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The map label for this gene is nuoM

Identifier: 45658585

GI number: 45658585

Start: 3347081

End: 3348769

Strand: Direct

Name: nuoM

Synonym: LIC12751

Alternate gene names: 45658585

Gene position: 3347081-3348769 (Clockwise)

Preceding gene: 45658584

Following gene: 45658586

Centisome position: 78.25

GC content: 38.31

Gene sequence:

>1689_bases
TTGGATTTCCCACCGTATATACTGAGTGTTTTTTTATTTTTACCGTTCATTGGGGTTCCACTTTTATTTTTATCCAACAA
AGTAAATTGGTTAAGATTCATAGCAGGATCGTTTACACTCCTTCCCTTTTTAATTATTGTAGGATTATATTTCAAATACG
ATCCTACGAACTCTTCACTTCAATTTGTAGATCGGATATGGGGAATCATCGTTTCCGGAAATCTAAAAGTAGATTACCAT
ATAGGACTGGACGGATTTAGTCTTTTACTTTGTGGAATGTCTTCTTTATTGTTTTTTCTTTCCACGTTAGCAACTTGGAC
GAGCATCACAAATCGAATTCGCGAATTTTATGTTTATCTAATGATCGTAGAAATGAGCGTGCATGGAGTGTTCTTATCCG
GAAACCTAGTATTATTCTACATCTTCTGGGAAGCAATGGTGTCCCCGATGGTTCTTATGGTGGGAATCTGGGGAGAAGAT
CAAAGGGTCAAGGCAGCGATTAAGTATCTGATCTTTTCTTTTACCGGATCGGTATTGATGCTTGCAGGAATTCTAATATT
ATATTTTAAAACAGGAACGATCGTAATAGAAGAATTATCCACAGGTTTATTACCGGAAATTCCTAAAAACATACGATTGT
TTATGTTTTTTGCATTTGTACTTGCGTTTGCGATCAAGGTTCCATTGTTCCCTCTACATACATGGATGCCGGACGTACAT
TCACAAGCTCCAACCGTGGGTTCAGTGGACCTTTCCGGAATATTATTAAAAATCGGATTGTATGGATTTATACGATTGGC
GATTCCACTTTTTCCGGAAGAAATGCTCGAGTACCGAGAACTTTTAGGCGCCCTTTGTATCGCAGGAATTATCTACGGGG
CAGTAATCGCGATGGCACAGGAAAATTCAAAACGAGTCGTGGCATTTTCTTCCCTTTCTCACATGAGTTTTTGTATGTTG
GGAATTTTAAGTTTCACCGAAGAAGGGATGGCCGGTGGAATGTTGCAGATGCTCAACCACGGATTTACCGCGGGAATGTT
ATTCTTTATGCTTGGAATGTTACACGAAAGAATCGGAAACAACGACATATCCAAAGCAGGCGGATTGTCAAAACTGCTGC
CAGTATTTTCAGTATTTTTTGCGATCGCAATTTTTTCTTCTCTTGGAGTGCCAGGAACCAACAGTTTTATAGGAGAATTT
TTAATCATACTCGGAAGTATCAAAGCAAATGTCGTATACGGCGCGTTAGCTGCAACGGGAGTTGTATTCGCAGCGGGTTA
TCTTTTGTTATTTGCAAAAAGGATGATCTTTGGAGAACCGACTAAAAACTTAATCGAACACAATGATCTTAATTTAAAAG
AATGGGTAATTTTAGTACCGACCGTAATTATGATTTTTTGGATCGGAATTTATCCGAAACCATTTTTAAAAGTATTAGAA
CCTTCCGTAAAAGTAGCATTAAACTCTGCATCTGCCAAAGTTATAGAAGATCGATCTAAAAAAACGTTTAAAAGCGCGGA
GCTAAACGATCCGTATCATAAGGACGTGGAACATCTAAGAAAATTCACTTCTTATAAATCCCTGGGAGTAGAACCGTCTA
AATATGCGGAACGTCTGCAAAGATATCCAAGCAAATATTCCTTACCGGAACCAATTCGAAAAAATTCCGATGAGGAGACA
CAAAAATGA

Upstream 100 bases:

>100_bases
TTAAGAAGGGCTCAAACCGGAATCGTAGTGGACTACGCAATTTTGATTGTATTAGGAACCGTGGTCATTCTTTCCTTTTT
TCTATTGAGGGGGCTATAAC

Downstream 100 bases:

>100_bases
ATCTATTTGATTTATCTATTTTACCATTTTTAAATCTTGCACAGGTCGTTAATGAAAGTAGGGTTCCGAACGTGCCAGAC
TTACTTTCCGTTTTACCTGC

Product: NADH dehydrogenase I subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDFPPYILSVFLFLPFIGVPLLFLSNKVNWLRFIAGSFTLLPFLIIVGLYFKYDPTNSSLQFVDRIWGIIVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWTSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFMFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDISKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAATGVVFAAGYLLLFAKRMIFGEPTKNLIEHNDLNLKEWVILVPTVIMIFWIGIYPKPFLKVLE
PSVKVALNSASAKVIEDRSKKTFKSAELNDPYHKDVEHLRKFTSYKSLGVEPSKYAERLQRYPSKYSLPEPIRKNSDEET
QK

Sequences:

>Translated_562_residues
MDFPPYILSVFLFLPFIGVPLLFLSNKVNWLRFIAGSFTLLPFLIIVGLYFKYDPTNSSLQFVDRIWGIIVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWTSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFMFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDISKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAATGVVFAAGYLLLFAKRMIFGEPTKNLIEHNDLNLKEWVILVPTVIMIFWIGIYPKPFLKVLE
PSVKVALNSASAKVIEDRSKKTFKSAELNDPYHKDVEHLRKFTSYKSLGVEPSKYAERLQRYPSKYSLPEPIRKNSDEET
QK
>Mature_562_residues
MDFPPYILSVFLFLPFIGVPLLFLSNKVNWLRFIAGSFTLLPFLIIVGLYFKYDPTNSSLQFVDRIWGIIVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWTSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFMFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDISKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAATGVVFAAGYLLLFAKRMIFGEPTKNLIEHNDLNLKEWVILVPTVIMIFWIGIYPKPFLKVLE
PSVKVALNSASAKVIEDRSKKTFKSAELNDPYHKDVEHLRKFTSYKSLGVEPSKYAERLQRYPSKYSLPEPIRKNSDEET
QK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=341, Percent_Identity=27.5659824046921, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI251831117, Length=352, Percent_Identity=24.4318181818182, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788613, Length=423, Percent_Identity=37.1158392434988, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1788831, Length=379, Percent_Identity=27.4406332453826, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788827, Length=256, Percent_Identity=26.953125, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI145693160, Length=451, Percent_Identity=23.2815964523282, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788829, Length=478, Percent_Identity=22.1757322175732, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788614, Length=339, Percent_Identity=22.7138643067847, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=241, Percent_Identity=25.3112033195021, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 62874; Mature: 62874

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFPPYILSVFLFLPFIGVPLLFLSNKVNWLRFIAGSFTLLPFLIIVGLYFKYDPTNSSL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
QFVDRIWGIIVSGNLKVDYHIGLDGFSLLLCGMSSLLFFLSTLATWTSITNRIREFYVYL
HHHHHHHHEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGEDQRVKAAIKYLIFSFTGSVLM
HHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFMFFAFVLAFAIKVPLFPLHTWMPDVH
HHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
SQAPTVGSVDLSGILLKIGLYGFIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSKRVVAFSSLSHMSFCMLGILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGN
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NDISKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEFLIILGSIKANVVYGALAATG
CCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFAAGYLLLFAKRMIFGEPTKNLIEHNDLNLKEWVILVPTVIMIFWIGIYPKPFLKVLE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PSVKVALNSASAKVIEDRSKKTFKSAELNDPYHKDVEHLRKFTSYKSLGVEPSKYAERLQ
CHHHEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RYPSKYSLPEPIRKNSDEETQK
HCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure
MDFPPYILSVFLFLPFIGVPLLFLSNKVNWLRFIAGSFTLLPFLIIVGLYFKYDPTNSSL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
QFVDRIWGIIVSGNLKVDYHIGLDGFSLLLCGMSSLLFFLSTLATWTSITNRIREFYVYL
HHHHHHHHEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGEDQRVKAAIKYLIFSFTGSVLM
HHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFMFFAFVLAFAIKVPLFPLHTWMPDVH
HHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
SQAPTVGSVDLSGILLKIGLYGFIRLAIPLFPEEMLEYRELLGALCIAGIIYGAVIAMAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSKRVVAFSSLSHMSFCMLGILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGN
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NDISKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEFLIILGSIKANVVYGALAATG
CCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFAAGYLLLFAKRMIFGEPTKNLIEHNDLNLKEWVILVPTVIMIFWIGIYPKPFLKVLE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PSVKVALNSASAKVIEDRSKKTFKSAELNDPYHKDVEHLRKFTSYKSLGVEPSKYAERLQ
CHHHEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RYPSKYSLPEPIRKNSDEETQK
HCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA