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The map label for this gene is lhgO [H]

Identifier: 45658053

GI number: 45658053

Start: 2657127

End: 2658224

Strand: Reverse

Name: lhgO [H]

Synonym: LIC12204

Alternate gene names: 45658053

Gene position: 2658224-2657127 (Counterclockwise)

Preceding gene: 45658054

Following gene: 45658052

Centisome position: 62.15

GC content: 32.97

Gene sequence:

>1098_bases
TTGATTTTAGTAATAGGTTCCGGCATAGTTGGAAGTTGGATCGCTTATCAAATTTCTAAGAATACCCAAGCAGATGTTTA
TTTATGTGATTCATCAGAAAATAGGGGCGATGGTATCAGCGGAAGGAATTCAGGTGTTTTACATTCTGGGATTTACTATG
CAGAAAATTCTCAAAAATTAAAACACTGTCTAAGAGGTTATGAGTTATCATTAGAGTTTTTTAATCGATTTAACGTCCCT
TATAGTATTTGTGGTAAGATAATCACAACCGGAGTTAAAGAAGATTCTTCTATTGAGTTGCAAAAAAAAGAAAAGTTAGA
TGAACTTTATTATAAATCTGTAAAATACGATATTCGAAATACATTTTATATAAAAAATCTTACTTCTGAATATCCTTTTC
TTTTGGGAGAAAATGCAATTTACCTTTCGAAAACCGGAGTAGTAGACGTTTCTCTTTATTTGAAAGCTTTGTGGAGAGAG
TGTGAAAATGCTGGAGTCACTTTCATTAAAGGTAAACGTTTTCTTTTTCGTGAAGAAACTCCCTTTTTTTATGATACGCA
GTCAGGGCAAATGGAAGAAATTGAGGCCGATTGTATTGTGAATGCTGGGGGGCTTCATTCAGATGAGCTTATAAGGCAGT
TGAAAGAATTAAAATATGAAATTCGTCCGAATAAAGGTGAGTATTACCGTTTAAGAAGAGAACTTCCATTTAAAAAATTG
GTTTATCCTCTTCCATCTTATTCAAGCACTGCATTAGGTGTTCATTATACGTTTCATCTCAATGGTGAGTCTTATGCAGG
TCCAAATTCTAATTGGGCTGAATCTAAAACGGATTATAAATTTCAAACGTCTAGAAATGTTTTCTTTAATTCTTTAAAAA
ATATTACCAATTATTACACTGAGGAAGATTTAACTCAAGGTTACGTAGGATTAAGACCTAGATTATTTTTTGATAATAAA
CCAATTACTGATTTTGTAATCAAAAAATATCCAGAAAATCGTCCCTGGATTCATCTACTGGGGATTGAAAGTCCCGGACT
TACTTCTTCTCCTTCGATTGGCGAAGAAGTGTTTCTATTAGTCAAATCGCTGATTTAG

Upstream 100 bases:

>100_bases
CTTCATAAAATGGGGTGGAAACATCAGGTGGAATTGAAAGAAGGGATTCGGTTGGCGTTTGAGGATTATAAAACGGTAAT
ATGAAGGACGTATTAACCAT

Downstream 100 bases:

>100_bases
TAATTTTTTCTTTATGTAAGAGGAAAAGCAGATGTTAGATCATTACAATGCCTATATAGGCCGTCTTCAATCCGTTCTTG
TTCCCGAAAGAGCATCAGAA

Product: FAD-dependent oxidoreductase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MILVIGSGIVGSWIAYQISKNTQADVYLCDSSENRGDGISGRNSGVLHSGIYYAENSQKLKHCLRGYELSLEFFNRFNVP
YSICGKIITTGVKEDSSIELQKKEKLDELYYKSVKYDIRNTFYIKNLTSEYPFLLGENAIYLSKTGVVDVSLYLKALWRE
CENAGVTFIKGKRFLFREETPFFYDTQSGQMEEIEADCIVNAGGLHSDELIRQLKELKYEIRPNKGEYYRLRRELPFKKL
VYPLPSYSSTALGVHYTFHLNGESYAGPNSNWAESKTDYKFQTSRNVFFNSLKNITNYYTEEDLTQGYVGLRPRLFFDNK
PITDFVIKKYPENRPWIHLLGIESPGLTSSPSIGEEVFLLVKSLI

Sequences:

>Translated_365_residues
MILVIGSGIVGSWIAYQISKNTQADVYLCDSSENRGDGISGRNSGVLHSGIYYAENSQKLKHCLRGYELSLEFFNRFNVP
YSICGKIITTGVKEDSSIELQKKEKLDELYYKSVKYDIRNTFYIKNLTSEYPFLLGENAIYLSKTGVVDVSLYLKALWRE
CENAGVTFIKGKRFLFREETPFFYDTQSGQMEEIEADCIVNAGGLHSDELIRQLKELKYEIRPNKGEYYRLRRELPFKKL
VYPLPSYSSTALGVHYTFHLNGESYAGPNSNWAESKTDYKFQTSRNVFFNSLKNITNYYTEEDLTQGYVGLRPRLFFDNK
PITDFVIKKYPENRPWIHLLGIESPGLTSSPSIGEEVFLLVKSLI
>Mature_365_residues
MILVIGSGIVGSWIAYQISKNTQADVYLCDSSENRGDGISGRNSGVLHSGIYYAENSQKLKHCLRGYELSLEFFNRFNVP
YSICGKIITTGVKEDSSIELQKKEKLDELYYKSVKYDIRNTFYIKNLTSEYPFLLGENAIYLSKTGVVDVSLYLKALWRE
CENAGVTFIKGKRFLFREETPFFYDTQSGQMEEIEADCIVNAGGLHSDELIRQLKELKYEIRPNKGEYYRLRRELPFKKL
VYPLPSYSSTALGVHYTFHLNGESYAGPNSNWAESKTDYKFQTSRNVFFNSLKNITNYYTEEDLTQGYVGLRPRLFFDNK
PITDFVIKKYPENRPWIHLLGIESPGLTSSPSIGEEVFLLVKSLI

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=258, Percent_Identity=29.0697674418605, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI87082148, Length=374, Percent_Identity=25.9358288770053, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17565764, Length=303, Percent_Identity=30.03300330033, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585081, Length=369, Percent_Identity=24.390243902439, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 41967; Mature: 41967

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00131 CARBOXYPEPT_SER_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVIGSGIVGSWIAYQISKNTQADVYLCDSSENRGDGISGRNSGVLHSGIYYAENSQKL
CEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCEEEECCCHHH
KHCLRGYELSLEFFNRFNVPYSICGKIITTGVKEDSSIELQKKEKLDELYYKSVKYDIRN
HHHHCCCEEEEHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHECCCC
TFYIKNLTSEYPFLLGENAIYLSKTGVVDVSLYLKALWRECENAGVTFIKGKRFLFREET
EEEEECCCCCCCEEECCCEEEEECCCCEEHHHHHHHHHHHHHHCCEEEEECCEEEEECCC
PFFYDTQSGQMEEIEADCIVNAGGLHSDELIRQLKELKYEIRPNKGEYYRLRRELPFKKL
CEEEECCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHEEECCCCCCEEHHHHHCCHHHH
VYPLPSYSSTALGVHYTFHLNGESYAGPNSNWAESKTDYKFQTSRNVFFNSLKNITNYYT
HCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHC
EEDLTQGYVGLRPRLFFDNKPITDFVIKKYPENRPWIHLLGIESPGLTSSPSIGEEVFLL
HHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
VKSLI
HHHHC
>Mature Secondary Structure
MILVIGSGIVGSWIAYQISKNTQADVYLCDSSENRGDGISGRNSGVLHSGIYYAENSQKL
CEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCEEEECCCHHH
KHCLRGYELSLEFFNRFNVPYSICGKIITTGVKEDSSIELQKKEKLDELYYKSVKYDIRN
HHHHCCCEEEEHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHECCCC
TFYIKNLTSEYPFLLGENAIYLSKTGVVDVSLYLKALWRECENAGVTFIKGKRFLFREET
EEEEECCCCCCCEEECCCEEEEECCCCEEHHHHHHHHHHHHHHCCEEEEECCEEEEECCC
PFFYDTQSGQMEEIEADCIVNAGGLHSDELIRQLKELKYEIRPNKGEYYRLRRELPFKKL
CEEEECCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHEEECCCCCCEEHHHHHCCHHHH
VYPLPSYSSTALGVHYTFHLNGESYAGPNSNWAESKTDYKFQTSRNVFFNSLKNITNYYT
HCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHC
EEDLTQGYVGLRPRLFFDNKPITDFVIKKYPENRPWIHLLGIESPGLTSSPSIGEEVFLL
HHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
VKSLI
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]