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The map label for this gene is sucD

Identifier: 45658412

GI number: 45658412

Start: 3121633

End: 3122508

Strand: Direct

Name: sucD

Synonym: LIC12574

Alternate gene names: 45658412

Gene position: 3121633-3122508 (Clockwise)

Preceding gene: 45658411

Following gene: 45658413

Centisome position: 72.98

GC content: 46.46

Gene sequence:

>876_bases
ATGGCAGTATTAGTAGATGAAAATACAAAAGTTGTAGTTCAAGGAATCACCGGTAAAGAAGGCTCGTTCCACGCGACTCA
GATGCTCGCTTACGGCACCAAGGTCGTAGCTGGAGTCACTCCAGGTAAAGGCGGAAGCAAATGGGAAGACAAGGTTCCAG
TTTTCAACACAATTAAGGATTCCATTAAAAACGAAGGCGTAAACGCAGCAGTTATTTTTGTTCCCCCCGCATTTGCAGCG
GACGCAATCATCGAAGGAATTCTCGCGGAACTTCCTCTCGTAATCTGTATCACGGAAGGAATACCGACCCACGATATGCT
GAAGGTTTACAGCGTACTCCGAAATTCTAAAACAAAACTAGTAGGCCCCAATTGTCCCGGAGTGATCACTCCTCGTGCAA
AACAAAAACTCGGGATCATGCCAGGTTTTATCCATAGTCCAGGTTCAGTGGGAATTGTATCCCGTTCCGGAACCTTGACT
TACGAATCCGTGGCTCAGATTACAAAACAAGGGTTGGGACAATCCACTTGTATTGGAATCGGTGGAGACCCAGTTCCAGG
AATGAACCATACCGAAGCGATCAAACTTTTAAACGAAGATCCGGAAACCAAAGGAATCGTAATGATCGGAGAAATCGGCG
GAACCTCCGAAGAAGAAGCTGCCGAATATATTAAAAATCACGTCAAAAAACCTGTAGTGGGATTTATCGCCGGCCAAACC
GCACCTCCGGGCAAAAGAATGGGACACGCGGGCGCAATCATCAGCGGCGGTTTAGGAACTGCTACTTCTAAGATGAAAGC
AATGCAAGAAGCAGGTATTCAAGTCTGCCAATCCATTGCAGAAGTTGGAGAAAAAATGAAGAAGGCCCTGGGTTAA

Upstream 100 bases:

>100_bases
AGAAGTGCTCAACAAAAGCGGACTAAAAATTACCGGAGTAGACGATCTCCGAGAAGCGGCAAGCACCATTGCCAAACTGA
TTGGGTAAGAGAGAATATAC

Downstream 100 bases:

>100_bases
TTTTTGTCCAATTTGAGACTTTTAAAAAGAAACAAAAGGTTGGAAAAGATTTTTTACCCTTTTTAAATGGTTCTCAAAGA
TAGAAGCGATTCAAAAGGGT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha; Vegetative protein 239; VEG239 [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAVLVDENTKVVVQGITGKEGSFHATQMLAYGTKVVAGVTPGKGGSKWEDKVPVFNTIKDSIKNEGVNAAVIFVPPAFAA
DAIIEGILAELPLVICITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVITPRAKQKLGIMPGFIHSPGSVGIVSRSGTLT
YESVAQITKQGLGQSTCIGIGGDPVPGMNHTEAIKLLNEDPETKGIVMIGEIGGTSEEEAAEYIKNHVKKPVVGFIAGQT
APPGKRMGHAGAIISGGLGTATSKMKAMQEAGIQVCQSIAEVGEKMKKALG

Sequences:

>Translated_291_residues
MAVLVDENTKVVVQGITGKEGSFHATQMLAYGTKVVAGVTPGKGGSKWEDKVPVFNTIKDSIKNEGVNAAVIFVPPAFAA
DAIIEGILAELPLVICITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVITPRAKQKLGIMPGFIHSPGSVGIVSRSGTLT
YESVAQITKQGLGQSTCIGIGGDPVPGMNHTEAIKLLNEDPETKGIVMIGEIGGTSEEEAAEYIKNHVKKPVVGFIAGQT
APPGKRMGHAGAIISGGLGTATSKMKAMQEAGIQVCQSIAEVGEKMKKALG
>Mature_290_residues
AVLVDENTKVVVQGITGKEGSFHATQMLAYGTKVVAGVTPGKGGSKWEDKVPVFNTIKDSIKNEGVNAAVIFVPPAFAAD
AIIEGILAELPLVICITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVITPRAKQKLGIMPGFIHSPGSVGIVSRSGTLTY
ESVAQITKQGLGQSTCIGIGGDPVPGMNHTEAIKLLNEDPETKGIVMIGEIGGTSEEEAAEYIKNHVKKPVVGFIAGQTA
PPGKRMGHAGAIISGGLGTATSKMKAMQEAGIQVCQSIAEVGEKMKKALG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=293, Percent_Identity=56.6552901023891, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI38569421, Length=305, Percent_Identity=30.1639344262295, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI38569423, Length=305, Percent_Identity=30.1639344262295, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=58.2758620689655, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17550194, Length=291, Percent_Identity=56.0137457044674, Blast_Score=302, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17553126, Length=293, Percent_Identity=52.2184300341297, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557344, Length=309, Percent_Identity=26.537216828479, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=309, Percent_Identity=26.537216828479, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=49.6575342465753, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=51.5679442508711, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI28574296, Length=291, Percent_Identity=52.233676975945, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI281363477, Length=277, Percent_Identity=32.129963898917, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI281363475, Length=277, Percent_Identity=32.129963898917, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI281363473, Length=277, Percent_Identity=32.129963898917, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30194; Mature: 30062

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVDENTKVVVQGITGKEGSFHATQMLAYGTKVVAGVTPGKGGSKWEDKVPVFNTIKD
CEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHH
SIKNEGVNAAVIFVPPAFAADAIIEGILAELPLVICITEGIPTHDMLKVYSVLRNSKTKL
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
VGPNCPGVITPRAKQKLGIMPGFIHSPGSVGIVSRSGTLTYESVAQITKQGLGQSTCIGI
ECCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEC
GGDPVPGMNHTEAIKLLNEDPETKGIVMIGEIGGTSEEEAAEYIKNHVKKPVVGFIAGQT
CCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
APPGKRMGHAGAIISGGLGTATSKMKAMQEAGIQVCQSIAEVGEKMKKALG
CCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVLVDENTKVVVQGITGKEGSFHATQMLAYGTKVVAGVTPGKGGSKWEDKVPVFNTIKD
EEEEECCCEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHH
SIKNEGVNAAVIFVPPAFAADAIIEGILAELPLVICITEGIPTHDMLKVYSVLRNSKTKL
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
VGPNCPGVITPRAKQKLGIMPGFIHSPGSVGIVSRSGTLTYESVAQITKQGLGQSTCIGI
ECCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEC
GGDPVPGMNHTEAIKLLNEDPETKGIVMIGEIGGTSEEEAAEYIKNHVKKPVVGFIAGQT
CCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
APPGKRMGHAGAIISGGLGTATSKMKAMQEAGIQVCQSIAEVGEKMKKALG
CCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]