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The map label for this gene is thrS

Identifier: 45658307

GI number: 45658307

Start: 2981653

End: 2983569

Strand: Reverse

Name: thrS

Synonym: LIC12465

Alternate gene names: 45658307

Gene position: 2983569-2981653 (Counterclockwise)

Preceding gene: 45658313

Following gene: 45658305

Centisome position: 69.76

GC content: 38.08

Gene sequence:

>1917_bases
ATGTATCAACTGACTCTGCCGGACAAATCAATCAAAGAAGTTGCATCCGGTTTCACTTATCGTGACTTTATTGAAAAAGA
ATTACCCTTTTTAAAGAACAAAGCACTTGCAGTGCGTTTGAATGGTGAAGAAATTTTAGACTTGTCCAGGACTGTGGAAA
AGAATTCAAACATAGAAGTATTGACCTATTCCGAAAAATTAGGTTGGGAAACGTTTCAACATTCCGCGGCGCATTTGCTC
GGAATGGCGGTTCAAAATTTATATAAAAATGCAAATCTCACCGTAGGTCCTGTGATCGATAACGGCCCTGGATTTTTTTA
TTACGATATAGACTTTCAAGGAGCGATTGTCACTCCGGAAGATTTTCCTAAAATCGAAGCTGAGATGGAGAAAATCGTAA
AAGCAGATCATCCAGTTTGGAGAAAGGTAGTCTCTAAAAAACAGGCGATTGAAACCTTTCAAAAACTAGGGGAAAAATAT
AAAATAGAAATCATAGACGGAATACCAAGCGAGGAAGTTTCCATCTATGGGATGGGAGAATGGTTCGATCTTTGTCGTGG
GCCACACGTTCCTAATTCTGGAGTATTAAAATCTTTTAAACTAACTGCAATTTCAGGTGCGTATTGGAAAGCCGACAAAA
ACAACTCGATGCTTACCCGTATTTATGGAGTTGCCTTTCCAACAAAAAAAGAATTGGATCAATATCTTTTTCAAATTGAG
GAAGCGAAGAAAAGAGATCATAGAAAGATCGGAAAAGAGATGGATCTATTTTCTTTTCAAAAGGAAGGTCCAGGGTTTCC
TTTTTGGCATCCCAAAGGAACAATTCTTTGGAATTCACTCGCAGAGTATCTTCGTTCCGAATGTAACAAAAGAGGTTATC
AGGAAATCAAAACGCCTGCGGTACTTTCTTCCGAACTTTGGAAGAAGTCCGGTCATTGGGATAATTTTCATGAGAACATG
TATTTTACGGACATAGACGAAGAAGATTACGCACTCAAACCGATGAACTGTCCAGGATGTTCTTTAATTTATAAACATCA
TCTGCATTCGTATCGGGAGCTTCCGCTTCGATTTGCCGAATTTGGAAGTGTACATCGTCACGAGTTACACGGAGTGTTAC
ACGGACTTTTTAGAGTTAGGGCATTTACTCAAGACGATTCTCATATCTATGCTCCTTTGGATTATTTGGAATCCGAAGTC
ATGGACATCATAGACTTTACATTTACAGTATATAAGAAATTTGGATTTTCAGAATTTAAAACTTTTATAGCAACCCGTCC
AGAAAAATCACAGGGGAAAGACGAAGATTGGGAATTTGCTACGAGCACCTTAAAACAATCTTTAGAAAAAAAAGGGATTC
CGTATGGAATTAAAGAAGGCGAAGGTGCGTTCTATGGACCGAAGATAGAATTTAATATTAAAGATTCTATTGGAAGACTT
TGGCAGTGTGGAACGATTCAAGTGGATTTTTCTATGCCAGAACGTTTTGATTTGGATTATACGGATAGTGATGGTCAGAA
AAAAAGACCGGTGATGATCCATCGCGCCATCTACGGTTCTTTAGAAAGATTCATCGGAATTTTAATTGAACATTACGAAG
GAAAATTTCCACTTTGGATTTCTCCGAATCAGATCCGAATTTTGACCGTAACCGAAAAAGTAACCGATTACGCTAAAAAC
GTTTATCGAGAATTACTCGACTCCGGTTTTCGAGTGGAACTGGATACTCGAAACGAAAAAATTGGAGCTAAAATCAGGGA
TTCTATATTAAAAAAAGCGAATTATCTTTTGATATTGGGAGAAAAGGAAATGGAATCGAACACACTTGCAGTGAGAATGC
GAGGTCAAGAAGATACTAAAATCTTGACCCGGACCGGTTTCATTTCGAATCTTCAAGATGAAATCAAGTCGAGTTAA

Upstream 100 bases:

>100_bases
TTTGAGAATGAAGGTTTAATATTTGTGGCGTGAAATCTTGATTTTATAGCCGAATTTTTCAGACAGGAAAAAATAGAATT
TTAGGATAAGCCGTAAGAAT

Downstream 100 bases:

>100_bases
AATAACTTTGGGTTTTCGAGAAAGACAAAATGTTTTGTCGGAATCTTTTTGGGAAATTTGAGACCTCTTCCAAATTTTGT
CCCAATTCTCAAAAACAAAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEVLTYSEKLGWETFQHSAAHLL
GMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPEDFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKY
KIEIIDGIPSEEVSIYGMGEWFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIE
EAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPAVLSSELWKKSGHWDNFHENM
YFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAEFGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEV
MDIIDFTFTVYKKFGFSEFKTFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRL
WQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWISPNQIRILTVTEKVTDYAKN
VYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILGEKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS

Sequences:

>Translated_638_residues
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEVLTYSEKLGWETFQHSAAHLL
GMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPEDFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKY
KIEIIDGIPSEEVSIYGMGEWFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIE
EAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPAVLSSELWKKSGHWDNFHENM
YFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAEFGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEV
MDIIDFTFTVYKKFGFSEFKTFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRL
WQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWISPNQIRILTVTEKVTDYAKN
VYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILGEKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS
>Mature_638_residues
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEVLTYSEKLGWETFQHSAAHLL
GMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPEDFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKY
KIEIIDGIPSEEVSIYGMGEWFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIE
EAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPAVLSSELWKKSGHWDNFHENM
YFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAEFGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEV
MDIIDFTFTVYKKFGFSEFKTFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRL
WQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWISPNQIRILTVTEKVTDYAKN
VYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILGEKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=573, Percent_Identity=42.7574171029668, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI38570111, Length=620, Percent_Identity=40.9677419354839, Blast_Score=481, Evalue=1e-135,
Organism=Homo sapiens, GI20070344, Length=634, Percent_Identity=36.9085173501577, Blast_Score=419, Evalue=1e-117,
Organism=Escherichia coli, GI1788013, Length=639, Percent_Identity=44.131455399061, Blast_Score=577, Evalue=1e-165,
Organism=Escherichia coli, GI1786392, Length=160, Percent_Identity=26.875, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71984184, Length=619, Percent_Identity=40.7108239095315, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=40.7108239095315, Blast_Score=498, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322112, Length=632, Percent_Identity=40.3481012658228, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322654, Length=395, Percent_Identity=39.4936708860759, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24583842, Length=604, Percent_Identity=40.2317880794702, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI28574141, Length=604, Percent_Identity=40.2317880794702, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583839, Length=604, Percent_Identity=40.2317880794702, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73787; Mature: 73787

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEV
CEEEECCCHHHHHHHCCCHHHHHHHHHCCHHCCCEEEEEECCHHHHHHHHHHCCCCCEEE
LTYSEKLGWETFQHSAAHLLGMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPE
EEECHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEECCCCEEEEEEEECCEEECCC
DFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKYKIEIIDGIPSEEVSIYGMGE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCH
WFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIE
HHHHHCCCCCCCCCCCCEEEEEEECCCEEECCCCCCEEEHEECCCCCCHHHHHHHHHHHH
EAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPA
HHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCH
VLSSELWKKSGHWDNFHENMYFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAE
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHH
FGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEVMDIIDFTFTVYKKFGFSEFK
HCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
TFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEEEEHHHHHHH
WQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWI
EECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEE
SPNQIRILTVTEKVTDYAKNVYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILG
CCCEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
EKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS
CCCCCCCEEEEEECCCCCCEEEEHHCCHHHHHHHHCCC
>Mature Secondary Structure
MYQLTLPDKSIKEVASGFTYRDFIEKELPFLKNKALAVRLNGEEILDLSRTVEKNSNIEV
CEEEECCCHHHHHHHCCCHHHHHHHHHCCHHCCCEEEEEECCHHHHHHHHHHCCCCCEEE
LTYSEKLGWETFQHSAAHLLGMAVQNLYKNANLTVGPVIDNGPGFFYYDIDFQGAIVTPE
EEECHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEECCCCEEEEEEEECCEEECCC
DFPKIEAEMEKIVKADHPVWRKVVSKKQAIETFQKLGEKYKIEIIDGIPSEEVSIYGMGE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCH
WFDLCRGPHVPNSGVLKSFKLTAISGAYWKADKNNSMLTRIYGVAFPTKKELDQYLFQIE
HHHHHCCCCCCCCCCCCEEEEEEECCCEEECCCCCCEEEHEECCCCCCHHHHHHHHHHHH
EAKKRDHRKIGKEMDLFSFQKEGPGFPFWHPKGTILWNSLAEYLRSECNKRGYQEIKTPA
HHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCH
VLSSELWKKSGHWDNFHENMYFTDIDEEDYALKPMNCPGCSLIYKHHLHSYRELPLRFAE
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHH
FGSVHRHELHGVLHGLFRVRAFTQDDSHIYAPLDYLESEVMDIIDFTFTVYKKFGFSEFK
HCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHH
TFIATRPEKSQGKDEDWEFATSTLKQSLEKKGIPYGIKEGEGAFYGPKIEFNIKDSIGRL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEEEEHHHHHHH
WQCGTIQVDFSMPERFDLDYTDSDGQKKRPVMIHRAIYGSLERFIGILIEHYEGKFPLWI
EECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEE
SPNQIRILTVTEKVTDYAKNVYRELLDSGFRVELDTRNEKIGAKIRDSILKKANYLLILG
CCCEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
EKEMESNTLAVRMRGQEDTKILTRTGFISNLQDEIKSS
CCCCCCCEEEEEECCCCCCEEEEHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA