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The map label for this gene is sph1 [H]

Identifier: 45658469

GI number: 45658469

Start: 3186233

End: 3188023

Strand: Direct

Name: sph1 [H]

Synonym: LIC12632

Alternate gene names: 45658469

Gene position: 3186233-3188023 (Clockwise)

Preceding gene: 45658468

Following gene: 45658472

Centisome position: 74.49

GC content: 33.84

Gene sequence:

>1791_bases
ATGATCACAAAGCGAAATATACCTTGTAAAAAAAACTGGAAATATAAGAAAAAATCTATAAGTTTAACACTGATTACAAT
TTGTTACATGTTTCTTTTCCTTACAAGTTGTAAACCTGGCAAACAAAATTCCATAAATCTTCTATTACTCTTACTGAACA
CTTTAGATAACAAAAATGTAAATGAGAAAATTGAAGATTCAACAAACACAGATCCTAGTTCAAATGTAAACGAGGAAGAT
GAAAATTCAATAAACGCAAATGCCAACGACAACGCCCCTTCGGATTCCGACTCTTCAAATCCACGCTCTCCAGACAAAAA
TCCTGTAAATCCTACTTCTCCAAATTCAAGCTCTGCAGATATAGGAATTAAAATTTTAAGCCACAGCATATTTATGGCAC
CTACGAATCTTTCAAGTTGGGGCGATTTGGGACAAGAAGAAAGGGCACAAAGAATTGCAAGTTCAAGTTATATAAAAAAT
CAAGACATTATTGTGTTTGAAGGGTTATCTCATAACAACGCTGAGAAAATTCTCTTAGAAAAAATTCGTTCCGAATACCC
ATACCAAACCAACGTAGTAGGTAGAACAAAAAAAGGTTGGAATGCAACTCTTGGAGCTTATACAACTTCTCCAATGGCTA
ACGGAGGAGTTATCATCGTTAGTAAATGGCCTATCGAAGAAAAAGTTCAATATATATTCAACAATTCAAATTGTGGTCAA
GACCAGTATTATAACAAAGGATTTGCTTATGTGAAAATCAACAAAGATGGAAAAAAATTTCATGTTATCGGAACTCAGCT
ACAAGCTCGTGAACCTGACTGCTTTAATTCTGGAGAAACCATACGTAAACTTCAACTCAATGATATTAAAAGTTTTATTG
ATTCTAAAGACATTCCAAAAGATGAAACCGTTTTGATTACGGGTGATTTAAACATTATCAAAGGAAGTAATGAATATTTC
GATATGATCTCTAAACTAAATGTCAACGAACCTAGATATGTCGGAGTTCCTTTTACTTTAGATACAAAAACAAACGCACT
TGCCGCATACTATTACGAAAAGGAAAAACCGATTTACCTGGATTATATTCTCGTTTCAAAATTACACGCTCAACCACCGG
TTTGGCAAAATTTAGCTTACGATCCAATTTCAAATACAACCTGGAAAAGATCTGATGGATATACAAGTTACGAATTTTCA
GATCGTTATCCGGTATACGGTTTTATATATGCGGATTCTTCCACTCCTACAAAATCTGGACATAAAAGAAAATACGATCA
GGTTTCTTTTCAATCGACCTTTAATCGTAAATTCATTCAAGCAGATCATAATAAAAAAGACGGATGGTTAAAAGCGGATA
CAAGAATAAAAACAGATTTTACTAAATTCAATTTATTGCAAGAGAATGTTTCCGAATCTAATCCGTCTTGTATGAATAGT
GGGTCAGTCAGAATTGAATCTTCCTATTATTTAAATTATTATTGGAATTGGTTTATTGGCGCAGCCAGCGGTGACTACGG
CTATTATACGAAATTTAATAACGGCTCCGATAGCTTAGGTATTAAAAATTTAGACAATGGATGTTTAAAAGATGGTAGTA
GAGTTGCCTTCTATGATTGGGATACAATTGGTGGTGGCTATTATTACCTAACAGTTTGGGACAAAGGAAGCTGGAAAGAA
CATTTGTTTCTTTGGGTACAATCCTTTCTTAGCTCAAGAGAGATTTTTTACTTACATCTAGACTCTAACCCACCCAAAGA
CTGGAGTAAAGATTTAATCTATCATCATTAG

Upstream 100 bases:

>100_bases
ATATTACCTAAGTACGTAGAAATAATCAAAACAAAAACATTTTCTAGAAATTACTTTCTTTTTTTTTAAAATACTATATA
AAAAATAATGGAGATTTGAG

Downstream 100 bases:

>100_bases
AGTTGTTGAAAAATCAATCCTCCATTTATTTCTATTTCATGAAAACGGACAATTAAAACAGTTTTGTTAATCTGAACTAG
GAAATTTTTCAACAATTCTA

Product: hemolysin

Products: NA

Alternate protein names: Sphingomyelin phosphodiesterase 1; SMase 1 [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNVNEKIEDSTNTDPSSNVNEED
ENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSADIGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKN
QDIIVFEGLSHNNAEKILLEKIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQ
DQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPKDETVLITGDLNIIKGSNEYF
DMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYLDYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFS
DRYPVYGFIYADSSTPTKSGHKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNS
GSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDWDTIGGGYYYLTVWDKGSWKE
HLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH

Sequences:

>Translated_596_residues
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNVNEKIEDSTNTDPSSNVNEED
ENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSADIGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKN
QDIIVFEGLSHNNAEKILLEKIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQ
DQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPKDETVLITGDLNIIKGSNEYF
DMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYLDYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFS
DRYPVYGFIYADSSTPTKSGHKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNS
GSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDWDTIGGGYYYLTVWDKGSWKE
HLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH
>Mature_596_residues
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNVNEKIEDSTNTDPSSNVNEED
ENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSADIGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKN
QDIIVFEGLSHNNAEKILLEKIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQ
DQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPKDETVLITGDLNIIKGSNEYF
DMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYLDYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFS
DRYPVYGFIYADSSTPTKSGHKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNS
GSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDWDTIGGGYYYLTVWDKGSWKE
HLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 68096; Mature: 68096

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNV
CCCCCCCCCCCCCCEEHHEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHCCCCCC
NEKIEDSTNTDPSSNVNEEDENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSAD
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKNQDIIVFEGLSHNNAEKILLE
EEEEEEECEEEEECCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
KIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQ
HHHHCCCEEECCCCCCCCCCCEEECCEECCCCCCCCEEEEECCCHHHHHHEEECCCCCCC
DQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPK
CHHCCCCEEEEEECCCCCEEEEEECEEECCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCC
DETVLITGDLNIIKGSNEYFDMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYL
CCEEEEECCEEEEECCCHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCEEE
DYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFSDRYPVYGFIYADSSTPTKSG
EEEEEHHHCCCCCHHHCCCCCCCCCCCEECCCCEEEEECCCCCCEEEEEEECCCCCCCCC
HKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNS
CCCCCHHHHHHHHHCCEEEECCCCCCCCEEEECCEEEECHHHHHHHHHHHCCCCCCCCCC
GSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDW
CCEEEEEEEEEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEC
DTIGGGYYYLTVWDKGSWKEHLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHCCCCCCC
>Mature Secondary Structure
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNV
CCCCCCCCCCCCCCEEHHEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHCCCCCC
NEKIEDSTNTDPSSNVNEEDENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSAD
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKNQDIIVFEGLSHNNAEKILLE
EEEEEEECEEEEECCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
KIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQ
HHHHCCCEEECCCCCCCCCCCEEECCEECCCCCCCCEEEEECCCHHHHHHEEECCCCCCC
DQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPK
CHHCCCCEEEEEECCCCCEEEEEECEEECCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCC
DETVLITGDLNIIKGSNEYFDMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYL
CCEEEEECCEEEEECCCHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCEEE
DYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFSDRYPVYGFIYADSSTPTKSG
EEEEEHHHCCCCCHHHCCCCCCCCCCCEECCCCEEEEECCCCCCEEEEEEECCCCCCCCC
HKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNS
CCCCCHHHHHHHHHCCEEEECCCCCCCCEEEECCEEEECHHHHHHHHHHHCCCCCCCCCC
GSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDW
CCEEEEEEEEEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEC
DTIGGGYYYLTVWDKGSWKEHLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12712204 [H]