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The map label for this gene is proC

Identifier: 45658123

GI number: 45658123

Start: 2747745

End: 2748518

Strand: Reverse

Name: proC

Synonym: LIC12275

Alternate gene names: 45658123

Gene position: 2748518-2747745 (Counterclockwise)

Preceding gene: 45658124

Following gene: 304570498

Centisome position: 64.26

GC content: 39.79

Gene sequence:

>774_bases
ATGAAATATACGATAGGAATTGCGGGTTGTGGAAATATGGGAGGAGCAATTTATTTCTCTCTTAAAGAACGTTATCCGAC
ACAAGTATTGGGATATGATCCTTATATAATTTCCAATCAAAAGATAGAACTTATATCTTCCTGGGATGAATTTGTTTCTA
AGTCCGATTTAATACTCGTTTGTGTAAAACCTGGAAAGGTGATTGAACTTTTAAGACAAATCAAAGTTCCTAAAAAAATT
ATATCCGTTGCCGCTGGAATTCATATCGATACAATTCTAAAAAATCTTCCGACGGGATCCAATGTAGTGAGGGTAATGCC
TAATTTACCTTTACTAGTTTCAGAAGGGGCGATCGGATTTTTCGGAGACGAAGAGTTATACGAAACCGTTTCCGAGATCT
TTCAGCCTTTAGGACATTCTGTAAAACTCGGTAGTGAGACTCTCATGGACGCGGTTACTGGACTTTCCGGATCGGGCCCG
GCCTATGTTTTTAAATTTATACAAGCTTTAGCAGAAGGTGGCGTTCTTTCCGGCTTGGGGTATCAAGAAGCGTTGGATCT
CAGCATACAAACAGTGATCGGTTCTGCACAGCTTCTTAGAAAAGAAAGAGAGAAAGATCCGACAACTCATCCAGAAGTGT
GGAAAAATAAAGTAACTTCTCCAGGAGGAACTACGATAGCTGGGCTTGTGGAATTGGAAAAAAATGGATTTAGCAATGCG
GTTTTAGAGGCGGTAAAAGCTGCAGCAAATCGTTCTAAAGAGTTGGGAGTTTAA

Upstream 100 bases:

>100_bases
AAACTTTCTATGGGAATGTCTGGAGATTATAAAATCGCGATCGAAGAGGGAAGTGATTTTGTTAGGATTGGAAGTGCGAT
TTTTGGAGAAAGAAATTGAT

Downstream 100 bases:

>100_bases
AATTATTTAAACAAACTATACTTGTTTCTAATTCATTTGGATCTGTAATTGGAATGTACTAAAATTTTATAAAAATCTAG
GAACTGCTTCCAAAAAAAGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILVCVKPGKVIELLRQIKVPKKI
ISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGFFGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGP
AYVFKFIQALAEGGVLSGLGYQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNA
VLEAVKAAANRSKELGV

Sequences:

>Translated_257_residues
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILVCVKPGKVIELLRQIKVPKKI
ISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGFFGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGP
AYVFKFIQALAEGGVLSGLGYQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNA
VLEAVKAAANRSKELGV
>Mature_257_residues
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILVCVKPGKVIELLRQIKVPKKI
ISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGFFGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGP
AYVFKFIQALAEGGVLSGLGYQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNA
VLEAVKAAANRSKELGV

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=225, Percent_Identity=37.7777777777778, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI24797097, Length=225, Percent_Identity=36, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24797095, Length=225, Percent_Identity=36, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=32.7067669172932, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=34.5588235294118, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=218, Percent_Identity=39.4495412844037, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=215, Percent_Identity=35.3488372093023, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=31.2714776632302, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21358587, Length=221, Percent_Identity=39.3665158371041, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=32.5, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=41.0404624277457, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27609; Mature: 27609

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILV
CEEEEEEECCCCCCCEEEEEECCCCCCEEECCCCEEECCCCHHHHHHHHHHCCCCCEEEE
CVKPGKVIELLRQIKVPKKIISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGF
EECCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCEEEECCCEEE
FGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGPAYVFKFIQALAEGGVLSGLG
CCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
YQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCHHH
VLEAVKAAANRSKELGV
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKYTIGIAGCGNMGGAIYFSLKERYPTQVLGYDPYIISNQKIELISSWDEFVSKSDLILV
CEEEEEEECCCCCCCEEEEEECCCCCCEEECCCCEEECCCCHHHHHHHHHHCCCCCEEEE
CVKPGKVIELLRQIKVPKKIISVAAGIHIDTILKNLPTGSNVVRVMPNLPLLVSEGAIGF
EECCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCEEEECCCEEE
FGDEELYETVSEIFQPLGHSVKLGSETLMDAVTGLSGSGPAYVFKFIQALAEGGVLSGLG
CCCHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
YQEALDLSIQTVIGSAQLLRKEREKDPTTHPEVWKNKVTSPGGTTIAGLVELEKNGFSNA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCHHH
VLEAVKAAANRSKELGV
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]