| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is sph2 [H]
Identifier: 45658468
GI number: 45658468
Start: 3183448
End: 3185319
Strand: Direct
Name: sph2 [H]
Synonym: LIC12631
Alternate gene names: 45658468
Gene position: 3183448-3185319 (Clockwise)
Preceding gene: 45658467
Following gene: 45658469
Centisome position: 74.43
GC content: 35.42
Gene sequence:
>1872_bases ATGATAAACAAAATAACAAAACCAAAACTACTTATAGGTTATTACCTATTGTTATTCTCTCTGATACGTTGTTTACCCGA AAAAGAATCCTCATATAAGGATTTATTTACTTCGTTATTATTCCTCCCCAACCAAACAAATAGTAATCAAGTAAATTCGG TTTCCATAAACAACGACCCTGCAAACCCAAATCCAGTTAACCCGGCATCCGCAAATAACAATCAGGTAAACGCAGTTCCA GAAAATGACAATCCAGCAAACCTAAATCCAGTTAATCCGGCATCTGCAAATAGCAATCAAGTAAATGCAGCTCCAGAAAA TGGCAGCTCCGCAGATCCAAATCCAGCCAACCTCGCATCTGGAAATAATAATCAAGTAAATGCAGTTCCAGCTAACAATT ATTTTACGAAAGAAGATTCCTCAAATAATATTCCTAAAAAAGTAAATTCTAAAAATGTAGAAATAAAAGTACTGAGTCAC AACGTATTTATGTTGCCCACAAATCTTCCACGATGGGGAAATTTGGGACACGATGAAAGAGCAAAACGAATTTCAAAATC AGATTACGTAAAAAATCAGGACGTTATCGTGTTCGAAGAAGCCTTCGACACAAGTGCAAGAAAAATTCTTTTAGACAATC TTCGAGAAGAATATCCGTATCAAACAGATGTGGTCGGAAGAACAAAAAAAAATTGGGACGCAAGCTTAGGCAATTTTAGA TCTTATTCGCTCGTTAACGGAGGAGTTGTAATCCTAAGTAAATGGCCTATCGAAGAAAAAATTCAATATATCTTTAACGA CTCAGGTTGTGGAACGGATTGGTTTGCAAATAAAGGATTTGTTTATGTAAAAATCAACAAAGAAGGAAAAAAATTCCATG TCATCGGAACCCACGCTCAGTCTCAGGATCAGAACTGTTCAAATCTAGGAATACCAAACAGAGCTAATCAATTTGATGAC ATTAGAAATTTCATATATTCTAAAAATATTCCAAAAGATGAAACCGTTTTAATCGTGGGCGATTTAAACGTTATCAAAGA AAGTAACGAATATTACGATATGATTTCTAGGTTAAATGTTAACGAACCTAGATATGTTGGAGTTCCTTTTACTTGGGATG CAAAAACAAACGAAATTGCTGCATACTATTACGAAAACGAAGAACCGGTTTACTTAGATTATATTTTCGTTTCAAAATCA CACGCTCAACCACCGGTTTGGCAAAATTTAGCTTACGATCCGGTTTCTAAACAAACTTGGACCGTATCTGGATATACAAG CGACGAATTTTCGGATCACTATCCGATATACGGTTTTGTATACGCGGATCCTTCTACTCCTACAAAGTCCGGACATAAAA AAAAATACGATCAAGTCTCTTTTCAATCAGCTGCTAATGGTAAATACATTCAAGCAGATCCTAATAGAAAAAACGGATGG TTAAAAGCGGACGCTGTAATAGAAACGGATTTTACTAAATTCAACCTATTGCAAGAAGGAAATTTAAATCCTTCCTGCAT AAAAAATGGTCTCGTTAGAATTGAATCTTCCCGTTTTTTAAACTACTTTTGGAACTGGTGGTTAGGCGGAGGTTCCGGTA ACTACGGCTATTACTCTAAGTTTAATGACGCTTCCAATCAACTTGAAATTATCAATTTGAGTGATGGATGCCTAGAAAAC GGTAGTAAAATCGTATTCAAAGATTATGATACTTATTCTAGAAACCATTACTATCTCACCGTTTGGGACAAAGGAAATTG GAATGAACATCTTTATCTTTGGAAAGATTCGATCAGCCAGAGAGAAATCTTTTATCTCAAATTAAATTCTACTCCGGTAA GAAATTGGAGTGCGGATCTTATTTATCGCTAA
Upstream 100 bases:
>100_bases AGATATTTTATGTTTATTAGTATTTTTTTATAAAATACTATTCATTTTTATGTTATATGATAACATAAAATACAAACATA CAGAATGGAGATAGAGAACG
Downstream 100 bases:
>100_bases TTTTTTTCCTGGCCTCTTAAATCCGGAGGCCAGGTTTTTCGAAAAGAAATATTAAAAAAATAATATATTTATAAAACGAA ATTATACAAAACTCTTCAAA
Product: hemolysin
Products: NA
Alternate protein names: Sphingomyelin phosphodiesterase 2; SMase 2 [H]
Number of amino acids: Translated: 623; Mature: 623
Protein sequence:
>623_residues MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDPANPNPVNPASANNNQVNAVP ENDNPANLNPVNPASANSNQVNAAPENGSSADPNPANLASGNNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSH NVFMLPTNLPRWGNLGHDERAKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFR SYSLVNGGVVILSKWPIEEKIQYIFNDSGCGTDWFANKGFVYVKINKEGKKFHVIGTHAQSQDQNCSNLGIPNRANQFDD IRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNVNEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKS HAQPPVWQNLAYDPVSKQTWTVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGW LKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSKFNDASNQLEIINLSDGCLEN GSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQREIFYLKLNSTPVRNWSADLIYR
Sequences:
>Translated_623_residues MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDPANPNPVNPASANNNQVNAVP ENDNPANLNPVNPASANSNQVNAAPENGSSADPNPANLASGNNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSH NVFMLPTNLPRWGNLGHDERAKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFR SYSLVNGGVVILSKWPIEEKIQYIFNDSGCGTDWFANKGFVYVKINKEGKKFHVIGTHAQSQDQNCSNLGIPNRANQFDD IRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNVNEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKS HAQPPVWQNLAYDPVSKQTWTVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGW LKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSKFNDASNQLEIINLSDGCLEN GSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQREIFYLKLNSTPVRNWSADLIYR >Mature_623_residues MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDPANPNPVNPASANNNQVNAVP ENDNPANLNPVNPASANSNQVNAAPENGSSADPNPANLASGNNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSH NVFMLPTNLPRWGNLGHDERAKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFR SYSLVNGGVVILSKWPIEEKIQYIFNDSGCGTDWFANKGFVYVKINKEGKKFHVIGTHAQSQDQNCSNLGIPNRANQFDD IRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNVNEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKS HAQPPVWQNLAYDPVSKQTWTVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGW LKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSKFNDASNQLEIINLSDGCLEN GSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQREIFYLKLNSTPVRNWSADLIYR
Specific function: Unknown
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: NA
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005135 - InterPro: IPR017766 [H]
Pfam domain/function: PF03372 Exo_endo_phos [H]
EC number: =3.1.4.12 [H]
Molecular weight: Translated: 70963; Mature: 70963
Theoretical pI: Translated: 6.61; Mature: 6.61
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 0.5 %Met (Translated Protein) 1.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 0.5 %Met (Mature Protein) 1.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDP CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCC ANPNPVNPASANNNQVNAVPENDNPANLNPVNPASANSNQVNAAPENGSSADPNPANLAS CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC GNNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSHNVFMLPTNLPRWGNLGHDER CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECEEEEEECCCCCCCCCCCHHH AKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFR HHHCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE SYSLVNGGVVILSKWPIEEKIQYIFNDSGCGTDWFANKGFVYVKINKEGKKFHVIGTHAQ EEEEECCCEEEEECCCHHHHHHEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCC SQDQNCSNLGIPNRANQFDDIRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNV CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHEEECCCHHHHHHHHCCC NEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKSHAQPPVWQNLAYDPVSKQTW CCCEEEECEEEECCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCHHHCCCCCCCCCCEE TVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGW EEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC LKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSK EEEEEEEEECCCEEEEEECCCCCHHHHHCCEEEEECCHHEEEEEEEEEECCCCCCCCCCC FNDASNQLEIINLSDGCLENGSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQ CCCCCCEEEEEECCCCHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCCC REIFYLKLNSTPVRNWSADLIYR CEEEEEEECCCCCCCCCCCEEEC >Mature Secondary Structure MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDP CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCC ANPNPVNPASANNNQVNAVPENDNPANLNPVNPASANSNQVNAAPENGSSADPNPANLAS CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC GNNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSHNVFMLPTNLPRWGNLGHDER CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECEEEEEECCCCCCCCCCCHHH AKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFR HHHCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE SYSLVNGGVVILSKWPIEEKIQYIFNDSGCGTDWFANKGFVYVKINKEGKKFHVIGTHAQ EEEEECCCEEEEECCCHHHHHHEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCC SQDQNCSNLGIPNRANQFDDIRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNV CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHEEECCCHHHHHHHHCCC NEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKSHAQPPVWQNLAYDPVSKQTW CCCEEEECEEEECCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCHHHCCCCCCCCCCEE TVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGW EEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC LKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSK EEEEEEEEECCCEEEEEECCCCCHHHHHCCEEEEECCHHEEEEEEEEEECCCCCCCCCCC FNDASNQLEIINLSDGCLENGSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQ CCCCCCEEEEEECCCCHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCCC REIFYLKLNSTPVRNWSADLIYR CEEEEEEECCCCCCCCCCCEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12712204 [H]