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The map label for this gene is acsA1 [H]

Identifier: 45658358

GI number: 45658358

Start: 3045302

End: 3047284

Strand: Reverse

Name: acsA1 [H]

Synonym: LIC12516

Alternate gene names: 45658358

Gene position: 3047284-3045302 (Counterclockwise)

Preceding gene: 45658360

Following gene: 45658357

Centisome position: 71.25

GC content: 36.96

Gene sequence:

>1983_bases
ATGGATCAAAAGTTATGGACACCTTCCTCCGATCGAATTGAGTCTTCTAATCTGGTTCGATATATAAAATTTCTCAAAGA
AAAAAAGAATCTTTCTCTTTCTACGTTTGAAGAACTCAGAGTTTGGTCGGTAAATGAGATCGGATCATTTTGGGAAAGTA
TCTGGGAATTTTCAGAAGTTGTCCATAGTCAAAAATATGATCTTGTGTATCAAAGTGGATCGAATTTTACAGATTCCAAA
TTTTTTCCAGGAGCGAAACTGAATTTTGCGGAAAATCTACTTCGTAGAACCGATTCTTTTCCTGCGTTAATTTATAGAGG
TGAGGACGGCTCTAAAAGAGAAGTAAGTTATGCGGAATTATATTCTTACGTAGGTGCGGTTGCAACGGATCTGAAAAAAA
GAGGAGTGGTTCCAGGAGATAGGGTAGTAGGTCTGATGCCTAACGTGCCTGAAACTGTAATTGCAATGTTGGCTACTACT
TCTATCGGGGCGATTTGGAGTTCTTGTTCTCCCGATTTTGGAGTAAAAGGTGTTTTAGATCGATTTGGTCAAATTGAACC
TAAGATTTTATTTACTACGAATTTATATTCTTTCAAAGGTAAGGACTTATCTCTTGCCGAAAATTTGACTCAGATTCTTA
AATCTATACCGTCTATTGAAGCGGTCATCGTATCTGATTATAAAAATGGAATTTTACATTTTAAGAATCGTACAAAAACG
GTTCTGCCTGAAAACTATCCTCAAAAAAATATTCATCTTTTTGAAACTGTTCTTTTTGAAAATGAAGGAGCCTCCCCTAA
TTTTTATCAGACAAATTTTGATCATCCGGTTTATATCATGTATTCTTCTGGAACGACTGGTCTTCCTAAATGTATGGTTC
AAGGAGTTGGAGTATTTCTCAATCATTGGAAAGAATTGGCGCTTCACTGCGATTTAAAACCAGGAGAAAGAATTTTTTAT
TATACTACGTGTGGTTGGATGATGTGGAATTGGCTCGTAAGTTCCTTGTCGATTGGGGCCACCTTAGTGTTGTTTGATGG
AAATCCTTTTTTTCCCACACAGGAAATTTTGTTTCAGATCGCTTCCGAAGAAAAAATCAACGTGTTTGGAGTAGGTGCCA
AGTATATTCTTACATTAGAAAAATCTAAATTTCAACCCAAGGATTTTGATCTTTCCACTATAAGAACCGTGTTGTCTACG
GGTTCTCCTCTTACTACGTCCGGTTTTAGATACGTATATCAACATTGGAAAAAGGATCTTCAACTTTCCTCTATTTCGGG
AGGAACGGATTTAAACGGATGTTTTGCCTTGGGGAATCCGATCTTGCCAGTTTATGAAGGAGAAATTCAATGCAGAGGTC
TTGGAATGGACGTAGAGATCTGGAACGAATCTGCAAAATCCGTAATAGAACAAAAAGGGGAACTCGTATGCAAACAACCT
TTTCCTTCTATGCCTCTTTATTTTTGGAAAGATCCAGAAGGAAAAAAATATAAGTCTGCTTATTTTGAATCGTATCCATC
GGTTTGGTGTCACGGAGATTTTGCGGAATTAAAAAAGTCCGGCGGGCTTGTGGTTTATGGAAGATCTGATGCAACTCTCA
ATCCGGGAGGTGTAAGAATCGGAACCTCGGATATTTACGGTCTGATTGAAACTTTTACAGAAATCGCGGACTCTGTCATC
ATCGGTCAAGATTGGAAAGAGGACGTAAGAATCGTATTATTTTTGAAAATGATTCCTGGAAAAAAATTGGAAGATTCTCT
CGTTCAAACTTTAAAAAGAGAAATTAAAGAAAAAATTTCTCCGAAACACGTCCCTTCTAAAATACTTGAGGTCGCAGACA
TTCCTTATACGATCAATATGAAAAAAGTAGAGATCGCTGTCAAAAAAACAATACAAGGGGAACCGGTCACAAACAAAGAA
GCCTTGAGTAACCCGGAAAGTTTAGAATATTATAAAAATATTTTGGAATTAAAAGAGGATTAG

Upstream 100 bases:

>100_bases
AAACATAAACGGAGCGGTTCGTTCCTCAATCAAAATTCATGTTGACCCTAGCTTTCTAAAAAAATGATATAGAGAGCTAA
AAAACGAAATCGAGTTTTAC

Downstream 100 bases:

>100_bases
AAATAAGTTATGTATTTTATATGAAGACACATGAAATTGTATTTATTTTTGAGTTTTTTAGAGAAAGAACTTAGAATTCT
CTGTCCCAAAACTGGGATAG

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MDQKLWTPSSDRIESSNLVRYIKFLKEKKNLSLSTFEELRVWSVNEIGSFWESIWEFSEVVHSQKYDLVYQSGSNFTDSK
FFPGAKLNFAENLLRRTDSFPALIYRGEDGSKREVSYAELYSYVGAVATDLKKRGVVPGDRVVGLMPNVPETVIAMLATT
SIGAIWSSCSPDFGVKGVLDRFGQIEPKILFTTNLYSFKGKDLSLAENLTQILKSIPSIEAVIVSDYKNGILHFKNRTKT
VLPENYPQKNIHLFETVLFENEGASPNFYQTNFDHPVYIMYSSGTTGLPKCMVQGVGVFLNHWKELALHCDLKPGERIFY
YTTCGWMMWNWLVSSLSIGATLVLFDGNPFFPTQEILFQIASEEKINVFGVGAKYILTLEKSKFQPKDFDLSTIRTVLST
GSPLTTSGFRYVYQHWKKDLQLSSISGGTDLNGCFALGNPILPVYEGEIQCRGLGMDVEIWNESAKSVIEQKGELVCKQP
FPSMPLYFWKDPEGKKYKSAYFESYPSVWCHGDFAELKKSGGLVVYGRSDATLNPGGVRIGTSDIYGLIETFTEIADSVI
IGQDWKEDVRIVLFLKMIPGKKLEDSLVQTLKREIKEKISPKHVPSKILEVADIPYTINMKKVEIAVKKTIQGEPVTNKE
ALSNPESLEYYKNILELKED

Sequences:

>Translated_660_residues
MDQKLWTPSSDRIESSNLVRYIKFLKEKKNLSLSTFEELRVWSVNEIGSFWESIWEFSEVVHSQKYDLVYQSGSNFTDSK
FFPGAKLNFAENLLRRTDSFPALIYRGEDGSKREVSYAELYSYVGAVATDLKKRGVVPGDRVVGLMPNVPETVIAMLATT
SIGAIWSSCSPDFGVKGVLDRFGQIEPKILFTTNLYSFKGKDLSLAENLTQILKSIPSIEAVIVSDYKNGILHFKNRTKT
VLPENYPQKNIHLFETVLFENEGASPNFYQTNFDHPVYIMYSSGTTGLPKCMVQGVGVFLNHWKELALHCDLKPGERIFY
YTTCGWMMWNWLVSSLSIGATLVLFDGNPFFPTQEILFQIASEEKINVFGVGAKYILTLEKSKFQPKDFDLSTIRTVLST
GSPLTTSGFRYVYQHWKKDLQLSSISGGTDLNGCFALGNPILPVYEGEIQCRGLGMDVEIWNESAKSVIEQKGELVCKQP
FPSMPLYFWKDPEGKKYKSAYFESYPSVWCHGDFAELKKSGGLVVYGRSDATLNPGGVRIGTSDIYGLIETFTEIADSVI
IGQDWKEDVRIVLFLKMIPGKKLEDSLVQTLKREIKEKISPKHVPSKILEVADIPYTINMKKVEIAVKKTIQGEPVTNKE
ALSNPESLEYYKNILELKED
>Mature_660_residues
MDQKLWTPSSDRIESSNLVRYIKFLKEKKNLSLSTFEELRVWSVNEIGSFWESIWEFSEVVHSQKYDLVYQSGSNFTDSK
FFPGAKLNFAENLLRRTDSFPALIYRGEDGSKREVSYAELYSYVGAVATDLKKRGVVPGDRVVGLMPNVPETVIAMLATT
SIGAIWSSCSPDFGVKGVLDRFGQIEPKILFTTNLYSFKGKDLSLAENLTQILKSIPSIEAVIVSDYKNGILHFKNRTKT
VLPENYPQKNIHLFETVLFENEGASPNFYQTNFDHPVYIMYSSGTTGLPKCMVQGVGVFLNHWKELALHCDLKPGERIFY
YTTCGWMMWNWLVSSLSIGATLVLFDGNPFFPTQEILFQIASEEKINVFGVGAKYILTLEKSKFQPKDFDLSTIRTVLST
GSPLTTSGFRYVYQHWKKDLQLSSISGGTDLNGCFALGNPILPVYEGEIQCRGLGMDVEIWNESAKSVIEQKGELVCKQP
FPSMPLYFWKDPEGKKYKSAYFESYPSVWCHGDFAELKKSGGLVVYGRSDATLNPGGVRIGTSDIYGLIETFTEIADSVI
IGQDWKEDVRIVLFLKMIPGKKLEDSLVQTLKREIKEKISPKHVPSKILEVADIPYTINMKKVEIAVKKTIQGEPVTNKE
ALSNPESLEYYKNILELKED

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=664, Percent_Identity=42.4698795180723, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI28416953, Length=644, Percent_Identity=25.9316770186335, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI253970489, Length=651, Percent_Identity=24.1167434715822, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI8923896, Length=638, Percent_Identity=24.4514106583072, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI13375727, Length=605, Percent_Identity=23.3057851239669, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1790505, Length=608, Percent_Identity=24.1776315789474, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786529, Length=654, Percent_Identity=21.7125382262997, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17569507, Length=639, Percent_Identity=39.4366197183099, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71982997, Length=642, Percent_Identity=22.2741433021807, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983001, Length=642, Percent_Identity=22.2741433021807, Blast_Score=118, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6323182, Length=651, Percent_Identity=24.8847926267281, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319264, Length=686, Percent_Identity=23.1778425655977, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=25, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI62472339, Length=567, Percent_Identity=25.0440917107584, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355225, Length=598, Percent_Identity=24.7491638795987, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24667959, Length=530, Percent_Identity=24.3396226415094, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 74577; Mature: 74577

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQKLWTPSSDRIESSNLVRYIKFLKEKKNLSLSTFEELRVWSVNEIGSFWESIWEFSEV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECHHHHHHHHHHHHHHHHH
VHSQKYDLVYQSGSNFTDSKFFPGAKLNFAENLLRRTDSFPALIYRGEDGSKREVSYAEL
HHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
YSYVGAVATDLKKRGVVPGDRVVGLMPNVPETVIAMLATTSIGAIWSSCSPDFGVKGVLD
HHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RFGQIEPKILFTTNLYSFKGKDLSLAENLTQILKSIPSIEAVIVSDYKNGILHFKNRTKT
HHCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCC
VLPENYPQKNIHLFETVLFENEGASPNFYQTNFDHPVYIMYSSGTTGLPKCMVQGVGVFL
CCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHH
NHWKELALHCDLKPGERIFYYTTCGWMMWNWLVSSLSIGATLVLFDGNPFFPTQEILFQI
HHHHHHHEEECCCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
ASEEKINVFGVGAKYILTLEKSKFQPKDFDLSTIRTVLSTGSPLTTSGFRYVYQHWKKDL
HCCCCEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
QLSSISGGTDLNGCFALGNPILPVYEGEIQCRGLGMDVEIWNESAKSVIEQKGELVCKQP
EEEECCCCCCCCCEEECCCCCCEEECCCEEEEECCCCCEEHHHHHHHHHHHCCCEEECCC
FPSMPLYFWKDPEGKKYKSAYFESYPSVWCHGDFAELKKSGGLVVYGRSDATLNPGGVRI
CCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHCCCEEEECCCCCEECCCCEEE
GTSDIYGLIETFTEIADSVIIGQDWKEDVRIVLFLKMIPGKKLEDSLVQTLKREIKEKIS
CHHHHHHHHHHHHHHHCCEEECCCCHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PKHVPSKILEVADIPYTINMKKVEIAVKKTIQGEPVTNKEALSNPESLEYYKNILELKED
CCCCHHHHHHHHCCCEEECCCEEEEEEHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDQKLWTPSSDRIESSNLVRYIKFLKEKKNLSLSTFEELRVWSVNEIGSFWESIWEFSEV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECHHHHHHHHHHHHHHHHH
VHSQKYDLVYQSGSNFTDSKFFPGAKLNFAENLLRRTDSFPALIYRGEDGSKREVSYAEL
HHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
YSYVGAVATDLKKRGVVPGDRVVGLMPNVPETVIAMLATTSIGAIWSSCSPDFGVKGVLD
HHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RFGQIEPKILFTTNLYSFKGKDLSLAENLTQILKSIPSIEAVIVSDYKNGILHFKNRTKT
HHCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCC
VLPENYPQKNIHLFETVLFENEGASPNFYQTNFDHPVYIMYSSGTTGLPKCMVQGVGVFL
CCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHH
NHWKELALHCDLKPGERIFYYTTCGWMMWNWLVSSLSIGATLVLFDGNPFFPTQEILFQI
HHHHHHHEEECCCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
ASEEKINVFGVGAKYILTLEKSKFQPKDFDLSTIRTVLSTGSPLTTSGFRYVYQHWKKDL
HCCCCEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
QLSSISGGTDLNGCFALGNPILPVYEGEIQCRGLGMDVEIWNESAKSVIEQKGELVCKQP
EEEECCCCCCCCCEEECCCCCCEEECCCEEEEECCCCCEEHHHHHHHHHHHCCCEEECCC
FPSMPLYFWKDPEGKKYKSAYFESYPSVWCHGDFAELKKSGGLVVYGRSDATLNPGGVRI
CCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHCCCEEEECCCCCEECCCCEEE
GTSDIYGLIETFTEIADSVIIGQDWKEDVRIVLFLKMIPGKKLEDSLVQTLKREIKEKIS
CHHHHHHHHHHHHHHHCCEEECCCCHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PKHVPSKILEVADIPYTINMKKVEIAVKKTIQGEPVTNKEALSNPESLEYYKNILELKED
CCCCHHHHHHHHCCCEEECCCEEEEEEHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]