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The map label for this gene is tyrS

Identifier: 45657564

GI number: 45657564

Start: 2063977

End: 2065194

Strand: Reverse

Name: tyrS

Synonym: LIC11698

Alternate gene names: 45657564

Gene position: 2065194-2063977 (Counterclockwise)

Preceding gene: 45657567

Following gene: 45657563

Centisome position: 48.28

GC content: 36.04

Gene sequence:

>1218_bases
ATGGACATTCAAAAACAAATCGAAATTATCCGTCGCGGCACCGTTGATCTGATTAGCGAAGAGGAATTAAAATCCAAACT
TCAAAAGAAAAAAACTCTTAAAATCAAAGCTGGTTTTGATCCAACCGCTCCCGATCTTCATTTAGGCCATTTTGTTCAGC
TCAAAAAATTAAAACATTTCCAAGACCTGGGTCATGAAGTTTCTTTTTTACTAGGAGACTTTACCGCAATGATCGGAGAT
CCTACCGGAAAATCAGAAACCAGAAAGAGGCTTTCCAGAGAAGAAGTTCTAGAAAACTCAAAAACTTATCAGAACCAAGT
TTTTAAAGTTTTAGACCCAGTTAAAACCAAAATCGTCTACAACTCAAACTGGTGTTCTAAAATGAATTTCGAAGACGTTT
TAGTTCTTAGTTCTAAATATAACGTAGCTAGAATGCTCGAAAGAGACGATTTCAGTAAACGTTATAAAGCGGGCCAACCC
ATCTCTATGATAGAATTCTTATACCCTTTAGTACAAGGTTATGATTCTGTTGCAATGGAATGTGACGTAGAGTTAGGCGG
AACCGATCAGAAATTTAATCTTCTCGTAGGAAGAGACTTACAAAGAGAATATGGAAAAGAAGCGCAGTGTGTTCTAACTC
TCCCGTTACTTGTAGGACTAGACGGATCCAAAAAGATGTCTAAATCCCTTGGAAATTATGTTGGGATTACAGAAACCCCA
ATTGATATGTTTGGAAAACTCATGTCAATTAGCGACGATCTAATGTGGAACTATTTCGAACTTTTAACCGATCTTCCTTT
GCCCGAAATTGAAAATCGAAAAAATGGAATGGCAAAAAAAGAACTTCATCCAAAAGAAATAAAAACCGAACTTGCAAAAT
TGATCATGGATCAATTTTCATCTCCTTCTGAAAATGAAGAAGCCATCCAGGAATGGAAAAAAATTCATAACCCTAAGTCC
AGAGCCGTTCCGGATGATGTAAAAGAAATTAAGTTAGGGGAAGAATTTTTTGCAGAAACACCAGAACCTTTGTTAGTTTG
GGTATTAAGTAAACTTTCCTTTATACCTTCCGTTTCCGAAGGAAGAAGACTGATCAAAGCGGGAGGGCTTTATCTTTCTG
AAGATAAAATTACAGACGAAAAATTTCCAATTCAAAAAGGAAAAGAATATCTAGTGAGGCAGGGGAAAAAAGGGAAATTT
TTAAAAATTATTTCCTAA

Upstream 100 bases:

>100_bases
CGTTTTTGTTTTTCCATTTTGAGAACTCTTCCTGCTTTACAGGTTTCTTTCCCCCTACAAATTTGCATTAAGTTTCACAA
TCCAATTCGGATTTTCTTTC

Downstream 100 bases:

>100_bases
AAATGATTTGAAGGATTCGAAATTCCTTATTTCAATCGAGTCTTTATGTTAAGCGAAGAAGAATCATCGGAACTTTTCAG
GACAATTTCCGAAATTAAAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDIQKQIEIIRRGTVDLISEEELKSKLQKKKTLKIKAGFDPTAPDLHLGHFVQLKKLKHFQDLGHEVSFLLGDFTAMIGD
PTGKSETRKRLSREEVLENSKTYQNQVFKVLDPVKTKIVYNSNWCSKMNFEDVLVLSSKYNVARMLERDDFSKRYKAGQP
ISMIEFLYPLVQGYDSVAMECDVELGGTDQKFNLLVGRDLQREYGKEAQCVLTLPLLVGLDGSKKMSKSLGNYVGITETP
IDMFGKLMSISDDLMWNYFELLTDLPLPEIENRKNGMAKKELHPKEIKTELAKLIMDQFSSPSENEEAIQEWKKIHNPKS
RAVPDDVKEIKLGEEFFAETPEPLLVWVLSKLSFIPSVSEGRRLIKAGGLYLSEDKITDEKFPIQKGKEYLVRQGKKGKF
LKIIS

Sequences:

>Translated_405_residues
MDIQKQIEIIRRGTVDLISEEELKSKLQKKKTLKIKAGFDPTAPDLHLGHFVQLKKLKHFQDLGHEVSFLLGDFTAMIGD
PTGKSETRKRLSREEVLENSKTYQNQVFKVLDPVKTKIVYNSNWCSKMNFEDVLVLSSKYNVARMLERDDFSKRYKAGQP
ISMIEFLYPLVQGYDSVAMECDVELGGTDQKFNLLVGRDLQREYGKEAQCVLTLPLLVGLDGSKKMSKSLGNYVGITETP
IDMFGKLMSISDDLMWNYFELLTDLPLPEIENRKNGMAKKELHPKEIKTELAKLIMDQFSSPSENEEAIQEWKKIHNPKS
RAVPDDVKEIKLGEEFFAETPEPLLVWVLSKLSFIPSVSEGRRLIKAGGLYLSEDKITDEKFPIQKGKEYLVRQGKKGKF
LKIIS
>Mature_405_residues
MDIQKQIEIIRRGTVDLISEEELKSKLQKKKTLKIKAGFDPTAPDLHLGHFVQLKKLKHFQDLGHEVSFLLGDFTAMIGD
PTGKSETRKRLSREEVLENSKTYQNQVFKVLDPVKTKIVYNSNWCSKMNFEDVLVLSSKYNVARMLERDDFSKRYKAGQP
ISMIEFLYPLVQGYDSVAMECDVELGGTDQKFNLLVGRDLQREYGKEAQCVLTLPLLVGLDGSKKMSKSLGNYVGITETP
IDMFGKLMSISDDLMWNYFELLTDLPLPEIENRKNGMAKKELHPKEIKTELAKLIMDQFSSPSENEEAIQEWKKIHNPKS
RAVPDDVKEIKLGEEFFAETPEPLLVWVLSKLSFIPSVSEGRRLIKAGGLYLSEDKITDEKFPIQKGKEYLVRQGKKGKF
LKIIS

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=395, Percent_Identity=27.5949367088608, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1787925, Length=421, Percent_Identity=26.8408551068884, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25145802, Length=281, Percent_Identity=28.1138790035587, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325160, Length=408, Percent_Identity=27.2058823529412, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130383, Length=379, Percent_Identity=26.1213720316623, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_LEPIC (Q72RP6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001650.1
- ProteinModelPortal:   Q72RP6
- SMR:   Q72RP6
- GeneID:   2771607
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11698
- HOGENOM:   HBG288125
- OMA:   FKEGIPI
- ProtClustDB:   PRK05912
- BioCyc:   LINT267671:LIC_11698-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02007
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 46319; Mature: 46319

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQKQIEIIRRGTVDLISEEELKSKLQKKKTLKIKAGFDPTAPDLHLGHFVQLKKLKHF
CCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QDLGHEVSFLLGDFTAMIGDPTGKSETRKRLSREEVLENSKTYQNQVFKVLDPVKTKIVY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEE
NSNWCSKMNFEDVLVLSSKYNVARMLERDDFSKRYKAGQPISMIEFLYPLVQGYDSVAME
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEE
CDVELGGTDQKFNLLVGRDLQREYGKEAQCVLTLPLLVGLDGSKKMSKSLGNYVGITETP
EEEEECCCCCEEEEECCCHHHHHCCCCCEEEEEEHHHHCCCCCHHHHHHHCCCCCCCCCC
IDMFGKLMSISDDLMWNYFELLTDLPLPEIENRKNGMAKKELHPKEIKTELAKLIMDQFS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
SPSENEEAIQEWKKIHNPKSRAVPDDVKEIKLGEEFFAETPEPLLVWVLSKLSFIPSVSE
CCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCCCHHH
GRRLIKAGGLYLSEDKITDEKFPIQKGKEYLVRQGKKGKFLKIIS
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MDIQKQIEIIRRGTVDLISEEELKSKLQKKKTLKIKAGFDPTAPDLHLGHFVQLKKLKHF
CCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QDLGHEVSFLLGDFTAMIGDPTGKSETRKRLSREEVLENSKTYQNQVFKVLDPVKTKIVY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEE
NSNWCSKMNFEDVLVLSSKYNVARMLERDDFSKRYKAGQPISMIEFLYPLVQGYDSVAME
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEE
CDVELGGTDQKFNLLVGRDLQREYGKEAQCVLTLPLLVGLDGSKKMSKSLGNYVGITETP
EEEEECCCCCEEEEECCCHHHHHCCCCCEEEEEEHHHHCCCCCHHHHHHHCCCCCCCCCC
IDMFGKLMSISDDLMWNYFELLTDLPLPEIENRKNGMAKKELHPKEIKTELAKLIMDQFS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
SPSENEEAIQEWKKIHNPKSRAVPDDVKEIKLGEEFFAETPEPLLVWVLSKLSFIPSVSE
CCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCCCHHH
GRRLIKAGGLYLSEDKITDEKFPIQKGKEYLVRQGKKGKFLKIIS
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA