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The map label for this gene is lolC [H]

Identifier: 45658274

GI number: 45658274

Start: 2948277

End: 2949515

Strand: Reverse

Name: lolC [H]

Synonym: LIC12429

Alternate gene names: 45658274

Gene position: 2949515-2948277 (Counterclockwise)

Preceding gene: 45658275

Following gene: 45658273

Centisome position: 68.96

GC content: 39.31

Gene sequence:

>1239_bases
ATGTGGTTTATCGCGATCAGACAAATGTTAGTCAGAGGAAAACAAACTCTGACTACACTCTCGGGGATTGTTTTGGGGAC
GGCAGCTTTTATCATCATATCCGGAGTTCTTTTAGGATTTAGAGGTTATCTAGTCGATCAGTTAATCAATTCCGATTGTC
ACATTCGGATTAGCTCTAGACAGGAAATTATTCAACCTAATGCTATGGATGATTTATTTCCAGGGGAAAACGTATTTTGG
ATTTCTCCCCCTTCTGGAAAACGAGGCTCCAACCATTTAAACAACGCAAGTCTTTGGTATGAAAGATTGGAACAAGATAA
AGAAGTGGAGGCGTACTCTCCTCAAGTGAGCGGAAGAATTTTTCTTTTTTCCGGTTCCAATCAAGAAGCGGGAAAAATTA
TAGGAATCATTCCATCCAGACAAACCTTGATTACTCCTCTTGCAGATTATATCATCGAAGGAAGTGTTGAATCTCTTTCG
GCGGGAAATAGAATCGTTTTAGGAGACGGACTTGCAAAACTTCTCGGACTTGGATTGAATAAAACTATCTGGTTGACTTC
GGGGTTGCAGGAAAAAACTCCGTTTCGGATTTCTGGAATTTTTCGTTCCGGGAATAAGGCTTTGGACGATGGAATCGCCT
ACGGGCTGTTATCTGAAGTTCAACTTTTGACGGCTCAGTCTGGGATGATTACCGATATAGCCGTTCGTCTCAAAGACGTA
AACCGTTCTCTACAAAAAGCGGGAGAATGGAAAAGTATCAGCGACGATAAAATTTTAAGTTGGGAAGAAGCAAATTCCAA
TTTTTTTGCGATTTTTAAATTACAAGATGCGATCCGTTATTCTATGACAGCGGCCATTTTGACGGTTGCTGGATTTGGAA
TATACAATATTTTAAATGTAATTATAAATCAGAAAAAGAGGGAAATTGCGATTCTTCGTTCAATAGGTTATAGACCAAAT
GAAGTTTTGACTATTTTCCTTTTACAAGGGTTGATTCTTGGAATTTCCGGCGGTTTAATCGGATTGTTGTTAGGTTTTTT
AGTTTGTTTAAGAATTGAATCTCTTCCTTTTACAAATCCTCTTTTTTCGGCAGGTGCCGGAAATATGGTGATTTCTTTTG
CTCCGGCGATTTATATGCAGGCGTTTATACAATCTATGGCAGCTACTTTGATCGCTAGTTGGATTCCCGCAAGATCTGCC
GGAAAACTTTCTCCAATCGAAATCATACGTGGAGAATAA

Upstream 100 bases:

>100_bases
CGGTTTCGGTCTCCTTTAAGCCGGGGTTAAAATCGGAACAGTTTGTAGAGGTAAAGGACGGAGACATACAAGCTGGGGAT
AAACTTTCGGAGGTCCCGTA

Downstream 100 bases:

>100_bases
GATGCAATTCGTAAATTCCGGAATTTCCGTAACCGATCTTAGAAAAACTTTTGGTAATTCCGAAATTATCAAAGGTGTTA
CGCTGGATATAGAGGACGGA

Product: lipoprotein releasing system, permease component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MWFIAIRQMLVRGKQTLTTLSGIVLGTAAFIIISGVLLGFRGYLVDQLINSDCHIRISSRQEIIQPNAMDDLFPGENVFW
ISPPSGKRGSNHLNNASLWYERLEQDKEVEAYSPQVSGRIFLFSGSNQEAGKIIGIIPSRQTLITPLADYIIEGSVESLS
AGNRIVLGDGLAKLLGLGLNKTIWLTSGLQEKTPFRISGIFRSGNKALDDGIAYGLLSEVQLLTAQSGMITDIAVRLKDV
NRSLQKAGEWKSISDDKILSWEEANSNFFAIFKLQDAIRYSMTAAILTVAGFGIYNILNVIINQKKREIAILRSIGYRPN
EVLTIFLLQGLILGISGGLIGLLLGFLVCLRIESLPFTNPLFSAGAGNMVISFAPAIYMQAFIQSMAATLIASWIPARSA
GKLSPIEIIRGE

Sequences:

>Translated_412_residues
MWFIAIRQMLVRGKQTLTTLSGIVLGTAAFIIISGVLLGFRGYLVDQLINSDCHIRISSRQEIIQPNAMDDLFPGENVFW
ISPPSGKRGSNHLNNASLWYERLEQDKEVEAYSPQVSGRIFLFSGSNQEAGKIIGIIPSRQTLITPLADYIIEGSVESLS
AGNRIVLGDGLAKLLGLGLNKTIWLTSGLQEKTPFRISGIFRSGNKALDDGIAYGLLSEVQLLTAQSGMITDIAVRLKDV
NRSLQKAGEWKSISDDKILSWEEANSNFFAIFKLQDAIRYSMTAAILTVAGFGIYNILNVIINQKKREIAILRSIGYRPN
EVLTIFLLQGLILGISGGLIGLLLGFLVCLRIESLPFTNPLFSAGAGNMVISFAPAIYMQAFIQSMAATLIASWIPARSA
GKLSPIEIIRGE
>Mature_412_residues
MWFIAIRQMLVRGKQTLTTLSGIVLGTAAFIIISGVLLGFRGYLVDQLINSDCHIRISSRQEIIQPNAMDDLFPGENVFW
ISPPSGKRGSNHLNNASLWYERLEQDKEVEAYSPQVSGRIFLFSGSNQEAGKIIGIIPSRQTLITPLADYIIEGSVESLS
AGNRIVLGDGLAKLLGLGLNKTIWLTSGLQEKTPFRISGIFRSGNKALDDGIAYGLLSEVQLLTAQSGMITDIAVRLKDV
NRSLQKAGEWKSISDDKILSWEEANSNFFAIFKLQDAIRYSMTAAILTVAGFGIYNILNVIINQKKREIAILRSIGYRPN
EVLTIFLLQGLILGISGGLIGLLLGFLVCLRIESLPFTNPLFSAGAGNMVISFAPAIYMQAFIQSMAATLIASWIPARSA
GKLSPIEIIRGE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=341, Percent_Identity=23.7536656891496, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787105, Length=126, Percent_Identity=32.5396825396825, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45026; Mature: 45026

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFIAIRQMLVRGKQTLTTLSGIVLGTAAFIIISGVLLGFRGYLVDQLINSDCHIRISSR
CHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
QEIIQPNAMDDLFPGENVFWISPPSGKRGSNHLNNASLWYERLEQDKEVEAYSPQVSGRI
HHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCEE
FLFSGSNQEAGKIIGIIPSRQTLITPLADYIIEGSVESLSAGNRIVLGDGLAKLLGLGLN
EEEECCCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHHHCCCCEEEECCCHHHHHCCCCC
KTIWLTSGLQEKTPFRISGIFRSGNKALDDGIAYGLLSEVQLLTAQSGMITDIAVRLKDV
CEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NRSLQKAGEWKSISDDKILSWEEANSNFFAIFKLQDAIRYSMTAAILTVAGFGIYNILNV
HHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IINQKKREIAILRSIGYRPNEVLTIFLLQGLILGISGGLIGLLLGFLVCLRIESLPFTNP
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
LFSAGAGNMVISFAPAIYMQAFIQSMAATLIASWIPARSAGKLSPIEIIRGE
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MWFIAIRQMLVRGKQTLTTLSGIVLGTAAFIIISGVLLGFRGYLVDQLINSDCHIRISSR
CHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
QEIIQPNAMDDLFPGENVFWISPPSGKRGSNHLNNASLWYERLEQDKEVEAYSPQVSGRI
HHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCEE
FLFSGSNQEAGKIIGIIPSRQTLITPLADYIIEGSVESLSAGNRIVLGDGLAKLLGLGLN
EEEECCCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHHHCCCCEEEECCCHHHHHCCCCC
KTIWLTSGLQEKTPFRISGIFRSGNKALDDGIAYGLLSEVQLLTAQSGMITDIAVRLKDV
CEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NRSLQKAGEWKSISDDKILSWEEANSNFFAIFKLQDAIRYSMTAAILTVAGFGIYNILNV
HHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IINQKKREIAILRSIGYRPNEVLTIFLLQGLILGISGGLIGLLLGFLVCLRIESLPFTNP
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
LFSAGAGNMVISFAPAIYMQAFIQSMAATLIASWIPARSAGKLSPIEIIRGE
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]