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The map label for this gene is slyD

Identifier: 45657597

GI number: 45657597

Start: 2109765

End: 2110247

Strand: Direct

Name: slyD

Synonym: LIC11731

Alternate gene names: 45657597

Gene position: 2109765-2110247 (Clockwise)

Preceding gene: 304570514

Following gene: 45657598

Centisome position: 49.33

GC content: 38.3

Gene sequence:

>483_bases
TTGGAGCTCTCCATGAAATCTAGAGTAGTTACTTTTCATTACACACTTCACGATACTGAAGGCAATTTGATCGATTCTTC
CGAAGGTAAGACTCCACTTTCTTATTTAGAAGGGGTTGGAAATATCATTTCCGGTTTAGAAGAAGAGATGAAAAAAATGG
AAACAGGCGAAAAGAAAAAAATCAACGTCTCTGCAGAAAAAGCCTACGGCATAAAAGATCCAGATCTTATTTTTGACGTT
CCTAGATCTCAATTTCCTCCCAATGAAGATTTACAAATAGGAATGATGTTTCAAACCGACGAACCGGATAAGGTTTTTAC
CATTACGGAACTCCAAGAAGAGTCTGTCATTGTAGATGGAAATCATCCACTTGCTGGTGTAGATTTAGTTTTTGATGTAG
AACTTACAGGAATTAGAGAAGCTACTCAAGAAGAAATTTCACACGGACACGTTCACGGAGAAGGTGGGCATCACCATCAT
TGA

Upstream 100 bases:

>100_bases
TTCATTACGATTCTAAAATAAAATTCTGATTGAGTTAAACTGCACTCAATTTACTCTGAAACGATTCAGATTCCTACCAG
AATTTTGACTTTATCCCCAT

Downstream 100 bases:

>100_bases
AGTGTCTTGGAAAGAAGAACTAAATCCGGCTCAAATGGAGGCGGTACTGACTCTAGACGGGCCAGTACTTGTTTTAGCCG
GTGCGGGTACAGGCAAAACT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MELSMKSRVVTFHYTLHDTEGNLIDSSEGKTPLSYLEGVGNIISGLEEEMKKMETGEKKKINVSAEKAYGIKDPDLIFDV
PRSQFPPNEDLQIGMMFQTDEPDKVFTITELQEESVIVDGNHPLAGVDLVFDVELTGIREATQEEISHGHVHGEGGHHHH

Sequences:

>Translated_160_residues
MELSMKSRVVTFHYTLHDTEGNLIDSSEGKTPLSYLEGVGNIISGLEEEMKKMETGEKKKINVSAEKAYGIKDPDLIFDV
PRSQFPPNEDLQIGMMFQTDEPDKVFTITELQEESVIVDGNHPLAGVDLVFDVELTGIREATQEEISHGHVHGEGGHHHH
>Mature_160_residues
MELSMKSRVVTFHYTLHDTEGNLIDSSEGKTPLSYLEGVGNIISGLEEEMKKMETGEKKKINVSAEKAYGIKDPDLIFDV
PRSQFPPNEDLQIGMMFQTDEPDKVFTITELQEESVIVDGNHPLAGVDLVFDVELTGIREATQEEISHGHVHGEGGHHHH

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789748, Length=145, Percent_Identity=42.7586206896552, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786211, Length=142, Percent_Identity=29.5774647887324, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17853; Mature: 17853

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50059 FKBP_PPIASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSMKSRVVTFHYTLHDTEGNLIDSSEGKTPLSYLEGVGNIISGLEEEMKKMETGEKKK
CCCCCCCEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
INVSAEKAYGIKDPDLIFDVPRSQFPPNEDLQIGMMFQTDEPDKVFTITELQEESVIVDG
EEEEHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEC
NHPLAGVDLVFDVELTGIREATQEEISHGHVHGEGGHHHH
CCCEEEEEEEEEEEECCCHHHHHHHHHCCEEECCCCCCCC
>Mature Secondary Structure
MELSMKSRVVTFHYTLHDTEGNLIDSSEGKTPLSYLEGVGNIISGLEEEMKKMETGEKKK
CCCCCCCEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
INVSAEKAYGIKDPDLIFDVPRSQFPPNEDLQIGMMFQTDEPDKVFTITELQEESVIVDG
EEEEHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEC
NHPLAGVDLVFDVELTGIREATQEEISHGHVHGEGGHHHH
CCCEEEEEEEEEEEECCCHHHHHHHHHCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]