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The map label for this gene is uvrC

Identifier: 45657622

GI number: 45657622

Start: 2148564

End: 2150393

Strand: Reverse

Name: uvrC

Synonym: LIC11756

Alternate gene names: 45657622

Gene position: 2150393-2148564 (Counterclockwise)

Preceding gene: 45657623

Following gene: 45657621

Centisome position: 50.28

GC content: 35.08

Gene sequence:

>1830_bases
ATGCCTGAAATTTTAAATCATACTTTAATTTTAGAAAAAATAAAAAACTTAGGAGCTTCTCCGGGTTGTTATCTTTGGAA
ATCTAAAAAAGGAGAAGTTTTATATGTAGGTAAGGCTAAAAATTTAGACAAAAGAGTTCGAAGTTATCTTAAGGAAAATC
ATCCGGATGTAAAAACAAAAGTACTTCAAAGAGAAATTTTCGATCTAGATTGGATCGCTACCGGAACTGAAAAAGAAGCT
TTGATTTTAGAAGCGACTCTGATTAAAAAACACAATCCTCGCTTTAATGTTCGTCTTAAAGACGATAAAAAATATCCTTA
TATTTGTGTGTCCTTGTCGGAACCTTATCCGATGGTTTATGTTACTAGAAAACTAAAGGATAACGGAGATCGTTATTTTG
GACCTTATTCAGACGTTAAATCGACTAGAGAAACATTAGACATTATTTTGAGAATTTTTCCGGTTCGTAAAACTAGACAA
GTTCTTCCTTTACCTAGACCTAGAAGACCGTGTCTAAATTTTGATATGGGTCGTTGTTTAGGGCCTTGCCAGGGAAATAT
TCCAGTAGAAGATTATAAAGTTATAATAGATCAAGTGATTCAATTTTTAGAGGGTAGAAAAGAATCTCTTGTAAGTGATT
TAAATATAAAGATGTCTAATGCTTCTGAGCGATTGGATTTTGAAAAGGCGGCGCGTTATAGAGATATGCTCCAGAGAATC
CAAAATTTTAGAGAAAAACAAACAGTTGTTAGCTTGGAAGGAGGAGACGAAGACGTAATTGGTTTTGCCAGAAAACAAGA
CGAAGGACAAGTGATTCTTTTAGAAATTAGAGGTGGAAGATTAGAAACTAAAAAGTCTTTTCCAATTCAAGGAGTTTTAG
ACGCAGAAAATTCGGAAATCTTAGGAGCTTTTTTTAGGGACTATTATTTAAACGCCTCTTTGGTTCCGCCTTGTATTTTT
ATTCCTGCGGATATTCAAGATGAAGTTATTCCCGTCATAGACGTTCTACAGGAAAAAACTGGATTTAGACCTAAAATCAA
ATTTCCTAAGGGCGGAGATAAACGTTCTCTTTTAAAAATCGCTGAAAAAAATGCTGAACTTGGATTGTCAGAAAGATTAC
TCGCAACTCATTATAGAGATCAAACGGCATCTTTAAAAGAAATTCAAGAAATGTTTTCTTTAGAACGTCTTCCTCATATT
ATAGAATGTTATGATATTAGCCATTTTCAAGGTTCGCAACCGGTTGCAAGTGGTGTGATGTTTGTAGAAGGAAAACCATT
TAAACAAGGATACAGAAAATATAATATACGAGGTTACGAAGGGATCAACGATCCTGGAATGATTCATGAAGTAATTTCTA
GACGTCTACAAAGAATCATCAATGAAGAAGGAGTGTTTCCGGATCTTATCGTGATCGACGGAGGACTAACTCAGTTAACA
AAGGCTTGCGAAGCGGCTGTGGAAGCGGGGGCCGAGGGAATTCCTATGGTAGGTCTTGCTAAAAAAAGAGAAGAAATTTT
TTTTCCAGGCGAAAACGAACCGTTTATATTTGATATGAATTCTCCCGGAATGAAACTTTTGCGTCATCTCAGAGATGAAG
CTCATAGGTTTGGAGTCAGCCATCATAGATCCCGTAGAAATAAGGAAACGATGCGTTCTCTGATTCAAGAGGTTCCAGAT
ATAGGTTTTAAAAGAAGTAAGTTACTTTTACAACATTTCTCGGGAGAAAAAAAAATCGAAGAAGCTACAAAAGAAGAGTT
ACTTTTAGTTCCTGGAATTGGAGAAAATCTCGCCGAAAAAATTTTAAAACAACTTCAAAAAAAAGAATAA

Upstream 100 bases:

>100_bases
ATAAATATAGAATTACGGAAAAAATAAAATTTTGTAAGAGTTCCTATAAAATTTAAGATCTTAGGGATTCCAATTTAAAC
TTATATTAAAAAAATACAAT

Downstream 100 bases:

>100_bases
AAAATCTCTAAAATTCAAAACGAAACGTATTTTCCCTAAACCGTATCAGGTGGAGGGAAACATGAAATTCAAATTCGTTT
TTGTAGCTTCGTTTCTTCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MPEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTKVLQREIFDLDWIATGTEKEA
LILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVYVTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQ
VLPLPRPRRPCLNFDMGRCLGPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRI
QNFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEILGAFFRDYYLNASLVPPCIF
IPADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKIAEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHI
IECYDISHFQGSQPVASGVMFVEGKPFKQGYRKYNIRGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLT
KACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQEVPD
IGFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEKILKQLQKKE

Sequences:

>Translated_609_residues
MPEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTKVLQREIFDLDWIATGTEKEA
LILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVYVTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQ
VLPLPRPRRPCLNFDMGRCLGPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRI
QNFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEILGAFFRDYYLNASLVPPCIF
IPADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKIAEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHI
IECYDISHFQGSQPVASGVMFVEGKPFKQGYRKYNIRGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLT
KACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQEVPD
IGFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEKILKQLQKKE
>Mature_608_residues
PEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTKVLQREIFDLDWIATGTEKEAL
ILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVYVTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQV
LPLPRPRRPCLNFDMGRCLGPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRIQ
NFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEILGAFFRDYYLNASLVPPCIFI
PADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKIAEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHII
ECYDISHFQGSQPVASGVMFVEGKPFKQGYRKYNIRGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLTK
ACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQEVPDI
GFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEKILKQLQKKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=35.1395730706076, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1788037, Length=201, Percent_Identity=28.8557213930348, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_LEPIC (Q72RI9)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001708.1
- ProteinModelPortal:   Q72RI9
- GeneID:   2771957
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11756
- NMPDR:   fig|267671.1.peg.1708
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   LINT267671:LIC_11756-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69791; Mature: 69660

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTK
CCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHH
VLQREIFDLDWIATGTEKEALILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVY
HHHHHHHCCCEEECCCCCCEEEEEEHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEEE
VTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPRPRRPCLNFDMGRCL
EEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHCC
GPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCHHHCCHHHHHHHHHHHHHH
QNFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEI
HHHHHHCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCEECCCCCCCCEEEECCCCCHH
LGAFFRDYYLNASLVPPCIFIPADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKI
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHH
AEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHIIECYDISHFQGSQPVASGVM
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEEHEECCCCCCCCCHHHCEE
FVEGKPFKQGYRKYNIRGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLT
EECCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
KACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVS
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCHH
HHRSRRNKETMRSLIQEVPDIGFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEK
HHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCEEECCCCCHHHHHH
ILKQLQKKE
HHHHHHCCC
>Mature Secondary Structure 
PEILNHTLILEKIKNLGASPGCYLWKSKKGEVLYVGKAKNLDKRVRSYLKENHPDVKTK
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHH
VLQREIFDLDWIATGTEKEALILEATLIKKHNPRFNVRLKDDKKYPYICVSLSEPYPMVY
HHHHHHHCCCEEECCCCCCEEEEEEHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEEE
VTRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPRPRRPCLNFDMGRCL
EEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHCC
GPCQGNIPVEDYKVIIDQVIQFLEGRKESLVSDLNIKMSNASERLDFEKAARYRDMLQRI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCHHHCCHHHHHHHHHHHHHH
QNFREKQTVVSLEGGDEDVIGFARKQDEGQVILLEIRGGRLETKKSFPIQGVLDAENSEI
HHHHHHCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCEECCCCCCCCEEEECCCCCHH
LGAFFRDYYLNASLVPPCIFIPADIQDEVIPVIDVLQEKTGFRPKIKFPKGGDKRSLLKI
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHH
AEKNAELGLSERLLATHYRDQTASLKEIQEMFSLERLPHIIECYDISHFQGSQPVASGVM
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEEHEECCCCCCCCCHHHCEE
FVEGKPFKQGYRKYNIRGYEGINDPGMIHEVISRRLQRIINEEGVFPDLIVIDGGLTQLT
EECCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
KACEAAVEAGAEGIPMVGLAKKREEIFFPGENEPFIFDMNSPGMKLLRHLRDEAHRFGVS
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCHH
HHRSRRNKETMRSLIQEVPDIGFKRSKLLLQHFSGEKKIEEATKEELLLVPGIGENLAEK
HHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCEEECCCCCHHHHHH
ILKQLQKKE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA