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The map label for this gene is uvrD2

Identifier: 45657598

GI number: 45657598

Start: 2110228

End: 2112246

Strand: Direct

Name: uvrD2

Synonym: LIC11732

Alternate gene names: 45657598

Gene position: 2110228-2112246 (Clockwise)

Preceding gene: 45657597

Following gene: 45657599

Centisome position: 49.34

GC content: 34.72

Gene sequence:

>2019_bases
GTGGGCATCACCATCATTGAAGTGTCTTGGAAAGAAGAACTAAATCCGGCTCAAATGGAGGCGGTACTGACTCTAGACGG
GCCAGTACTTGTTTTAGCCGGTGCGGGTACAGGCAAAACTAAAACCATCGTTAGTCGGTTGGCGCAATTAGTTGCCTCCG
GTATCCCTGCTTCTTCTATTTTGTTACTTACATTTTCTAGAAAGGCCGCCAGAGAAATGATTCTCAGGGCTTCTATGATC
GGTAATAAAAAATGCTCCGAGGTTCAAGGCGGAACCTTTCATTCTTTTTGCAACGGAGTTTTGAGAAAATTCGCTCCCGT
TTTAGACATTTCTTCTGGGTTTACGATTCTAGACGAATCTGATTGTTTGGATGTATTTCAATTTTTAAGAAACGAAAAAA
ATTTCGGTAAAACTAAATCTAGATTTCCTTCCAATGAAACCCTAGTATCTATCCACAGTGAAATTCAAAATACAGGAAAA
CCGCTTTATAGTATATTAGAAAAAGATTATCCTTTATTTCTACAAAAAGCAAATGATATTTCTCAAATTTTTGAAGATTA
TAAATCTTATAAAAAAGAACAATCTCTTTTAGATTACGACGACCTACTCTATTTTACCAGAGAGCTTCTGACCAATCATC
CAGGGGTCAGAAACGCACTTTCCGAAAAATACAGATTTATCATGGTGGATGAATTTCAAGATACAAATAAAATACAAGCG
CATATAGCGTGTCTTCTTGCTTCAGAACATTCCAATTTGATGGTGGTTGGAGATGACGCTCAGTGTATCTATACGTTTCG
AGGGGCTTCCGTCAGAGGTATTTTAGATTTTCCTAAAATATTCCCAAATACAAAAACAATCTTTTTAGAAAAAAATTATA
GAAGTACACCCTCTATTTTAAATCTCGCAAATGAAGTACTTAAAAATTTTTCGGAAAAATACGACAAATATCTTTTTACA
GATAACGAAAATGGTCCGCTTCCGCAAGTTTTACAATTCGAAGACGAGTTAGAAGAAGCGGAAGGGATTTCTAAAATCCT
TTTGCAAAAAAGAGAGGAAGGAATTCCGTTTCAAAAAATGTGTGTTCTTTTCCGTGCTGGGTGGAACTCAAATCAACTCG
AACTTGTACTCGCAAAACGGAATATTCCTTTTGTGAAATTTGGTGGAAAAAAGTTTATTGAAACCGCTCATATCAAAGAT
CTACTTTCTTTGTTAAAGTTGCTCGTAAATCCTCTAGATTCTGTTTCTTGGATTCGAACGTTAAAATTAATTCCAGGAAT
TGGAAATGCGAAGGCAAATTCTATTTTAGATAAGATTCGAAAATCATCTGGTTCTTTCGAAGTACTTTCTGAAGAAAACG
GAACTACAATCGATAAATATATTTCCCCTCTTTATCATCTTTATCAAAAGTATAAGGAAACCCACTCTGAAGTAAAAAAG
ATGGTTTCTGAGTTTATAGATTACTACCGGGTTCTTTTGGAAAAAAATTACGATGATTCCAAACGAAGATCGGAAGACTT
GGATGCGGTTTTAGGATTTTCATTGAAATATAATTCTTTGAGTGATTTTTTATCGGATCTTACAATGGATCCTACTTCTT
TAAGTTTAGATAAAATGAAACCGGACGACACAGATTCAGACCTACTCAATTTATCTACGGTTCATTCTGCAAAAGGATTA
GAGTTCGATCTTGTGTTCGTTTTAAATACGACCGAAGGTATTTTTCCTTCCAGTAAAAATACGAATATTGAAGAAGAAAG
AAGACTTTTTTACGTAGCTATCACAAGAGCCAGAAAGGAATTATATCTAACCAGACCTTCTTTGGCTCAATCTAGATCTG
GACCGTATTATACAAAACTTTCTCGTTTTTTAAGTGAAATTCAATTTCCAGAAAAGATTTACGAATTAAAGTTGATGTCT
GGAAAATCCGTTTCTAAAAATCCTTTTGCAAATCAAGGTTCTTTTGTAAAAAATACAAACGATTCTTTTTCTAGAATTCA
AGATTACTTTGGAAACTAG

Upstream 100 bases:

>100_bases
CATCCACTTGCTGGTGTAGATTTAGTTTTTGATGTAGAACTTACAGGAATTAGAGAAGCTACTCAAGAAGAAATTTCACA
CGGACACGTTCACGGAGAAG

Downstream 100 bases:

>100_bases
AAACTTTATGTTTTCTAAGTTTCAAAATCGAACCGAAAAAATCGAACCCACTTTTGTTTTAGACATTTTAGAAAAAAGAA
TATTTGAATTTTGTAAACTT

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MGITIIEVSWKEELNPAQMEAVLTLDGPVLVLAGAGTGKTKTIVSRLAQLVASGIPASSILLLTFSRKAAREMILRASMI
GNKKCSEVQGGTFHSFCNGVLRKFAPVLDISSGFTILDESDCLDVFQFLRNEKNFGKTKSRFPSNETLVSIHSEIQNTGK
PLYSILEKDYPLFLQKANDISQIFEDYKSYKKEQSLLDYDDLLYFTRELLTNHPGVRNALSEKYRFIMVDEFQDTNKIQA
HIACLLASEHSNLMVVGDDAQCIYTFRGASVRGILDFPKIFPNTKTIFLEKNYRSTPSILNLANEVLKNFSEKYDKYLFT
DNENGPLPQVLQFEDELEEAEGISKILLQKREEGIPFQKMCVLFRAGWNSNQLELVLAKRNIPFVKFGGKKFIETAHIKD
LLSLLKLLVNPLDSVSWIRTLKLIPGIGNAKANSILDKIRKSSGSFEVLSEENGTTIDKYISPLYHLYQKYKETHSEVKK
MVSEFIDYYRVLLEKNYDDSKRRSEDLDAVLGFSLKYNSLSDFLSDLTMDPTSLSLDKMKPDDTDSDLLNLSTVHSAKGL
EFDLVFVLNTTEGIFPSSKNTNIEEERRLFYVAITRARKELYLTRPSLAQSRSGPYYTKLSRFLSEIQFPEKIYELKLMS
GKSVSKNPFANQGSFVKNTNDSFSRIQDYFGN

Sequences:

>Translated_672_residues
MGITIIEVSWKEELNPAQMEAVLTLDGPVLVLAGAGTGKTKTIVSRLAQLVASGIPASSILLLTFSRKAAREMILRASMI
GNKKCSEVQGGTFHSFCNGVLRKFAPVLDISSGFTILDESDCLDVFQFLRNEKNFGKTKSRFPSNETLVSIHSEIQNTGK
PLYSILEKDYPLFLQKANDISQIFEDYKSYKKEQSLLDYDDLLYFTRELLTNHPGVRNALSEKYRFIMVDEFQDTNKIQA
HIACLLASEHSNLMVVGDDAQCIYTFRGASVRGILDFPKIFPNTKTIFLEKNYRSTPSILNLANEVLKNFSEKYDKYLFT
DNENGPLPQVLQFEDELEEAEGISKILLQKREEGIPFQKMCVLFRAGWNSNQLELVLAKRNIPFVKFGGKKFIETAHIKD
LLSLLKLLVNPLDSVSWIRTLKLIPGIGNAKANSILDKIRKSSGSFEVLSEENGTTIDKYISPLYHLYQKYKETHSEVKK
MVSEFIDYYRVLLEKNYDDSKRRSEDLDAVLGFSLKYNSLSDFLSDLTMDPTSLSLDKMKPDDTDSDLLNLSTVHSAKGL
EFDLVFVLNTTEGIFPSSKNTNIEEERRLFYVAITRARKELYLTRPSLAQSRSGPYYTKLSRFLSEIQFPEKIYELKLMS
GKSVSKNPFANQGSFVKNTNDSFSRIQDYFGN
>Mature_671_residues
GITIIEVSWKEELNPAQMEAVLTLDGPVLVLAGAGTGKTKTIVSRLAQLVASGIPASSILLLTFSRKAAREMILRASMIG
NKKCSEVQGGTFHSFCNGVLRKFAPVLDISSGFTILDESDCLDVFQFLRNEKNFGKTKSRFPSNETLVSIHSEIQNTGKP
LYSILEKDYPLFLQKANDISQIFEDYKSYKKEQSLLDYDDLLYFTRELLTNHPGVRNALSEKYRFIMVDEFQDTNKIQAH
IACLLASEHSNLMVVGDDAQCIYTFRGASVRGILDFPKIFPNTKTIFLEKNYRSTPSILNLANEVLKNFSEKYDKYLFTD
NENGPLPQVLQFEDELEEAEGISKILLQKREEGIPFQKMCVLFRAGWNSNQLELVLAKRNIPFVKFGGKKFIETAHIKDL
LSLLKLLVNPLDSVSWIRTLKLIPGIGNAKANSILDKIRKSSGSFEVLSEENGTTIDKYISPLYHLYQKYKETHSEVKKM
VSEFIDYYRVLLEKNYDDSKRRSEDLDAVLGFSLKYNSLSDFLSDLTMDPTSLSLDKMKPDDTDSDLLNLSTVHSAKGLE
FDLVFVLNTTEGIFPSSKNTNIEEERRLFYVAITRARKELYLTRPSLAQSRSGPYYTKLSRFLSEIQFPEKIYELKLMSG
KSVSKNPFANQGSFVKNTNDSFSRIQDYFGN

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=678, Percent_Identity=30.8259587020649, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI48994965, Length=650, Percent_Identity=30, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322369, Length=478, Percent_Identity=29.2887029288703, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324477, Length=424, Percent_Identity=23.1132075471698, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76328; Mature: 76197

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITIIEVSWKEELNPAQMEAVLTLDGPVLVLAGAGTGKTKTIVSRLAQLVASGIPASSI
CCEEEEEECCHHCCCHHHEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHEE
LLLTFSRKAAREMILRASMIGNKKCSEVQGGTFHSFCNGVLRKFAPVLDISSGFTILDES
EEEEECHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCC
DCLDVFQFLRNEKNFGKTKSRFPSNETLVSIHSEIQNTGKPLYSILEKDYPLFLQKANDI
CHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEHHCCHHH
SQIFEDYKSYKKEQSLLDYDDLLYFTRELLTNHPGVRNALSEKYRFIMVDEFQDTNKIQA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCCHHHHH
HIACLLASEHSNLMVVGDDAQCIYTFRGASVRGILDFPKIFPNTKTIFLEKNYRSTPSIL
HHHHEEECCCCCEEEEECCCEEEEEECCCCEEEECCCHHHCCCCEEEEEECCCCCCHHHH
NLANEVLKNFSEKYDKYLFTDNENGPLPQVLQFEDELEEAEGISKILLQKREEGIPFQKM
HHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
CVLFRAGWNSNQLELVLAKRNIPFVKFGGKKFIETAHIKDLLSLLKLLVNPLDSVSWIRT
HHHHHCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LKLIPGIGNAKANSILDKIRKSSGSFEVLSEENGTTIDKYISPLYHLYQKYKETHSEVKK
HHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MVSEFIDYYRVLLEKNYDDSKRRSEDLDAVLGFSLKYNSLSDFLSDLTMDPTSLSLDKMK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCCCCCCCC
PDDTDSDLLNLSTVHSAKGLEFDLVFVLNTTEGIFPSSKNTNIEEERRLFYVAITRARKE
CCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHEEEEEEHHHHHH
LYLTRPSLAQSRSGPYYTKLSRFLSEIQFPEKIYELKLMSGKSVSKNPFANQGSFVKNTN
HEEECCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DSFSRIQDYFGN
HHHHHHHHHHCC
>Mature Secondary Structure 
GITIIEVSWKEELNPAQMEAVLTLDGPVLVLAGAGTGKTKTIVSRLAQLVASGIPASSI
CEEEEEECCHHCCCHHHEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHEE
LLLTFSRKAAREMILRASMIGNKKCSEVQGGTFHSFCNGVLRKFAPVLDISSGFTILDES
EEEEECHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCC
DCLDVFQFLRNEKNFGKTKSRFPSNETLVSIHSEIQNTGKPLYSILEKDYPLFLQKANDI
CHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEHHCCHHH
SQIFEDYKSYKKEQSLLDYDDLLYFTRELLTNHPGVRNALSEKYRFIMVDEFQDTNKIQA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCCHHHHH
HIACLLASEHSNLMVVGDDAQCIYTFRGASVRGILDFPKIFPNTKTIFLEKNYRSTPSIL
HHHHEEECCCCCEEEEECCCEEEEEECCCCEEEECCCHHHCCCCEEEEEECCCCCCHHHH
NLANEVLKNFSEKYDKYLFTDNENGPLPQVLQFEDELEEAEGISKILLQKREEGIPFQKM
HHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
CVLFRAGWNSNQLELVLAKRNIPFVKFGGKKFIETAHIKDLLSLLKLLVNPLDSVSWIRT
HHHHHCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LKLIPGIGNAKANSILDKIRKSSGSFEVLSEENGTTIDKYISPLYHLYQKYKETHSEVKK
HHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MVSEFIDYYRVLLEKNYDDSKRRSEDLDAVLGFSLKYNSLSDFLSDLTMDPTSLSLDKMK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCCCCCCCC
PDDTDSDLLNLSTVHSAKGLEFDLVFVLNTTEGIFPSSKNTNIEEERRLFYVAITRARKE
CCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHEEEEEEHHHHHH
LYLTRPSLAQSRSGPYYTKLSRFLSEIQFPEKIYELKLMSGKSVSKNPFANQGSFVKNTN
HEEECCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DSFSRIQDYFGN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]