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The map label for this gene is sucC

Identifier: 45658411

GI number: 45658411

Start: 3120448

End: 3121620

Strand: Direct

Name: sucC

Synonym: LIC12573

Alternate gene names: 45658411

Gene position: 3120448-3121620 (Clockwise)

Preceding gene: 45658410

Following gene: 45658412

Centisome position: 72.96

GC content: 43.65

Gene sequence:

>1173_bases
ATGAAAATTCACGAGTATCAGGCAAAAGAAATCCTGAGAAGGCATAAAGCCAACGTTCCTTTTGGAGTCGTAATTGATAA
AAAAGAAAACGCTTCCAAAGCCCATGACGAAGTTACCTCTAAAACAGGTGGTTCCGTCGTAGTCGTAAAAGCTCAAATTC
ACGCCGGAGGGCGGGGAAAAGGTGGCGGAGTCAAGGTAACTAAAACCAAAGAAGACGCGATCGCAGCCGTAGATAAAATC
TTAGGTATGCAGCTCATCACTCCTCAAACCGGACCGGAAGGAAAAAAAGTCCTTAAAGTATATCTGGAACAAGGAATCGA
CATTGCTAAAGAATACTATCTGAGCATACTACTCGATCGTTCCATCCGCAAAACCATCATTATGGCATCTACAGAAGGTG
GAATGGAAATCGAAGAAGTAGCGGAAACTCATCCGGAAAAGATTCTAAAAATTGCAATCGATCCTGGAATCGGACTCCAA
GTAAATCAAGCCAGACAGCTTGCATTTGAACTTGGACTACCTGCAGAATCTCACAAATCTTTCCAAAGTCTTCTCGCGGC
GATTTACGAAGCTTATATCAAAGAAGATGCTTCTCTGTTAGAAATCAATCCACTGATTCTCACAAAACAAAATGAAATCA
TCGCTGGAGATTGTAAGATAGATTTAGACGAAAACGCTCTCTACAGACACGCGGACAACGCGGCCTTTAGAGACATCACC
GAAGAAGATCCTCTCGAAGTTCAGGCTTCCGAGTTTAACCTCAACTACGTCAAGTTAGACGGAAACATAGGTTGTATGGT
CAACGGAGCGGGACTCGCTATGGCGACGATGGACATCGTAAAACTCGCAGGTGCAGAACCTGCCAACTTCTTGGATGTAG
GTGGTGGAGCCAACAAAACCACAGTAACCAACGGATTCAAAATTATTTTAGGAGATCCAAACGTAAAAGGAATCTTCGTA
AATATTTTTGGTGGAATTGTTCGTTGTGACATGGTCGCCGAAGGAATTATAGAAGCAGCAAAAGCAGTGGATCTCAAAGT
TCCTCTTGTGGTTCGTCTTCAAGGTACCAACTCGGAACTAGGAAGAGAAGTGCTCAACAAAAGCGGACTAAAAATTACCG
GAGTAGACGATCTCCGAGAAGCGGCAAGCACCATTGCCAAACTGATTGGGTAA

Upstream 100 bases:

>100_bases
CCAAGATTCAATTTTTTACTGACACCAAAGTTCGTACCGAAAACAGTATCTATTTCGAGTAAATCATCATCTTATAAAAG
CACTGAACTAAGGTTAATTC

Downstream 100 bases:

>100_bases
GAGAGAATATACATGGCAGTATTAGTAGATGAAAATACAAAAGTTGTAGTTCAAGGAATCACCGGTAAAGAAGGCTCGTT
CCACGCGACTCAGATGCTCG

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKIHEYQAKEILRRHKANVPFGVVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDAIAAVDKI
LGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTIIMASTEGGMEIEEVAETHPEKILKIAIDPGIGLQ
VNQARQLAFELGLPAESHKSFQSLLAAIYEAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDIT
EEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFV
NIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIG

Sequences:

>Translated_390_residues
MKIHEYQAKEILRRHKANVPFGVVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDAIAAVDKI
LGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTIIMASTEGGMEIEEVAETHPEKILKIAIDPGIGLQ
VNQARQLAFELGLPAESHKSFQSLLAAIYEAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDIT
EEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFV
NIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIG
>Mature_390_residues
MKIHEYQAKEILRRHKANVPFGVVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDAIAAVDKI
LGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTIIMASTEGGMEIEEVAETHPEKILKIAIDPGIGLQ
VNQARQLAFELGLPAESHKSFQSLLAAIYEAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDIT
EEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFV
NIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=398, Percent_Identity=43.21608040201, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI157779135, Length=389, Percent_Identity=42.4164524421594, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI294862256, Length=368, Percent_Identity=42.3913043478261, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1786948, Length=385, Percent_Identity=51.4285714285714, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17539378, Length=399, Percent_Identity=44.1102756892231, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17567829, Length=397, Percent_Identity=44.5843828715365, Blast_Score=328, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6321683, Length=398, Percent_Identity=43.9698492462312, Blast_Score=333, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161078106, Length=390, Percent_Identity=44.3589743589744, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24645208, Length=390, Percent_Identity=44.3589743589744, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI21356231, Length=393, Percent_Identity=45.8015267175573, Blast_Score=314, Evalue=9e-86,
Organism=Drosophila melanogaster, GI281361397, Length=391, Percent_Identity=44.2455242966752, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI281361395, Length=391, Percent_Identity=44.2455242966752, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 41891; Mature: 41891

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHEYQAKEILRRHKANVPFGVVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGK
CCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCC
GGGVKVTKTKEDAIAAVDKILGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDR
CCCEEEEECHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCC
SIRKTIIMASTEGGMEIEEVAETHPEKILKIAIDPGIGLQVNQARQLAFELGLPAESHKS
CCCEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHHCCCCCHHHHH
FQSLLAAIYEAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDIT
HHHHHHHHHHHHHHCCCCEEEECCEEEECCCCEEEECEEEECCCCHHHCCCCCCHHCCCC
EEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKT
CCCCCEEEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCCC
TVTNGFKIILGDPNVKGIFVNIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSEL
EEECCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEECCCHHH
GREVLNKSGLKITGVDDLREAASTIAKLIG
HHHHHHCCCCEEECHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKIHEYQAKEILRRHKANVPFGVVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGK
CCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCC
GGGVKVTKTKEDAIAAVDKILGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDR
CCCEEEEECHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCC
SIRKTIIMASTEGGMEIEEVAETHPEKILKIAIDPGIGLQVNQARQLAFELGLPAESHKS
CCCEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHHCCCCCHHHHH
FQSLLAAIYEAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDIT
HHHHHHHHHHHHHHCCCCEEEECCEEEECCCCEEEECEEEECCCCHHHCCCCCCHHCCCC
EEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKT
CCCCCEEEEEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCCC
TVTNGFKIILGDPNVKGIFVNIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSEL
EEECCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEECCCHHH
GREVLNKSGLKITGVDDLREAASTIAKLIG
HHHHHHCCCCEEECHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA