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The map label for this gene is ggt

Identifier: 45657678

GI number: 45657678

Start: 2204854

End: 2206587

Strand: Reverse

Name: ggt

Synonym: LIC11813

Alternate gene names: 45657678

Gene position: 2206587-2204854 (Counterclockwise)

Preceding gene: 45657679

Following gene: 45657677

Centisome position: 51.59

GC content: 37.95

Gene sequence:

>1734_bases
ATGAAACAAATTACAATTCGTATCTTTTTGATACTTTTACTCTTCTCTTGTAGGGAAAATTCTCTTCTGATTGAGGGGAA
AAAAATTTCCACCGATCTGCTCGTAGTTCCTTCCCACCAAAAAACGCATACTGATTACTTTAGTGAAAGTAAAAATTTAA
TGATATCCTCCGATTCTCCTGAGGCGACACAGGCCGGGATCGAAGTAGGCGCGTTAGGCGGAAATGTAGTGGACGTAGTA
GTAGCGACTTCTTTTGCAATTTCTGTTACAAGACCCCATTCTACTGGTTTGGGAGGAGGAGGTTTTTTAATTCTTTATTT
AAAAGAATTTCCAGAACCGATCGCTTTCGATTTTAGAGAAAGGGCGCCGAATACGTCTTCTAGAGATATGTATAAACTAA
AACCTAAGGAAGATTCTCTTTTAGGGTTTAGGGCAGTAGGTGTTCCGGGTAACGTTGCAGGGCTTGTGCAGATCCAAAGA
CGTTTTGGAAAACTTCCGCTTAAAACTGTGATCTCCCCCTCGATCCGACTCGCCGAGAATGGATTTCCAGTTTATCCAGA
CCTTCAGTCCGCAATTCAAAAATCTTCTAAAGATATGAGCGAAGAAATGAAAAATATCTTTCTTCCCAAAGGAAAAATTC
CGGAGTTAAACAGTATTCTCGTTCAAAAGGATCTTGCAAATTCTCTCAGACTCATTTCCGAAACTGGCGATAAAGAGTTT
TATCACGGTAAAATTGCGAATTCGATTGTCAATGCGATGAAAAAAAACGATGGTCTTATCACTCTACAAGATCTGAGCGG
TTATAAAGTAATCGAGAAAAAAACAGTACATACAACTTACCACGATTATACGATTTACACGATGCCTCCTCCTTCTTCTG
GAGTTCATTTACTGACTATGTTGTCTATGGTGGAAACAAAACCTCTGAAAGAGACGTATGAAAAAGATCCTGTTTTATAT
TATCATTTTATTGTAGAAGCGATGAGAAGAGGTTATGCGGACAGAGCGATGTTAGGTGGAGATCCTGCCTTTACAAAAAT
TCCAATTGAACGTCTTGTTTCTAAAAAATACGCGGAAGAAAAAATTTCAAATTTTAATCCTAAAACAGCTTCTAGTAGCT
CTTCTTTTTTAAAAACTTTAAACTTTGGAGTAGAATCTCCACAAACTACACATATTTCCGTTATGGATCGTGAAGGAAAT
TCAGTTTCTACAACTCAGTCTATCAATTTTAGATTTGGAGCTTCTGTAGTCGCTCCTGGAACTGGAATTGTGTTAAACGA
TACAATGGATGATTTTAGTCGAGCTCCAGGAGAACCAAATGTATACGGTTTAATCGGTGCGGAAGCAAATTCTATACTTC
CTAAGAAAACTCCTTTGAGCAGTATGTCTCCTACAATTGTATTTAAAAATAAAGAACCTTTTTTAGTTACTGGTGCTCCT
GGAGGTTCTTATATCGTAAACGCCGTTTTACAGTCTTTGATCTATAATTTAGATTTTAATCTGACTTTGTATGAATCCGT
AGCCAGGGGAAGAATACATCATCAATTTTTTCCGGATGCGGTATTTATAGAAAAATCAGTAAATGAAAGAAACGTATTTG
ATGGTCTTTCCTCTAAAAAACACGATCTTAGAATTGCTCCGAACTTTGCGAAACTATTTTCTGTCAAAAGAGAGAATGGA
ATGCTCTATGGAGCTTGCGATCCACGTGGAGAAGGGGCCACAGGCGGACTTTGA

Upstream 100 bases:

>100_bases
GGCGTTTTAAAATCCGGTGGAAAAGCAAAATTGATTTCCGGTAAAGAAGGAATCGAAATGGAATTCTCTTCCGGAAAAAA
GAATTAAAACCGGAAACCAG

Downstream 100 bases:

>100_bases
AAACAAAAGAACTTACTCAATCAAAAATAGAAGAGGTTTCTTTAGAAATCCTTCTGAGACACGCGGTAAAAGCAAAACAC
GGTTTAGAAAAAGAAAGTAT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKQITIRIFLILLLFSCRENSLLIEGKKISTDLLVVPSHQKTHTDYFSESKNLMISSDSPEATQAGIEVGALGGNVVDVV
VATSFAISVTRPHSTGLGGGGFLILYLKEFPEPIAFDFRERAPNTSSRDMYKLKPKEDSLLGFRAVGVPGNVAGLVQIQR
RFGKLPLKTVISPSIRLAENGFPVYPDLQSAIQKSSKDMSEEMKNIFLPKGKIPELNSILVQKDLANSLRLISETGDKEF
YHGKIANSIVNAMKKNDGLITLQDLSGYKVIEKKTVHTTYHDYTIYTMPPPSSGVHLLTMLSMVETKPLKETYEKDPVLY
YHFIVEAMRRGYADRAMLGGDPAFTKIPIERLVSKKYAEEKISNFNPKTASSSSSFLKTLNFGVESPQTTHISVMDREGN
SVSTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKNKEPFLVTGAP
GGSYIVNAVLQSLIYNLDFNLTLYESVARGRIHHQFFPDAVFIEKSVNERNVFDGLSSKKHDLRIAPNFAKLFSVKRENG
MLYGACDPRGEGATGGL

Sequences:

>Translated_577_residues
MKQITIRIFLILLLFSCRENSLLIEGKKISTDLLVVPSHQKTHTDYFSESKNLMISSDSPEATQAGIEVGALGGNVVDVV
VATSFAISVTRPHSTGLGGGGFLILYLKEFPEPIAFDFRERAPNTSSRDMYKLKPKEDSLLGFRAVGVPGNVAGLVQIQR
RFGKLPLKTVISPSIRLAENGFPVYPDLQSAIQKSSKDMSEEMKNIFLPKGKIPELNSILVQKDLANSLRLISETGDKEF
YHGKIANSIVNAMKKNDGLITLQDLSGYKVIEKKTVHTTYHDYTIYTMPPPSSGVHLLTMLSMVETKPLKETYEKDPVLY
YHFIVEAMRRGYADRAMLGGDPAFTKIPIERLVSKKYAEEKISNFNPKTASSSSSFLKTLNFGVESPQTTHISVMDREGN
SVSTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKNKEPFLVTGAP
GGSYIVNAVLQSLIYNLDFNLTLYESVARGRIHHQFFPDAVFIEKSVNERNVFDGLSSKKHDLRIAPNFAKLFSVKRENG
MLYGACDPRGEGATGGL
>Mature_577_residues
MKQITIRIFLILLLFSCRENSLLIEGKKISTDLLVVPSHQKTHTDYFSESKNLMISSDSPEATQAGIEVGALGGNVVDVV
VATSFAISVTRPHSTGLGGGGFLILYLKEFPEPIAFDFRERAPNTSSRDMYKLKPKEDSLLGFRAVGVPGNVAGLVQIQR
RFGKLPLKTVISPSIRLAENGFPVYPDLQSAIQKSSKDMSEEMKNIFLPKGKIPELNSILVQKDLANSLRLISETGDKEF
YHGKIANSIVNAMKKNDGLITLQDLSGYKVIEKKTVHTTYHDYTIYTMPPPSSGVHLLTMLSMVETKPLKETYEKDPVLY
YHFIVEAMRRGYADRAMLGGDPAFTKIPIERLVSKKYAEEKISNFNPKTASSSSSFLKTLNFGVESPQTTHISVMDREGN
SVSTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKNKEPFLVTGAP
GGSYIVNAVLQSLIYNLDFNLTLYESVARGRIHHQFFPDAVFIEKSVNERNVFDGLSSKKHDLRIAPNFAKLFSVKRENG
MLYGACDPRGEGATGGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=532, Percent_Identity=30.0751879699248, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI73915090, Length=532, Percent_Identity=30.0751879699248, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI73915096, Length=532, Percent_Identity=30.0751879699248, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI73915094, Length=532, Percent_Identity=30.0751879699248, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI113429324, Length=533, Percent_Identity=28.5178236397749, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI113429326, Length=539, Percent_Identity=28.7569573283859, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI109148539, Length=536, Percent_Identity=28.7313432835821, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI153266901, Length=526, Percent_Identity=26.425855513308, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI153266885, Length=525, Percent_Identity=26.0952380952381, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI153266907, Length=524, Percent_Identity=25.5725190839695, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI30581157, Length=190, Percent_Identity=36.8421052631579, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI30581155, Length=190, Percent_Identity=36.8421052631579, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI218505805, Length=189, Percent_Identity=34.9206349206349, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310124095, Length=189, Percent_Identity=31.2169312169312, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1789856, Length=529, Percent_Identity=39.5085066162571, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212646519, Length=500, Percent_Identity=33.6, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=500, Percent_Identity=33.6, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17542894, Length=583, Percent_Identity=30.3602058319039, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI193208247, Length=506, Percent_Identity=32.2134387351779, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI193208245, Length=506, Percent_Identity=32.2134387351779, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17506189, Length=535, Percent_Identity=30.0934579439252, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI72001497, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001495, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17564448, Length=441, Percent_Identity=26.0770975056689, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323330, Length=491, Percent_Identity=30.5498981670061, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI18859893, Length=501, Percent_Identity=32.9341317365269, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI161077496, Length=545, Percent_Identity=29.1743119266055, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI161077878, Length=541, Percent_Identity=27.9112754158965, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI161077880, Length=541, Percent_Identity=27.9112754158965, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24642670, Length=541, Percent_Identity=27.9112754158965, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24642666, Length=541, Percent_Identity=27.9112754158965, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45551474, Length=541, Percent_Identity=27.9112754158965, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI18859741, Length=541, Percent_Identity=25.8780036968577, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63500; Mature: 63500

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQITIRIFLILLLFSCRENSLLIEGKKISTDLLVVPSHQKTHTDYFSESKNLMISSDSP
CCEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCHHHHCCCCEEEECCCC
EATQAGIEVGALGGNVVDVVVATSFAISVTRPHSTGLGGGGFLILYLKEFPEPIAFDFRE
CHHHCCCEEEECCCCEEEEEEECEEEEEEECCCCCCCCCCCEEEEEHHHCCCCCEEHHHH
RAPNTSSRDMYKLKPKEDSLLGFRAVGVPGNVAGLVQIQRRFGKLPLKTVISPSIRLAEN
CCCCCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCEEEECC
GFPVYPDLQSAIQKSSKDMSEEMKNIFLPKGKIPELNSILVQKDLANSLRLISETGDKEF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
YHGKIANSIVNAMKKNDGLITLQDLSGYKVIEKKTVHTTYHDYTIYTMPPPSSGVHLLTM
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEEEEECEEEEECCCCCCCHHHHHH
LSMVETKPLKETYEKDPVLYYHFIVEAMRRGYADRAMLGGDPAFTKIPIERLVSKKYAEE
HHHHHCCCHHHHHCCCCEEHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
KISNFNPKTASSSSSFLKTLNFGVESPQTTHISVMDREGNSVSTTQSINFRFGASVVAPG
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECEEEEEEEECCEEECCC
TGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKNKEPFLVTGAP
CCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCC
GGSYIVNAVLQSLIYNLDFNLTLYESVARGRIHHQFFPDAVFIEKSVNERNVFDGLSSKK
CCHHHHHHHHHHHHHHCCCCEEEHHHHHCCCHHHHHCCCEEEEECCCCCHHHHCCCCCCC
HDLRIAPNFAKLFSVKRENGMLYGACDPRGEGATGGL
CCEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKQITIRIFLILLLFSCRENSLLIEGKKISTDLLVVPSHQKTHTDYFSESKNLMISSDSP
CCEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCHHHHCCCCEEEECCCC
EATQAGIEVGALGGNVVDVVVATSFAISVTRPHSTGLGGGGFLILYLKEFPEPIAFDFRE
CHHHCCCEEEECCCCEEEEEEECEEEEEEECCCCCCCCCCCEEEEEHHHCCCCCEEHHHH
RAPNTSSRDMYKLKPKEDSLLGFRAVGVPGNVAGLVQIQRRFGKLPLKTVISPSIRLAEN
CCCCCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCEEEECC
GFPVYPDLQSAIQKSSKDMSEEMKNIFLPKGKIPELNSILVQKDLANSLRLISETGDKEF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
YHGKIANSIVNAMKKNDGLITLQDLSGYKVIEKKTVHTTYHDYTIYTMPPPSSGVHLLTM
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEEEEECEEEEECCCCCCCHHHHHH
LSMVETKPLKETYEKDPVLYYHFIVEAMRRGYADRAMLGGDPAFTKIPIERLVSKKYAEE
HHHHHCCCHHHHHCCCCEEHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
KISNFNPKTASSSSSFLKTLNFGVESPQTTHISVMDREGNSVSTTQSINFRFGASVVAPG
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECEEEEEEEECCEEECCC
TGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKNKEPFLVTGAP
CCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCC
GGSYIVNAVLQSLIYNLDFNLTLYESVARGRIHHQFFPDAVFIEKSVNERNVFDGLSSKK
CCHHHHHHHHHHHHHHCCCCEEEHHHHHCCCHHHHHCCCEEEEECCCCCHHHHCCCCCCC
HDLRIAPNFAKLFSVKRENGMLYGACDPRGEGATGGL
CCEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]