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The map label for this gene is mtr [H]

Identifier: 45657668

GI number: 45657668

Start: 2196195

End: 2197577

Strand: Direct

Name: mtr [H]

Synonym: LIC11803

Alternate gene names: 45657668

Gene position: 2196195-2197577 (Clockwise)

Preceding gene: 45657667

Following gene: 45657669

Centisome position: 51.35

GC content: 36.01

Gene sequence:

>1383_bases
ATGAAAGAATATGATATTATTGTAATTGGAACTGGAGGGGGAACAAAATTAGTTACTCCTCCTTCTAAAATCGGTTACAA
GATCGCCGTAATCGAAAAAGAAAATCCAGGCGGCACCTGCCTCAATCGAGGATGTATTCCTTCTAAGATGTTGATCTATC
CCGCAGAGATCCTTTCTCTGACAAAACATTCAGAAAAATTTCAGATTTCATTTCCTAAAAAACCCGAAGTAGATTTTAAA
ACTCTTATAGAAAGGATTTCTAAAACCGTAGATGACGAATCTGCTTCTATCCTTCCCGCTTATGATAAAAATTCAAACAT
TACTTATATTTCAGGAACAGCGAGTTTTATCTCGGATAAGGTTATCACAGTAAACGGGGAACAACTAACCGCAGAAAGAA
TTTTTATCGCCTCAGGTGCAAGGCCAGCGATCCCGGATATTCCTGGACTTGCTGGAACCCCTTTTATGACAAGTAGAGAA
ACACTTAGAAGAACCGATCTTCCCAAATCTATGATTGTAATCGGAGGTGGTTTTATTGCATTAGAACTAGGTTTTGCTTA
TTCGTCTTTTGGTAGTGAAGTCACTTTTTTAGTCAGAAATAGAATGCTCAAAAACGAGGACAAAGACATAGTTGATGAGT
TCGAAAGAATTTTTACAAAAGAACACAATGTATTATTACACACAAACATTCATAAAATAGAATATAATAAAAATTTATTT
TATGTAGAAGCAATTTCACAGGGAAAAACGATTTTGCTTCAATCCGAAGCCCTTTTGGTAGCCACTGGAATTAAACCCAA
CACAGATCTTTTAAATTTACAAAATACGAATATTCAGACGGATAAAAACGGATACATAGTCGTAAACGAATATTTAGAAA
CTACTTCTCCAGGTGTATATGCATTAGGCGATATTACAGGAAAATACTTTTACAGACATTCCGTAAACTTTGAAGGAGAA
TTTTTATTCCGCACCTTATACCAAGAAAAAAAAAGAACTCCTATCGAATATCCTCCAGTCCCACATGCAGTGTTTACACA
TCCCCAGATCGCCAAAGTAGGAAAAACAGAAGAAGAACTAATCCAAGAAGGAATCGACTACGTAGCTGCAAAAAATTCAT
ACAGTGCTAGCGCTACTGGAATGGCGAGATTATCCGATTCCGGATTTGTAAAAATCCTAATAGATAAAAAATCCAAAATG
GTTTTAGGAGCTCACGTAATCGGAGACGAAGCTTCGAACTTGATTCATCTTTTTATCCTTTTAATGACGATGAAAGGCAC
TTTAGACGATCTTTTAAAAATGATCTACGTACATCCTGCGTTACCCGAAATTGCAAGAAATGCCGCTCGAAAAGCAAAAG
AACTTTTACAATCCAAAAAATAA

Upstream 100 bases:

>100_bases
AATTTTATTTTTGAAAAATTTTAGTTTAAGATCTAATCTTAGAAATCGTTTGCTCTCTCCGACATCGGTTTAAAATCTGT
AACCAAGGCGGTTCTTTTTT

Downstream 100 bases:

>100_bases
TAGGAATATTCAAAATTTATGAAGTTTGCGTTGCAAATTGAAAATTTAGTCAAAACATACTCAGGTGGAGTCACGGCTCT
CAAAGGGATCAGCCTAAATG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKEYDIIVIGTGGGTKLVTPPSKIGYKIAVIEKENPGGTCLNRGCIPSKMLIYPAEILSLTKHSEKFQISFPKKPEVDFK
TLIERISKTVDDESASILPAYDKNSNITYISGTASFISDKVITVNGEQLTAERIFIASGARPAIPDIPGLAGTPFMTSRE
TLRRTDLPKSMIVIGGGFIALELGFAYSSFGSEVTFLVRNRMLKNEDKDIVDEFERIFTKEHNVLLHTNIHKIEYNKNLF
YVEAISQGKTILLQSEALLVATGIKPNTDLLNLQNTNIQTDKNGYIVVNEYLETTSPGVYALGDITGKYFYRHSVNFEGE
FLFRTLYQEKKRTPIEYPPVPHAVFTHPQIAKVGKTEEELIQEGIDYVAAKNSYSASATGMARLSDSGFVKILIDKKSKM
VLGAHVIGDEASNLIHLFILLMTMKGTLDDLLKMIYVHPALPEIARNAARKAKELLQSKK

Sequences:

>Translated_460_residues
MKEYDIIVIGTGGGTKLVTPPSKIGYKIAVIEKENPGGTCLNRGCIPSKMLIYPAEILSLTKHSEKFQISFPKKPEVDFK
TLIERISKTVDDESASILPAYDKNSNITYISGTASFISDKVITVNGEQLTAERIFIASGARPAIPDIPGLAGTPFMTSRE
TLRRTDLPKSMIVIGGGFIALELGFAYSSFGSEVTFLVRNRMLKNEDKDIVDEFERIFTKEHNVLLHTNIHKIEYNKNLF
YVEAISQGKTILLQSEALLVATGIKPNTDLLNLQNTNIQTDKNGYIVVNEYLETTSPGVYALGDITGKYFYRHSVNFEGE
FLFRTLYQEKKRTPIEYPPVPHAVFTHPQIAKVGKTEEELIQEGIDYVAAKNSYSASATGMARLSDSGFVKILIDKKSKM
VLGAHVIGDEASNLIHLFILLMTMKGTLDDLLKMIYVHPALPEIARNAARKAKELLQSKK
>Mature_460_residues
MKEYDIIVIGTGGGTKLVTPPSKIGYKIAVIEKENPGGTCLNRGCIPSKMLIYPAEILSLTKHSEKFQISFPKKPEVDFK
TLIERISKTVDDESASILPAYDKNSNITYISGTASFISDKVITVNGEQLTAERIFIASGARPAIPDIPGLAGTPFMTSRE
TLRRTDLPKSMIVIGGGFIALELGFAYSSFGSEVTFLVRNRMLKNEDKDIVDEFERIFTKEHNVLLHTNIHKIEYNKNLF
YVEAISQGKTILLQSEALLVATGIKPNTDLLNLQNTNIQTDKNGYIVVNEYLETTSPGVYALGDITGKYFYRHSVNFEGE
FLFRTLYQEKKRTPIEYPPVPHAVFTHPQIAKVGKTEEELIQEGIDYVAAKNSYSASATGMARLSDSGFVKILIDKKSKM
VLGAHVIGDEASNLIHLFILLMTMKGTLDDLLKMIYVHPALPEIARNAARKAKELLQSKK

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=30.3879310344828, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI50301238, Length=444, Percent_Identity=29.954954954955, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI22035672, Length=446, Percent_Identity=22.6457399103139, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI33519430, Length=427, Percent_Identity=24.3559718969555, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519428, Length=427, Percent_Identity=24.3559718969555, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519426, Length=427, Percent_Identity=24.3559718969555, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI148277065, Length=427, Percent_Identity=24.3559718969555, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI148277071, Length=427, Percent_Identity=24.3559718969555, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=23.8979118329466, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI291045268, Length=426, Percent_Identity=22.0657276995305, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=28.3813747228381, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=28.9183222958057, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789915, Length=427, Percent_Identity=29.7423887587822, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87082354, Length=474, Percent_Identity=27.6371308016878, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=30.952380952381, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71983429, Length=431, Percent_Identity=29.0023201856148, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71983419, Length=431, Percent_Identity=29.0023201856148, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=28.7211740041929, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71982272, Length=477, Percent_Identity=25.1572327044025, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=28.8135593220339, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=438, Percent_Identity=25.3424657534247, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=24.7916666666667, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=31.317494600432, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=26.6524520255864, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=26.6524520255864, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=26.6524520255864, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=24.9471458773784, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 51106; Mature: 51106

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYDIIVIGTGGGTKLVTPPSKIGYKIAVIEKENPGGTCLNRGCIPSKMLIYPAEILSL
CCCEEEEEEECCCCCEEECCHHHHCEEEEEEEECCCCCCEECCCCCCCCEEEEHHHHHHH
TKHSEKFQISFPKKPEVDFKTLIERISKTVDDESASILPAYDKNSNITYISGTASFISDK
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEECCHHHHCCC
VITVNGEQLTAERIFIASGARPAIPDIPGLAGTPFMTSRETLRRTDLPKSMIVIGGGFIA
EEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEE
LELGFAYSSFGSEVTFLVRNRMLKNEDKDIVDEFERIFTKEHNVLLHTNIHKIEYNKNLF
EEECCHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECEEEEEECCCEE
YVEAISQGKTILLQSEALLVATGIKPNTDLLNLQNTNIQTDKNGYIVVNEYLETTSPGVY
EEEEECCCCEEEEECCEEEEEECCCCCCCEEEEECCCEEECCCCEEEEECCCCCCCCCEE
ALGDITGKYFYRHSVNFEGEFLFRTLYQEKKRTPIEYPPVPHAVFTHPQIAKVGKTEEEL
EEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHCCCCHHHH
IQEGIDYVAAKNSYSASATGMARLSDSGFVKILIDKKSKMVLGAHVIGDEASNLIHLFIL
HHHHHHHEEECCCCCCCCCCEEEECCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHH
LMTMKGTLDDLLKMIYVHPALPEIARNAARKAKELLQSKK
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEYDIIVIGTGGGTKLVTPPSKIGYKIAVIEKENPGGTCLNRGCIPSKMLIYPAEILSL
CCCEEEEEEECCCCCEEECCHHHHCEEEEEEEECCCCCCEECCCCCCCCEEEEHHHHHHH
TKHSEKFQISFPKKPEVDFKTLIERISKTVDDESASILPAYDKNSNITYISGTASFISDK
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEECCHHHHCCC
VITVNGEQLTAERIFIASGARPAIPDIPGLAGTPFMTSRETLRRTDLPKSMIVIGGGFIA
EEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEE
LELGFAYSSFGSEVTFLVRNRMLKNEDKDIVDEFERIFTKEHNVLLHTNIHKIEYNKNLF
EEECCHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECEEEEEECCCEE
YVEAISQGKTILLQSEALLVATGIKPNTDLLNLQNTNIQTDKNGYIVVNEYLETTSPGVY
EEEEECCCCEEEEECCEEEEEECCCCCCCEEEEECCCEEECCCCEEEEECCCCCCCCCEE
ALGDITGKYFYRHSVNFEGEFLFRTLYQEKKRTPIEYPPVPHAVFTHPQIAKVGKTEEEL
EEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHCCCCHHHH
IQEGIDYVAAKNSYSASATGMARLSDSGFVKILIDKKSKMVLGAHVIGDEASNLIHLFIL
HHHHHHHEEECCCCCCCCCCEEEECCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHH
LMTMKGTLDDLLKMIYVHPALPEIARNAARKAKELLQSKK
HHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]