGAATCAGATATTTTCGAAAGTTGA

Upstream 100 bases:

>100_bases
TTCGAACCGGATGAACCGCAGTTTCCTGCCCGTTTCTGGGTCCGGACTCTGCGGTTTTTTGTTTTTAAATCAGTTTTAAA
ATTTAGAATATTCAAATATT

Downstream 100 bases:

>100_bases
AGGATAAAGTAGAATGAAACCGGAACGAAACTCACTTTCTGAAAAGATCCGTAACGCTGAAAAGATCGTTATCAAAGTAG
GTTCGGCAAGGCTTTCTGGA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKYLSKRKFKAQAGFPGVGDNCS
GKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVARGGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLL
ADVGIVGLPNAGKSTLISKITDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERV
KGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKVSHLGKVVAISADQEVNLEEL
LENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES

Sequences:

>Translated_356_residues
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKYLSKRKFKAQAGFPGVGDNCS
GKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVARGGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLL
ADVGIVGLPNAGKSTLISKITDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERV
KGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKVSHLGKVVAISADQEVNLEEL
LENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES
>Mature_356_residues
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKYLSKRKFKAQAGFPGVGDNCS
GKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVARGGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLL
ADVGIVGLPNAGKSTLISKITDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERV
KGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKVSHLGKVVAISADQEVNLEEL
LENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=326, Percent_Identity=41.1042944785276, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI111955139, Length=272, Percent_Identity=35.2941176470588, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI111955063, Length=153, Percent_Identity=40.5228758169935, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI58761500, Length=169, Percent_Identity=29.585798816568, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789574, Length=336, Percent_Identity=42.8571428571429, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=40.1215805471125, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=310, Percent_Identity=30, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71981008, Length=116, Percent_Identity=39.6551724137931, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=29.4964028776978, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=159, Percent_Identity=47.1698113207547, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321612, Length=90, Percent_Identity=42.2222222222222, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129375, Length=323, Percent_Identity=38.6996904024768, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=32.475884244373, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21356473, Length=115, Percent_Identity=33.9130434782609, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 39098; Mature: 39098

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKY
CCHHHHHHHHHHEECCCCCCCEEEEHHHHEECCCCCCCCCCCCCCEEECCCCCHHHHHHH
LSKRKFKAQAGFPGVGDNCSGKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVAR
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCHHHHHHHCCCCEEEEEE
GGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLLADVGIVGLPNAGKSTLISKI
CCCCCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCEEECCCCCHHHHHHHH
TDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERV
HHCCCCCCEEEEEECCCCCCEEEECCCEEEEECCCCCCHHCCCCCCHHHHHHHHHHHHHH
KGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKV
CCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCCCHHHHHHHHH
SHLGKVVAISADQEVNLEELLENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES
HHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MESFVDEVAIEVFAGHGGAGSVHFRREKYVEFGGPDGGDGGIGGNVVIRPNLSMYTLDKY
CCHHHHHHHHHHEECCCCCCCEEEEHHHHEECCCCCCCCCCCCCCEEECCCCCHHHHHHH
LSKRKFKAQAGFPGVGDNCSGKKGEDLVLFVPLGTQIYDEETGDLLFDFVSDSQEFVVAR
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCHHHHHHHCCCCEEEEEE
GGRGGKGNAHFKTSTNQTPRFAQPGEEGEYKFLRLSLKLLADVGIVGLPNAGKSTLISKI
CCCCCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCEEECCCCCHHHHHHHH
TDAHPKIAGYAFTTLSPNLGVVKRRGDIFRFTIADIPGIIEGASMGIGLGLSFLRHIERV
HHCCCCCCEEEEEECCCCCCEEEECCCEEEEECCCCCCHHCCCCCCHHHHHHHHHHHHHH
KGILYLFDASSLDIEEDLKMLRNELSTYNPELLNRPYLIVLNKIDIWNDPEFTKDVIAKV
CCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCCCHHHHHHHHH
SHLGKVVAISADQEVNLEELLENMDEVFFKNEIEKILNPIKDTKPISLDESDIFES
HHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA