Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 45657463

GI number: 45657463

Start: 1950228

End: 1951496

Strand: Reverse

Name: xseA

Synonym: LIC11591

Alternate gene names: 45657463

Gene position: 1951496-1950228 (Counterclockwise)

Preceding gene: 45657464

Following gene: 45657462

Centisome position: 45.63

GC content: 37.75

Gene sequence:

>1269_bases
TTGGAAGATTCCAAACCTCTTTCCGTTTCGGAAGTTACTAGAATCATTAAAAATCTGATTTCCGGTTCCAAAGATTTAAA
AAATATCTGGGTCCGAGGAGAAATTTCTAACTATAGCAAGGCCAGTTCAGGACATATTTACTTTTCTCTCAAAGACGCTG
GATCTTTGATTCGATGTACTTTTTTCAATTACTCAAACAAAAATTATTCCGGAAAACCATTATCCGATGGAAAAGAAATC
CAGGTCTATGGAACCATCACTCTCTACGAAGCAGGTGGTTCTTATAATCTCAACGTAACCAGAGTAGAAGAATTAGGACA
AGGGGATATACTACTCCAAATCGAAAAACTCAAACAAAAGCTCGCAGTAGAAGGAATTTTTGATCCGGAAAAAAAAAGAA
GAATTCCATCTTTTCCAAAAACGTTAGGAATCGCCACTTCTCCTACTGGAGCCGCAATCGAAGACATTATCAAAATTTCC
CGTTCCCGTTTTCCAGGGATCAATATACTTATCGCTCCTTGTATTGTTCAAGGAGAAGACGCTCCGGATTCAATCGTCGC
AGCTATAGAAGAATTAAACCATCCGAACTGGAAAGTAGATGTGATTATCGCAGGAAGAGGAGGAGGAAGTTTTGAAGATC
TAATGGCGTTTAACGACGAAAAGGTGGTCAGAGCCTATGCAAATTCCAGGATTCCGATCATATCAGCAGTAGGTCATCAA
ACCGACGTTTTATTAAGCGACTTTGCTGCTGACCATTTTACTCCTACTCCCACCGCTGCTGCAGAATATGCAATTCCCAA
AGAAGAAGACGTACTTCAATTTTTATCCCAGTTAGAAGGAAGAATTAAAAGCTCTTTAGTAACAAAAATTTCTTCTAACA
GAGACAGACTTAGACTTTTATCTGGAAAGTTCATCTTTAAAGAACCGATGCAACTTCTCAATCAAAGAAGTCAAAGAGTA
GATGAAATTGGAATTCGATTACAAAAGGCGTTATCCAACAAACTGAATTTAGCCAGAGTTCGATTGGAAAGATACCAAAA
TCTTACTTCCAGAATTCAAAACATTCTTTTTCATAAAAAACAAAAAGCTGAATTTTGGACTAGCAAAGTGGAAGATCTTT
CTCCCGCGGCTACGATGAAACGTGGATATTCAATTCTTAGAAACGAAAATGGAAAAATCATACGATCTCCGGAAGAAACA
AAACCGGAAGAAGAATTGCAAGTTTTACTTTCAGGTGGAACGATGCAAGTGATTAGAAAAGGAAAATAA

Upstream 100 bases:

>100_bases
GGTTGTAGGGCCGGTTACAGTCACGTTAGTTGTCATTTTATGGGATTTTTGGAAATTGTATCGCCGAGAATTGATTTTGA
ACAAAGGACATAGATAAACA

Downstream 100 bases:

>100_bases
AATGGTGGAGACAAAATCTAAAATTTCATTTGAAGACGCTCTGATGGAACTGGAACAAATTGCAGAAAAACTAGAACGAC
AAGATTTCAGTTTAGAAGAA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEDSKPLSVSEVTRIIKNLISGSKDLKNIWVRGEISNYSKASSGHIYFSLKDAGSLIRCTFFNYSNKNYSGKPLSDGKEI
QVYGTITLYEAGGSYNLNVTRVEELGQGDILLQIEKLKQKLAVEGIFDPEKKRRIPSFPKTLGIATSPTGAAIEDIIKIS
RSRFPGINILIAPCIVQGEDAPDSIVAAIEELNHPNWKVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADHFTPTPTAAAEYAIPKEEDVLQFLSQLEGRIKSSLVTKISSNRDRLRLLSGKFIFKEPMQLLNQRSQRV
DEIGIRLQKALSNKLNLARVRLERYQNLTSRIQNILFHKKQKAEFWTSKVEDLSPAATMKRGYSILRNENGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK

Sequences:

>Translated_422_residues
MEDSKPLSVSEVTRIIKNLISGSKDLKNIWVRGEISNYSKASSGHIYFSLKDAGSLIRCTFFNYSNKNYSGKPLSDGKEI
QVYGTITLYEAGGSYNLNVTRVEELGQGDILLQIEKLKQKLAVEGIFDPEKKRRIPSFPKTLGIATSPTGAAIEDIIKIS
RSRFPGINILIAPCIVQGEDAPDSIVAAIEELNHPNWKVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADHFTPTPTAAAEYAIPKEEDVLQFLSQLEGRIKSSLVTKISSNRDRLRLLSGKFIFKEPMQLLNQRSQRV
DEIGIRLQKALSNKLNLARVRLERYQNLTSRIQNILFHKKQKAEFWTSKVEDLSPAATMKRGYSILRNENGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK
>Mature_422_residues
MEDSKPLSVSEVTRIIKNLISGSKDLKNIWVRGEISNYSKASSGHIYFSLKDAGSLIRCTFFNYSNKNYSGKPLSDGKEI
QVYGTITLYEAGGSYNLNVTRVEELGQGDILLQIEKLKQKLAVEGIFDPEKKRRIPSFPKTLGIATSPTGAAIEDIIKIS
RSRFPGINILIAPCIVQGEDAPDSIVAAIEELNHPNWKVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADHFTPTPTAAAEYAIPKEEDVLQFLSQLEGRIKSSLVTKISSNRDRLRLLSGKFIFKEPMQLLNQRSQRV
DEIGIRLQKALSNKLNLARVRLERYQNLTSRIQNILFHKKQKAEFWTSKVEDLSPAATMKRGYSILRNENGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=431, Percent_Identity=33.1786542923434, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_LEPIC (Q72RZ7)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001549.1
- GeneID:   2771875
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11591
- NMPDR:   fig|267671.1.peg.1549
- HOGENOM:   HBG634411
- OMA:   SSQIRCA
- ProtClustDB:   PRK00286
- BioCyc:   LINT267671:LIC_11591-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47108; Mature: 47108

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSKPLSVSEVTRIIKNLISGSKDLKNIWVRGEISNYSKASSGHIYFSLKDAGSLIRCT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEE
FFNYSNKNYSGKPLSDGKEIQVYGTITLYEAGGSYNLNVTRVEELGQGDILLQIEKLKQK
EEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEHHHCCCCCEEEEHHHHHHH
LAVEGIFDPEKKRRIPSFPKTLGIATSPTGAAIEDIIKISRSRFPGINILIAPCIVQGED
HHHCCCCCCHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCC
APDSIVAAIEELNHPNWKVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
CCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHCCCHHHHHHHCCCCCCEEEECCCC
TDVLLSDFAADHFTPTPTAAAEYAIPKEEDVLQFLSQLEGRIKSSLVTKISSNRDRLRLL
HHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHC
SGKFIFKEPMQLLNQRSQRVDEIGIRLQKALSNKLNLARVRLERYQNLTSRIQNILFHKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QKAEFWTSKVEDLSPAATMKRGYSILRNENGKIIRSPEETKPEEELQVLLSGGTMQVIRK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEHCC
GK
CC
>Mature Secondary Structure
MEDSKPLSVSEVTRIIKNLISGSKDLKNIWVRGEISNYSKASSGHIYFSLKDAGSLIRCT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEE
FFNYSNKNYSGKPLSDGKEIQVYGTITLYEAGGSYNLNVTRVEELGQGDILLQIEKLKQK
EEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEHHHCCCCCEEEEHHHHHHH
LAVEGIFDPEKKRRIPSFPKTLGIATSPTGAAIEDIIKISRSRFPGINILIAPCIVQGED
HHHCCCCCCHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCC
APDSIVAAIEELNHPNWKVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
CCHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHCCCHHHHHHHCCCCCCEEEECCCC
TDVLLSDFAADHFTPTPTAAAEYAIPKEEDVLQFLSQLEGRIKSSLVTKISSNRDRLRLL
HHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHC
SGKFIFKEPMQLLNQRSQRVDEIGIRLQKALSNKLNLARVRLERYQNLTSRIQNILFHKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QKAEFWTSKVEDLSPAATMKRGYSILRNENGKIIRSPEETKPEEELQVLLSGGTMQVIRK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEHCC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA