Click here to switch to the map view.

The map label for this gene is glpK

Identifier: 45657665

GI number: 45657665

Start: 2192229

End: 2193719

Strand: Reverse

Name: glpK

Synonym: LIC11799

Alternate gene names: 45657665

Gene position: 2193719-2192229 (Counterclockwise)

Preceding gene: 45657666

Following gene: 45657658

Centisome position: 51.29

GC content: 38.03

Gene sequence:

>1491_bases
ATGAGTGATTATATCATCGGTATAGACGCCGGAACTACCGGGATTCGAATTTTTTGTTTTAATAAATCAGGAAACGTAAT
TTCCAGCGCGTATTCCGAATTTAACCAGCATTATCCGAAACCTGGTTGGGTGGAACACGATGCGGAAGAAATCTGGGCCA
AAACTGAAAAGCTCATATTAAAAGCGATTCGAAATGGAAAGTTGAGTCCTTCTAAAGCAGTCGCAATTGGAATTACAAAT
CAAAGAGAAACCACAGTATTGTTTGATAAAGATACCGGAAAACCTGTTTATAATGCGATCGTATGGCAATGTAGAAGAAC
TTCTGAAACCTGTATGGATCTTAAATCTAAAGGATTGGAATCTTTTTTTCGTAAAAAAACGGGATTGGTTTTAGATGCAT
ACTTTAGTGGAACCAAAATTCAATGGATTTTGGAAAATGTAAAAGGTGTAAAAGCCAGAGCGGAAAAAGGAAAGATATTT
TTTGGAACCATAGATACGTATTTACTATATCGTTTGACCAACGGAAAATCGCATAAGACCGATCATACGAATGCAAGTAG
AACTTTGATCTACAATATCGAAAAGAAAGAATGGGATAAGGAATTAACTCAAATATTAGGAATTCCTGATTCTATTTTAC
CAGAGACGCATAATTCTAGTTCATTGTTCGGAAGAACGGAAAAGGTAAAAGGACTTCCTGACGGAATTCCAATTTCCTCT
CTTGTGGGAGATCAACAAGGGGCCTTATTTGGCCAACTTTGCACAGAGCCTGGGGAAGCCAAGAACACGTATGGAACCGG
ATGTTTTCTTCTTTTTAATACTGGAAATAATTTTCAGATTTCTAAGAACAATTTACTTACTACCTTAGGATGTGGACCGG
AAGGAAAGACTGTTTATTGTTTGGAAGGATCCGTTTTTATAGGAGGCGCTGTCGTTCAATTTTTAAGAGATAATCTGAAA
TTTTTTAAAGAATCCAAAATTTCCGAAAAGTATGCGTCTTCGGTAAAAAAAGAAGACGATGTAGTTTTTATTCCCGCCTT
TGCAGGGTTAGGTGCTCCTTATTGGGATATGAACGCGAGGGGTGCAATTTTAGGTCTGACAAGAGATACTACAGCGGAAC
AGATCACAAGAGCTGCGCTCAAATCGATTGCCCTCCAATCTTATGAACTTGTAGAGGCAATGGAAAACGATACTGGTTCT
AAATTAAAAGTTTTAAAAGTAGACGGGGGTGCGACTGGAAATTCTTGGTTGATGCAGTATCAATCTGATATATTAGGAAA
ACGTGTAGTTCGTCCTTCCAATGTAGATACCACGGTATTAGGTGCGGCATTTTTGGCGGGATTAGAAAGGGGATTTTTTC
CTTCCGTAGTGGATCTAAAAAAGAAACTAAAAACGAGTAAGGAGTTTTCTCCACAGATGAAACAACCTCAGAGAGAAAAA
GAGATTCAGATTTGGAAGGATTCTGTCCATAGGATCCGAACCAATCAATAA

Upstream 100 bases:

>100_bases
GGCGCATGAAGGCCTAGAACTGGAAGTATAGCTTGCAGTTTTTCTAATATTATAAATTAAATTTCATCTTTCACTTTAAA
TTTTTTGGAGACGATCTTCT

Downstream 100 bases:

>100_bases
TCAAAACCTAATAAACAAAATTCAAATGTCTTTTTAGAGGATGTAATTCCAGCTCCGCATAAAACTCTAAATTCAGAAAA
AAAAAGAATTTCTAAAATTC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSDYIIGIDAGTTGIRIFCFNKSGNVISSAYSEFNQHYPKPGWVEHDAEEIWAKTEKLILKAIRNGKLSPSKAVAIGITN
QRETTVLFDKDTGKPVYNAIVWQCRRTSETCMDLKSKGLESFFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIF
FGTIDTYLLYRLTNGKSHKTDHTNASRTLIYNIEKKEWDKELTQILGIPDSILPETHNSSSLFGRTEKVKGLPDGIPISS
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISKNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLK
FFKESKISEKYASSVKKEDDVVFIPAFAGLGAPYWDMNARGAILGLTRDTTAEQITRAALKSIALQSYELVEAMENDTGS
KLKVLKVDGGATGNSWLMQYQSDILGKRVVRPSNVDTTVLGAAFLAGLERGFFPSVVDLKKKLKTSKEFSPQMKQPQREK
EIQIWKDSVHRIRTNQ

Sequences:

>Translated_496_residues
MSDYIIGIDAGTTGIRIFCFNKSGNVISSAYSEFNQHYPKPGWVEHDAEEIWAKTEKLILKAIRNGKLSPSKAVAIGITN
QRETTVLFDKDTGKPVYNAIVWQCRRTSETCMDLKSKGLESFFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIF
FGTIDTYLLYRLTNGKSHKTDHTNASRTLIYNIEKKEWDKELTQILGIPDSILPETHNSSSLFGRTEKVKGLPDGIPISS
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISKNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLK
FFKESKISEKYASSVKKEDDVVFIPAFAGLGAPYWDMNARGAILGLTRDTTAEQITRAALKSIALQSYELVEAMENDTGS
KLKVLKVDGGATGNSWLMQYQSDILGKRVVRPSNVDTTVLGAAFLAGLERGFFPSVVDLKKKLKTSKEFSPQMKQPQREK
EIQIWKDSVHRIRTNQ
>Mature_495_residues
SDYIIGIDAGTTGIRIFCFNKSGNVISSAYSEFNQHYPKPGWVEHDAEEIWAKTEKLILKAIRNGKLSPSKAVAIGITNQ
RETTVLFDKDTGKPVYNAIVWQCRRTSETCMDLKSKGLESFFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIFF
GTIDTYLLYRLTNGKSHKTDHTNASRTLIYNIEKKEWDKELTQILGIPDSILPETHNSSSLFGRTEKVKGLPDGIPISSL
VGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISKNNLLTTLGCGPEGKTVYCLEGSVFIGGAVVQFLRDNLKF
FKESKISEKYASSVKKEDDVVFIPAFAGLGAPYWDMNARGAILGLTRDTTAEQITRAALKSIALQSYELVEAMENDTGSK
LKVLKVDGGATGNSWLMQYQSDILGKRVVRPSNVDTTVLGAAFLAGLERGFFPSVVDLKKKLKTSKEFSPQMKQPQREKE
IQIWKDSVHRIRTNQ

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=497, Percent_Identity=44.0643863179074, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI189409120, Length=497, Percent_Identity=44.0643863179074, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI42794763, Length=501, Percent_Identity=44.1117764471058, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI41393575, Length=495, Percent_Identity=43.6363636363636, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI88196792, Length=506, Percent_Identity=33.201581027668, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI164663828, Length=535, Percent_Identity=22.0560747663551, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790361, Length=488, Percent_Identity=50.6147540983607, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1789987, Length=494, Percent_Identity=23.6842105263158, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790005, Length=493, Percent_Identity=22.7180527383367, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789168, Length=499, Percent_Identity=22.8456913827655, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787789, Length=515, Percent_Identity=21.9417475728155, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=501, Percent_Identity=40.5189620758483, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=24.8543689320388, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=31.1284046692607, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=550, Percent_Identity=36.1818181818182, Blast_Score=292, Evalue=9e-80,
Organism=Drosophila melanogaster, GI17864214, Length=510, Percent_Identity=40.3921568627451, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24655555, Length=451, Percent_Identity=40.3547671840355, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24655560, Length=451, Percent_Identity=40.3547671840355, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24655570, Length=451, Percent_Identity=40.3547671840355, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24655574, Length=451, Percent_Identity=40.3547671840355, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24655565, Length=451, Percent_Identity=40.3547671840355, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24654573, Length=434, Percent_Identity=43.0875576036866, Blast_Score=341, Evalue=8e-94,
Organism=Drosophila melanogaster, GI19922058, Length=535, Percent_Identity=32.8971962616822, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=33.8056680161943, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24656367, Length=496, Percent_Identity=30.241935483871, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI21357867, Length=504, Percent_Identity=29.9603174603175, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24656372, Length=348, Percent_Identity=31.6091954022989, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI45552909, Length=307, Percent_Identity=29.9674267100977, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55087; Mature: 54955

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYIIGIDAGTTGIRIFCFNKSGNVISSAYSEFNQHYPKPGWVEHDAEEIWAKTEKLIL
CCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KAIRNGKLSPSKAVAIGITNQRETTVLFDKDTGKPVYNAIVWQCRRTSETCMDLKSKGLE
HHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
SFFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIFFGTIDTYLLYRLTNGKSHKT
HHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCCCCC
DHTNASRTLIYNIEKKEWDKELTQILGIPDSILPETHNSSSLFGRTEKVKGLPDGIPISS
CCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHCCCCCCCCCHHH
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISKNNLLTTLGCGPEGKTVYC
HHCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCEEEEECCCCCCCEEEE
LEGSVFIGGAVVQFLRDNLKFFKESKISEKYASSVKKEDDVVFIPAFAGLGAPYWDMNAR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCCCCCCCC
GAILGLTRDTTAEQITRAALKSIALQSYELVEAMENDTGSKLKVLKVDGGATGNSWLMQY
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
QSDILGKRVVRPSNVDTTVLGAAFLAGLERGFFPSVVDLKKKLKTSKEFSPQMKQPQREK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCCCHHH
EIQIWKDSVHRIRTNQ
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDYIIGIDAGTTGIRIFCFNKSGNVISSAYSEFNQHYPKPGWVEHDAEEIWAKTEKLIL
CCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KAIRNGKLSPSKAVAIGITNQRETTVLFDKDTGKPVYNAIVWQCRRTSETCMDLKSKGLE
HHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
SFFRKKTGLVLDAYFSGTKIQWILENVKGVKARAEKGKIFFGTIDTYLLYRLTNGKSHKT
HHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCCCCC
DHTNASRTLIYNIEKKEWDKELTQILGIPDSILPETHNSSSLFGRTEKVKGLPDGIPISS
CCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHCCCCCCCCHHCCCHHHCCCCCCCCCHHH
LVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNTGNNFQISKNNLLTTLGCGPEGKTVYC
HHCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCEEEEECCCCCCCEEEE
LEGSVFIGGAVVQFLRDNLKFFKESKISEKYASSVKKEDDVVFIPAFAGLGAPYWDMNAR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCCCCCCCC
GAILGLTRDTTAEQITRAALKSIALQSYELVEAMENDTGSKLKVLKVDGGATGNSWLMQY
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
QSDILGKRVVRPSNVDTTVLGAAFLAGLERGFFPSVVDLKKKLKTSKEFSPQMKQPQREK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCCCHHH
EIQIWKDSVHRIRTNQ
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA