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The map label for this gene is groEL

Identifier: 45657213

GI number: 45657213

Start: 1646985

End: 1648625

Strand: Reverse

Name: groEL

Synonym: LIC11335

Alternate gene names: 45657213

Gene position: 1648625-1646985 (Counterclockwise)

Preceding gene: 45657214

Following gene: 45657212

Centisome position: 38.54

GC content: 42.29

Gene sequence:

>1641_bases
ATGGCGAAAGATATTGAATATAACGAAACGGCAAGACGTAAGCTCCTCGAAGGAGTGAACAAACTCGCAAACGCAGTCAA
AGTTACTCTCGGACCTAAGGGTCGTAACGTAGTAATCGATAAAAAATTCGGAGCACCTACCATCACTAAAGATGGTGTTA
CCGTTGCAAAAGAAATCGAACTAGAAGATCCGTTAGAAAACATGGGAGCTCAAATGGTAAAAGAAGTTTCCACTAAGACG
AACGACGTCGCTGGAGACGGAACCACAACGGCAACCATTCTCGCTCAATCCATCATCAACGAAGGTCTAAAAAACGTAAC
CGCAGGTGCAAACCCTATGTCTCTCAAAAAAGGAATCGACAAAGCGGTTACCGCAGCAGTGGAAAGTATCCAAAAAAGAG
CGGTTAAAATAGAAAACAAAAAAGACATTGCAAACGTTGCTAGTATTTCAGCTAACAACGATAATACGATTGGAAATCTG
ATCGCAGACGCAATGGACAAAGTTGGAAAAGACGGAGTGATCACCGTAGAAGAAGCAAAATCCATCGAAACAACTTTAGA
CGTTGTAGAAGGAATGCAATTCGATAGAGGTTATATTTCTCCTTACATGGTAACTGACGCAGAATCCATGGTAGCGACTC
TAAATGATCCTTTCATATTGATCTACGACAAAAAGATCTCTTCTATGAAAGATCTGATCCATATCTTAGAAAAAGTAGCT
CAAGCAGGAAAACCTCTCGTGATCATCTCCGAAGAAGTGGAAGGAGAAGCACTCGCAACTATCGTTGTCAATACTCTCAG
AAAAACCATTTCTTGTGTTGCGGTTAAAGCTCCAGGTTTTGGAGATAGAAGAAAATCAATGCTTGAAGACATTGCGATTC
TAACAGGTGGCCAAGTGATTTCTGAAGATTTAGGAATGAAACTAGAAAACACAACTCTTCAAATGTTGGGCCGCGCAAAT
AAAGTGACCGTTGATAAAGAAAACACTACGATCATCGAAGGCAAAGGTCAAACAAAAGAGATCCAAGGAAGAATCGGTCA
AATCAAAAAACAAATCGAAGACACAACTTCCGAATATGATAGAGAAAAACTACAAGAAAGACTCGCTAAACTTGCAGGTG
GTGTTGCCGTAATCCACGTAGGTGCAGCTACCGAAGTAGAAATGAAAGAGAAAAAAGCTCGAGTAGAAGACGCTCTTTCT
GCAACCCGTGCGGCTGTAGAAGAAGGAATCGTTCCAGGTGGTGGACTCACTCTTCTCAAAGCACAAGAAGCGGTAGGCTC
TCTCAAACTGGATGGAGACGAGGCGACTGGAGCAAAAATCATTTTTAGAGCTTTAGAAGAACCGATTCGTATGATTACTT
CAAACGCTGGTTTAGAAGGTTCCGTAATTGTGGAACACGCAAAGGCTAAAAAAGGAAACGAAGGATTTAACGCACTCACT
ATGGTTTGGGAAGATATGATCCAAGCCGGAGTTGTAGATCCTGCAAAAGTAGTTCGTTCTGCACTTCAAAATGCGGCTTC
TATCGGTTCTATGATTTTAACCACAGAAGTTACAATCACAGACAAACCAGATAAAGACGCTCCAAACCCGATGGCGGGAA
TGGGCGGAGGCGGTATGGGAGGAATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
AGTATTCCGGAACTGAAATCAAATCAGAAGGCAAAGAATATCTAATCATCCGTGAAAGCGATATTCTGGCCGTAGTTAAA
AAATAATCAGGAGTTAAATC

Downstream 100 bases:

>100_bases
TTCATCCGAACTTTCTTTTCCAATCGCAAAAGGCGGCGGAGGTTTTCCTCTACCGCCTTTTTTTGTAGGCAATAAATGGA
TCCTAAAAAATCATTCACAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIELEDPLENMGAQMVKEVSTKT
NDVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKKGIDKAVTAAVESIQKRAVKIENKKDIANVASISANNDNTIGNL
IADAMDKVGKDGVITVEEAKSIETTLDVVEGMQFDRGYISPYMVTDAESMVATLNDPFILIYDKKISSMKDLIHILEKVA
QAGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKSMLEDIAILTGGQVISEDLGMKLENTTLQMLGRAN
KVTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYDREKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALS
ATRAAVEEGIVPGGGLTLLKAQEAVGSLKLDGDEATGAKIIFRALEEPIRMITSNAGLEGSVIVEHAKAKKGNEGFNALT
MVWEDMIQAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPDKDAPNPMAGMGGGGMGGMGGMM

Sequences:

>Translated_546_residues
MAKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIELEDPLENMGAQMVKEVSTKT
NDVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKKGIDKAVTAAVESIQKRAVKIENKKDIANVASISANNDNTIGNL
IADAMDKVGKDGVITVEEAKSIETTLDVVEGMQFDRGYISPYMVTDAESMVATLNDPFILIYDKKISSMKDLIHILEKVA
QAGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKSMLEDIAILTGGQVISEDLGMKLENTTLQMLGRAN
KVTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYDREKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALS
ATRAAVEEGIVPGGGLTLLKAQEAVGSLKLDGDEATGAKIIFRALEEPIRMITSNAGLEGSVIVEHAKAKKGNEGFNALT
MVWEDMIQAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPDKDAPNPMAGMGGGGMGGMGGMM
>Mature_545_residues
AKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIELEDPLENMGAQMVKEVSTKTN
DVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKKGIDKAVTAAVESIQKRAVKIENKKDIANVASISANNDNTIGNLI
ADAMDKVGKDGVITVEEAKSIETTLDVVEGMQFDRGYISPYMVTDAESMVATLNDPFILIYDKKISSMKDLIHILEKVAQ
AGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKSMLEDIAILTGGQVISEDLGMKLENTTLQMLGRANK
VTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYDREKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALSA
TRAAVEEGIVPGGGLTLLKAQEAVGSLKLDGDEATGAKIIFRALEEPIRMITSNAGLEGSVIVEHAKAKKGNEGFNALTM
VWEDMIQAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPDKDAPNPMAGMGGGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=47.7443609022556, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=47.7443609022556, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI38455427, Length=134, Percent_Identity=31.3432835820896, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=62.1928166351607, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=46.7924528301887, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=47.39336492891, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147750, Length=555, Percent_Identity=23.4234234234234, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17564182, Length=582, Percent_Identity=21.1340206185567, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50.5725190839695, Blast_Score=509, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322350, Length=560, Percent_Identity=23.75, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=582, Percent_Identity=21.8213058419244, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=47.9166666666667, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=47.9166666666667, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=45.2290076335878, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=45.2290076335878, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=45.2290076335878, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=39.4213381555154, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=34.0264650283554, Blast_Score=295, Evalue=7e-80,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=34.0264650283554, Blast_Score=295, Evalue=7e-80,
Organism=Drosophila melanogaster, GI28571140, Length=569, Percent_Identity=24.780316344464, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18858175, Length=569, Percent_Identity=24.780316344464, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57943; Mature: 57811

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECC
LEDPLENMGAQMVKEVSTKTNDVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKKGID
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVTAAVESIQKRAVKIENKKDIANVASISANNDNTIGNLIADAMDKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
SIETTLDVVEGMQFDRGYISPYMVTDAESMVATLNDPFILIYDKKISSMKDLIHILEKVA
HHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
QAGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKSMLEDIAILTGGQVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCHHH
SEDLGMKLENTTLQMLGRANKVTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYD
HHHHCCEECHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
REKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALSATRAAVEEGIVPGGGLTLLK
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AQEAVGSLKLDGDEATGAKIIFRALEEPIRMITSNAGLEGSVIVEHAKAKKGNEGFNALT
EHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCHHHHH
MVWEDMIQAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPDKDAPNPMAGMGGGGMG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AKDIEYNETARRKLLEGVNKLANAVKVTLGPKGRNVVIDKKFGAPTITKDGVTVAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECC
LEDPLENMGAQMVKEVSTKTNDVAGDGTTTATILAQSIINEGLKNVTAGANPMSLKKGID
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVTAAVESIQKRAVKIENKKDIANVASISANNDNTIGNLIADAMDKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHH
SIETTLDVVEGMQFDRGYISPYMVTDAESMVATLNDPFILIYDKKISSMKDLIHILEKVA
HHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHH
QAGKPLVIISEEVEGEALATIVVNTLRKTISCVAVKAPGFGDRRKSMLEDIAILTGGQVI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCHHH
SEDLGMKLENTTLQMLGRANKVTVDKENTTIIEGKGQTKEIQGRIGQIKKQIEDTTSEYD
HHHHCCEECHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
REKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALSATRAAVEEGIVPGGGLTLLK
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AQEAVGSLKLDGDEATGAKIIFRALEEPIRMITSNAGLEGSVIVEHAKAKKGNEGFNALT
EHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCHHHHH
MVWEDMIQAGVVDPAKVVRSALQNAASIGSMILTTEVTITDKPDKDAPNPMAGMGGGGMG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA