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The map label for this gene is engA

Identifier: 45658262

GI number: 45658262

Start: 2930862

End: 2932331

Strand: Reverse

Name: engA

Synonym: LIC12417

Alternate gene names: 45658262

Gene position: 2932331-2930862 (Counterclockwise)

Preceding gene: 45658263

Following gene: 45658261

Centisome position: 68.56

GC content: 38.64

Gene sequence:

>1470_bases
ATGGCTAAAGCCGTAAAAAAAGAAATCGCAAAATCGGAAGAAGTCGTTTCGATCAAAGCCCCTCGTAAAGAACCTGGAAA
GAAAATACCAGTCGTGTCGATCGTAGGAAGACAGAACGTAGGTAAGTCTACATTATTCAATTCTCTCTTAAAGAAAAAAT
TAGCGATTACAGAAGACTATCCAGGTGTGACGCGTGACGTTCTTTCCGCAAGAATCTATCAGGAAGAAAAGGATCTCGAT
TTTTATCTTTGTGATACTCCCGGACTCGACATAGAAAATCCGGATTCACTTTCTCAAACTATATTAGAAACCGCTTATGG
ACAATTGAGAGAATCGGACGTGATCGTATTTTTACTAGATAAAAATCTGATCACTACGGCAGATCACGGTCTTCTCAATT
ATTTAAGAAGAGAAGATAAAGTGGCAAACAAACCTATCATCTATTGTGTCAATAAAGCGGATAAGGAACTGGATGAGTTT
GATCTAGAAGAATTTTACAGAATGGGACTTTCGGAAGTATTGCCGATTTCTGCAATTGGTAGAAAAAACCTAGGACTTTT
ACTTGAGAAAATTCAATTTTTTTTAAAGGATAAACCGGGTAAGGTTTGGATCGAAAAAATTTCGGCTTCTAAAAAGAAGG
AAGCGCAGCCGTTGCCGCTGGCGGAAGAAGACTACGAGTTCCGTCTTGCGATCGTTGGAAAGCCTAACTCCGGAAAATCT
AGTCTTTTAAACGCTATCTGCGGTTACGAACGTGCTGTGGTAAGTGACGTTGCGGGAACTACCCGGGATTCTATAGATAC
TCTATTAGAATTTGGTGATAGACGATTGCTTCTAACCGACACGGCGGGAATTCGAAAACAAAGTAAAACCGCAGAAGCTT
TGGAGTTTTATTCTTATCAAAGAACTATCAAGGCGATAGAATCTAGCGATTTGGTAATTCATCTTTTGGATGCAAAAAAA
GGGTTTGGGGATTTTGATAAAAAGATTACCTCACTTCTTCAAGAAAAAGGAAAACCCTTTTTGCTTGCAGTTAACAAGTG
GGATTCGATCGAAGATAAAACGGATAAAACTTTTAAAGAATATAAAGAAAAACTCTACAGTCGTTTTCCGTTGTTAAACG
AAGTGCCGATCATCACGATTAGTGCGACCGAAAGACTCCGGGTTCAAAAACTCATGGATCTTTCCTTTGATCTCGCCTCG
CGTTCACACAGAAAGGTGAGCACTTCTGAACTCAATAAAAATCTAAAAAACTGGATGGGACTTGCAGGAAGGTCTTTTTC
TGCACATCAACCTCCTAAGATGCTTTATTGTACTCAAGTATCCACTTCTCCTTTTCATCTCATTTTGTTTGTAAATCACG
TAGAATACTTTAAATCGAATTTAGTTTCTTTTCTGAAAAAAAAACTCACGGAAACCTATGACCTTCAAGGAATTCCGATT
CGATTAGAGTTTCGATCGGATCGAAAATGA

Upstream 100 bases:

>100_bases
ACGGGACGATTTACAAAAAAAAGACGCTCAACAAGAAATTGCACGCGCATTGAAATCATCCAATCGTTATCAATGAACGA
CCGCAAAAATTAGGATTAAG

Downstream 100 bases:

>100_bases
ATTTTCCAATTTTTGCATTATTTAGTTTTATATCTGGTTCGATTCCTTTCGGATATTGGATTGCACTTCGGTTTGCCGGA
GTAGATATTCGTAAATTAGG

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MAKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDYPGVTRDVLSARIYQEEKDLD
FYLCDTPGLDIENPDSLSQTILETAYGQLRESDVIVFLLDKNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEF
DLEEFYRMGLSEVLPISAIGRKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKS
SLLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQRTIKAIESSDLVIHLLDAKK
GFGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKEYKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLAS
RSHRKVSTSELNKNLKNWMGLAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPI
RLEFRSDRK

Sequences:

>Translated_489_residues
MAKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDYPGVTRDVLSARIYQEEKDLD
FYLCDTPGLDIENPDSLSQTILETAYGQLRESDVIVFLLDKNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEF
DLEEFYRMGLSEVLPISAIGRKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKS
SLLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQRTIKAIESSDLVIHLLDAKK
GFGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKEYKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLAS
RSHRKVSTSELNKNLKNWMGLAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPI
RLEFRSDRK
>Mature_488_residues
AKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDYPGVTRDVLSARIYQEEKDLDF
YLCDTPGLDIENPDSLSQTILETAYGQLRESDVIVFLLDKNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEFD
LEEFYRMGLSEVLPISAIGRKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKSS
LLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQRTIKAIESSDLVIHLLDAKKG
FGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKEYKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLASR
SHRKVSTSELNKNLKNWMGLAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPIR
LEFRSDRK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=474, Percent_Identity=31.2236286919831, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI2367268, Length=92, Percent_Identity=40.2173913043478, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788919, Length=152, Percent_Identity=32.2368421052632, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17507259, Length=89, Percent_Identity=41.5730337078652, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323665, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550813, Length=92, Percent_Identity=43.4782608695652, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_LEPIC (Q72PQ1)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002348.1
- ProteinModelPortal:   Q72PQ1
- SMR:   Q72PQ1
- GeneID:   2771800
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12417
- NMPDR:   fig|267671.1.peg.2348
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   LINT267671:LIC_12417-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 55606; Mature: 55475

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDY
CCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCC
PGVTRDVLSARIYQEEKDLDFYLCDTPGLDIENPDSLSQTILETAYGQLRESDVIVFLLD
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
KNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEFDLEEFYRMGLSEVLPISAIG
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCHHHHHHCCHHHHCCHHHCC
RKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKS
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCEEEEEEEECCCCCHH
SLLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RTIKAIESSDLVIHLLDAKKGFGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKE
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
YKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLASRSHRKVSTSELNKNLKNWMG
HHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
LAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPI
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
RLEFRSDRK
EEEECCCCC
>Mature Secondary Structure 
AKAVKKEIAKSEEVVSIKAPRKEPGKKIPVVSIVGRQNVGKSTLFNSLLKKKLAITEDY
CHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCC
PGVTRDVLSARIYQEEKDLDFYLCDTPGLDIENPDSLSQTILETAYGQLRESDVIVFLLD
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
KNLITTADHGLLNYLRREDKVANKPIIYCVNKADKELDEFDLEEFYRMGLSEVLPISAIG
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCHHHHHHCCHHHHCCHHHCC
RKNLGLLLEKIQFFLKDKPGKVWIEKISASKKKEAQPLPLAEEDYEFRLAIVGKPNSGKS
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCEEEEEEEECCCCCHH
SLLNAICGYERAVVSDVAGTTRDSIDTLLEFGDRRLLLTDTAGIRKQSKTAEALEFYSYQ
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RTIKAIESSDLVIHLLDAKKGFGDFDKKITSLLQEKGKPFLLAVNKWDSIEDKTDKTFKE
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
YKEKLYSRFPLLNEVPIITISATERLRVQKLMDLSFDLASRSHRKVSTSELNKNLKNWMG
HHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
LAGRSFSAHQPPKMLYCTQVSTSPFHLILFVNHVEYFKSNLVSFLKKKLTETYDLQGIPI
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
RLEFRSDRK
EEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA