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The map label for this gene is cyaA [H]

Identifier: 45657221

GI number: 45657221

Start: 1655628

End: 1656965

Strand: Reverse

Name: cyaA [H]

Synonym: LIC11343

Alternate gene names: 45657221

Gene position: 1656965-1655628 (Counterclockwise)

Preceding gene: 45657223

Following gene: 45657216

Centisome position: 38.74

GC content: 34.38

Gene sequence:

>1338_bases
GTGAATCCTTTCCAATCGATCCAAAAAATGTTTCATACTCTAGACAGAAAATCCATGCCAGATTCCGTTTTAGATGTACT
TCAAAAAGAAGAAAGAAGCGGAATTATAATCACCAATTATTTTCGTTACCTGATTGCACTTTTCTTTTTAGTTCAAATAG
CGGTCAACGTAGAAAATGGAAATGGTAAATTCAATTTCATCGCATTTTCAATTTATCTTTTTTTAACTCTTTCGCATACA
ATCGTTATTCGAGTTTGTCCAATTTCCATCGTAAACGTTTTCAATTACTTTACCTTATTTGCAGAATATCTCCTGATTTT
AGGGGTTTTACTTTTTTATACTTTTACGATAAAGAACGTAAATTTAGGATTTGCTCTTAAACATACGATCAATCTTTTCT
TTCTTTTTCCAATTATTTATTCTCTTTTACAATTTAAGATTCGTTTCGTTTTTATTGGACTCTTTCTTTTTTATGCAATT
TATTTTTCAATTCTTTGGATCGCGGTTTCTACCAATCAACTTACTTATACCAAGGATTGGGGTCATTATATCAGCGGGCC
AGGTATTTTGATTGAGGACATTGTCGCAGGTAAACCGGGTATGTACTTTTGTTTTGCCATGATGATTTCTATGGGAATCT
TTCGAACTATTTCTATGGTAAGAAGAATTGGAATTGCAGAAGGTCAAAAAAAGGAACTCTCTAGATATTTTTCTCCCAAG
ATCGTAAACGAAATGGTGGAAAATCCTGGGGCACTTCAAAATGGAAATCGCCAAATTGTAAGTATTCTTTTTTTAGATAT
TCGTAACTTTACTGCAATGTCCGAAAATATGAATCCTGAAGAACTAAGTAACTTTCTATCAGAATTTCGTAAAATTATGA
TGGAATGTGTTTTTGAACATAACGGCACATTAGATAAATATATTGGAGACGCAGTAATGGCTACGTTCGGAACTCCTCAT
CCTTCCCCTTCCGCCGAAGTGGATGCAAGAAATGCGGTAGGTTGTGGGGTCATCATGCAAAAGAGACTCTCAGAATGGAA
TCTACTGAGAAAATCGGAAGGAAAAACTTCTATCTCAATCGGTATTGGTATTCATACGGGAGAAGTTTTTGCAGGAAATA
TAGGCAACGATCTTCATAGAGAATATTCAGTGATCGGTGATGCAGTCAATACGGCTTCTAGAATCGAATCTATTTGTAAG
GTTTTGAAAAAATCGTTTTTGATTTCTAAAGAAACAATGGAGTTGTTAGGCGGTAAATACACTCTCAATCGAATGCCTAG
AGTAAAAGTGAAAGGCAAACAAGAACCATTACAACTTTATGAAGTTGTATGGAGATGA

Upstream 100 bases:

>100_bases
AATGTTTCTCTTCTTTTTTTATGAAAGAATTTTTTTCAAAATCGACCCTTCTTTCCGGAAAGAATTGATTTCGAATCCGT
AAATTTCTATCTTGAACTTT

Downstream 100 bases:

>100_bases
ATTTCTCGAACGACCCCGTCATTTACTCAAATTAACTACCCTTAAGATAGCCTAATTTACTACATCTAATGATTTCTTGA
TCGGCTGTAATTAATTCAGT

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNPFQSIQKMFHTLDRKSMPDSVLDVLQKEERSGIIITNYFRYLIALFFLVQIAVNVENGNGKFNFIAFSIYLFLTLSHT
IVIRVCPISIVNVFNYFTLFAEYLLILGVLLFYTFTIKNVNLGFALKHTINLFFLFPIIYSLLQFKIRFVFIGLFLFYAI
YFSILWIAVSTNQLTYTKDWGHYISGPGILIEDIVAGKPGMYFCFAMMISMGIFRTISMVRRIGIAEGQKKELSRYFSPK
IVNEMVENPGALQNGNRQIVSILFLDIRNFTAMSENMNPEELSNFLSEFRKIMMECVFEHNGTLDKYIGDAVMATFGTPH
PSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKTSISIGIGIHTGEVFAGNIGNDLHREYSVIGDAVNTASRIESICK
VLKKSFLISKETMELLGGKYTLNRMPRVKVKGKQEPLQLYEVVWR

Sequences:

>Translated_445_residues
MNPFQSIQKMFHTLDRKSMPDSVLDVLQKEERSGIIITNYFRYLIALFFLVQIAVNVENGNGKFNFIAFSIYLFLTLSHT
IVIRVCPISIVNVFNYFTLFAEYLLILGVLLFYTFTIKNVNLGFALKHTINLFFLFPIIYSLLQFKIRFVFIGLFLFYAI
YFSILWIAVSTNQLTYTKDWGHYISGPGILIEDIVAGKPGMYFCFAMMISMGIFRTISMVRRIGIAEGQKKELSRYFSPK
IVNEMVENPGALQNGNRQIVSILFLDIRNFTAMSENMNPEELSNFLSEFRKIMMECVFEHNGTLDKYIGDAVMATFGTPH
PSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKTSISIGIGIHTGEVFAGNIGNDLHREYSVIGDAVNTASRIESICK
VLKKSFLISKETMELLGGKYTLNRMPRVKVKGKQEPLQLYEVVWR
>Mature_445_residues
MNPFQSIQKMFHTLDRKSMPDSVLDVLQKEERSGIIITNYFRYLIALFFLVQIAVNVENGNGKFNFIAFSIYLFLTLSHT
IVIRVCPISIVNVFNYFTLFAEYLLILGVLLFYTFTIKNVNLGFALKHTINLFFLFPIIYSLLQFKIRFVFIGLFLFYAI
YFSILWIAVSTNQLTYTKDWGHYISGPGILIEDIVAGKPGMYFCFAMMISMGIFRTISMVRRIGIAEGQKKELSRYFSPK
IVNEMVENPGALQNGNRQIVSILFLDIRNFTAMSENMNPEELSNFLSEFRKIMMECVFEHNGTLDKYIGDAVMATFGTPH
PSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKTSISIGIGIHTGEVFAGNIGNDLHREYSVIGDAVNTASRIESICK
VLKKSFLISKETMELLGGKYTLNRMPRVKVKGKQEPLQLYEVVWR

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561804, Length=199, Percent_Identity=29.1457286432161, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330468, Length=216, Percent_Identity=28.2407407407407, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221330470, Length=216, Percent_Identity=28.2407407407407, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI62484298, Length=176, Percent_Identity=34.0909090909091, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62484477, Length=176, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116008008, Length=176, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366459, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281366457, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281366455, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI56292422, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI56292424, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24666940, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24663843, Length=198, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 50775; Mature: 50775

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50125 GUANYLATE_CYCLASES_2 ; PS00256 AKH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPFQSIQKMFHTLDRKSMPDSVLDVLQKEERSGIIITNYFRYLIALFFLVQIAVNVENG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHEEEECC
NGKFNFIAFSIYLFLTLSHTIVIRVCPISIVNVFNYFTLFAEYLLILGVLLFYTFTIKNV
CCCEEHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLGFALKHTINLFFLFPIIYSLLQFKIRFVFIGLFLFYAIYFSILWIAVSTNQLTYTKDW
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCC
GHYISGPGILIEDIVAGKPGMYFCFAMMISMGIFRTISMVRRIGIAEGQKKELSRYFSPK
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHH
IVNEMVENPGALQNGNRQIVSILFLDIRNFTAMSENMNPEELSNFLSEFRKIMMECVFEH
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
NGTLDKYIGDAVMATFGTPHPSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKTSISI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
GIGIHTGEVFAGNIGNDLHREYSVIGDAVNTASRIESICKVLKKSFLISKETMELLGGKY
EEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLNRMPRVKVKGKQEPLQLYEVVWR
EECCCCCEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MNPFQSIQKMFHTLDRKSMPDSVLDVLQKEERSGIIITNYFRYLIALFFLVQIAVNVENG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHEEEECC
NGKFNFIAFSIYLFLTLSHTIVIRVCPISIVNVFNYFTLFAEYLLILGVLLFYTFTIKNV
CCCEEHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLGFALKHTINLFFLFPIIYSLLQFKIRFVFIGLFLFYAIYFSILWIAVSTNQLTYTKDW
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCC
GHYISGPGILIEDIVAGKPGMYFCFAMMISMGIFRTISMVRRIGIAEGQKKELSRYFSPK
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHH
IVNEMVENPGALQNGNRQIVSILFLDIRNFTAMSENMNPEELSNFLSEFRKIMMECVFEH
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
NGTLDKYIGDAVMATFGTPHPSPSAEVDARNAVGCGVIMQKRLSEWNLLRKSEGKTSISI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
GIGIHTGEVFAGNIGNDLHREYSVIGDAVNTASRIESICKVLKKSFLISKETMELLGGKY
EEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLNRMPRVKVKGKQEPLQLYEVVWR
EECCCCCEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]