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The map label for this gene is 45658561

Identifier: 45658561

GI number: 45658561

Start: 3320385

End: 3321326

Strand: Direct

Name: 45658561

Synonym: LIC12727

Alternate gene names: NA

Gene position: 3320385-3321326 (Clockwise)

Preceding gene: 45658559

Following gene: 45658562

Centisome position: 77.63

GC content: 35.35

Gene sequence:

>942_bases
ATGCCGACAGGTTTTATCTACTCTCAAGATTTTCTTTATCACAATGCGAATTCTACAATTCCACATTATGAGAATTCCGA
CAGACTACTTGCGTGTTTGAATAGATTGCATCAAAGTAGCTATTTTAATTCTTTATTTTTTCCTGAAATGAAAAAGCTTC
CTAATGAATTTCTCAACGAAATCCATTCTCAAAATCACATTCAAAAAATTGAAAACTCTAAAGGAAAAAGAGGTTATTTT
GATTCAGATACTCCTTTTACGGAAAAATCGTGGATATCAGCCTACTCCGCAGCAAATTCTGGAATAATATTGTCGGAATT
CTTAATTTCGGGAACAATCAAAAATGGTTTCTCTCTTCTTAGACCTCCAGGCCATCATGCGGAGCATAATCGTATCATGG
GTTTTTGTATGTTAAACAATGTGGCCATTACTGCCCGATATTTACAAAACAATGGATTTAAAAAAATCTTTATTATTGAT
TGGGATGTCCATCACGGAAATGGAACACAAGAAATCTTTTATGAAGACCCAAATATTTTTTATCTATCGATTCATCAATT
CCCATTTTATCCAATGACCGGTTTAGCAACGGAAACCGGCAAAGGAAAAGGTATTGGAACTACAAAAAATATCCCTATGC
AAGTAAATTCTGGAGACCAAGCCTATATTCAGAAATTCAAAGAGATCATTGTTCCTACAATGGAACGTTTTGAGCCAGAT
ATAGTTTTGATTTCTGCAGGTTTTGACGCACATAAAAACGATCCTCTCGGAGGAATGAATATAACAACAAAAGGATTCGA
AGACCTCACCCGTATCATTTTAGAAAGCGCAGATAAAATTTGTAGTGGCAAGGTTCTATCCTTTTTAGAAGGGGGTTACG
ACTTGGCTGCGTTATCAGAATCCGTAGAGGTTCACGTAGCAGCTTTAAATTCTTTTTCTTAA

Upstream 100 bases:

>100_bases
AAATTAATTTTTTTGTTTCTTTACATTGAAAAATTTGAGTTTTTATTTTATGAATGATATAAATTTTTAACTATCCGTAA
TAGAAAAACAGAAAAATAAA

Downstream 100 bases:

>100_bases
GAATTATTCCAAAACCTTAGTAGAAATCTCAAATAAAACTTTACTTAAAACTATGCAACAGAGTTCAACAATACAGATTT
TTATAAAATTGAGTACCTTA

Product: acetoin-histone deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPTGFIYSQDFLYHNANSTIPHYENSDRLLACLNRLHQSSYFNSLFFPEMKKLPNEFLNEIHSQNHIQKIENSKGKRGYF
DSDTPFTEKSWISAYSAANSGIILSEFLISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQNNGFKKIFIID
WDVHHGNGTQEIFYEDPNIFYLSIHQFPFYPMTGLATETGKGKGIGTTKNIPMQVNSGDQAYIQKFKEIIVPTMERFEPD
IVLISAGFDAHKNDPLGGMNITTKGFEDLTRIILESADKICSGKVLSFLEGGYDLAALSESVEVHVAALNSFS

Sequences:

>Translated_313_residues
MPTGFIYSQDFLYHNANSTIPHYENSDRLLACLNRLHQSSYFNSLFFPEMKKLPNEFLNEIHSQNHIQKIENSKGKRGYF
DSDTPFTEKSWISAYSAANSGIILSEFLISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQNNGFKKIFIID
WDVHHGNGTQEIFYEDPNIFYLSIHQFPFYPMTGLATETGKGKGIGTTKNIPMQVNSGDQAYIQKFKEIIVPTMERFEPD
IVLISAGFDAHKNDPLGGMNITTKGFEDLTRIILESADKICSGKVLSFLEGGYDLAALSESVEVHVAALNSFS
>Mature_312_residues
PTGFIYSQDFLYHNANSTIPHYENSDRLLACLNRLHQSSYFNSLFFPEMKKLPNEFLNEIHSQNHIQKIENSKGKRGYFD
SDTPFTEKSWISAYSAANSGIILSEFLISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQNNGFKKIFIIDW
DVHHGNGTQEIFYEDPNIFYLSIHQFPFYPMTGLATETGKGKGIGTTKNIPMQVNSGDQAYIQKFKEIIVPTMERFEPDI
VLISAGFDAHKNDPLGGMNITTKGFEDLTRIILESADKICSGKVLSFLEGGYDLAALSESVEVHVAALNSFS

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795202, Length=349, Percent_Identity=37.8223495702006, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI30795204, Length=349, Percent_Identity=37.8223495702006, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI17158039, Length=349, Percent_Identity=37.8223495702006, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI148539870, Length=348, Percent_Identity=35.9195402298851, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI169234807, Length=348, Percent_Identity=35.9195402298851, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI153085395, Length=348, Percent_Identity=34.4827586206897, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI20070354, Length=329, Percent_Identity=34.3465045592705, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI13128864, Length=315, Percent_Identity=33.6507936507937, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI62750349, Length=346, Percent_Identity=34.971098265896, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI62750347, Length=346, Percent_Identity=34.971098265896, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI226529806, Length=329, Percent_Identity=31.6109422492401, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI8923769, Length=243, Percent_Identity=29.2181069958848, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI293336691, Length=150, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI13128860, Length=142, Percent_Identity=33.0985915492958, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073088, Length=176, Percent_Identity=30.1136363636364, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13128862, Length=143, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073092, Length=184, Percent_Identity=29.8913043478261, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI209862883, Length=174, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI217272877, Length=174, Percent_Identity=24.1379310344828, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193209491, Length=339, Percent_Identity=38.3480825958702, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI193206283, Length=207, Percent_Identity=42.512077294686, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17540334, Length=207, Percent_Identity=42.512077294686, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17540332, Length=207, Percent_Identity=42.512077294686, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17537347, Length=306, Percent_Identity=31.6993464052288, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25154020, Length=324, Percent_Identity=29.0123456790123, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25154022, Length=324, Percent_Identity=28.3950617283951, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17561978, Length=148, Percent_Identity=35.1351351351351, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508561, Length=142, Percent_Identity=33.8028169014084, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=138, Percent_Identity=31.1594202898551, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=341, Percent_Identity=31.9648093841642, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321244, Length=151, Percent_Identity=34.4370860927152, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=142, Percent_Identity=32.3943661971831, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=241, Percent_Identity=27.3858921161826, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641720, Length=342, Percent_Identity=38.0116959064327, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI281360799, Length=342, Percent_Identity=38.0116959064327, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281360801, Length=342, Percent_Identity=38.0116959064327, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642144, Length=209, Percent_Identity=40.6698564593301, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642142, Length=209, Percent_Identity=40.6698564593301, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642146, Length=209, Percent_Identity=40.6698564593301, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281360899, Length=219, Percent_Identity=39.2694063926941, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24657891, Length=142, Percent_Identity=35.9154929577465, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24644244, Length=153, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24649807, Length=259, Percent_Identity=22.7799227799228, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 35224; Mature: 35093

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTGFIYSQDFLYHNANSTIPHYENSDRLLACLNRLHQSSYFNSLFFPEMKKLPNEFLNE
CCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IHSQNHIQKIENSKGKRGYFDSDTPFTEKSWISAYSAANSGIILSEFLISGTIKNGFSLL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHCCHHHC
RPPGHHAEHNRIMGFCMLNNVAITARYLQNNGFKKIFIIDWDVHHGNGTQEIFYEDPNIF
CCCCCCCCCCCEEEEEEECCEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEECCCEE
YLSIHQFPFYPMTGLATETGKGKGIGTTKNIPMQVNSGDQAYIQKFKEIIVPTMERFEPD
EEEEECCCCCCCCCCEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCC
IVLISAGFDAHKNDPLGGMNITTKGFEDLTRIILESADKICSGKVLSFLEGGYDLAALSE
EEEEECCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
SVEVHVAALNSFS
CCEEEEEEECCCC
>Mature Secondary Structure 
PTGFIYSQDFLYHNANSTIPHYENSDRLLACLNRLHQSSYFNSLFFPEMKKLPNEFLNE
CCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IHSQNHIQKIENSKGKRGYFDSDTPFTEKSWISAYSAANSGIILSEFLISGTIKNGFSLL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHCCHHHC
RPPGHHAEHNRIMGFCMLNNVAITARYLQNNGFKKIFIIDWDVHHGNGTQEIFYEDPNIF
CCCCCCCCCCCEEEEEEECCEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEECCCEE
YLSIHQFPFYPMTGLATETGKGKGIGTTKNIPMQVNSGDQAYIQKFKEIIVPTMERFEPD
EEEEECCCCCCCCCCEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCC
IVLISAGFDAHKNDPLGGMNITTKGFEDLTRIILESADKICSGKVLSFLEGGYDLAALSE
EEEEECCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
SVEVHVAALNSFS
CCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]