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The map label for this gene is thrB

Identifier: 45657652

GI number: 45657652

Start: 2176817

End: 2177779

Strand: Reverse

Name: thrB

Synonym: LIC11786

Alternate gene names: 45657652

Gene position: 2177779-2176817 (Counterclockwise)

Preceding gene: 45657654

Following gene: 45657651

Centisome position: 50.92

GC content: 33.96

Gene sequence:

>963_bases
ATGTCTTCGATTTTACAATATTCCATTCGAGTTCCTGGAACCTCGGCTAACTTAGGGCCAGGTTTTGATCTTTTTGGTCT
TGCGTTTCGAATTTACAATCAATTTCAATTTCAATTTTTACCCGGAAAGGAGTTTAAAACTTCTGTAAAAGGAATGGAAA
CACTTCCATTTGGTCCGGATGAAGATCTAGTTTTATCATCGTATCGATCTTATTTTAAAAGATTTTTATCAGGAAAAGAA
ATTATTCCATATTCTCTTTTGATGGATTTAAAACTTCCCATGAAAGGAGGGCTTGGTTCTAGCGCCAGCGCAGCCGTTGC
TGGAGTCTGTTCTGCTAGATTTGTACATAAAAAATTTTATCCAGAAATTTCTATTCCTAAAGAAAACGAGTTTTTATTTC
ATCTTGGTCAGATCGAAGGACATCCGGATAATACAATTCCAGCTTATTTAGGTGGTTTTGTGTTTTCTTATTTCAACGGA
AATCGTTTAGAATTTGTCAAAAAAAAATTTCCAAAGAAAGTGCGTTGTTTTTTGATCGTGCCGAATTTAGAAACTTCTAC
TCATCAATCTAGAAAAACTCTTCCTAGTTCGTATTCCACAGAAGACGTGATTTTTAATATGAGTCGGGTTGTTACTTGGA
TGGAATTTTTGGACTCCGGAAAAATTTCACTTTTGAAACTGGCGCTGGATGATCGAATTCACACTCCATATAGAATGCAT
TCAGAATTCGAATTAAATCCTTTTTTAATGCAGATCCATAAAAATTTAATTGGATATTCTCTTTCCGGGAGTGGTCCTTC
TGTTCTTTTATTTTCGGAAAGAAATAAGGCAGTAAGAGTCGAAAAGATTCTCAAAGAAAAAATCTCCGAGTTTGTGCAAG
AAAATCATTTTCATTGTCAGATTCTTTCTTTAAAAGTAGAAGAGGATGGTATTTTAGAATCCTCAAAAGAAATTAAAATT
TGA

Upstream 100 bases:

>100_bases
AAAATCCTGATTTTGAAAGCGGAAAATAAAATGACGTTTTCATTCGGAAAGAAATTCTGGTCGTAACTTTTTCGATCTTT
CTAAGATCGATTTTCTTTTT

Downstream 100 bases:

>100_bases
GAATATTCTAATTGATTAAAATATGTGTGTTAAAAAAGAGAGAATTAAAAATTAATTACGCTACATTTGAGAATTTTACG
TTTTTATTTCTGTATCGTCT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSSILQYSIRVPGTSANLGPGFDLFGLAFRIYNQFQFQFLPGKEFKTSVKGMETLPFGPDEDLVLSSYRSYFKRFLSGKE
IIPYSLLMDLKLPMKGGLGSSASAAVAGVCSARFVHKKFYPEISIPKENEFLFHLGQIEGHPDNTIPAYLGGFVFSYFNG
NRLEFVKKKFPKKVRCFLIVPNLETSTHQSRKTLPSSYSTEDVIFNMSRVVTWMEFLDSGKISLLKLALDDRIHTPYRMH
SEFELNPFLMQIHKNLIGYSLSGSGPSVLLFSERNKAVRVEKILKEKISEFVQENHFHCQILSLKVEEDGILESSKEIKI

Sequences:

>Translated_320_residues
MSSILQYSIRVPGTSANLGPGFDLFGLAFRIYNQFQFQFLPGKEFKTSVKGMETLPFGPDEDLVLSSYRSYFKRFLSGKE
IIPYSLLMDLKLPMKGGLGSSASAAVAGVCSARFVHKKFYPEISIPKENEFLFHLGQIEGHPDNTIPAYLGGFVFSYFNG
NRLEFVKKKFPKKVRCFLIVPNLETSTHQSRKTLPSSYSTEDVIFNMSRVVTWMEFLDSGKISLLKLALDDRIHTPYRMH
SEFELNPFLMQIHKNLIGYSLSGSGPSVLLFSERNKAVRVEKILKEKISEFVQENHFHCQILSLKVEEDGILESSKEIKI
>Mature_319_residues
SSILQYSIRVPGTSANLGPGFDLFGLAFRIYNQFQFQFLPGKEFKTSVKGMETLPFGPDEDLVLSSYRSYFKRFLSGKEI
IPYSLLMDLKLPMKGGLGSSASAAVAGVCSARFVHKKFYPEISIPKENEFLFHLGQIEGHPDNTIPAYLGGFVFSYFNGN
RLEFVKKKFPKKVRCFLIVPNLETSTHQSRKTLPSSYSTEDVIFNMSRVVTWMEFLDSGKISLLKLALDDRIHTPYRMHS
EFELNPFLMQIHKNLIGYSLSGSGPSVLLFSERNKAVRVEKILKEKISEFVQENHFHCQILSLKVEEDGILESSKEIKI

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321814, Length=370, Percent_Identity=26.4864864864865, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 36396; Mature: 36264

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSILQYSIRVPGTSANLGPGFDLFGLAFRIYNQFQFQFLPGKEFKTSVKGMETLPFGPD
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHCCCEECCCCCC
EDLVLSSYRSYFKRFLSGKEIIPYSLLMDLKLPMKGGLGSSASAAVAGVCSARFVHKKFY
HHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PEISIPKENEFLFHLGQIEGHPDNTIPAYLGGFVFSYFNGNRLEFVKKKFPKKVRCFLIV
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEE
PNLETSTHQSRKTLPSSYSTEDVIFNMSRVVTWMEFLDSGKISLLKLALDDRIHTPYRMH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEECC
SEFELNPFLMQIHKNLIGYSLSGSGPSVLLFSERNKAVRVEKILKEKISEFVQENHFHCQ
CCCCCCHHHHHHHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ILSLKVEEDGILESSKEIKI
EEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SSILQYSIRVPGTSANLGPGFDLFGLAFRIYNQFQFQFLPGKEFKTSVKGMETLPFGPD
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHCCCEECCCCCC
EDLVLSSYRSYFKRFLSGKEIIPYSLLMDLKLPMKGGLGSSASAAVAGVCSARFVHKKFY
HHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PEISIPKENEFLFHLGQIEGHPDNTIPAYLGGFVFSYFNGNRLEFVKKKFPKKVRCFLIV
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEE
PNLETSTHQSRKTLPSSYSTEDVIFNMSRVVTWMEFLDSGKISLLKLALDDRIHTPYRMH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEECC
SEFELNPFLMQIHKNLIGYSLSGSGPSVLLFSERNKAVRVEKILKEKISEFVQENHFHCQ
CCCCCCHHHHHHHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ILSLKVEEDGILESSKEIKI
EEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]