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The map label for this gene is pqqL

Identifier: 45658535

GI number: 45658535

Start: 3285093

End: 3286379

Strand: Reverse

Name: pqqL

Synonym: LIC12700

Alternate gene names: 45658535

Gene position: 3286379-3285093 (Counterclockwise)

Preceding gene: 45658536

Following gene: 45658534

Centisome position: 76.84

GC content: 35.9

Gene sequence:

>1287_bases
TTGATGCAGGAACCTTCACAGATAGTTCATAGAAAAGTTCTACCTGGCGGAATAACGGTTCTTTTTCAAAAAGCTCCTCA
TACAGTCAGCGCGTCTGCCGGAGTTTTTGTTCGAGTTGGTTCCAGGCATGAATCTTCTAAAAATGCAGGTTACTGTCATT
TTTTAGAGCATATGCTCTTTAAGGATACCGCTAAACGTTCCGCAAAACAACAAGCAGAAGATATAGAAAGAGTAGGTGGT
TTTACAAATGCAGCCACTTCGAGAGAATATACTTACTTTCACGTTACCGTCGCAGGAAAACATATTGGCATAGGCTTAGA
ATTGTTAGCCGAAATGATTTATGAACCTTTGCTTAAGCAGTCTGATATAGACAATGAAGCAGGAGTTATTTTGGAGGAAC
TTCAAGGTTATGAGGATTCTCCTGAAGATTATATTCACGATTTTTACTATCAGAATTTTTTTCCTAAAAATTCTTTAGGA
CGCGATATTATAGGTACGAGAGAATCCGTTTCCGGTGTTACTCATAAAAGTATATTAGATTTTTATGATACGTATTATCA
TACGGAAAATATGTTTCTTTCTATTTCTGGCAACTTTGAACCAGATGAAATTTTTACGATTGCCGCCAAATATTTCAACC
GAACCAGAGTTAAGAAAAGGGAAGGGAATTCACTTTCCTTACCTAAGAAAAAATGGGGTTATTTCCCGAAAAAGAAAAAA
TTGGAACAGGTTTATTTTATTTTAGGTGGAGAAGGATTTGCCAGAGAATTTCATAACGCTTCCTCTGCGAGTTTATTTAC
TCATATCTTGGGCGGAGGAACCTCTTCTAGGCTCTTTCAAAAGGTGAGAGAAGAGAAAGGACTTTGTTATCATATCACTG
CTTATCCTTCTTCTTATGCTGATGTTGGCATCAATAGTATTGTTTGTTCTACTTCTAAAGAAAAGTTTATTACTTGTTTG
GAGATTATTTCGGACGAAATTAAATCGGTTTTAGATCACGGTATTTCGGAGAAAGAACTTTTAGACGCTCAGACTAATCA
CGAAGGCACTCTTTCGATTAGTTATGAACAAACCGAATCTCGTATGAATACAATTGCCCTAATGGAGTTATACTACGGCC
GTAATTTTTCTTATGAAGAAAGAGTGAAGGAAATTTATTCTATTACTTTAGAGGATTTGAATATGTTTGCCAAGTCCGTT
TTTGGAATTCCTAAATTACACCTTTCTGCGCTTGGAAATTTGAGTCTGAAAGAAGAAAAAGCAGTTCAAAGAATTTTTTC
CATTTAA

Upstream 100 bases:

>100_bases
TCGAGTGAAAGTTTTAAACGTAGATAAAACCGGAAAAATTGATCTTTCCAGAAAAGACGCTCTCGAAGAAGAACAAGTAT
AAGATTTTTTTAATATTCCA

Downstream 100 bases:

>100_bases
TTATTCTATATAGATACCAAACTACTATTGGCGCCTAATGAGAGTAAGCTGATTCGAAATTTAAGAGAACGGATTCACAA
ATTTTTTTTCTAAAAACAAT

Product: metalloprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MMQEPSQIVHRKVLPGGITVLFQKAPHTVSASAGVFVRVGSRHESSKNAGYCHFLEHMLFKDTAKRSAKQQAEDIERVGG
FTNAATSREYTYFHVTVAGKHIGIGLELLAEMIYEPLLKQSDIDNEAGVILEELQGYEDSPEDYIHDFYYQNFFPKNSLG
RDIIGTRESVSGVTHKSILDFYDTYYHTENMFLSISGNFEPDEIFTIAAKYFNRTRVKKREGNSLSLPKKKWGYFPKKKK
LEQVYFILGGEGFAREFHNASSASLFTHILGGGTSSRLFQKVREEKGLCYHITAYPSSYADVGINSIVCSTSKEKFITCL
EIISDEIKSVLDHGISEKELLDAQTNHEGTLSISYEQTESRMNTIALMELYYGRNFSYEERVKEIYSITLEDLNMFAKSV
FGIPKLHLSALGNLSLKEEKAVQRIFSI

Sequences:

>Translated_428_residues
MMQEPSQIVHRKVLPGGITVLFQKAPHTVSASAGVFVRVGSRHESSKNAGYCHFLEHMLFKDTAKRSAKQQAEDIERVGG
FTNAATSREYTYFHVTVAGKHIGIGLELLAEMIYEPLLKQSDIDNEAGVILEELQGYEDSPEDYIHDFYYQNFFPKNSLG
RDIIGTRESVSGVTHKSILDFYDTYYHTENMFLSISGNFEPDEIFTIAAKYFNRTRVKKREGNSLSLPKKKWGYFPKKKK
LEQVYFILGGEGFAREFHNASSASLFTHILGGGTSSRLFQKVREEKGLCYHITAYPSSYADVGINSIVCSTSKEKFITCL
EIISDEIKSVLDHGISEKELLDAQTNHEGTLSISYEQTESRMNTIALMELYYGRNFSYEERVKEIYSITLEDLNMFAKSV
FGIPKLHLSALGNLSLKEEKAVQRIFSI
>Mature_428_residues
MMQEPSQIVHRKVLPGGITVLFQKAPHTVSASAGVFVRVGSRHESSKNAGYCHFLEHMLFKDTAKRSAKQQAEDIERVGG
FTNAATSREYTYFHVTVAGKHIGIGLELLAEMIYEPLLKQSDIDNEAGVILEELQGYEDSPEDYIHDFYYQNFFPKNSLG
RDIIGTRESVSGVTHKSILDFYDTYYHTENMFLSISGNFEPDEIFTIAAKYFNRTRVKKREGNSLSLPKKKWGYFPKKKK
LEQVYFILGGEGFAREFHNASSASLFTHILGGGTSSRLFQKVREEKGLCYHITAYPSSYADVGINSIVCSTSKEKFITCL
EIISDEIKSVLDHGISEKELLDAQTNHEGTLSISYEQTESRMNTIALMELYYGRNFSYEERVKEIYSITLEDLNMFAKSV
FGIPKLHLSALGNLSLKEEKAVQRIFSI

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=381, Percent_Identity=26.509186351706, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI46593007, Length=183, Percent_Identity=28.9617486338798, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI24308013, Length=428, Percent_Identity=22.196261682243, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI155969707, Length=247, Percent_Identity=25.9109311740891, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787770, Length=180, Percent_Identity=26.1111111111111, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI2367164, Length=329, Percent_Identity=24.0121580547112, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=426, Percent_Identity=25.3521126760563, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17553678, Length=292, Percent_Identity=23.6301369863014, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323192, Length=420, Percent_Identity=26.6666666666667, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321813, Length=412, Percent_Identity=21.3592233009709, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357875, Length=290, Percent_Identity=26.2068965517241, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646943, Length=290, Percent_Identity=26.2068965517241, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI19921772, Length=441, Percent_Identity=20.6349206349206, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641429, Length=190, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48511; Mature: 48511

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQEPSQIVHRKVLPGGITVLFQKAPHTVSASAGVFVRVGSRHESSKNAGYCHFLEHMLF
CCCCHHHHHHHHCCCCCEEEEEECCCCCEECCCCEEEEECCCCCCCCCCCHHHHHHHHHH
KDTAKRSAKQQAEDIERVGGFTNAATSREYTYFHVTVAGKHIGIGLELLAEMIYEPLLKQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
SDIDNEAGVILEELQGYEDSPEDYIHDFYYQNFFPKNSLGRDIIGTRESVSGVTHKSILD
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHH
FYDTYYHTENMFLSISGNFEPDEIFTIAAKYFNRTRVKKREGNSLSLPKKKWGYFPKKKK
HHHHHEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHH
LEQVYFILGGEGFAREFHNASSASLFTHILGGGTSSRLFQKVREEKGLCYHITAYPSSYA
HCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHH
DVGINSIVCSTSKEKFITCLEIISDEIKSVLDHGISEKELLDAQTNHEGTLSISYEQTES
HCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHHHH
RMNTIALMELYYGRNFSYEERVKEIYSITLEDLNMFAKSVFGIPKLHLSALGNLSLKEEK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
AVQRIFSI
HHHHHHCC
>Mature Secondary Structure
MMQEPSQIVHRKVLPGGITVLFQKAPHTVSASAGVFVRVGSRHESSKNAGYCHFLEHMLF
CCCCHHHHHHHHCCCCCEEEEEECCCCCEECCCCEEEEECCCCCCCCCCCHHHHHHHHHH
KDTAKRSAKQQAEDIERVGGFTNAATSREYTYFHVTVAGKHIGIGLELLAEMIYEPLLKQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
SDIDNEAGVILEELQGYEDSPEDYIHDFYYQNFFPKNSLGRDIIGTRESVSGVTHKSILD
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHH
FYDTYYHTENMFLSISGNFEPDEIFTIAAKYFNRTRVKKREGNSLSLPKKKWGYFPKKKK
HHHHHEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHH
LEQVYFILGGEGFAREFHNASSASLFTHILGGGTSSRLFQKVREEKGLCYHITAYPSSYA
HCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHH
DVGINSIVCSTSKEKFITCLEIISDEIKSVLDHGISEKELLDAQTNHEGTLSISYEQTES
HCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHHHH
RMNTIALMELYYGRNFSYEERVKEIYSITLEDLNMFAKSVFGIPKLHLSALGNLSLKEEK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
AVQRIFSI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]