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The map label for this gene is clpA

Identifier: 45657679

GI number: 45657679

Start: 2206601

End: 2208823

Strand: Reverse

Name: clpA

Synonym: LIC11814

Alternate gene names: 45657679

Gene position: 2208823-2206601 (Counterclockwise)

Preceding gene: 45657680

Following gene: 45657678

Centisome position: 51.64

GC content: 38.19

Gene sequence:

>2223_bases
ATGGAACGTACTTTAAGAAAGGCTTGGGAAGAAGCTAAAAAAAGAAGAAACGAATTTATTACCTTGGAACATATACTTTT
AGCTCTGACTTATGATTCTGTTGCCAAAGAAGTTTTGGAAGCCTGTGGAGCCGATATAGAAAGGTTAAGAAAGGATTTGA
TCGATTATTTGGAAAGTGAACTGGAATCTTTTCCGGAATCTTCTGGAGAAGTAGACCCTATTTATACGATTGGTGTACAA
CACGTTCTTCAGCTTGCTGAGTTTCATGTTCAATCTACTCGAAATAAAAAAATGGATGGAGGAGATGTTCTTGCCGCTTT
ATTTCGAGAAGATCAATCCAACGCTGTTTATTTTTTAGGTTCTCAGGATATTTCCAGACTGGACATCGTTCGTTATATTT
CTCACGGGATTCGTAAAGATTCTAAAAAAAATCCAGGCAAAGAAATGGCAGGAGAAGAAGGGGAAAAAATCTCCGATCCT
CTACGAGCATTTTGTGTGGATCTAACCGCAAAAGCAAAAGAAGGAAAATTAGATCCTATGGTGGGAAGAGAAGACGAACT
CGATCGGACCATTCATATTCTATGTAGAAGAAGAAAGAACAATCCTATCTTTGTGGGAGAAGCAGGAGTTGGTAAAACTT
CCATTGTGGAAGGACTTGCACAAAGAGTGGTGGACGGAAAGGTTCCGGAACCATTAAAGAATTTGAAAGTATATTCTTTA
GATATGGGGCTTTTACTCGCCGGAACTAAGTTTAGAGGGGAATTTGAAGAAAGGCTGAAAAACGTTGTCGCTCAAATCAC
CGCACAAGAAGATCACGTTCTTTTTATAGACGAAATTCATACGATTATAGGAGCCGGAGCGGTCTCTGGTGGTTCTTTAG
ATGCTTCTAATCTTTTAAAACCCGCTCTTTCCAGCGGGGAGCTTCGTTGTATCGGAACTACTACCTATAAAGAATTCAAA
ACTATATTCGAAAAAGATCATGCACTTTCCAGAAGATTTCAAAAAGTAGAAGTAGGAGAACCTTCTATTTCCGAAACGAT
AGAAATTTTAAAAGGTCTTTTGGAAAAATACGAAAGTTTTCATAAGGTCAAATATTCTTCTTCTGCAGTAGAGCAAGCTG
CTGAGTTATCGGCGCGATATATTTTAGATCGTAAACTTCCGGATAAGGCAATTGATCTTTTGGACGAGGCTGGTGCTAGG
GTTCGTCTTAGAGAAAGTGGTAAAAAAACTGTCACGGTTCGTGAAATTGAAGATTTAGTTTCTAAAATTGCAAAGGTTCC
TTCAGTCACAGTCAAAGCAGACGATCGGGAAAAACTTAAAAATTTAGATGAAGAGCTAAAGGCCAAAATTTACGGACAAG
ATTCTGCAATTGACCAACTTGTTCAGTCGATTCGACTTTCTAGAAGTGGGCTTTCTGAGCCAGGAAAACCAGTCGGCTCT
TTTTTATTTGCTGGTCCGACTGGTGTAGGTAAAACGGAATTAACTCGTAAACTCGCTGAAATCTTAGGAGTGGAACTAAT
TCGTTTTGATATGAGCGAGTATATGGAGAAACATACAGTTTCTCGTTTGATCGGTTCCCCTCCCGGTTATGTAGGTTTTG
AACAAGGGGGACAACTTACAGACGCGGTTTATAGAAATCCTCACTGTGTTCTGCTTCTAGACGAAATCGAAAAAGCTCAT
GAAGATATTTATAATATACTGTTACAGATTATGGATCACGCGACTCTAACAGATAATAATGGAAGAAAATCCGATTTTCG
TCAGGTAATTTTAGTAATGACCACAAATACGGGTGCACGAGAACGTTCTACAAATCCTGTAGGTTTTGCAAATGATCTTT
TAGAAGATAGAAGTTTGAAAGCGATCGAAAAACAATTTTCTCCAGAGTTTAGAAATCGTCTTACTGCGGTTATAGAGTTC
TCTTCTTTAAATCAAGAAAATGTAACTAAAGTGGTTGCAAAACAGCTTGCTCTTTTACAGGAAAGATTGAATTCTAAACA
AATTGAATTGGAGTTTAACGAAGATGTACTCGTTTACATCGCAGATAAGGCTTATACTCCGGAGTTTGGCGCAAGACCCG
TTCAAAGATGGATTGATACTCATATTTCAAAACGGATCTCAGAAGAAATTCTTTTTGGCGTTTTAAAATCCGGTGGAAAA
GCAAAATTGATTTCCGGTAAAGAAGGAATCGAAATGGAATTCTCTTCCGGAAAAAAGAATTAA

Upstream 100 bases:

>100_bases
TGGCGCAAGTGCAACAATTGGCGGAACAACATGGATACCCGCTTCATTGTACGATGGAAGTGGAGGAAGGAGAGGAGGAG
TCATGATTCTTACGGAAGAA

Downstream 100 bases:

>100_bases
AACCGGAAACCAGATGAAACAAATTACAATTCGTATCTTTTTGATACTTTTACTCTTCTCTTGTAGGGAAAATTCTCTTC
TGATTGAGGGGAAAAAAATT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 740

Protein sequence:

>740_residues
MERTLRKAWEEAKKRRNEFITLEHILLALTYDSVAKEVLEACGADIERLRKDLIDYLESELESFPESSGEVDPIYTIGVQ
HVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGSQDISRLDIVRYISHGIRKDSKKNPGKEMAGEEGEKISDP
LRAFCVDLTAKAKEGKLDPMVGREDELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKVYSL
DMGLLLAGTKFRGEFEERLKNVVAQITAQEDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYKEFK
TIFEKDHALSRRFQKVEVGEPSISETIEILKGLLEKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGAR
VRLRESGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKAKIYGQDSAIDQLVQSIRLSRSGLSEPGKPVGS
FLFAGPTGVGKTELTRKLAEILGVELIRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAVYRNPHCVLLLDEIEKAH
EDIYNILLQIMDHATLTDNNGRKSDFRQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEF
SSLNQENVTKVVAKQLALLQERLNSKQIELEFNEDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGVLKSGGK
AKLISGKEGIEMEFSSGKKN

Sequences:

>Translated_740_residues
MERTLRKAWEEAKKRRNEFITLEHILLALTYDSVAKEVLEACGADIERLRKDLIDYLESELESFPESSGEVDPIYTIGVQ
HVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGSQDISRLDIVRYISHGIRKDSKKNPGKEMAGEEGEKISDP
LRAFCVDLTAKAKEGKLDPMVGREDELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKVYSL
DMGLLLAGTKFRGEFEERLKNVVAQITAQEDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYKEFK
TIFEKDHALSRRFQKVEVGEPSISETIEILKGLLEKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGAR
VRLRESGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKAKIYGQDSAIDQLVQSIRLSRSGLSEPGKPVGS
FLFAGPTGVGKTELTRKLAEILGVELIRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAVYRNPHCVLLLDEIEKAH
EDIYNILLQIMDHATLTDNNGRKSDFRQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEF
SSLNQENVTKVVAKQLALLQERLNSKQIELEFNEDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGVLKSGGK
AKLISGKEGIEMEFSSGKKN
>Mature_740_residues
MERTLRKAWEEAKKRRNEFITLEHILLALTYDSVAKEVLEACGADIERLRKDLIDYLESELESFPESSGEVDPIYTIGVQ
HVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGSQDISRLDIVRYISHGIRKDSKKNPGKEMAGEEGEKISDP
LRAFCVDLTAKAKEGKLDPMVGREDELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKVYSL
DMGLLLAGTKFRGEFEERLKNVVAQITAQEDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYKEFK
TIFEKDHALSRRFQKVEVGEPSISETIEILKGLLEKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGAR
VRLRESGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKAKIYGQDSAIDQLVQSIRLSRSGLSEPGKPVGS
FLFAGPTGVGKTELTRKLAEILGVELIRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAVYRNPHCVLLLDEIEKAH
EDIYNILLQIMDHATLTDNNGRKSDFRQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEF
SSLNQENVTKVVAKQLALLQERLNSKQIELEFNEDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGVLKSGGK
AKLISGKEGIEMEFSSGKKN

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=31.438127090301, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=51.673360107095, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=394, Percent_Identity=44.4162436548223, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=267, Percent_Identity=53.5580524344569, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323002, Length=346, Percent_Identity=40.4624277456647, Blast_Score=253, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 82782; Mature: 82782

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTLRKAWEEAKKRRNEFITLEHILLALTYDSVAKEVLEACGADIERLRKDLIDYLESE
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LESFPESSGEVDPIYTIGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEC
SQDISRLDIVRYISHGIRKDSKKNPGKEMAGEEGEKISDPLRAFCVDLTAKAKEGKLDPM
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VGREDELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKVYSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCEEEEE
DMGLLLAGTKFRGEFEERLKNVVAQITAQEDHVLFIDEIHTIIGAGAVSGGSLDASNLLK
CCCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHH
PALSSGELRCIGTTTYKEFKTIFEKDHALSRRFQKVEVGEPSISETIEILKGLLEKYESF
HHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
HKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGARVRLRESGKKTVTVREIEDLV
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHH
SKIAKVPSVTVKADDREKLKNLDEELKAKIYGQDSAIDQLVQSIRLSRSGLSEPGKPVGS
HHHHHCCCEEEECCCHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLFAGPTGVGKTELTRKLAEILGVELIRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLT
HEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DAVYRNPHCVLLLDEIEKAHEDIYNILLQIMDHATLTDNNGRKSDFRQVILVMTTNTGAR
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHEEEEEEECCCCCC
ERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEFSSLNQENVTKVVAKQLALLQ
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERLNSKQIELEFNEDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGVLKSGGK
HHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AKLISGKEGIEMEFSSGKKN
EEEECCCCCCEEECCCCCCC
>Mature Secondary Structure
MERTLRKAWEEAKKRRNEFITLEHILLALTYDSVAKEVLEACGADIERLRKDLIDYLESE
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LESFPESSGEVDPIYTIGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEC
SQDISRLDIVRYISHGIRKDSKKNPGKEMAGEEGEKISDPLRAFCVDLTAKAKEGKLDPM
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VGREDELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKVYSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCEEEEE
DMGLLLAGTKFRGEFEERLKNVVAQITAQEDHVLFIDEIHTIIGAGAVSGGSLDASNLLK
CCCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHH
PALSSGELRCIGTTTYKEFKTIFEKDHALSRRFQKVEVGEPSISETIEILKGLLEKYESF
HHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
HKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGARVRLRESGKKTVTVREIEDLV
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHH
SKIAKVPSVTVKADDREKLKNLDEELKAKIYGQDSAIDQLVQSIRLSRSGLSEPGKPVGS
HHHHHCCCEEEECCCHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLFAGPTGVGKTELTRKLAEILGVELIRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLT
HEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DAVYRNPHCVLLLDEIEKAHEDIYNILLQIMDHATLTDNNGRKSDFRQVILVMTTNTGAR
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHEEEEEEECCCCCC
ERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEFSSLNQENVTKVVAKQLALLQ
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERLNSKQIELEFNEDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGVLKSGGK
HHCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AKLISGKEGIEMEFSSGKKN
EEEECCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]