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The map label for this gene is pdxB [H]

Identifier: 45658395

GI number: 45658395

Start: 3094124

End: 3095143

Strand: Reverse

Name: pdxB [H]

Synonym: LIC12554

Alternate gene names: 45658395

Gene position: 3095143-3094124 (Counterclockwise)

Preceding gene: 45658400

Following gene: 45658389

Centisome position: 72.36

GC content: 36.47

Gene sequence:

>1020_bases
GTGGAGCTAAAAAAACCGATTTTATATTATCCTGAAGGAACCATCGGGGCTAAGGAAATTTTTTCAAGTTTCGAAAAGCT
GGAAGTAAGATCTTATCCTAACGATCAAATCAGAGAGATTTCAAGAGACGAACCCACGATTTTAATCGCAAACACTAGGT
TTCAAGTAAACCGAGATAATATACAAAACTTTCCTACGGTAAAAATTTTTGCTACTGTTAGTTCTGGAACGGATCACGTA
GATTTTAATGCACTTAAGGAATTCAAAAAAATTTTTCTAAACGCTCCCGGTTGTAATGCCGGTTCTGTCGCAGAATATTG
TTTTGCGGGGCTTTTAAATCGGTTTAAAGAATCCGAACTTAAGGGATTAAAAATCGGCTTGGTAGGACACGGTCATACAG
GAAAAGAATTTTATAAAATTCTAATATCTAAGGGAGTAAACTGTATATTTTATGACCCGTTTTATAAGACAGAATCCAGA
CCTTTGAGTGAAGTTTTAGATGCTTCCGTTCTGAGTTTTCACGTTCCACTGACCAAAGACGGACCGGAGCCCACGTTTCG
ATTTGTGAGCACGTCTTTAATTGATTCTTTAAAGTCGGGTACGATTTTTATCAATACGAGTCGCGGAGAAATACTTTCTC
GAGAAGCGTTTAATCGATTGATTGCAAGAAATGATATATTCAAAATTTTAGATGTATTTGATCCGGAGCCACCTACGTTG
GAAATGGGAAGAAAACTTTCAGAAGTAAAACATTCTATTTTGACTCCTCATGTTGCGGGTTACAGTCAGCTGGGCAGAAT
TGGCGGAACTTACCGAGTTGCGGAAAAGTTATCAATTTTATACCAGGACAAACCTTTGCCACCTTTAAATTTTTTTTTAC
AAACATCCGGAGAATTTAAAACTTCTACTTTTTTAAAGGAAGAGGATCGTCTTTTGAGAGAAGCCTGGAGAAATGGAGAT
ACAAATTATTTTGAAAAAAGAAGAAATACTTATCCAATAAGACTCGATTGGGATTTTTAG

Upstream 100 bases:

>100_bases
TGAAGAGTTTTCATAGGCCGTGATTTTTTTAAAAAATCTTTTTCAAAGCAAACCTTTTTTGTTTTTTCTAAAAAAGAGGT
TGGGATGAGATGACAAAGTA

Downstream 100 bases:

>100_bases
AAAGTTCGTTTAACGATCAAAGGCGAGTTTACTTTTAAAAAATTTTTCTCGTGAATTTATGTTATTTAGAGTTATATAAT
AAAGTAAAATGAATCTTTAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHV
DFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESR
PLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTL
EMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGD
TNYFEKRRNTYPIRLDWDF

Sequences:

>Translated_339_residues
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHV
DFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESR
PLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTL
EMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGD
TNYFEKRRNTYPIRLDWDF
>Mature_339_residues
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHV
DFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESR
PLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTL
EMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGD
TNYFEKRRNTYPIRLDWDF

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=21.9512195121951, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=21.9512195121951, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=21.5447154471545, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4557497, Length=246, Percent_Identity=21.5447154471545, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=21.9512195121951, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788660, Length=273, Percent_Identity=34.0659340659341, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789279, Length=311, Percent_Identity=27.9742765273312, Blast_Score=82, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=288, Percent_Identity=24.6527777777778, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322116, Length=286, Percent_Identity=23.4265734265734, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 38735; Mature: 38735

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDN
CCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCEEEEECCC
IQNFPTVKIFATVSSGTDHVDFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESEL
CCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
KGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKD
CCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHCCHHHEEECCCCCC
GPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTL
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFK
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEECCCCCC
TSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDQIREISRDEPTILIANTRFQVNRDN
CCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCEEEEECCC
IQNFPTVKIFATVSSGTDHVDFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESEL
CCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
KGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKD
CCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHCCHHHEEECCCCCC
GPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTL
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFK
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEECCCCCC
TSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA